KEGG   PATHWAY: caty04810
Entry
caty04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Cercocebus atys (sooty mangabey)
Class
Cellular Processes; Cell motility
Pathway map
caty04810  Regulation of actin cytoskeleton
caty04810

Other DBs
GO: 0030036
Organism
Cercocebus atys (sooty mangabey) [GN:caty]
Gene
105595544  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
105601742  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
105596153  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
105583023  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
105571555  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
105590357  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
105592805  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
105599189  F2R; proteinase-activated receptor 1 [KO:K03914]
105577261  INS; insulin [KO:K04526]
105571434  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
105599949  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
105595795  FGF2; fibroblast growth factor 2 [KO:K18497]
105577303  FGF3; fibroblast growth factor 3 [KO:K04358]
105577304  FGF4; fibroblast growth factor 4 [KO:K04358]
105601381  FGF20; fibroblast growth factor 20 [KO:K04358]
105579245  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105588213  FGF7; fibroblast growth factor 7 [KO:K04358]
105581649  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
105581863  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
105581939  FGF16; fibroblast growth factor 16 [KO:K04358]
105583515  FGF10; fibroblast growth factor 10 [KO:K04358]
105591678  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
105591918  FGF9; fibroblast growth factor 9 [KO:K04358]
105576825  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
105577305  FGF19; fibroblast growth factor 19 [KO:K22603]
105595256  FGF21; fibroblast growth factor 21 [KO:K22429]
105582993  FGF23; fibroblast growth factor 23 [KO:K22428]
105571784  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
105572960  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
105588762  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105597890  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105594538  INSRR; insulin receptor-related protein isoform X1 [KO:K05086] [EC:2.7.10.1]
105588269  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105590801  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105577985  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105585485  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105581716  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
105592013  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105589876  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
105580156  FN1; fibronectin isoform X1 [KO:K05717]
105598098  ITGA1; LOW QUALITY PROTEIN: integrin alpha-1 [KO:K06480]
105598094  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
105585282  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
105579450  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
105579895  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
105580236  ITGA5; integrin alpha-5 [KO:K06484]
105579809  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
105587332  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
105583846  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
105573915  ITGA9; integrin alpha-9 [KO:K06585]
105592859  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
105600967  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
105579920  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
105599804  ITGAL; LOW QUALITY PROTEIN: integrin alpha-L [KO:K05718]
105599606  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
105599647  ITGAX; integrin alpha-X [KO:K06462]
105599624  ITGAD; integrin alpha-D isoform X1 [KO:K06594]
105584616  ITGAE; LOW QUALITY PROTEIN: integrin alpha-E [KO:K06524]
105597013  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
105575545  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
105590709  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105577720  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
105589795  ITGB5; integrin beta-5 [KO:K06588]
105576036  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
105580282  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
105589534  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
105575221  KNG1; kininogen-1 isoform X1 [KO:K03898]
105596657  BDKRB1; B1 bradykinin receptor [KO:K03915]
105596655  BDKRB2; B2 bradykinin receptor [KO:K03916]
105577528  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
105589633  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
105574914  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
105592796  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
105600623  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
105601300  C5; complement C5 [KO:K03994]
105583474  C6; complement component C6 isoform X1 [KO:K03995]
105583469  C7; complement component C7 [KO:K03996]
105595981  C8A; complement component C8 alpha chain [KO:K03997]
105595979  C8B; complement component C8 beta chain isoform X1 [KO:K03998]
105580594  C8G; complement component C8 gamma chain [KO:K03999]
105583454  C9; complement component C9 [KO:K04000]
105571739  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
105573047  GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
105601524  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
105595886  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
105598634  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
105578810  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
105581292  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105572979  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
105598246  CRKL; crk-like protein [KO:K04438]
105584307  CRK; adapter molecule crk isoform X1 [KO:K04438]
105578039  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
105582359  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
105586728  SOS2; son of sevenless homolog 2 [KO:K03099]
105597205  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105577198  HRAS; GTPase HRas isoform X1 [KO:K02833]
105585038  KRAS; GTPase KRas isoform X1 [KO:K07827]
105596344  NRAS; GTPase NRas isoform X1 [KO:K07828]
105595298  RRAS; ras-related protein R-Ras [KO:K07829]
105595718  RRAS2; ras-related protein R-Ras2 [KO:K07830]
105586388  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
105592682  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
105586383  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105580892  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105597716  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105571321  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105594576  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105599262  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105580524  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
105588248  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
105591875  VAV1; proto-oncogene vav [KO:K05730]
105575576  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
105590503  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
