KEGG   PATHWAY: dnm05165
Entry
dnm05165                    Pathway                                
Name
Human papillomavirus infection - Dasypus novemcinctus (nine-banded armadillo)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
dnm05165  Human papillomavirus infection
dnm05165

Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:dnm]
Gene
100913180  VWF; von Willebrand factor precursor [KO:K03900]
101410694  [KO:K03456]
101410920  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
101410923  IFNB1; interferon beta [KO:K05415]
101411009  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101411165  [KO:K06751]
101411174  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
101411204  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101411225  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
101411446  [KO:K21098]
101411454  [KO:K06751]
101411457  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
101411463  AXIN1; axin-1 [KO:K02157]
101411471  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
101411552  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101411644  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
101411831  [KO:K06751]
101411890  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101411992  [KO:K03120]
101412070  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
101412139  [KO:K06751]
101412233  KRAS; GTPase KRas isoform X4 [KO:K07827]
101412377  FOXO1; forkhead box protein O1 [KO:K07201]
101412391  WNT9A; LOW QUALITY PROTEIN: protein Wnt-9a [KO:K01064]
101412468  [KO:K06751]
101412476  AXIN2; axin-2 isoform X1 [KO:K04385]
101412608  [KO:K06751]
101412902  [KO:K06751]
101413115  TCIRG1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
101413159  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
101413233  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
101413281  TSC2; tuberin [KO:K07207]
101413304  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
101413382  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4 [KO:K03456]
101413670  LLGL1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
101413678  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
101413723  SPP1; osteopontin [KO:K06250]
101413764  [KO:K06751]
101413809  [KO:K04345] [EC:2.7.11.11]
101413834  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
101413935  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
101414002  TNR; tenascin-R isoform X1 [KO:K06252]
101414193  ITGA1; LOW QUALITY PROTEIN: integrin alpha-1 [KO:K06480]
101414240  [KO:K07828]
101414245  RELN; LOW QUALITY PROTEIN: reelin [KO:K06249] [EC:3.4.21.-]
101414407  BAD; bcl2-associated agonist of cell death [KO:K02158]
101414493  [KO:K06751]
101414539  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
101414637  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101414894  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
101415111  WNT16; protein Wnt-16 [KO:K01558]
101415212  [KO:K06751]
101415391  [KO:K06751]
101415427  APC; adenomatous polyposis coli protein [KO:K02085]
101415471  WNT6; protein Wnt-6 [KO:K00445]
101415698  FADD; FAS-associated death domain protein [KO:K02373]
101415823  [KO:K06751]
101415824  [KO:K06751]
101415906  TNN; tenascin-N [KO:K06252]
101415954  IRF3; interferon regulatory factor 3 [KO:K05411]
101416017  WNT3; proto-oncogene Wnt-3 [KO:K00312]
101416069  TP53; cellular tumor antigen p53 [KO:K04451]
101416079  COL2A1; collagen alpha-1(II) chain [KO:K19719]
101416305  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101416334  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
101416613  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X3 [KO:K04354]
101416622  ITGB7; LOW QUALITY PROTEIN: integrin beta-7 [KO:K06590]
101416831  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
101416957  ITGA2; LOW QUALITY PROTEIN: integrin alpha-2 [KO:K06481]
101417003  [KO:K06238]
101417330  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101417353  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101417744  CHAD; chondroadherin [KO:K06248]
101417882  NFX1; LOW QUALITY PROTEIN: transcriptional repressor NF-X1 [KO:K12236]
101417885  RELA; transcription factor p65 [KO:K04735]
101417902  TCF7L1; transcription factor 7-like 1 [KO:K04490]
101417966  FZD3; frizzled-3 [KO:K02329]
101417998  RHEB; GTP-binding protein Rheb [KO:K07208]
101418100  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
101418152  PATJ; inaD-like protein isoform X1 [KO:K06092]
101418409  HES3; transcription factor HES-3 [KO:K09088]
101418463  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101418722  VEGFA; vascular endothelial growth factor A [KO:K05448]
101418741  [KO:K06751]
101418748  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
101418767  CTNNB1; catenin beta-1 [KO:K02105]
101418836  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
101418842  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
101418868  [KO:K05414]
101418970  [KO:K02152]
101419014  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
