KEGG   PATHWAY: mcc05202
Entry
mcc05202                    Pathway                                
Name
Transcriptional misregulation in cancer - Macaca mulatta (rhesus monkey)
Description
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.
Class
Human Diseases; Cancer: overview
Pathway map
mcc05202  Transcriptional misregulation in cancer
mcc05202

Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100424446  [KO:K15624]
100427119  KDM6A; lysine-specific demethylase 6A isoform X1 [KO:K11447] [EC:1.14.11.68]
100427400  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
100429321  NSD2; histone-lysine N-methyltransferase NSD2 isoform X1 [KO:K11424] [EC:2.1.1.357]
100430668  [KO:K11253]
106992288  BMI1; polycomb complex protein BMI-1 [KO:K11459]
106992354  ELANE; neutrophil elastase [KO:K01327] [EC:3.4.21.37]
106992384  HOXA11; homeobox protein Hox-A11 [KO:K21951]
106995090  MAF; transcription factor Maf [KO:K09035]
106995582  MEN1; menin isoform X1 [KO:K14970]
106995770  [KO:K15624]
106995824  [KO:K15624]
106996003  [KO:K06856]
106997505  ETV1; ETS translocation variant 1 isoform X1 [KO:K09431]
106999628  [KO:K06856]
107000233  [KO:K11253]
114669830  [KO:K11253]
114669851  [KO:K05092] [EC:2.7.10.1]
114672263  [KO:K10140]
114675335  [KO:K04388] [EC:2.7.11.30]
114675515  [KO:K14021]
114675805  [KO:K06856]
114677623  [KO:K11253]
114677671  [KO:K11253]
114679736  [KO:K06856]
114680386  [KO:K05230]
574121  RTD1C; demidefensin-3 precursor [KO:K05230]
574122  RTD1A; rhesus theta defensin-1/3 subunit A precursor [KO:K05230]
574123  RTD1B; rhesus theta defensin-1/2 subunit B precursor [KO:K05230]
574133  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
574190  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
574196  MNP1A; neutrophil defensin 8 precursor [KO:K05230]
574197  MNP2; neutrophil defensin 6 precursor [KO:K05230]
574304  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
574309  [KO:K05230]
574310  [KO:K05230]
574311  DEFA4; neutrophil defensin 4 precursor [KO:K05230]
574340  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
574371  CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427]
613028  CXCL8; interleukin-8 precursor [KO:K10030]
677694  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
693300  ERG; transcriptional regulator ERG isoform X2 [KO:K09435]
693394  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
693644  ATF1; cyclic AMP-dependent transcription factor ATF-1 [KO:K09053]
693797  CCNA1; cyclin-A1 isoform X3 [KO:K06627]
693887  [KO:K11253]
693939  [KO:K11253]
694024  HIST3H3; histone H3.1 [KO:K11253]
694069  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
694152  [KO:K11253]
694364  EYA1; eyes absent homolog 1 isoform X4 [KO:K15616] [EC:3.1.3.48]
694416  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
694626  MYC; myc proto-oncogene protein [KO:K04377]
694662  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
694807  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
694992  MEF2C; myocyte-specific enhancer factor 2C [KO:K04454]
695064  ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
695092  HIST1H3D; histone H3.1 [KO:K11253]
695427  [KO:K11253]
695537  MITF; microphthalmia-associated transcription factor [KO:K09455]
695663  [KO:K11253]
695734  ETV6; transcription factor ETV6 [KO:K03211]
696061  WT1; Wilms tumor protein isoform X1 [KO:K09234]
696306  [KO:K10785]
696327  ZBTB17; zinc finger and BTB domain-containing protein 17 [KO:K10500]
696331  IL2RB; interleukin-2 receptor subunit beta precursor [KO:K05069]
696351  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
696476  PER2; period circadian protein homolog 2 isoform X2 [KO:K02633]
696749  RUNX1; runt-related transcription factor 1 [KO:K08367]
696868  IGFBP3; insulin-like growth factor-binding protein 3 precursor [KO:K10138]
696934  RUNX1T1; protein CBFA2T1 isoform X2 [KO:K10053]
697001  BMP2K; BMP-2-inducible protein kinase isoform X1 [KO:K08854] [EC:2.7.11.1]
697188  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
697420  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
697470  PTCRA; pre T-cell antigen receptor alpha precursor [KO:K06056]
697482  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
