KEGG   PATHWAY: hmh04151
Entry
hmh04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Hylobates moloch (silvery gibbon)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
hmh04151  PI3K-Akt signaling pathway
hmh04151

Other DBs
GO: 0043491
Organism
Hylobates moloch (silvery gibbon) [GN:hmh]
Gene
116456172  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
116456560  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
116456569  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
116456636  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
116456678  FGF10; fibroblast growth factor 10 [KO:K04358]
116456707  FGFR3; fibroblast growth factor receptor 3 isoform X5 [KO:K05094] [EC:2.7.10.1]
116456713  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
116456814  PRLR; prolactin receptor [KO:K05081]
116456888  GHR; growth hormone receptor [KO:K05080]
116456961  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
116456980  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X2 [KO:K04354]
116457092  OSMR; oncostatin-M-specific receptor subunit beta isoform X2 [KO:K05057]
116457311  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
116457403  LAMB3; laminin subunit beta-3 [KO:K06244]
116457634  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
116457708  LAMC1; laminin subunit gamma-1 [KO:K05635]
116457829  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
116457866  [KO:K04542]
116457897  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
116457903  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116457985  LAMC2; laminin subunit gamma-2 [KO:K06246]
116458112  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
116458259  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
116458285  YWHAE; 14-3-3 protein epsilon [KO:K06630]
116458330  [KO:K05414]
116458331  [KO:K05414]
116458332  [KO:K05414]
116458453  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
116458527  [KO:K05414]
116458584  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
116458600  OSM; oncostatin-M [KO:K05418]
116458611  [KO:K05414]
116458613  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
116458660  [KO:K05414]
116458708  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
116458711  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
116458733  [KO:K05438]
116458843  IFNB1; interferon beta [KO:K05415]
116458845  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
116459052  TP53; cellular tumor antigen p53 [KO:K04451]
116459111  RPS6; small ribosomal subunit protein eS6 [KO:K02991]
116459126  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116459242  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
116459370  YWHAH; 14-3-3 protein eta [KO:K16198]
116459715  PRL; prolactin isoform X2 [KO:K05439]
116459737  VEGFA; vascular endothelial growth factor A, long form isoform X1 [KO:K05448]
116459782  TNXB; tenascin-X [KO:K06252]
116460133  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
116460213  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
116460313  [KO:K09049]
116460459  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
116460475  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
116460812  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
116460923  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
116461063  ANGPT4; angiopoietin-4 [KO:K05467]
116461134  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
116461242  YWHAB; 14-3-3 protein beta/alpha isoform X1 [KO:K16197]
116461332  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
116461353  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
116461395  LAMA5; laminin subunit alpha-5 [KO:K06240]
116461447  SPP1; osteopontin isoform X1 [KO:K06250]
116461632  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
116461658  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
116461687  [KO:K03259]
116461711  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
116461729  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
116461731  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
116461734  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
116461858  ITGB1; integrin beta-1 [KO:K05719]
116461880  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
116461936  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
116462068  COL2A1; collagen alpha-1(II) chain [KO:K19719]
116462088  [KO:K06238]
116462105  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116462129  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
116462147  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
116462272  ITGA2; integrin alpha-2 [KO:K06481]
116462301  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
116462304  ITGA1; integrin alpha-1 [KO:K06480]
116462500  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
116462653  TSC2; tuberin isoform X1 [KO:K07207]
116462749  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116462932  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116463464  [KO:K05450]
116463488  [KO:K05450]
116463600  FGF2; fibroblast growth factor 2 [KO:K18497]
116463853  [KO:K04537]
116463856  [KO:K05437]
116463857  [KO:K04537]
116463860  [KO:K05437]
116464141  [KO:K11583]
116464144  [KO:K11583]
116464802  [KO:K25414]
116464818  IKBKG; NF-kappa-B essential modulator isoform X2 [KO:K07210]
116464828  [KO:K23691]
116464888  [KO:K25414]
116464897  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
116465256  [KO:K23691]
116465400  TLR2; toll-like receptor 2 [KO:K10159]
116466046  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
116466374  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
116466571  HRAS; GTPase HRas isoform X3 [KO:K02833]
116466631  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X2 [KO:K05631]
116466754  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116466843  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
116466895  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
116466917  EREG; proepiregulin [KO:K09784]
116466926  [KO:K03259]
116467120  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
116467123  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
116467157  FGF9; fibroblast growth factor 9 [KO:K04358]
116467163  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
116467262  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
116467343  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
116467394  [KO:K23691]
116467486  [KO:K23691]
116467540  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
116467558  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
116467559  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
116467560  COL4A1; collagen alpha-1(IV) chain isoform X5 [KO:K06237]
116467918  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
116467997  ITGA10; integrin alpha-10 [KO:K06586]
116468256  FGF19; fibroblast growth factor 19 [KO:K22603]
116468258  FGF4; fibroblast growth factor 4 [KO:K04358]
116468259  FGF3; fibroblast growth factor 3 [KO:K04358]
116468350  NGF; beta-nerve growth factor [KO:K02582]
116468390  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
116468493  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
116468494  PHLPP1; LOW QUALITY PROTEIN: PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
116468664  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
116468730  LAMA1; laminin subunit alpha-1 [KO:K05637]
116468774  [KO:K16197]