101419022  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101419124  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
101419186  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
101419317  [KO:K05414]
101419396  WNT8A; protein Wnt-8a [KO:K00714]
101419419  [KO:K06751]
101419480  HRAS; GTPase HRas isoform X1 [KO:K02833]
101419603  MAML3; mastermind-like protein 3 isoform X1 [KO:K06061]
101419695  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
101419758  [KO:K05414]
101419767  DLG2; disks large homolog 2 [KO:K12075]
101419977  LAMA2; laminin subunit alpha-2 [KO:K05637]
101420015  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
101420176  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101420251  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
101420273  RBL1; retinoblastoma-like protein 1 isoform X2 [KO:K04681]
101420422  ITGA7; integrin alpha-7 [KO:K06583]
101420445  TNF; tumor necrosis factor [KO:K03156]
101420546  [KO:K04369] [EC:2.7.12.2]
101420557  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
101420590  LAMB2; LOW QUALITY PROTEIN: laminin subunit beta-2 [KO:K06243]
101420624  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
101420648  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101420800  [KO:K06751]
101420809  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
101420952  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
101421000  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
101421211  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101421444  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
101421532  [KO:K06751]
101421534  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101422116  FZD7; frizzled-7 [KO:K02432]
101422146  ITGA5; integrin alpha-5 [KO:K06484]
101422156  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101422200  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
101422259  [KO:K06751]
101422560  [KO:K06751]
101422608  [KO:K03120]
101422709  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
101422917  [KO:K06751]
101423342  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X4 [KO:K11643] [EC:5.6.2.-]
101423380  ITGA8; integrin alpha-8 [KO:K06584]
101423495  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
101423692  PRKACB; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101423744  [KO:K02649]
101423869  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
101423941  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101423956  LAMC1; laminin subunit gamma-1 [KO:K05635]
101424204  THBS1; thrombospondin-1 [KO:K16857]
101424334  [KO:K06751]
101424389  ITGA11; integrin alpha-11 [KO:K06587]
101424488  LLGL2; LOW QUALITY PROTEIN: lethal(2) giant larvae protein homolog 2 [KO:K06094]
101424579  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
101424631  CREB3L3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
101424781  [KO:K06751]
101424904  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
101424943  IBSP; bone sialoprotein 2 [KO:K06253]
101424995  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
101425091  ITGA3; integrin alpha-3 [KO:K06482]
101425111  [KO:K05414]
101425169  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
101425194  HES5; LOW QUALITY PROTEIN: transcription factor HES-5 [KO:K06055]
101425286  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
101425725  MAML2; mastermind-like protein 2 [KO:K06061]
101425815  ITGA4; integrin alpha-4 [KO:K06483]
101425823  WNT4; protein Wnt-4 [KO:K00408]
101425904  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
101425952  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
101426088  FZD6; frizzled-6 [KO:K02376]
101426177  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
101426255  NOTCH1; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1 [KO:K02599]
101426399  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
101426543  FZD1; frizzled-1 [KO:K02432]
101426756  [KO:K06751]
101426836  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
101426878  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
101426945  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101426982  TLR3; toll-like receptor 3 [KO:K05401]
101427017  LAMC3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
101427038  [KO:K06751]
101427325  [KO:K06751]
101427420  WNT8B; protein Wnt-8b [KO:K00714]
101427484  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
101427733  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
101427751  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101428152  [KO:K04632]
101428156  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
101428270  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
101428513  [KO:K06751]
101428578  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
101428656  ITGB1; integrin beta-1 [KO:K05719]
101428688  TYK2; LOW QUALITY PROTEIN: non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
101428728  [KO:K00572]
101428737  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101428761  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
101428799  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101428809  [KO:K06751]
