Entry
Name
Cytokine-cytokine receptor interaction - Hylobates moloch (silvery gibbon)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
hmh04060 Cytokine-cytokine receptor interaction
Organism
Hylobates moloch (silvery gibbon) [GN:
hmh ]
Gene
116457092 OSMR; oncostatin-M-specific receptor subunit beta isoform X2 [KO:K05057 ]
116457529 TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376 ]
116457822 FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390 ]
116458548 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
116458855 CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738 ]
116459037 TNFSF12; tumor necrosis factor ligand superfamily member 12 isoform X2 [KO:K05474 ]
116459038 TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X2 [KO:K05475 ]
116459944 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
116461078 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
116461680 IL20RB; interleukin-20 receptor subunit beta isoform X2 [KO:K05137 ]
116461997 TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722 ]
116462001 TNFRSF10A; tumor necrosis factor receptor superfamily member 10A isoform X1 [KO:K04722 ]
116462241 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
116462310 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
116463892 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
116465011 TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X2 [KO:K05152 ]
116466882 IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
116467154 TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
116467163 IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068 ]
116467215 TNFSF11; tumor necrosis factor ligand superfamily member 11 isoform X1 [KO:K05473 ]
116467556 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
116468497 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
116469074 CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421 ]
116469359 IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055 ]
116469921 IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064 ]
116470324 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
116471167 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
116472296 FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389 ]
116472576 LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159 ]
116472954 CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061 ]
116473226 TNFSF4; tumor necrosis factor ligand superfamily member 4 isoform X1 [KO:K05469 ]
116473229 TNFSF18; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
116474266 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
116474666 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
116475031 CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059 ]
116475585 TNFSF8; tumor necrosis factor ligand superfamily member 8 isoform X1 [KO:K05471 ]
116476657 RELT; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156 ]
116478334 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
116478337 TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477 ]
116478688 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X3 [KO:K05063 ]
116479965 IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
116481248 TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721 ]
116482630 IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135 ]
116483297 EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X2 [KO:K05162 ]
116483673 IL18RAP; interleukin-18 receptor accessory protein isoform X1 [KO:K05174 ]
116484243 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
116484577 CSF2RA; LOW QUALITY PROTEIN: granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066 ]
116811749 EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X2 [KO:K05163 ]
116812765 TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154 ]
116812766 TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X1 [KO:K05142 ]
116812849 TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160 ]
116812939 TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145 ]
116812940 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X2 [KO:K05141 ]
116813544 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
116813893 TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
116813932 IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway