KEGG   PATHWAY: caty04510
Entry
caty04510                   Pathway                                
Name
Focal adhesion - Cercocebus atys (sooty mangabey)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
caty04510  Focal adhesion
caty04510

Other DBs
GO: 0005925
Organism
Cercocebus atys (sooty mangabey) [GN:caty]
Gene
105571321  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105571434  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
105571720  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
105571784  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
105571986  [KO:K04393]
105572159  EMP2; epithelial membrane protein 2 [KO:K26256]
105572413  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
105572960  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
105572979  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
105573192  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
105573290  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
105573305  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
105573406  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
105573682  LAMB2; laminin subunit beta-2 [KO:K06243]
105573691  RHOA; transforming protein RhoA [KO:K04513]
105573861  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
105573915  ITGA9; integrin alpha-9 [KO:K06585]
105574099  TNXB; tenascin-X isoform X1 [KO:K06252]
105574105  [KO:K06252]
105574152  THBS1; thrombospondin-1 [KO:K16857]
105574159  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
105574688  FIGF; vascular endothelial growth factor D [KO:K05449]
105574942  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105574978  [KO:K05692]
105575040  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
105575136  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
105575556  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
105575559  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
105575564  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
105575821  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
105576036  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
105576169  LAMC3; laminin subunit gamma-3 [KO:K06247]
105576753  SPP1; osteopontin isoform X1 [KO:K06250]
105576757  IBSP; bone sialoprotein 2 [KO:K06253]
105576775  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105576962  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
105577076  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
105577198  HRAS; GTPase HRas isoform X1 [KO:K02833]
105577306  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
105577361  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
105577493  BAD; bcl2-associated agonist of cell death [KO:K02158]
105577498  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
105577720  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
105577731  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105578039  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
105578227  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
105578338  [KO:K06238]
105578364  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
105578365  COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
105578430  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
105578625  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
105578700  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
105579298  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
105579435  CHAD; chondroadherin [KO:K06248]
105579443  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
105579450  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
105579553  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
105579809  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
105579895  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
105579920  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
105580156  FN1; fibronectin isoform X1 [KO:K05717]
105580236  ITGA5; integrin alpha-5 [KO:K06484]
105580281  LAMC1; LOW QUALITY PROTEIN: laminin subunit gamma-1 [KO:K05635]
105580282  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
105580283  LAMC2; laminin subunit gamma-2 [KO:K06246]
105580434  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
105580524  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
105580892  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105581076  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
105581292  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105581387  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
105581392  LAMA4; laminin subunit alpha-4 [KO:K06241]
105582086  PAK7; serine/threonine-protein kinase PAK 7 isoform X1 [KO:K05736] [EC:2.7.11.1]
105582238  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
105582343  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
105582359  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
105582740  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
105582877  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
105582988  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
105583007  VWF; von Willebrand factor [KO:K03900]
105583130  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
105583134  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
105583175  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
105583213  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105583846  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
105583909  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
105583964  [KO:K12757]
105583966  [KO:K12757]
105583987  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
105584145  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
105584282  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
105584307  CRK; adapter molecule crk isoform X1 [KO:K04438]
105584356  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105584651  ZYX; zyxin isoform X1 [KO:K06273]
105584909  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
105584910  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
105585128  EMP1; epithelial membrane protein 1 [KO:K26255]
105585282  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
105585292  [KO:K06279]
105585293  [KO:K06279]
105585509  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
105585619  FLNB; filamin-B isoform X1 [KO:K27392]
105585740  CAV3; caveolin-3 [KO:K12959]
105585803  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105586076  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105586304  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
105586383  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105586728  SOS2; son of sevenless homolog 2 [KO:K03099]
105586970  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
105586971  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
105587171  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105587332  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
105588205  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
105588248  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
105588269  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105588572  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
105588610  ACTG1; actin, cytoplasmic 2 [KO:K05692]
105588762  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105589176  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
105589245  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
105589534  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
105589671  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105589738  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105589789  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
105589795  ITGB5; integrin beta-5 [KO:K06588]
105589876  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
105590006  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
105590224  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
105590417  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105590424  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
105590499  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
105590709  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105590861  PGF; placenta growth factor isoform X1 [KO:K16859]
105590933  PXN; paxillin isoform X1 [KO:K05760]
105591186  BIRC8; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 8 [KO:K04725] [EC:2.3.2.27]
105591224  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
105591400  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
105591401  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
105591436  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105591516  VTN; vitronectin [KO:K06251]
105591788  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
105591815  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
105591875  VAV1; proto-oncogene vav [KO:K05730]
105591876  SHC2; LOW QUALITY PROTEIN: SHC-transforming protein 2 [KO:K17447]
105591984  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
105592013  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105592183  COL1A2; collagen alpha-2(I) chain [KO:K06236]
105592248  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
105592375  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
105592376  LAMA5; laminin subunit alpha-5 [KO:K06240]
105592859  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
105593398  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
105593504  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
105593526  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
105594004  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
105594162  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
105594236  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
105594391  RAP1A; ras-related protein Rap-1A [KO:K04353]
105594457  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
105594576  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105594700  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
105595026  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105595149  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
105595194  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
105595654  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105595706  PARVA; alpha-parvin isoform X1 [KO:K06275]
105595973  JUN; transcription factor AP-1 [KO:K04448]
105596420  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
105596769  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105596911  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
105597013  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
105597064  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105597205  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105597348  VCL; vinculin isoform X1 [KO:K05700]
105597502  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
105597588  TNR; tenascin-R isoform X1 [KO:K06252]
105597592  TNN; tenascin-N [KO:K06252]
105597716  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105597772  VEGFC; vascular endothelial growth factor C [KO:K05449]
105597890  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105597977  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105598094  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
105598098  ITGA1; LOW QUALITY PROTEIN: integrin alpha-1 [KO:K06480]
105598149  TLN1; talin-1 [KO:K06271]
105598233  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105598246  CRKL; crk-like protein [KO:K04438]
105598301  PARVG; gamma-parvin isoform X1 [KO:K06275]
105598302  PARVB; beta-parvin isoform X1 [KO:K06275]
105598339  ACTB; actin, cytoplasmic 1 [KO:K05692]
105598444  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
105598464  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
105598472  CAV2; caveolin-2 isoform X1 [KO:K12958]
105598475  CAV1; caveolin-1 isoform X1 [KO:K06278]
105598476  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105598710  FLNA; filamin-A isoform X1 [KO:K04437]
105598850  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105599117  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
105599262  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105599275  THBS4; thrombospondin-4 [KO:K04659]
105599331  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105599931  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
105600471  LAMA2; LOW QUALITY PROTEIN: laminin subunit alpha-2 [KO:K05637]
105600503  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
105600508  TNC; tenascin isoform X1 [KO:K06252]
105600967  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
105601056  TLN2; talin-2 isoform X1 [KO:K06271]
105601165  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105601714  COMP; cartilage oligomeric matrix protein [KO:K04659]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
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J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
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Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
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Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
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Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
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Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
caty04010  MAPK signaling pathway
caty04060  Cytokine-cytokine receptor interaction
caty04070  Phosphatidylinositol signaling system
caty04110  Cell cycle
caty04151  PI3K-Akt signaling pathway
caty04310  Wnt signaling pathway
caty04512  ECM-receptor interaction
caty04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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