KEGG   PATHWAY: lve04510
Entry
lve04510                    Pathway                                
Name
Focal adhesion - Lipotes vexillifer (Yangtze River dolphin)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
lve04510  Focal adhesion
lve04510

Other DBs
GO: 0005925
Organism
Lipotes vexillifer (Yangtze River dolphin) [GN:lve]
Gene
103068454  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
103068519  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
103068687  CAV2; caveolin-2 [KO:K12958]
103068905  THBS3; thrombospondin-3 [KO:K04659]
103068921  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103069239  RAP1A; ras-related protein Rap-1A [KO:K04353]
103069249  [KO:K06236]
103069406  CHAD; chondroadherin isoform X1 [KO:K06248]
103069915  PARVA; alpha-parvin [KO:K06275]
103070260  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103070292  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
103070306  COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
103070370  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103070575  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
103070633  FLNA; filamin-A isoform X1 [KO:K04437]
103070717  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
103070821  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
103070825  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
103071106  LAMC3; laminin subunit gamma-3 [KO:K06247]
103071141  ITGA11; integrin alpha-11 [KO:K06587]
103071252  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
103071281  COL6A3; LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238]
103071469  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
103071473  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103071744  LAMB1; laminin subunit beta-1 [KO:K05636]
103071829  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
103071840  PPP1R12B; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
103071861  JUN; transcription factor AP-1 [KO:K04448]
103071962  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
103071970  LAMB2; laminin subunit beta-2 [KO:K06243]
103071971  [KO:K06236]
103071997  PPP1R12A; protein phosphatase 1 regulatory subunit 12A-like isoform X1 [KO:K06270]
103072342  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103072491  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
103072598  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
103072869  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
103072994  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
103073004  VWF; von Willebrand factor [KO:K03900]
103073028  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103073252  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
103073424  LAMA5; laminin subunit alpha-5 [KO:K06240]
103073514  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
103073883  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
103074298  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103074358  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
103074387  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
103074553  ITGA5; integrin alpha-5 [KO:K06484]
103074641  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
103074732  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
103074749  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
103074757  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
103074827  VEGFC; vascular endothelial growth factor C [KO:K05449]
103074830  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
103074885  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
103075356  ITGA2B; integrin alpha-IIb [KO:K06476]
103075416  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
103075543  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103075672  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
103076043  HRAS; GTPase HRas isoform X1 [KO:K02833]
103076365  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103076387  PDGFC; platelet-derived growth factor C [KO:K05450]
103076541  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
103076801  VTN; vitronectin isoform X1 [KO:K06251]
103077106  ITGA4; integrin alpha-4 [KO:K06483]
103077180  ITGB4; integrin beta-4 [KO:K06525]
103077223  ACTB; actin, cytoplasmic 1 [KO:K05692]
103077228  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
103077294  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
103077310  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
103077329  TNC; tenascin isoform X1 [KO:K06252]
103077393  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
103077564  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
103077706  PAK7; serine/threonine-protein kinase PAK 7 isoform X1 [KO:K05736] [EC:2.7.11.1]
103077707  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
103077775  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
103077970  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
103077986  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
103078101  ITGA6; integrin alpha-6 [KO:K06485]
103078122  SHC3; SHC-transforming protein 3 [KO:K17448]
103078299  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
103078301  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
103078515  PXN; paxillin-like isoform X1 [KO:K05760]
103078532  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
103078725  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103078728  SPP1; osteopontin isoform X1 [KO:K06250]
103078792  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103078804  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
103078928  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
103078952  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
103079072  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
103079242  SOS1; son of sevenless homolog 1 [KO:K03099]
103079256  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
103079280  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
103079514  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103079754  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
103079766  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103079981  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
103080002  IBSP; bone sialoprotein 2 [KO:K06253]
103080471  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
103080579  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
