KEGG   PATHWAY: acat04510
Entry
acat04510                   Pathway                                
Name
Focal adhesion - Aquarana catesbeiana (American bullfrog)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
acat04510  Focal adhesion
acat04510

Other DBs
GO: 0005925
Organism
Aquarana catesbeiana (American bullfrog) [GN:acat]
Gene
141101732  [KO:K04392]
141101733  [KO:K04392]
141101734  [KO:K04392]
141101826  EMP2; epithelial membrane protein 2 [KO:K26256]
141102385  CAV3; caveolin-3 [KO:K12959]
141102739  RHOA; transforming protein RhoA [KO:K04513]
141102796  [KO:K06243]
141102797  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
141103058  FLNB; filamin-B isoform X1 [KO:K27392]
141103121  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
141103166  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
141103206  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
141103289  EMP1; epithelial membrane protein 1 [KO:K26255]
141103421  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
141103596  LAMC1; laminin subunit gamma-1 [KO:K05635]
141103597  LAMC2; laminin subunit gamma-2 [KO:K06246]
141103617  TNR; tenascin-R [KO:K06252]
141103620  TNN; tenascin-N [KO:K06252]
141103837  JUN; transcription factor Jun [KO:K04448]
141103897  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
141103997  SHC2; SHC-transforming protein 2 [KO:K17447]
141104680  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
141105693  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
141105806  ZYX; zyxin isoform X1 [KO:K06273]
141105914  COMP; cartilage oligomeric matrix protein [KO:K04659]
141106014  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
141106209  VCL; vinculin isoform X1 [KO:K05700]
141106367  [KO:K04440] [EC:2.7.11.24]
141107381  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
141107566  TNXB; tenascin-X [KO:K06252]
141107629  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
141107755  [KO:K03853] [EC:3.4.22.53]
141107784  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
141107793  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
141108110  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
141108121  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
141108122  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
141108139  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
141108162  [KO:K05096] [EC:2.7.10.1]
141108206  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
141108210  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
141108294  [KO:K04513]
141108346  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
141108462  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
141108513  ITGAV; integrin alpha-V [KO:K06487]
141108551  FLNA; filamin-A isoform X1 [KO:K04437]
141108569  [KO:K12958]
141108570  [KO:K12959]
141108676  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
141108770  TNC; tenascin isoform X1 [KO:K06252]
141109558  IBSP; integrin-binding sialoprotein isoform X1 [KO:K06253]
141110037  [KO:K04503]
141110782  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
141110934  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
141110985  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
141111241  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
141111334  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
141111875  PARVA; alpha-parvin isoform X1 [KO:K06275]
141111981  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
141112118  [KO:K06270]
141112268  HRAS; GTPase HRas [KO:K02833]
141112482  BAD; bcl2-associated agonist of cell death [KO:K02158]
141112524  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
141112676  PDGFC; platelet-derived growth factor C [KO:K05450]
141112758  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
141113355  [KO:K06525]
141113433  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
141113437  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
141113512  CHAD; chondroadherin [KO:K06248]
141113534  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
141113547  VEGFC; vascular endothelial growth factor C [KO:K05449]
141113637  ACTG1; actin, cytoplasmic 2 [KO:K05692]
141113950  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
141114036  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
141114057  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
141114148  ITGB3; integrin beta-3 [KO:K06493]
141114169  [KO:K06476]
141114170  [KO:K06476]
141114175  [KO:K06476]
141114176  [KO:K06476]
141114197  [KO:K00907] [EC:2.7.11.18]
141114202  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
141114219  COL1A1; collagen alpha-1(I) chain [KO:K06236]
141114265  [KO:K02677] [EC:2.7.11.13]
141114430  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
141114452  ITGB4; integrin beta-4 [KO:K06525]
141114465  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
141114970  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
141115002  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
141116415  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
141116428  SHC1; LOW QUALITY PROTEIN: SHC-transforming protein 1 [KO:K06279]
141116455  THBS3; thrombospondin-3 [KO:K04659]
141116860  ITGA10; integrin alpha-10 [KO:K06586]
141116864  THBS1; thrombospondin-1 [KO:K16857]
141116929  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
141116983  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
141117244  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
141117660  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
141117779  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
141124064  TLN1; talin-1 isoform X1 [KO:K06271]
141126735  ILK; scaffold protein ILK [KO:K06272] [EC:2.7.11.1]
141126824  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
141126976  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
141126996  PDGFD; platelet-derived growth factor D [KO:K05450]
141127159  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