101428978  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
101429184  FZD10; frizzled-10 [KO:K02842]
101429634  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
101429637  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
101429654  [KO:K02152]
101429772  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101429820  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101429916  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101430041  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
101430113  [KO:K06751]
101430252  [KO:K06751]
101430321  ITGA9; integrin alpha-9 [KO:K06585]
101430570  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101430585  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
101430613  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
101430685  WNT10B; protein Wnt-10b isoform X2 [KO:K01357]
101430782  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
101430817  NRAS; GTPase NRas [KO:K07828]
101431024  FZD4; LOW QUALITY PROTEIN: frizzled-4 [KO:K02354]
101431053  COL4A3; collagen alpha-3(IV) chain isoform X2 [KO:K06237]
101431125  WNT1; proto-oncogene Wnt-1 [KO:K03209]
101431219  UBR4; E3 ubiquitin-protein ligase UBR4 [KO:K10691] [EC:2.3.2.27]
101431300  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
101431462  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
101431702  PKM; pyruvate kinase PKM isoform X2 [KO:K00873] [EC:2.7.1.40]
101431715  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
101431819  RBPJ; recombining binding protein suppressor of hairless isoform X2 [KO:K06053]
101431862  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101431880  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
101432034  [KO:K06751]
101432154  BAX; apoptosis regulator BAX [KO:K02159]
101432213  WNT2; protein Wnt-2 precursor [KO:K00182]
101432371  THBS4; thrombospondin-4 [KO:K04659]
101432586  COL1A1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain [KO:K06236]
101432628  FN1; LOW QUALITY PROTEIN: fibronectin [KO:K05717]
101432715  HES7; transcription factor HES-7 [KO:K09087]
101432742  [KO:K06751]
101432776  JAK1; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101432853  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
101432987  [KO:K05414]
101432996  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
101433224  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
101433286  TCF7L2; LOW QUALITY PROTEIN: transcription factor 7-like 2 [KO:K04491]
101433347  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101433497  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
101433530  TADA3; transcriptional adapter 3 [KO:K11315]
101433544  SOS2; son of sevenless homolog 2 [KO:K03099]
101433564  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101433765  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
101433846  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
101434005  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
101434069  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101434210  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
101434268  [KO:K11584]
101434680  CCNA1; cyclin-A1 [KO:K06627]
101434860  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
101435196  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
101435268  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101435274  TBP; LOW QUALITY PROTEIN: TATA-box-binding protein [KO:K03120]
101435351  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101435448  [KO:K06751]
101435491  PXN; paxillin isoform X1 [KO:K05760]
101435527  WNT10A; protein Wnt-10a [KO:K01357]
101435586  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X4 [KO:K02148]
101435604  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
101435613  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1 [KO:K09091]
101435623  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
101435675  [KO:K06751]
101435742  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101435750  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
101436399  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101436426  FZD5; frizzled-5 [KO:K02375]
101436471  ITGB3; integrin beta-3 [KO:K06493]
101436598  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
101436827  WNT2B; protein Wnt-2b [KO:K00182]
101437002  HES6; transcription cofactor HES-6 [KO:K09087]
101437013  COL4A1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237]
101437077  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
101437187  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
101437332  MAML1; mastermind-like protein 1 isoform X2 [KO:K06061]
101437375  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
101437422  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
101437450  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
101437556  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
101437632  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
101437790  FZD9; frizzled-9 [KO:K02842]
101437850  [KO:K06751]
101438038  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
