Entry
Name
Cytokine-cytokine receptor interaction - Cercocebus atys (sooty mangabey)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
caty04060 Cytokine-cytokine receptor interaction
Organism
Cercocebus atys (sooty mangabey) [GN:
caty ]
Gene
105572057 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
105572438 TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X1 [KO:K05142 ]
105572439 TNFRSF18; tumor necrosis factor receptor superfamily member 18 isoform X1 [KO:K05154 ]
105574782 IL3RA; LOW QUALITY PROTEIN: interleukin-3 receptor subunit alpha [KO:K04737 ]
105575191 IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
105575377 IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135 ]
105575809 CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738 ]
105575817 IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
105577359 CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421 ]
105578773 RELT; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156 ]
105579211 TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722 ]
105579213 TNFRSF10D; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 10D [KO:K22702 ]
105579216 TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722 ]
105579277 TNFRSF10C; tumor necrosis factor receptor superfamily member 10C [KO:K22701 ]
105579459 NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583 ]
105579566 CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423 ]
105580845 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141 ]
105580846 TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145 ]
105580916 TNFRSF9; tumor necrosis factor receptor superfamily member 9 isoform X1 [KO:K05146 ]
105580936 TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160 ]
105583011 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
105583012 LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159 ]
105583450 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
105583740 IL1RL2; LOW QUALITY PROTEIN: interleukin-1 receptor-like 2 [KO:K05172 ]
105584542 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
105584897 TNFSF13B; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476 ]
105585716 IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067 ]
105586081 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
105586158 EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163 ]
105586401 IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137 ]
105587157 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
105587810 TNFSF11; tumor necrosis factor ligand superfamily member 11 isoform X1 [KO:K05473 ]
105588507 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
105589999 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147 ]
105590039 GALT; galactose-1-phosphate uridylyltransferase isoform X1 [KO:K05056 ]
105590054 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
105590318 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066 ]
105590724 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
105591115 IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
105591162 EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162 ]
105591866 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
105591870 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
105591906 TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155 ]
105592307 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
105594352 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
105594458 TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
105594754 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
105597428 IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068 ]
105597557 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
105597559 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
105597561 TNFSF4; tumor necrosis factor ligand superfamily member 4 isoform X1 [KO:K05469 ]
105598222 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
105598400 IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076 ]
105599627 IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630 ]
105599628 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
105599730 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
105600396 IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136 ]
105600556 TNFSF8; tumor necrosis factor ligand superfamily member 8 isoform X1 [KO:K05471 ]
105600578 TNFSF15; tumor necrosis factor ligand superfamily member 15 isoform X1 [KO:K05478 ]
105601574 IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598 ]
105601688 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway