KEGG   PATHWAY: ko05166
Entry
ko05166                     Pathway                                
Name
Human T-cell leukemia virus 1 infection
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
ko05166  Human T-cell leukemia virus 1 infection
ko05166

Disease
H00009  Adult T-cell leukemia
Orthology
K00787  FDPS; farnesyl diphosphate synthase [EC:2.5.1.1 2.5.1.10]
K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K01110  PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K01397  MMP7; matrix metalloproteinase-7 (matrilysin, uterine) [EC:3.4.24.23]
K02089  CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K02159  BAX; apoptosis regulator BAX
K02180  BUB3; cell cycle arrest protein BUB3
K02206  CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K02216  CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
K02330  POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
K02365  ESP1; separase [EC:3.4.22.49]
K02537  MAD2; mitotic spindle assembly checkpoint protein MAD2
K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02678  ETS1, pnt; C-ets-1
K02833  HRAS; GTPase HRas
K03120  TBP; transcription initiation factor TFIID TATA-box-binding protein
K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
K03159  TNFRSF3, LTBR; lymphotoxin beta receptor TNFR superfamily member 3
K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
K03348  APC1, ANAPC1; anaphase-promoting complex subunit 1
K03349  APC2, ANAPC2; anaphase-promoting complex subunit 2
K03350  APC3, CDC27; anaphase-promoting complex subunit 3
K03351  APC4, ANAPC4; anaphase-promoting complex subunit 4
K03352  APC5, ANAPC5; anaphase-promoting complex subunit 5
K03353  APC6, CDC16; anaphase-promoting complex subunit 6
K03354  APC7, ANAPC7; anaphase-promoting complex subunit 7
K03355  APC8, CDC23; anaphase-promoting complex subunit 8
K03357  APC10, ANAPC10, DOC1; anaphase-promoting complex subunit 10
K03358  APC11, ANAPC11; anaphase-promoting complex subunit 11
K03359  APC12, CDC26; anaphase-promoting complex subunit 12
K03363  CDC20; cell division cycle 20, cofactor of APC complex
K04345  PKA; protein kinase A [EC:2.7.11.11]
K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
K04375  ELK1; ETS domain-containing protein Elk-1
K04376  ELK4, SAP1; ETS domain-containing protein Elk-4
K04377  MYC; Myc proto-oncogene protein
K04378  SRF; serum response factor
K04379  FOS; proto-oncogene protein c-fos
K04386  IL1R1, CD121a; interleukin 1 receptor type I
K04387  IL1R2, CD121b; interleukin 1 receptor type II
K04388  TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25]
K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
K04448  JUN; transcription factor AP-1
K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
K04451  TP53, P53; tumor protein p53
K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K04469  NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K04498  EP300, CREBBP, KAT3; E1A/CREB-binding protein [EC:2.3.1.48]
K04500  SMAD2; mothers against decapentaplegic homolog 2
K04501  SMAD4; mothers against decapentaplegic homolog 4
K04502  FOSL1; fos-like antigen 1
K04503  CCND1; G1/S-specific cyclin-D1
K04570  BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K04674  TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
K04685  CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B
K04725  XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
K04728  ATM, TEL1; serine-protein kinase ATM [EC:2.7.11.1]
K04734  NFKBIA; NF-kappa-B inhibitor alpha
K04735  RELA; transcription factor p65
K05068  IL2RA, CD25; interleukin 2 receptor alpha
K05069  IL2RB, CD122; interleukin 2 receptor beta
K05070  IL2RG, CD132; interleukin 2 receptor gamma
K05074  IL15RA, CD215; interleukin 15 receptor alpha
K05151  TNFRSF13C, BAFFR, CD268; tumor necrosis factor receptor superfamily member 13C