101438192  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
101438244  COL1A2; collagen alpha-2(I) chain [KO:K06236]
101438484  [KO:K06751]
101438696  [KO:K11583]
101438715  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
101438778  CRB3; protein crumbs homolog 3 [KO:K06090]
101438934  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
101439037  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
101439095  [KO:K06751]
101439136  [KO:K06751]
101439209  CSNK1A1; casein kinase I [KO:K08957] [EC:2.7.11.1]
101439225  NOTCH4; neurogenic locus notch homolog protein 4 [KO:K20996]
101439255  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101439489  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101439564  [KO:K06751]
101439692  DVL2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
101439719  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
101439742  ITGA10; integrin alpha-10 isoform X2 [KO:K06586]
101439821  LAMB3; laminin subunit beta-3 [KO:K06244]
101439875  HES4; transcription factor HES-4 [KO:K09089]
101440502  LAMC2; laminin subunit gamma-2 [KO:K06246]
101440765  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
101440768  THBS2; thrombospondin-2 [KO:K04659]
101440782  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
101440851  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
101441006  LAMB1; laminin subunit beta-1 [KO:K05636]
101441030  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
101441152  WNT5B; protein Wnt-5b [KO:K00444]
101441323  [KO:K02152]
101441522  TUBG2; tubulin gamma-2 chain [KO:K10389]
101441616  TNC; LOW QUALITY PROTEIN: tenascin [KO:K06252]
101441656  [KO:K06093]
101441690  [KO:K06751]
101441708  [KO:K06618]
101441801  VTN; vitronectin [KO:K06251]
101441936  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101441952  [KO:K08957] [EC:2.7.11.1]
101442162  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
101442198  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
101442251  [KO:K06751]
101442310  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
101442355  [KO:K02151]
101442557  [KO:K06751]
101442654  [KO:K06751]
101442691  [KO:K06751]
101442799  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
101442840  [KO:K06751]
101442886  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
101443001  WNT11; protein Wnt-11 isoform X3 [KO:K01384]
101443121  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
101443141  EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
101443494  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101443748  FZD2; LOW QUALITY PROTEIN: frizzled-2 [KO:K02235]
101443761  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101443829  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
101443919  LAMA4; LOW QUALITY PROTEIN: laminin subunit alpha-4 [KO:K06241]
101444031  [KO:K10389]
101444108  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
101444123  WNT9B; protein Wnt-9b [KO:K01064]
101444276  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101444673  [KO:K06751]
101444704  [KO:K06751]
101444780  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
101445227  [KO:K06751]
101445371  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
101445493  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101445596  [KO:K04345] [EC:2.7.11.11]
101445740  IRF1; interferon regulatory factor 1 [KO:K09444]
101445775  PARD6A; partitioning defective 6 homolog alpha isoform X2 [KO:K06093]
101445813  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101445939  IRF9; interferon regulatory factor 9 [KO:K04693]
101446223  [KO:K06751]
101446715  DLG1; disks large homolog 1 isoform X7 [KO:K12076]
101446774  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X5 [KO:K02154]
101446801  TSC1; hamartin isoform X1 [KO:K07206]
101446816  JAG1; protein jagged-1 [KO:K06052]
101446901  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
101447133  HES1; LOW QUALITY PROTEIN: transcription factor HES-1 [KO:K06054]
101447227  [KO:K06751]
101447314  WNT3A; protein Wnt-3a [KO:K00312]
101447727  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
101447879  [KO:K05414]
101447889  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
105744121  CCNA2; cyclin-A2 [KO:K06627]
105744147  [KO:K06751]
105745292  [KO:K07201]
105746538  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
111758663  [KO:K06751]
111765656  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Human papillomavirus oncoproteins: pathways to transformation.
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Nat Rev Cancer 10:550-60 (2010)
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Reference
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Signaling pathways in HPV-associated cancers and therapeutic implications.
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Rev Med Virol 25 Suppl 1:24-53 (2015)
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Reference
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High-risk human papillomavirus targets crossroads in immune signaling.