697630  JMJD1C; probable JmjC domain-containing histone demethylation protein 2C isoform X1 [KO:K11449] [EC:1.14.11.-]
697685  MEIS1; homeobox protein Meis1 isoform X2 [KO:K15613]
697724  KLF3; Krueppel-like factor 3 [KO:K15605]
697835  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
697864  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
697904  [KO:K10785]
698011  TSPAN7; tetraspanin-7 [KO:K06571]
698105  [KO:K11253]
698396  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
698444  IGF1; insulin-like growth factor I precursor [KO:K05459]
698699  MYCN; N-myc proto-oncogene protein isoform X1 [KO:K09109]
698785  [KO:K10785]
699012  HHEX; hematopoietically-expressed homeobox protein HHEX [KO:K08024]
699015  [KO:K11253]
699281  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
699405  ITGB7; integrin beta-7 [KO:K06590]
699443  [KO:K11253]
699729  HOXA9; homeobox protein Hox-A9 [KO:K21950]
699840  CDK9; cyclin-dependent kinase 9 [KO:K02211] [EC:2.7.11.22 2.7.11.23]
700030  FOXO1; forkhead box protein O1 [KO:K07201]
700206  RARA; retinoic acid receptor alpha isoform X2 [KO:K08527]
700308  SS18L1; calcium-responsive transactivator isoform X1 [KO:K15623]
700379  PML; protein PML [KO:K10054] [EC:2.3.2.-]
700583  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
700634  PTK2; focal adhesion kinase 1 isoform X8 [KO:K05725] [EC:2.7.10.2]
700733  AFF1; AF4/FMR2 family member 1 isoform X3 [KO:K15184]
700907  ETV5; ETS translocation variant 5 isoform X1 [KO:K15593]
701054  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
701065  FEV; protein FEV [KO:K09437]
701157  ZEB1; zinc finger E-box-binding homeobox 1 isoform X1 [KO:K09299]
701703  TLX3; T-cell leukemia homeobox protein 3 [KO:K15607]
701906  PAX8; paired box protein Pax-8 isoform X6 [KO:K09293]
702013  PAX7; paired box protein Pax-7 isoform X2 [KO:K09381]
702105  MLLT1; protein ENL isoform X1 [KO:K15187]
702468  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
702592  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
702710  SP1; transcription factor Sp1 [KO:K04684]
702846  NFKBIZ; NF-kappa-B inhibitor zeta isoform X2 [KO:K14242]
703029  [KO:K10785]
703088  TGFBR2; TGF-beta receptor type-2 precursor [KO:K04388] [EC:2.7.11.30]
703331  RUNX2; runt-related transcription factor 2 isoform X2 [KO:K09278]
703442  CDK14; cyclin-dependent kinase 14 isoform X1 [KO:K08821] [EC:2.7.11.22]
703447  SUPT3H; transcription initiation protein SPT3 homolog [KO:K11313]
703696  SIX1; homeobox protein SIX1 [KO:K15614]
703762  MMP3; stromelysin-1 [KO:K01394] [EC:3.4.24.17]
703798  SIX4; homeobox protein SIX4 isoform X1 [KO:K15615]
703889  [KO:K11253]
704104  [KO:K11253]
704116  MLF1; myeloid leukemia factor 1 [KO:K15622]
704475  PLAT; tissue-type plasminogen activator [KO:K01343] [EC:3.4.21.68]
704562  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
704578  SPINT1; LOW QUALITY PROTEIN: kunitz-type protease inhibitor 1 [KO:K15619]
704713  HOXA10; homeobox protein Hox-A10 [KO:K17443]
704845  HIST2H3A; uncharacterized protein HIST2H3A [KO:K11253]
705220  [KO:K11253]
705238  BCL11B; B-cell lymphoma/leukemia 11B isoform X1 [KO:K22046]
705315  PAX3; paired box protein Pax-3 isoform X1 [KO:K09381]
705511  KMT2A; histone-lysine N-methyltransferase 2A isoform X2 [KO:K09186] [EC:2.1.1.354]
705713  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
705719  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
705819  IL6; interleukin-6 precursor [KO:K05405]
705853  PLAU; urokinase-type plasminogen activator isoform X1 [KO:K01348] [EC:3.4.21.73]
706534  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
706946  IL3; interleukin-3 precursor [KO:K04736]
707259  CCNA2; cyclin-A2 [KO:K06627]
707725  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
707749  CD40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160]
707754  CCNT1; cyclin-T1 [KO:K15188]
707769  JUP; junction plakoglobin [KO:K10056]
708084  MMP9; matrix metalloproteinase-9 precursor [KO:K01403] [EC:3.4.24.35]
708227  IGF1R; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
708228  MAX; protein max [KO:K04453]
708441  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
708657  [KO:K15624]
708736  BCL6; B-cell lymphoma 6 protein [KO:K15618]
708813  CCNT2; cyclin-T2 isoform X2 [KO:K15188]