K05405  IL6; interleukin 6
K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
K05429  IL2; interleukin 2
K05433  IL15; interleukin 15
K05468  LTA, TNFB; lymphotoxin alpha (TNF superfamily, member 1)
K05718  ITGAL, CD11a; integrin alpha L
K05770  TSPO, BZRP; translocator protein
K05856  LCK; lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]
K05862  VDAC1; voltage-dependent anion channel protein 1
K05863  SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31
K05870  CREB1; cyclic AMP-responsive element-binding protein 1
K06062  PCAF, KAT2, GCN5; histone acetyltransferase [EC:2.3.1.48]
K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
K06271  TLN; talin
K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
K06452  CD3G; T-cell surface glycoprotein CD3 gamma chain
K06454  CD4; T-cell surface glycoprotein CD4
K06464  ITGB2, CD18; integrin beta 2
K06490  ICAM1, CD54; intercellular adhesion molecule 1
K06618  RB1; retinoblastoma-associated protein
K06620  E2F3; transcription factor E2F3
K06621  CDKN2A, P16, INK4A; cyclin-dependent kinase inhibitor 2A
K06622  CDKN2C, P18, INK4C; cyclin-dependent kinase inhibitor 2C
K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
K06626  CCNE; G1/S-specific cyclin-E1
K06627  CCNA; cyclin-A
K06635  PTTG; securin
K06637  BUB1B, BUBR1, MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [EC:2.7.11.1]
K06640  ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
K06641  CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
K06679  MAD1; mitotic spindle assembly checkpoint protein MAD1
K06724  NRP1, CD304; neuropilin 1
K06751  MHC1; MHC class I antigen
K06752  MHC2; MHC class II antigen
K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K07299  SLC2A1, GLUT1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
K07827  KRAS, KRAS2; GTPase KRas
K07828  NRAS; GTPase NRas
K07936  RAN; GTP-binding nuclear protein Ran
K08041  ADCY1; adenylate cyclase 1 [EC:4.6.1.1]
K08042  ADCY2; adenylate cyclase 2 [EC:4.6.1.1]
K08043  ADCY3; adenylate cyclase 3 [EC:4.6.1.1]
K08044  ADCY4; adenylate cyclase 4 [EC:4.6.1.1]
K08045  ADCY5; adenylate cyclase 5 [EC:4.6.1.1]
K08046  ADCY6; adenylate cyclase 6 [EC:4.6.1.1]
K08047  ADCY7; adenylate cyclase 7 [EC:4.6.1.1]
K08048  ADCY8; adenylate cyclase 8 [EC:4.6.1.1]
K08049  ADCY9; adenylate cyclase 9 [EC:4.6.1.1]
K08054  CANX; calnexin
K08055  B2M; beta-2-microglobulin
K08057  CALR; calreticulin
K08065  NFYB, HAP3; nuclear transcription Y subunit beta
K08874  TRRAP; transformation/transcription domain-associated protein
K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
K09048  CREB3; cyclic AMP-responsive element-binding protein 3
K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
K09063  TCF3, E2A; transcription factor E2-alpha
K09203  EGR1; early growth response protein 1
K09253  RELB; transcription factor RelB
K09341  MSX; homeobox protein MSX
K09389  E2F2; transcription factor E2F2
K09438  SPI1; transcription factor PU.1
K10151  CCND2; G1/S-specific cyclin-D2
K10152  CCND3; G1/S-specific cyclin-D3
K10784  TRAV; T cell receptor alpha chain V region
K10785  TRBV; T-cell receptor beta chain V region
K11126  TERT, EST2; telomerase reverse transcriptase [EC:2.7.7.49]
K11217  JAK1; Janus kinase 1 [EC:2.7.10.2]
K11218  JAK3; Janus kinase 3 [EC:2.7.10.2]
K11223  STAT5A; signal transducer and activator of transcription 5A
K11224  STAT5B; signal transducer and activator of transcription 5B
K11304  TIP60, KAT5, ESA1; histone acetyltransferase HTATIP [EC:2.3.1.48]
K12076  DLG1; disks large protein 1
K12456  APC13, ANAPC13; anaphase-promoting complex subunit 13
K12496  EGR2; early growth response protein 2
K13375  TGFB1; transforming growth factor beta-1
K13376  TGFB2; transforming growth factor beta-2
K13377  TGFB3; transforming growth factor beta-3
K14290  XPO1, CRM1; exportin-1