141127281  ITGB7; integrin beta-7 [KO:K06590]
141127321  ITGA5; integrin alpha-5 [KO:K06484]
141127337  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
141127382  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
141127502  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
141127744  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
141127745  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
141128186  VAV1; proto-oncogene vav [KO:K05730]
141128242  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
141128436  RHOC; rho-related GTP-binding protein RhoC [KO:K04513]
141128449  RAP1A; ras-related protein Rap-1A [KO:K04353]
141128464  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
141128608  [KO:K12329]
141128942  VTN; vitronectin [KO:K06251]
141128976  CRK; adapter molecule crk isoform X1 [KO:K04438]
141129127  VEGFD; vascular endothelial growth factor D [KO:K05449]
141129467  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
141130007  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
141130061  MYL10; myosin regulatory light chain 10 [KO:K12756]
141131197  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
141131215  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
141131231  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
141131277  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
141131418  SHC4; SHC-transforming protein 4 [KO:K17449]
141131626  TLN2; talin-2 isoform X1 [KO:K06271]
141131833  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
141131860  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
141131887  LAMB1; laminin subunit beta-1 [KO:K05636]
141131888  LAMB4; laminin subunit beta-4 [KO:K06245]
141131968  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
141131970  CAV1; caveolin-1 isoform X1 [KO:K06278]
141131971  CAV2; caveolin-2 [KO:K12958]
141132034  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
141132079  RAP1B; ras-related protein Rap-1b [KO:K07836]
141132197  IGF1; insulin-like growth factor 1 [KO:K05459]
141132489  [KO:K05740]
141132525  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
141132533  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
141132638  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
141132658  VWF; von Willebrand factor [KO:K03900]
141132888  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
141132933  PARVG; gamma-parvin [KO:K06275]
141132934  PARVB; beta-parvin isoform X1 [KO:K06275]
141133129  ITGA1; LOW QUALITY PROTEIN: integrin alpha-1 [KO:K06480]
141133137  ITGA2; integrin alpha-2 [KO:K06481]
141133751  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
141134665  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
141139353  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
141139470  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
141139587  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
141139779  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
141139800  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
141140023  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
141140198  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
141140202  LAMA4; laminin subunit alpha-4 [KO:K06241]
141140270  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
141140457  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
141140549  THBS2; thrombospondin-2 [KO:K04659]
141140828  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
141141005  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
141141045  VEGFA; vascular endothelial growth factor A, long form isoform X1 [KO:K05448]
141141085  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
141141353  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
141141954  CRKL; crk-like protein [KO:K04438]
141143274  PXN; paxillin [KO:K05760]
141144171  COL1A2; collagen alpha-2(I) chain [KO:K06236]
141144217  ITGA8; integrin alpha-8 [KO:K06584]
141144314  [KO:K05719]
141144315  [KO:K05719]
141144316  [KO:K05719]
141144317  [KO:K05719]
141144401  ITGB8; integrin beta-8 [KO:K06591]
141144549  [KO:K06238]
141144550  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
141144584  CTNNB1; catenin beta-1 [KO:K02105]
141144607  [KO:K04361] [EC:2.7.10.1]
141144666  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
141144850  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
141144870  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
141145072  LAMA1; laminin subunit alpha-1 [KO:K05637]
141145083  [KO:K12757]
141145100  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
141145117  LAMA3; laminin subunit alpha-3 [KO:K06240]
141145535  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
141146354  SHC3; SHC-transforming protein 3 [KO:K17448]
141146683  ACTB; actin, cytoplasmic 1 [KO:K05692]
141146867  FN1; fibronectin isoform X1 [KO:K05717]
141146877  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
141146917  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
141146920  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
141146937  ITGA4; integrin alpha-4 [KO:K06483]
141146989  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
141147056  ITGB6; integrin beta-6 [KO:K06589]
141147279  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
141147290  [KO:K06588]
141147509  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
141148118  MYL11; myosin regulatory light chain 11 [KO:K12758]
141148611  [KO:K06269] [EC:3.1.3.16]
141148777  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
141148912  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
141148944  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
acat04010  MAPK signaling pathway
acat04060  Cytokine-cytokine receptor interaction
acat04070  Phosphatidylinositol signaling system
acat04110  Cell cycle
acat04310  Wnt signaling pathway
acat04512  ECM-receptor interaction
acat04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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