708839  FUT8; alpha-(1,6)-fucosyltransferase [KO:K00717] [EC:2.4.1.68]
708847  [KO:K11253]
708899  [KO:K11253]
708907  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
709052  [KO:K15624]
709149  [KO:K15624]
709251  [KO:K15624]
709296  [KO:K11253]
709349  ETV4; ETS translocation variant 4 isoform X5 [KO:K15592]
709597  SSX3; protein SSX3 [KO:K15624]
709684  [KO:K15624]
709767  NUPR1; nuclear protein 1 [KO:K15626]
709897  SS18; protein SSXT [KO:K15623]
710033  DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X2 [KO:K11427] [EC:2.1.1.360]
710149  [KO:K10784]
710324  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
710379  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
710748  [KO:K11253]
711257  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
711512  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
711584  TLX1; T-cell leukemia homeobox protein 1 [KO:K09340]
711638  IL1R2; interleukin-1 receptor type 2 precursor [KO:K04387]
711691  PBX3; pre-B-cell leukemia transcription factor 3 isoform X1 [KO:K15610]
711732  MLLT3; protein AF-9 isoform X1 [KO:K15187]
711877  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
712010  SPI1; transcription factor PU.1 isoform X3 [KO:K09438]
712161  TFE3; transcription factor E3 [KO:K09105]
712571  BCL2A1; bcl-2-related protein A1 [KO:K02162]
712653  LDB1; LIM domain-binding protein 1 [KO:K15617]
712786  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 isoform X1 [KO:K15589]
713035  BCL2L1; bcl-2-like protein 1 [KO:K04570]
713191  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
713433  FUS; RNA-binding protein FUS isoform X2 [KO:K13098]
713442  CEBPE; CCAAT/enhancer-binding protein epsilon [KO:K10051]
713813  DDB2; DNA damage-binding protein 2 [KO:K10140]
713973  [KO:K15624]
714246  MPO; myeloperoxidase isoform X1 [KO:K10789] [EC:1.11.2.2]
714390  CD86; T-lymphocyte activation antigen CD86 precursor [KO:K05413]
714419  [KO:K06856]
714432  EWSR1; RNA-binding protein EWS [KO:K13209]
714610  PROM1; prominin-1 precursor [KO:K06532]
714664  FCGR1A; high affinity immunoglobulin gamma Fc receptor I precursor [KO:K06498]
714748  FLI1; Friend leukemia integration 1 transcription factor isoform X2 [KO:K09436]
714832  ITGAM; integrin alpha-M isoform X3 [KO:K06461]
714901  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
715138  TMPRSS2; transmembrane protease serine 2 isoform X3 [KO:K09633] [EC:3.4.21.122]
715326  ASPSCR1; tether containing UBX domain for GLUT4 isoform X1 [KO:K15627]
715919  RELA; transcription factor p65 isoform X1 [KO:K04735]
716170  TP53; cellular tumor antigen p53 [KO:K04451]
716349  TAF15; TATA-binding protein-associated factor 2N isoform X1 [KO:K14651]
716518  GZMB; granzyme B [KO:K01353] [EC:3.4.21.79]
716839  PAX5; paired box protein Pax-5 isoform X1 [KO:K09383]
717000  DEFA6; defensin-6 [KO:K05230]
717153  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
717368  RXRB; retinoic acid receptor RXR-beta isoform X2 [KO:K08525]
717502  LMO2; rhombotin-2 [KO:K15612]
717560  NR4A3; nuclear receptor subfamily 4 group A member 3 isoform X2 [KO:K08559]
717721  HMGA2; high mobility group protein HMGI-C isoform X1 [KO:K09283]
717804  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
718185  LYL1; protein lyl-1 [KO:K15604]
718280  [KO:K11253]
718284  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
718660  PRCC; proline-rich protein PRCC [KO:K13105]
718948  BAX; apoptosis regulator BAX [KO:K02159]
719151  ETV7; transcription factor ETV7 isoform X1 [KO:K03211]
719199  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
719670  NTRK1; high affinity nerve growth factor receptor isoform X3 [KO:K03176] [EC:2.7.10.1]
720452  [KO:K06856]
720904  [KO:K06856]
720935  [KO:K06856]
720985  [KO:K06856]
721002  [KO:K06856]
721083  [KO:K06856]
721325  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
721712  FLT3; LOW QUALITY PROTEIN: receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
722068  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
722278  [KO:K06856]
722437  BAIAP3; BAI1-associated protein 3 isoform X2 [KO:K15621]
Reference
PMID:11607818
  Authors
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG
  Title
Common themes in the pathogenesis of acute myeloid leukemia.
