KEGG    Network variation - Shigella
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ENTRYnt06182
NameShigella
CategoryDisease view; Bacterial infection
Pathwayhsa05131 Shigellosis
DiseaseH00299 Shigellosis
Display drug-target relation   disease type
TNF signaling
N00151    TNFTNFRSF1A(RIPK1+TRADD+TRAF2..(TAB1/2/3+TAK1)IKKNFKBIANFKB
N00944    OspIUBC13TRAF2
N00945    IpaH1.4/2.5RFN31RIPK1
N00927        NleE(TAB2/3)
N00942          OspG(UBE2D2+(RBX1+CUL1..NFKBIA
N00943              IpaH4.5RELA
 
Autophagy
N00156    LC3ATG4ATG7ATG3(ATG12+ATG5+ATG16L..LC3-II
N01284        IcsPC3=ATG16L
 
TLR signaling
N00438    (TLR2,TLR4)(TIRAP+MYD88)(IRAK4+IRAK1)(TRAF6+TAK1+TAB2)(MEK,MKK3/6,MKK4/7..(ERK,p38,JNK)AP1
N01283            OspF(ERK,p38)
 
NLR signaling
N00940    (NOD1,NOD2)RIPK2IKKNFKBIANFKB
N00941      (IpaH9.8+TNIP1)IKBKG
N00742        (NLRP3+PYCARD)CASP1(IL1B,IL18,IL33)
N00948    IpaH7.8GLMN(NLRP3+PYCARD)CASP1IL1B
N00867        (NLRC4+PYCARD)CASP1(IL1B,IL18)
N00949    IpaBK+(NLRC4+PYCARD)CASP1IL1B
 
CGAS-STING signaling
N00395    DNACGAScGAMPSTING1TBK1IRF3(IFNA,IFNB)
N00946      IpaJARF1STING1
N00947          Ipa4.5TBK1
 
Cytoskeletal regulation
N01072    FN1(ITGA+ITGB)PTK2ARHGEF28RHOA
N01074          IpaARHOAROCK1/2MLC
N01073          IpgB2RHOA
N01075          IcsBRHOA
N01068    FN1(ITGA+ITGB)(SRC,PTK2)(PXN,CRK+BCAR1)(DOCK1+ELMO1)RAC
N01069            IpgB1RAC1
N01077            IcsBRAC1
N00952          IpgB1(DOCK1+ELMO)RAC1
N01070    FN1(ITGA+ITGB)(SRC,PTK2)PXN(GIT2+ARHGEF7)CDC42
N01071            IpgB1CDC42
N01076            IcsBCDC42
N01066            ARNOARF6ARF1(WASF+ABI1+HSPC300..ARP2/3(ACTB,ACTG1)
N01067    IpgDPI(5)PPI3KPIP3ARNOARF6ARF1(WASF+ABI1+HSPC300..ARP2/3(ACTB,ACTG1)
N01078    EGFEGFRSRCCTTNNCK(WASL+WIPF)ARP2/3(ACTB,ACTG1)
N01079      IpaCSRCCTTNARP2/3(ACTB,ACTG1)
N01080    FN1(ITGA+ITGB)(PTK2+PXN+ILK)(TLN+ACTN1/4+VCN)(ACTB,ACTG1)
N01081    (IpaB+IpaC,IpaD)(ITGA5+ITGB1)(PTK2+PXN)(TLN+VCN)(ACTB,ACTG1)
N01083      OspE(PTK2+PXN+ILK)
N01082        IpaA(ACTN1/4+VCN)