Entry
Name
C-type lectin receptor signaling pathway - Homo sapiens (human)
Description
C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of one or more C-type lectin-like domains (CTLDs). CLRs function as pattern-recognition receptors (PRRs) for pathogen-derived ligands in dendric cells, macrophages, neutrophils, etc., such as Dectin-1 and Dectin-2 for recognition of fungi-derived B-glucan and high mannose-type carbohydrates. Upon ligand binding, CLRs stimulate intracellular signaling cascades that induce the production of inflammatory cytokines and chemokines, consequently triggering innate and adaptive immunity to pathogens.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
hsa04625 C-type lectin receptor signaling pathway
Ortholog table
Drug
D12423 Selnoflast potassium (USAN)
Organism
Homo sapiens (human) [GN:
hsa ]
Gene
64581 CLEC7A; C-type lectin domain containing 7A [KO:K10074 ]
4046 LSP1; lymphocyte specific protein 1 [KO:K14957 ]
3265 HRAS; HRas proto-oncogene, GTPase [KO:K02833 ]
3845 KRAS; KRAS proto-oncogene, GTPase [KO:K07827 ]
4893 NRAS; NRAS proto-oncogene, GTPase [KO:K07828 ]
5970 RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735 ]
5971 RELB; RELB proto-oncogene, NF-kB subunit [KO:K09253 ]
1147 CHUK; component of inhibitor of nuclear factor kappa B kinase complex [KO:K04467 ] [EC:2.7.11.10 ]
4791 NFKB2; nuclear factor kappa B subunit 2 [KO:K04469 ]
3708 ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958 ]
3709 ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959 ]
3710 ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960 ]
5534 PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268 ]
5535 PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268 ]
4772 NFATC1; nuclear factor of activated T cells 1 [KO:K04446 ]
4773 NFATC2; nuclear factor of activated T cells 2 [KO:K17332 ]
4775 NFATC3; nuclear factor of activated T cells 3 [KO:K17333 ]
4776 NFATC4; nuclear factor of activated T cells 4 [KO:K17334 ]
114548 NLRP3; NLR family pyrin domain containing 3 [KO:K12800 ]
29108 PYCARD; PYD and CARD domain containing [KO:K12799 ]
64170 CARD9; caspase recruitment domain family member 9 [KO:K12794 ]
8915 BCL10; BCL10 immune signaling adaptor [KO:K07368 ]
10892 MALT1; MALT1 paracaspase [KO:K07369 ] [EC:3.4.22.-]
8517 IKBKG; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma [KO:K07210 ]
4790 NFKB1; nuclear factor kappa B subunit 1 [KO:K02580 ]
3725 JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448 ]
93978 CLEC6A; C-type lectin domain containing 6A [KO:K17514 ]
10332 CLEC4M; C-type lectin domain family 4 member M [KO:K06563 ]
23365 ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532 ]
387 RHOA; ras homolog family member A [KO:K04513 ]
9641 IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211 ] [EC:2.7.11.10 ]
6772 STAT1; signal transducer and activator of transcription 1 [KO:K11220 ]
6773 STAT2; signal transducer and activator of transcription 2 [KO:K11221 ]
602 BCL3; BCL3 transcription coactivator [KO:K09258 ]
6361 CCL17; C-C motif chemokine ligand 17 [KO:K21083 ]
6367 CCL22; C-C motif chemokine ligand 22 [KO:K21095 ]
26253 CLEC4E; C-type lectin domain family 4 member E [KO:K10059 ]
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922 ] [EC:2.7.1.153 ]
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922 ] [EC:2.7.1.153 ]
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922 ] [EC:2.7.1.153 ]
5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649 ]
5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649 ]
8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649 ]
3659 IRF1; interferon regulatory factor 1 [KO:K09444 ]
338339 CLEC4D; C-type lectin domain family 4 member D [KO:K10058 ]
51266 CLEC1B; C-type lectin domain family 1 member B [KO:K10070 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C21790 Mycobacterial trehalose dimycolate
G13115 Mannose-capped lipoarabinomannan
Reference
Authors
Geijtenbeek TB, Gringhuis SI
Title
C-type lectin receptors in the control of T helper cell differentiation.
Journal
Reference
Authors
Hajishengallis G, Lambris JD
Title
Microbial manipulation of receptor crosstalk in innate immunity.
Journal
Reference
Authors
Iliev ID, Leonardi I
Title
Fungal dysbiosis: immunity and interactions at mucosal barriers.
Journal
Reference
Authors
Richardson MB, Williams SJ
Title
MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns.
Journal
Reference
Authors
Vautier S, MacCallum DM, Brown GD
Title
C-type lectin receptors and cytokines in fungal immunity.
Journal
Reference
Authors
Gauglitz GG, Callenberg H, Weindl G, Korting HC
Title
Host defence against Candida albicans and the role of pattern-recognition receptors.
Journal
Reference
Authors
Cunha C, Carvalho A, Esposito A, Bistoni F, Romani L
Title
DAMP signaling in fungal infections and diseases.
Journal
Reference
Authors
Tang J, Lin G, Langdon WY, Tao L, Zhang J
Title
Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity.
Journal
Reference
Authors
Mayer S, Raulf MK, Lepenies B
Title
C-type lectins: their network and roles in pathogen recognition and immunity.
Journal
Reference
Authors
Plato A, Willment JA, Brown GD
Title
C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways.
Journal
Reference
Authors
Dupaul-Chicoine J, Saleh M
Title
A new path to IL-1beta production controlled by caspase-8.
Journal
Reference
Authors
Batbayar S, Lee DH, Kim HW
Title
Immunomodulation of Fungal beta-Glucan in Host Defense Signaling by Dectin-1.
Journal
Reference
Authors
Bendickova K, Tidu F, Fric J
Title
Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy.
Journal
Reference
Authors
den Dunnen J, Gringhuis SI, Geijtenbeek TB
Title
Innate signaling by the C-type lectin DC-SIGN dictates immune responses.
Journal
Reference
Authors
Marakalala MJ, Ndlovu H
Title
Signaling C-type lectin receptors in antimycobacterial immunity.
Journal
Reference
Authors
Gringhuis SI, Kaptein TM, Wevers BA, Mesman AW, Geijtenbeek TB
Title
Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKepsilon- and CYLD-dependent Bcl3 activation.
Journal
Reference
Authors
Geijtenbeek TB, Gringhuis SI
Title
Signalling through C-type lectin receptors: shaping immune responses.
Journal
Reference
Authors
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB
Title
Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.
Journal
Related pathway
hsa04658 Th1 and Th2 cell differentiation
KO pathway
LinkDB
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