116468899  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
116468912  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
116468948  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
116468949  BAD; bcl2-associated agonist of cell death [KO:K02158]
116468973  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
116469011  RELA; transcription factor p65 isoform X1 [KO:K04735]
116469076  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
116469117  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
116469151  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
116469239  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
116469325  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
116469334  EFNA1; ephrin-A1 [KO:K05462]
116469337  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
116469338  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
116469359  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
116469375  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
116469376  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
116469427  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
116469481  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
116469568  NRAS; GTPase NRas [KO:K07828]
116469641  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
116469780  [KO:K09487]
116469808  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
116469841  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
116469917  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
116470199  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
116470222  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116470325  IL3; interleukin-3 [KO:K04736]
116470667  FOXO3; forkhead box protein O3 isoform X1 [KO:K09408]
116470836  IL4; interleukin-4 isoform X1 [KO:K05430]
116470959  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
116471062  THBS4; thrombospondin-4 [KO:K04659]
116471090  F2R; proteinase-activated receptor 1 [KO:K03914]
116471121  LAMA4; laminin subunit alpha-4 [KO:K06241]
116471167  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
116471255  RBL2; retinoblastoma-like protein 2 isoform X2 [KO:K16332]
116471472  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
116471508  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
116471654  FGF1; LOW QUALITY PROTEIN: fibroblast growth factor 1 [KO:K18496]
116471675  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
116471709  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
116471711  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
116471846  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
116471901  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
116471910  EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X1 [KO:K03259]
116471959  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
116472213  FGF23; fibroblast growth factor 23 [KO:K22428]
116472296  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
116472375  FGF20; fibroblast growth factor 20 [KO:K04358]
116472548  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
116472553  FGF6; fibroblast growth factor 6 [KO:K04358]
116472566  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
116472569  VWF; von Willebrand factor [KO:K03900]
116472584  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
116472587  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
116472600  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
116472627  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
116472702  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
116472766  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
116472788  KRAS; GTPase KRas isoform X1 [KO:K07827]
116472954  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
116473008  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
116473063  ARTN; artemin isoform X1 [KO:K25415]
116473104  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
116473198  TNR; tenascin-R isoform X1 [KO:K06252]
116473202  TNN; tenascin-N [KO:K06252]
116473484  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
116473673  ITGA9; integrin alpha-9 [KO:K06585]
116473842  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
116474153  G6PC1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
116474442  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
116474495  ITGA8; integrin alpha-8 [KO:K06584]
116474619  VTN; vitronectin [KO:K06251]
116474643  CHAD; chondroadherin [KO:K06248]
116474649  COL1A1; collagen alpha-1(I) chain [KO:K06236]
116474657  ITGA3; integrin alpha-3 isoform X2 [KO:K06482]
116474666  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
116474673  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
116474757  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
116474768  CSF3; granulocyte colony-stimulating factor [KO:K05423]
116474903  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
116474918  IBSP; bone sialoprotein 2 [KO:K06253]
116474929  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
116474939  ITGA2B; integrin alpha-IIb [KO:K06476]
116475015  ITGB3; integrin beta-3 [KO:K06493]
116475043  [KO:K16197]
116475072  AREG; amphiregulin [KO:K09782]
116475074  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
116475199  NTRK2; BDNF/NT-3 growth factors receptor isoform X2 [KO:K04360] [EC:2.7.10.1]
116475231  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
116475535  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
116475542  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
116475587  TNC; tenascin [KO:K06252]
116475593  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
116475728  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
116475776  LAMC3; laminin subunit gamma-3 isoform X2 [KO:K06247]
116475805  TSC1; hamartin isoform X1 [KO:K07206]
116475838  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
116476303  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
116476405  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
116476763  [KO:K04542]
116476871  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
116476913  LAMA2; laminin subunit alpha-2 [KO:K05637]
116476925  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2 [KO:K03456]
116477024  [KO:K04659]
116477213  [KO:K04542]
116478026  HSP90B1; endoplasmin [KO:K09487]
116478036  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
116478074  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
116478208  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
116478219  NTF4; neurotrophin-4 [KO:K12457]
116478223  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
116478306  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
116478328  PSPN; persephin [KO:K25416]
116478448  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
116478479  EPOR; erythropoietin receptor [KO:K05079]
116478498  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
116478549  [KO:K02991]
116478681  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
116478691  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116478719  COMP; cartilage oligomeric matrix protein [KO:K04659]
116478752  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
116478827  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
116478988  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X2 [KO:K06643] [EC:2.3.2.27]
116479070  KITLG; kit ligand isoform X1 [KO:K05461]
