KEGG   PATHWAY: hsa04370
hsa04370                    Pathway                                
VEGF signaling pathway - Homo sapiens (human)
There is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic angiogenesis. The binding of VEGF to VEGFR-2 leads to a cascade of different signaling pathways, resulting in the up-regulation of genes involved in mediating the proliferation and migration of endothelial cells and promoting their survival and vascular permeability. For example, the binding of VEGF to VEGFR-2 leads to dimerization of the receptor, followed by intracellular activation of the PLCgamma;PKC-Raf kinase-MEK-mitogen-activated protein kinase (MAPK) pathway and subsequent initiation of DNA synthesis and cell growth, whereas activation of the phosphatidylinositol 3' -kinase (PI3K)-Akt pathway leads to increased endothelial-cell survival. Activation of PI3K, FAK, and p38 MAPK is implicated in cell migration signaling.
Environmental Information Processing; Signal transduction
Pathway map
hsa04370  VEGF signaling pathway

D03218  Axitinib (JAN/USAN)
D03658  Dasatinib (JAN/INN)
D03736  Doramapimod (USAN/INN)
D05029  Midostaurin (JAN/USAN/INN)
D05386  Pegaptanib sodium (JAN/USAN)
D05697  Ranibizumab (USAN/INN)
D05819  Semaxanib (USAN/INN)
D06272  Sorafenib tosylate (USAN)
D06285  Vatalanib (USAN/INN)
D06402  Sunitinib malate (JAN/USAN)
D06407  Vandetanib (JAN/USAN/INN)
D06409  Bevacizumab (USAN)
D06414  Dasatinib (USAN)
D08503  Toceranib (USAN)
D08524  Sorafenib (USAN/INN)
D08544  Toceranib phosphate (USAN)
D08552  Sunitinib (INN)
D08874  Bevasiranib sodium (USAN)
D08878  Brivanib alaninate (JAN/USAN/INN)
D08881  Cediranib (USAN/INN)
D08883  Cediranib maleate (JAN/USAN)
D08947  Motesanib diphosphate (USAN)
D08963  Pamapimod (INN/USAN)
D09371  Ramucirumab (USAN)
D09386  Talmapimod (USAN/INN)
D09574  Aflibercept (USAN/INN)
D09589  Brivanib (USAN)
D09602  Dilmapimod (USAN/INN)
D09603  Dilmapimod tosylate (USAN)
D09618  Foretinib (USAN/INN)
D09635  Linifanib (USAN/INN)
D09639  Losmapimod (USAN/INN)
D09664  Saracatinib (USAN/INN)
D09665  Saracatinib difumarate (USAN)
D09683  Tivozanib (USAN/INN)
D09919  Lenvatinib (USAN/INN)
D09920  Lenvatinib mesylate (USAN)
D09945  Pegdinetanib (USAN/INN)
D10062  Cabozantinib (USAN)
D10095  Cabozantinib s-malate (USAN)
D10137  Regorafenib hydrate (JAN)
D10138  Regorafenib (USAN/INN)
D10190  Tivozanib hydrochloride (USAN)
D10224  Golvatinib (USAN)
D10396  Nintedanib esylate (USAN)
D10426  Pimasertib (USAN/INN)
D10465  Golvatinib tartrate (USAN)
D10481  Nintedanib (USAN/INN)
D10486  Pimasertib hydrochloride (USAN)
D11083  Brolucizumab (USAN/INN)
D11126  Navicixizumab (USAN/INN)
D11244  Vanucizumab (USAN/INN)
D11288  Rivoceranib (USAN/INN)
D11289  Rivoceranib mesylate (USAN)
D11517  Abicipar pegol (USAN/INN)
D11642  Dilpacimab (USAN/INN)
D11890  Emvododstat (USAN)
D12237  Zunsemetinib (USAN)
D12507  Tarcocimab (INN)
D12508  Tarcocimab tedromer (INN)
D12560  Gamcemetinib (USAN)
Other DBs
GO: 0048010
Homo sapiens (human) [GN:hsa]
7422  VEGFA; vascular endothelial growth factor A [KO:K05448]
3791  KDR; kinase insert domain receptor [KO:K05098] [EC:]
9047  SH2D2A; SH2 domain containing 2A [KO:K08273]
5335  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:]
5336  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:]
5578  PRKCA; protein kinase C alpha [KO:K02677] [EC:]
5579  PRKCB; protein kinase C beta [KO:K19662] [EC:]
5582  PRKCG; protein kinase C gamma [KO:K19663] [EC:]
8877  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:]
56848  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:]
3265  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
3845  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
4893  NRAS; NRAS proto-oncogene, GTPase [KO:K07828]
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:]
5604  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:]