105589671  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105585803  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105592155  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
105601165  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105591800  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
105598233  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105598850  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105596769  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105597977  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105574942  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105587819  RGCC; regulator of cell cycle RGCC [KO:K26108]
105598037  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
105582525  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
105595194  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
105573691  RHOA; transforming protein RhoA [KO:K04513]
105584356  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105575821  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
105588572  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
105595026  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105571986  cell division control protein 42 homolog [KO:K04393]
105578700  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
105575136  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
105598444  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
105594236  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
105582086  PAK7; serine/threonine-protein kinase PAK 7 isoform X1 [KO:K05736] [EC:2.7.11.1]
105574159  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
105584922  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
105591551  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
105583987  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
105578625  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
105589245  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
105596420  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
105589789  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
105582238  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
105577361  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
105578430  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
105573406  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
105581076  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
105575564  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
105582740  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
105573192  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
105585509  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
105596911  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
105582343  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
105593398  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
105583964  myosin regulatory light chain 12B [KO:K12757]
105583966  myosin regulatory light chain 12A isoform X1 [KO:K12757]
105599117  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
105572211  MYH11; myosin-11 isoform X1 [KO:K10352]
105595453  MYH14; LOW QUALITY PROTEIN: myosin-14 [KO:K10352]
105581811  MYH10; myosin-10 isoform X1 [KO:K10352]
105575799  MYH9; myosin-9 [KO:K10352]
105599931  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
105592066  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
105594911  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
105590224  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
105584145  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
105591788  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
105579530  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
105587346  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
105583793  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
105580121  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
105593347  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
105575749  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
105587361  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
105588619  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
105576944  ENAH; protein enabled homolog isoform X1 [KO:K05746]
105598511  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
105594901  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
105592980  CYFIP1; LOW QUALITY PROTEIN: cytoplasmic FMR1-interacting protein 1 [KO:K05749]
105581560  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
105579906  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
105580471  NCKAP1L; nck-associated protein 1-like [KO:K05750]
105580069  ABI2; abl interactor 2 isoform X1 [KO:K05751]
105585774  BRK1; protein BRICK1 [KO:K05752]
105581361  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
105576480  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
105584768  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
105590323  ACTR3; actin-related protein 3 [KO:K18584]
105584379  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
105584380  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
105587073  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
105573201  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
105580226  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
105576287  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
105577106  LOW QUALITY PROTEIN: actin, alpha skeletal muscle-like [KO:K05692]
105588610  ACTG1; actin, cytoplasmic 2 [KO:K05692]
105574978  LOW QUALITY PROTEIN: actin-like [KO:K05692]
105598339  ACTB; actin, cytoplasmic 1 [KO:K05692]
105578536  PFN4; profilin-4 [KO:K05759]
105581725  PFN3; profilin-3 [KO:K05759]
105597363  PFN2; profilin-2 isoform X1 [KO:K05759]
105583310  PFN1; profilin-1 [KO:K05759]
105590933  PXN; paxillin isoform X1 [KO:K05760]
105588897  EZR; ezrin isoform X1 [KO:K08007]
105588719  RDX; radixin isoform X1 [KO:K05762]
105586167  MSN; moesin isoform X1 [KO:K05763]
105574712  TMSB4X; thymosin beta-4 [KO:K05764]
105592075  uncharacterized protein LOC105592075 [KO:K05764]
105599937  cofilin-2 [KO:K05765]
105577423  CFL1; cofilin-1 isoform X1 [KO:K05765]
105589114  CFL2; LOW QUALITY PROTEIN: cofilin-2 [KO:K05765]
105577362  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
105573230  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
105591555  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
105597348  VCL; vinculin isoform X1 [KO:K05700]
105601189  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
105594521  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
105599191  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
105600161  GSN; gelsolin isoform X1 [KO:K05768]
105589600  SCIN; adseverin [KO:K05768]
105594457  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
105582877  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
105590693  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
105591719  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
105600113  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
105591904  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
caty04010  MAPK signaling pathway
caty04510  Focal adhesion
caty04520  Adherens junction
KO pathway
ko04810   
LinkDB

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