Entry Name JAK-STAT signaling pathway - Manis javanica (Malayan pangolin)
Description The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Manis javanica (Malayan pangolin) [GN:
mjv ]
Gene 108383561 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
108385818 STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225 ]
108386068 STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
108387774 IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138 ]
108389002 IL3RA; interleukin-3 receptor subunit alpha isoform X4 [KO:K04737 ]
108389965 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066 ]
108390189 IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
108390365 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
108390475 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
108392655 CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738 ]
108392662 IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
108392857 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
108393156 CLCF1; cardiotrophin-like cytokine factor 1 isoform X2 [KO:K05421 ]
108393777 IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137 ]
108393946 IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055 ]
108394461 IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076 ]
108394855 PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063 ] [EC:2.3.2.-]
108395488 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
108395551 GALT; galactose-1-phosphate uridylyltransferase isoform X1 [KO:K05056 ]
108395975 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649 ]
108396286 FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365 ]
108397360 PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386 ]
108399808 IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X3 [KO:K05077 ]
108400080 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
108400081 STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222 ]
108400380 PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064 ] [EC:2.3.2.-]
108400801 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
108401571 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
108402236 STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221 ]
108403236 MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539 ]
108403518 IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598 ]
108404506 STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705 ]
108405149 IL4R; interleukin-4 receptor subunit alpha isoform X4 [KO:K05071 ]
108406656 PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706 ] [EC:2.3.2.-]
108406858 IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072 ]
108407553 IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
108408073 EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357 ]
108409506 IL10RB; interleukin-10 receptor subunit beta isoform X2 [KO:K05135 ]
118970652 PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359 ]
Reference Authors Harrison DA
Title The Jak/STAT pathway.
Journal Reference Authors Kiu H, Nicholson SE
Title Biology and significance of the JAK/STAT signalling pathways.
Journal Reference Authors Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Title Direct effects of type I interferons on cells of the immune system.
Journal Reference Authors Fish EN, Platanias LC
Title Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Journal Reference Authors Ivanenkov YA, Balakin KV, Lavrovsky Y
Title Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Journal Reference Authors O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
Title The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Journal Reference Authors Zoranovic T, Grmai L, Bach EA
Title Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
Journal Reference Authors Ungureanu D, Silvennoinen O
Title SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Journal Reference Authors Richard AJ, Stephens JM
Title The role of JAK-STAT signaling in adipose tissue function.
Journal Reference Authors Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
Title STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Journal Reference Authors Hirano T, Ishihara K, Hibi M
Title Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Journal Reference Authors Rane SG, Reddy EP
Title Janus kinases: components of multiple signaling pathways.
Journal Reference Authors Heim MH
Title The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Journal Reference Authors Morris R, Kershaw NJ, Babon JJ
Title The molecular details of cytokine signaling via the JAK/STAT pathway.
Journal Reference Authors Tzeng HT, Chyuan IT, Lai JH
Title Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
Journal Reference Authors Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
Title JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
Journal Related mjv04060 Cytokine-cytokine receptor interaction
KO pathway