116479486  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
116479519  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
116479721  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
116479726  FGF21; fibroblast growth factor 21 [KO:K22429]
116479944  IL2; interleukin-2 [KO:K05429]
116480214  YWHAQ; 14-3-3 protein theta [KO:K16197]
116480287  [KO:K04392]
116480683  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116480850  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
116480929  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
116480938  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
116480953  ITGA7; integrin alpha-7 isoform X2 [KO:K06583]
116480965  ITGA5; integrin alpha-5 [KO:K06484]
116481014  ITGB7; integrin beta-7 [KO:K06590]
116481023  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
116481263  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116481481  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
116481505  THBS1; thrombospondin-1 [KO:K16857]
116481672  [KO:K16339] [EC:3.1.2.2]
116481707  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
116481730  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
116481731  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
116481894  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
116482110  IGF1R; insulin-like growth factor 1 receptor isoform X4 [KO:K05087] [EC:2.7.10.1]
116482295  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116482335  ITGA11; integrin alpha-11 [KO:K06587]
116482607  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116482629  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
116482647  FGF7; fibroblast growth factor 7 [KO:K04358]
116483152  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
116483190  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
116483317  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
116483343  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116483374  BCL2L11; bcl-2-like protein 11 isoform X2 [KO:K16341]
116483502  TGFA; protransforming growth factor alpha [KO:K08774]
116483538  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
116483548  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116483932  EFNA2; ephrin-A2 [KO:K05462]
116483940  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
116483969  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
116484062  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
116484080  ITGB4; integrin beta-4 [KO:K06525]
116484153  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
116484246  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
116484470  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
116484566  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X3 [KO:K07826]
116484616  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
116484668  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
116484687  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
116484949  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
116484982  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
116484983  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
116485057  PGF; placenta growth factor isoform X1 [KO:K16859]
116485121  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
116485139  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116485178  HSP90AA1; heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
116809645  LAMB4; laminin subunit beta-4 [KO:K06245]
116809682  COL6A3; collagen alpha-3(VI) chain isoform X2 [KO:K06238]
116810056  [KO:K16197]
116810071  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
116810136  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
116810138  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
116810145  IRS1; insulin receptor substrate 1 [KO:K16172]
116810327  [KO:K04374]
116810333  FN1; fibronectin isoform X1 [KO:K05717]
116810355  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X5 [KO:K05085] [EC:2.7.10.1]
116810385  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X3 [KO:K05870]
116810565  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
116810585  ITGA4; integrin alpha-4 [KO:K06483]
116810639  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
116810655  ITGA6; integrin alpha-6 isoform X3 [KO:K06485]
116810699  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
116810755  ITGB6; integrin beta-6 [KO:K06589]
116810870  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116810921  LAMB1; laminin subunit beta-1 [KO:K05636]
116811148  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
116811152  YWHAG; 14-3-3 protein gamma [KO:K16198]
116811338  FGF16; fibroblast growth factor 16 [KO:K04358]
116811340  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
116811530  VEGFD; vascular endothelial growth factor D [KO:K05449]
116811947  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
116811956  GNG5B; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5B [KO:K04542]
116812144  MTCP1; protein p13 MTCP-1 [KO:K16837]
116812436  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116812715  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X5 [KO:K09047]
116812793  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
116812889  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116812918  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
116812958  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
116812973  EPHA2; ephrin type-A receptor 2 isoform X2 [KO:K05103] [EC:2.7.10.1]
116813186  IL6; interleukin-6 isoform X1 [KO:K05405]
116813226  SGK3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
116813251  ITGB8; integrin beta-8 [KO:K06591]
116813340  IL7; interleukin-7 [KO:K05431]
116813431  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
116813515  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
116813588  MYC; myc proto-oncogene protein [KO:K04377]
116813620  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
116814099  COL1A2; collagen alpha-2(I) chain [KO:K06236]
116814102  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
116814103  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
116814109  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
116814166  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
116814200  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
116814224  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
116814273  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
116814342  [KO:K04369] [EC:2.7.12.2]
116814401  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
116814406  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
116814534  NOS3; nitric oxide synthase 3 isoform X1 [KO:K13242] [EC:1.14.13.39]
116814554  RHEB; GTP-binding protein Rheb [KO:K07208]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
hmh00010  Glycolysis / Gluconeogenesis
hmh04010  MAPK signaling pathway
hmh04012  ErbB signaling pathway
hmh04062  Chemokine signaling pathway
hmh04064  NF-kappa B signaling pathway
hmh04068  FoxO signaling pathway
hmh04110  Cell cycle
hmh04115  p53 signaling pathway
hmh04150  mTOR signaling pathway
hmh04210  Apoptosis
hmh04370  VEGF signaling pathway
hmh04510  Focal adhesion
hmh04620  Toll-like receptor signaling pathway
hmh04630  JAK-STAT signaling pathway
hmh04662  B cell receptor signaling pathway
hmh04910  Insulin signaling pathway
KO pathway
ko04151   

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