103080694  THBS1; thrombospondin-1 [KO:K16857]
103080867  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
103081084  SOS2; son of sevenless homolog 2-like [KO:K03099]
103081122  [KO:K26255]
103081291  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103081453  ITGB7; integrin beta-7 [KO:K06590]
103081507  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
103081594  LAMA1; laminin subunit alpha-1 [KO:K05637]
103081640  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
103081765  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
103081872  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
103082053  PGF; placenta growth factor isoform X1 [KO:K16859]
103082256  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
103082310  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
103082363  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
103082438  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
103082455  [KO:K04514] [EC:2.7.11.1]
103082487  EMP1; epithelial membrane protein 1 [KO:K26255]
103082555  FLNB; filamin-B isoform X1 [KO:K27392]
103082615  CAV3; caveolin-3 [KO:K12959]
103082805  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
103082841  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
103083426  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
103083485  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
103083507  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
103083551  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
103083608  BAD; bcl2 antagonist of cell death [KO:K02158]
103083668  THBS4; thrombospondin-4 [KO:K04659]
103083960  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103084224  FN1; LOW QUALITY PROTEIN: fibronectin [KO:K05717]
103084474  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
103084630  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103084753  LAMA3; laminin subunit alpha-3 [KO:K06240]
103084885  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
103084946  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
103084975  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103084985  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
103085046  PDGFD; platelet-derived growth factor D-like isoform X1 [KO:K05450]
103085092  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
103085145  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
103085204  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
103085303  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103085446  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
103085747  ZYX; zyxin isoform X1 [KO:K06273]
103085886  TLN1; LOW QUALITY PROTEIN: talin-1 [KO:K06271]
103085988  ITGA2; integrin alpha-2 [KO:K06481]
103086084  [KO:K06269] [EC:3.1.3.16]
103086383  ACTG1; actin, cytoplasmic 2 [KO:K05692]
103086398  THBS2; LOW QUALITY PROTEIN: thrombospondin-2 [KO:K04659]
103086550  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
103086653  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103086689  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
103086871  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
103087072  ITGAV; integrin alpha-V [KO:K06487]
103087133  FIGF; vascular endothelial growth factor D [KO:K05449]
103087142  BIRC2; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 2 [KO:K16060]
103087166  LAMB3; laminin subunit beta-3 [KO:K06244]
103087566  TLN2; talin-2 [KO:K06271]
103087655  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
103087676  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103087802  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
103087905  CRK; adapter molecule crk isoform X1 [KO:K04438]
103087933  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103088294  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
103088361  PARVG; gamma-parvin [KO:K06275]
103088369  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
103088449  [KO:K12758]
103088616  [KO:K06238]
103088624  PARVB; beta-parvin isoform X1 [KO:K06275]
103088628  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
103088639  [KO:K12757]
103088756  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103088802  TNR; tenascin-R [KO:K06252]
103088833  SHC2; SHC-transforming protein 2 [KO:K17447]
103088874  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
103088885  [KO:K06238]
103088900  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
103088976  [KO:K07836]
103089007  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
103089053  ITGB5; integrin beta-5 [KO:K06588]
103089055  MYL10; myosin regulatory light chain 10 [KO:K12756]
103089095  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
103089216  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
103089257  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103089268  MYL12B; myosin regulatory light chain 12B isoform X1 [KO:K12757]
103089331  TNN; tenascin-N [KO:K06252]
103089400  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
103089438  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
103089640  ITGA9; integrin alpha-9 [KO:K06585]
103090009  LAMC1; LOW QUALITY PROTEIN: laminin subunit gamma-1 [KO:K05635]
103090157  ITGA8; integrin alpha-8 [KO:K06584]
103090223  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
103090274  LAMC2; laminin subunit gamma-2 [KO:K06246]
103090456  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
103090463  CRKL; crk-like protein [KO:K04438]
103090549  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103090612  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103090939  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
103090942  EMP2; epithelial membrane protein 2 [KO:K26256]
103090984  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
103091453  CAV1; caveolin-1 isoform X1 [KO:K06278]
103091613  VCL; vinculin isoform X1 [KO:K05700]
103091628  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
103091674  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
lve04010  MAPK signaling pathway
lve04060  Cytokine-cytokine receptor interaction
lve04070  Phosphatidylinositol signaling system
lve04110  Cell cycle
lve04151  PI3K-Akt signaling pathway
lve04310  Wnt signaling pathway
lve04512  ECM-receptor interaction
lve04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

DBGET integrated database retrieval system