K15040  VDAC2; voltage-dependent anion channel protein 2
K15041  VDAC3; voltage-dependent anion channel protein 3
K15304  RANBP3; Ran-binding protein 3
K15305  VAC14, TAX1BP2; vacuole morphology and inheritance protein 14
K15306  RANBP1; Ran-binding protein 1
K15307  GPS2; G protein pathway suppressor 2
K15308  TTP; tristetraprolin
K15309  CRTC1, TORC1; CREB-regulated transcription coactivator 1
K16333  CRTC2, TORC2; CREB-regulated transcription coactivator 2
K16334  CRTC3, TORC3; CREB-regulated transcription coactivator 3
K17332  NFATC2, NFAT1, NFATP; nuclear factor of activated T-cells, cytoplasmic 2
K17333  NFATC3, NFAT4; nuclear factor of activated T-cells, cytoplasmic 3
K17334  NFATC4, NFAT3; nuclear factor of activated T-cells, cytoplasmic 4
K17454  E2F1; transcription factor E2F1
K19259  env; Deltaretrovirus envelope glycoprotein gp62
K21770  CCNB2; G2/mitotic-specific cyclin-B2
K21857  tax; Deltaretrovirus protein Tax-1
K21932  ETS2; C-ets-2
K23018  rex; HTLV-1 rex polyprotein
K23068  p30II; HTLV-1 accessory protein p30II
K23069  p12I; HTLV-1 accessory protein p12I
K23070  p13; HTLV-1 accessory protein p13
K23071  HBZ; HTLV-1 basic zipper factor
K23605  SMAD3; mothers against decapentaplegic homolog 3
K24862  gp46; HTLV envelope surface glycoprotein gp46
K24863  gp21; HTLV envelope transmembrane protein gp21
K25051  MA; HTLV-1 matrix protein
K25052  CA; HTLV-1 capsid protein
K25053  NC; HTLV-1 nucleocapsid protein
K25054  PR; HTLV-1 protease
K25055  RT; HTLV-1 reverse transcriptase / ribonuclease H
K25056  IN; HTLV-1 integrase
K25228  APC15, ANAPC15; anaphase-promoting complex subunit 15
K25229  APC16, ANAPC16; anaphase-promoting complex subunit 16
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
  Journal
BioSciences Master Reviews, July 2013
Reference
PMID:18923409
  Authors
Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
  Journal
Nat Rev Microbiol 6:815-26 (2008)
DOI:10.1038/nrmicro1972
Reference
PMID:15040584
  Authors
Vicente-Manzanares M, Sanchez-Madrid F
  Title
Role of the cytoskeleton during leukocyte responses.
  Journal
Nat Rev Immunol 4:110-22 (2004)
DOI:10.1038/nri1268
Reference
PMID:27334587
  Authors
Dutartre H, Claviere M, Journo C, Mahieux R
  Title
Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
  Journal
J Virol 90:7607-17 (2016)
DOI:10.1128/JVI.00407-16
Reference
PMID:15988028
  Authors
Awasthi S, Sharma A, Wong K, Zhang J, Matlock EF, Rogers L, Motloch P, Takemoto S, Taguchi H, Cole MD, Luscher B, Dittrich O, Tagami H, Nakatani Y, McGee M, Girard AM, Gaughan L, Robson CN, Monnat RJ Jr, Harrod R
  Title
A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
  Journal
Mol Cell Biol 25:6178-98 (2005)
DOI:10.1128/MCB.25.14.6178-6198.2005
Reference
PMID:21994758
  Authors
Edwards D, Fenizia C, Gold H, de Castro-Amarante MF, Buchmann C, Pise-Masison CA, Franchini G
  Title
Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
  Journal
Viruses 3:861-85 (2011)
DOI:10.3390/v3060861
Reference
PMID:26927155
  Authors
Nakano K, Watanabe T
  Title
HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
  Journal
Viruses 8:58 (2016)
DOI:10.3390/v8030058
Reference
PMID:22783232
  Authors
Shida H
  Title
Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
  Journal
Front Microbiol 3:179 (2012)
DOI:10.3389/fmicb.2012.00179
Reference
PMID:23248621
  Authors
Bai XT, Nicot C
  Title
Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
  Journal
Front Microbiol 3:400 (2012)
DOI:10.3389/fmicb.2012.00400
Reference
PMID:18421579
  Authors
Taylor JM, Nicot C
  Title
HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
  Journal
Apoptosis 13:733-47 (2008)
DOI:10.1007/s10495-008-0208-7
Reference
PMID:15761473
  Authors
D'Agostino DM, Silic-Benussi M, Hiraragi H, Lairmore MD, Ciminale V
  Title
The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth.