5605  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:]
5594  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:]
5595  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:]
123745  PLA2G4E; phospholipase A2 group IVE [KO:K16342] [EC:]
5321  PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:]
8681  JMJD7-PLA2G4B; JMJD7-PLA2G4B readthrough [KO:K16342] [EC:]
100137049  PLA2G4B; phospholipase A2 group IVB [KO:K16342] [EC:]
8605  PLA2G4C; phospholipase A2 group IVC [KO:K16342] [EC:]
283748  PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:]
255189  PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:]
5530  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:]
5532  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:]
5533  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:]
5534  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
5535  PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
4773  NFATC2; nuclear factor of activated T cells 2 [KO:K17332]
5743  PTGS2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:]
5747  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:]
25759  SHC2; SHC adaptor protein 2 [KO:K17447]
5829  PXN; paxillin [KO:K05760]
998  CDC42; cell division cycle 42 [KO:K04393]
5600  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:]
6300  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:]
5603  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:]
1432  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:]
9261  MAPKAPK2; MAPK activated protein kinase 2 [KO:K04443] [EC:]
7867  MAPKAPK3; MAPK activated protein kinase 3 [KO:K04444] [EC:]
3315  HSPB1; heat shock protein family B (small) member 1 [KO:K04455]
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:]
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:]
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:]
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:]
5295  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
5296  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
8503  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
5879  RAC1; Rac family small GTPase 1 [KO:K04392]
5880  RAC2; Rac family small GTPase 2 [KO:K07860]
5881  RAC3; Rac family small GTPase 3 [KO:K07861]
207  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:]
208  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:]
10000  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:]
4846  NOS3; nitric oxide synthase 3 [KO:K13242] [EC:]
842  CASP9; caspase 9 [KO:K04399] [EC:]
572  BAD; BCL2 associated agonist of cell death [KO:K02158]
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Cross MJ, Dixelius J, Matsumoto T, Claesson-Welsh L.
VEGF-receptor signal transduction.
Trends Biochem Sci 28:488-94 (2003)
Matsumoto T, Claesson-Welsh L.
VEGF receptor signal transduction.
Sci STKE 2001:RE21 (2001)
Hoeben A, Landuyt B, Highley MS, Wildiers H, Van Oosterom AT, De Bruijn EA.
Vascular endothelial growth factor and angiogenesis.
Pharmacol Rev 56:549-80 (2004)
Takahashi H, Shibuya M.
The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions.
Clin Sci (Lond) 109:227-41 (2005)
Zachary I.
VEGF signalling: integration and multi-tasking in endothelial cell biology.
Biochem Soc Trans 31:1171-7 (2003)
Munoz-Chapuli R, Quesada AR, Angel Medina M.
Angiogenesis and signal transduction in endothelial cells.
Cell Mol Life Sci 61:2224-43 (2004)
Lamalice L, Houle F, Jourdan G, Huot J.
Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38.
Oncogene 23:434-45 (2004)
Shu X, Wu W, Mosteller RD, Broek D.
Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases.
Mol Cell Biol 22:7758-68 (2002)
hsa00590  Arachidonic acid metabolism
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04510  Focal adhesion
KO pathway

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