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Viruses 7:2485-506 (2015)
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Molecular mechanisms of human papillomavirus-induced carcinogenesis.
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Public Health Genomics 12:268-80 (2009)
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Reference
PMID:23164805
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Human papillomavirus proteins as prospective therapeutic targets.
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Microb Pathog 58:55-65 (2013)
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Reference
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Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.
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Rev Med Virol 19:97-113 (2009)
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Reference
PMID:17645777
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Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
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Cancer Sci 98:1505-11 (2007)
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Reference
PMID:11486705
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Wolf JK, Ramirez PT.
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The molecular biology of cervical cancer.
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Cancer Invest 19:621-9 (2001)
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Reference
PMID:10793105
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zur Hausen H
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Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
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J Natl Cancer Inst 92:690-8 (2000)
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Aberrant cell cycle regulation in cervical carcinoma.
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Yonsei Med J 46:597-613 (2005)
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Reference
PMID:15956361
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Human papillomaviruses and cell signaling.
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Sci STKE 2005:pe29 (2005)
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Reference
PMID:15342967
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Motoyama S, Ladines-Llave CA, Luis Villanueva S, Maruo T
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The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
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Reference
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Tommasino M
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The human papillomavirus family and its role in carcinogenesis.
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Semin Cancer Biol 26:13-21 (2014)
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Reference
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Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
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Viruses 7:4734-55 (2015)
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Reference
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In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response.
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Sci Rep 5:13446 (2015)
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Reference
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James CD, Roberts S
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Pathogens 5:E8 (2016)
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Reference
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Ganti K, Broniarczyk J, Manoubi W, Massimi P, Mittal S, Pim D, Szalmas A, Thatte J, Thomas M, Tomaic V, Banks L
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The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
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Viruses 7:3530-51 (2015)
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Reference
PMID:21954943
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PDZ domains: the building blocks regulating tumorigenesis.
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Biochem J 439:195-205 (2011)
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Human tumour viruses and the deregulation of cell polarity in cancer.
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Human papillomaviruses, cervical cancer and cell polarity.
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Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.
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The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses.
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Reference
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Papillomavirus E5: the smallest oncoprotein with many functions.
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Reference
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Chung CH, Gillison ML
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Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications.
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Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis.
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Sandberg A, Lindell G, Kallstrom BN, Branca RM, Danielsson KG, Dahlberg M, Larson B, Forshed J, Lehtio J
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Tumor proteomics by multivariate analysis on individual pathway data for characterization of vulvar cancer phenotypes.
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Mol Cell Proteomics 11:M112.016998 (2012)
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Reference
PMID:9990017
  Authors
Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Durr P
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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Proc Natl Acad Sci U S A 96:1291-6 (1999)
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Reference
PMID:15175323
  Authors
Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
  Title
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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J Biol Chem 279:35664-70 (2004)
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Reference
PMID:18505829
  Authors
Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Mol Cell Biol 28:4819-28 (2008)
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Reference
PMID:23536685
  Authors
Raff AB, Woodham AW, Raff LM, Skeate JG, Yan L, Da Silva DM, Schelhaas M, Kast WM
  Title
The evolving field of human papillomavirus receptor research: a review of binding and entry.
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J Virol 87:6062-72 (2013)
DOI:10.1128/JVI.00330-13
Related
pathway
dnm04064  NF-kappa B signaling pathway
dnm04110  Cell cycle
dnm04115  p53 signaling pathway
dnm04150  mTOR signaling pathway
dnm04151  PI3K-Akt signaling pathway
dnm04210  Apoptosis
dnm04310  Wnt signaling pathway
dnm04330  Notch signaling pathway
dnm04510  Focal adhesion
dnm04520  Adherens junction
dnm04530  Tight junction
dnm04612  Antigen processing and presentation
dnm04620  Toll-like receptor signaling pathway
dnm04630  JAK-STAT signaling pathway
KO pathway
ko05165   

DBGET integrated database retrieval system