  Journal
Cell Death Differ 12 Suppl 1:905-15 (2005)
DOI:10.1038/sj.cdd.4401576
Reference
PMID:20332002
  Authors
Silic-Benussi M, Biasiotto R, Andresen V, Franchini G, D'Agostino DM, Ciminale V
  Title
HTLV-1 p13, a small protein with a busy agenda.
  Journal
Mol Aspects Med 31:350-8 (2010)
DOI:10.1016/j.mam.2010.03.001
Reference
PMID:23741982
  Authors
Fuentes-Gonzalez AM, Contreras-Paredes A, Manzo-Merino J, Lizano M
  Title
The modulation of apoptosis by oncogenic viruses.
  Journal
Virol J 10:182 (2013)
DOI:10.1186/1743-422X-10-182
Reference
PMID:21743832
  Authors
Qu Z, Xiao G
  Title
Human T-cell lymphotropic virus: a model of NF-kappaB-associated tumorigenesis.
  Journal
Viruses 3:714-49 (2011)
DOI:10.3390/v3060714
Reference
PMID:21994767
  Authors
Saggioro D
  Title
Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way?
  Journal
Viruses 3:1001-14 (2011)
DOI:10.3390/v3071001
Reference
PMID:16036567
  Authors
Harhaj EW, Harhaj NS
  Title
Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
  Journal
IUBMB Life 57:83-91 (2005)
DOI:10.1080/15216540500078715
Reference
PMID:16155602
  Authors
Sun SC, Yamaoka S
  Title
Activation of NF-kappaB by HTLV-I and implications for cell transformation.
  Journal
Oncogene 24:5952-64 (2005)
DOI:10.1038/sj.onc.1208969
Reference
PMID:9710600
  Authors
Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET Jr, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC
  Title
Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
  Journal
Mol Cell Biol 18:5157-65 (1998)
DOI:10.1128/MCB.18.9.5157
Reference
PMID:21315773
  Authors
Nakachi S, Nakazato T, Ishikawa C, Kimura R, Mann DA, Senba M, Masuzaki H, Mori N
  Title
Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
  Journal
Biochim Biophys Acta 1813:731-41 (2011)
DOI:10.1016/j.bbamcr.2011.02.002
Reference
PMID:26797638
  Authors
James CD, Roberts S
  Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
  Journal
Pathogens 5:E8 (2016)
DOI:10.3390/pathogens5010008
Reference
PMID:26324707
  Authors
Cherian MA, Baydoun HH, Al-Saleem J, Shkriabai N, Kvaratskhelia M, Green P, Ratner L
  Title
Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.
  Journal
J Biol Chem 290:26270-81 (2015)
DOI:10.1074/jbc.M115.684746
Reference
PMID:11264182
  Authors
Mori N, Morishita M, Tsukazaki T, Giam CZ, Kumatori A, Tanaka Y, Yamamoto N
  Title
Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
  Journal
Blood 97:2137-44 (2001)
DOI:10.1182/blood.v97.7.2137
Reference
PMID:15310405
  Authors
Azran I, Schavinsky-Khrapunsky Y, Aboud M
  Title
Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
  Journal
Retrovirology 1:20 (2004)
DOI:10.1186/1742-4690-1-20
Reference
PMID:11244044
  Authors
Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
  Journal
Annu Rev Immunol 19:475-96 (2001)
DOI:10.1146/annurev.immunol.19.1.475
Reference
PMID:12802280
  Authors
Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
  Title
Inactivation of hTERT transcription by Tax.
  Journal
Oncogene 22:3734-41 (2003)
DOI:10.1038/sj.onc.1206468
Related
pathway
ko03013  Nucleocytoplasmic transport
ko04010  MAPK signaling pathway
ko04064  NF-kappa B signaling pathway
ko04110  Cell cycle
ko04115  p53 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04350  TGF-beta signaling pathway
ko04612  Antigen processing and presentation
ko04660  T cell receptor signaling pathway
ko04668  TNF signaling pathway

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