  Journal
Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642
Reference
PMID:12032780
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
PMID:12529654
  Authors
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C
  Title
New mechanisms of AML1 gene alteration in hematological malignancies.
  Journal
Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766
Reference
PMID:10717473
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7
Reference
PMID:19075268
  Authors
Koschmieder S, Halmos B, Levantini E, Tenen DG
  Title
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
  Journal
J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812
Reference
PMID:11340171
  Authors
Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG
  Title
c-Myc is a critical target for c/EBPalpha in granulopoiesis.
  Journal
Mol Cell Biol 21:3789-806 (2001)
DOI:10.1128/MCB.21.11.3789-3806.2001
Reference
PMID:15985538
  Authors
Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP
  Title
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
  Journal
Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358
Reference
PMID:12393465
  Authors
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G
  Title
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
  Journal
Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288
Reference
PMID:12130514
  Authors
Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG
  Title
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
  Journal
Blood 100:998-1007 (2002)
DOI:10.1182/blood.V100.3.998
Reference
PMID:15160934
  Authors
Jing Y
  Title
The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.
  Journal
Leuk Lymphoma 45:639-48 (2004)
DOI:10.1080/10428190310001609933
Reference
PMID:15024077
  Authors
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H
  Title
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
  Journal
Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004
Reference
PMID:19855079
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
Reference
PMID:10500199
  Authors
McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C
  Title
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.
  Journal
Proc Natl Acad Sci U S A 96:11464-9 (1999)
DOI:10.1073/pnas.96.20.11464
Reference
PMID:15156184
  Authors
Zelent A, Greaves M, Enver T
  Title
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
  Journal
Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672
Reference
PMID:14630078
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
PMID:19141473
  Authors
Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA
  Title
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
  Journal
Genes Dev 22:3403-8 (2008)
DOI:10.1101/gad.1741408
Reference
PMID:16169901
  Authors
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ
  Title
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
  Journal
Proc Natl Acad Sci U S A 102:14028-33 (2005)
DOI:10.1073/pnas.0506464102
Reference
PMID:21518926
  Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
  Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
  Journal
Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699
Reference
PMID:14701735
  Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
  Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
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Mol Cell Biol 24:617-28 (2004)
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PMID:19133982
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Riz I, Hawley TS, Johnston H, Hawley RG
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Br J Haematol 145:140-3 (2009)
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Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.
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Blood 101:3681-6 (2003)
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Blood 97:2798-807 (2001)
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Best Pract Res Clin Haematol 16:1-13 (2003)
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Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.
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Cancer Cell 5:191-9 (2004)
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Curr Opin Genet Dev 19:82-91 (2009)
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Biochim Biophys Acta 1796:201-15 (2009)
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The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
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Endocrinology 148:932-5 (2007)
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Exp Cell Res 315:2399-409 (2009)
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Nat Rev Cancer 8:497-511 (2008)
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An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.
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Cancer Cell 17:443-54 (2010)
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TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.
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PLoS One 6:e21650 (2011)
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ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion.
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Mol Endocrinol 21:1835-46 (2007)
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Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.
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Cancer Res 68:73-80 (2008)
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The MYCN oncogene and differentiation in neuroblastoma.
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MYCN oncoprotein targets and their therapeutic potential.
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The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.
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Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma.
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p53 is a direct transcriptional target of MYCN in neuroblastoma.
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Cancer Res 70:1377-88 (2010)
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J Biol Chem 282:12503-16 (2007)
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Mechanisms of disease: multiple endocrine neoplasia type 1-relation to chromatin modifications and transcription regulation.
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Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma.
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Oncogene 22:1-9 (2003)
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Cancer Res 69:7140-50 (2009)
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Semin Cancer Biol 15:197-205 (2005)
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Oncogene 28:270-8 (2009)
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PAX3-FOXO1 fusion gene in rhabdomyosarcoma.
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Cancer Lett 270:10-8 (2008)
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Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma.
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Genomics 79:278-84 (2002)
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PMID:17101797
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The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma.
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Mol Cell Biol 27:1348-55 (2007)
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PMID:19472090
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Expression of MET in alveolar soft part sarcoma.
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Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.
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Genes Cancer 2:466-74 (2011)
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Recent advances in p53 research and cancer treatment.
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J Biomed Biotechnol 2011:978312 (2011)
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Related
pathway
mcc04115  p53 signaling pathway
mcc05211  Renal cell carcinoma
mcc05215  Prostate cancer
mcc05216  Thyroid cancer
mcc05221  Acute myeloid leukemia
KO pathway
ko05202   

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