KEGG   PATHWAY: mjv04060
Entry
mjv04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Manis javanica (Malayan pangolin)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
mjv04060  Cytokine-cytokine receptor interaction
mjv04060

Organism
Manis javanica (Malayan pangolin) [GN:mjv]
Gene
108383372  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X3 [KO:K04721]
108383562  [KO:K05063]
108383567  IL2; interleukin-2 [KO:K05429]
108383569  IL21; interleukin-21 [KO:K05434]
108383720  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
108383754  [KO:K05408]
108383755  [KO:K12964]
108383756  [KO:K05408]
108383807  TNFSF4; tumor necrosis factor ligand superfamily member 4 isoform X1 [KO:K05469]
108383809  TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479]
108383849  GDF3; growth/differentiation factor 3 [KO:K22672]
108383886  CCR9; C-C chemokine receptor type 9 [KO:K04184]
108383888  XCR1; chemokine XC receptor 1 [KO:K04193]
108383891  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
108384008  IFNG; interferon gamma [KO:K04687]
108384285  [KO:K04723]
108384676  TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160]
108385040  EBI3; interleukin-27 subunit beta [KO:K24476]
108385153  CSF3; granulocyte colony-stimulating factor [KO:K05423]
108385350  MSTN; growth/differentiation factor 8 [KO:K05497]
108385396  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
108385400  PRL; prolactin [KO:K05439]
108385416  EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162]
108385428  [KO:K24382]
108385437  CTF1; cardiotrophin-1 isoform X3 [KO:K05422]
108385612  IL17C; LOW QUALITY PROTEIN: interleukin-17C [KO:K05491]
108385695  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
108385980  IL15; interleukin-15 isoform X1 [KO:K05433]
108385993  IFNGR2; interferon gamma receptor 2 [KO:K05133]
108386067  CCR10; C-C chemokine receptor type 10 [KO:K04185]
108386081  NGF; beta-nerve growth factor [KO:K02582]
108386265  GDF5; growth/differentiation factor 5 [KO:K04664]
108386385  CCL1; LOW QUALITY PROTEIN: C-C motif chemokine 1 [KO:K05514]
108386386  CCL8; C-C motif chemokine 8 isoform X1 [KO:K16596]
108386387  [KO:K16595]
108386389  [KO:K16597]
108386490  [KO:K04181]
108387059  CCR7; C-C chemokine receptor type 7 [KO:K04182]
108387107  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151]
108387357  [KO:K04175]
108387368  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
108387576  TNFRSF21; tumor necrosis factor receptor superfamily member 21 isoform X2 [KO:K05157]
108387605  LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159]
108387607  CD27; CD27 antigen isoform X1 [KO:K05144]
108387612  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
108387644  TNFRSF18; tumor necrosis factor receptor superfamily member 18 isoform X1 [KO:K05154]
108387646  TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X1 [KO:K05142]
108387774  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
108387775  IFNLR1; interferon lambda receptor 1 isoform X1 [KO:K05140]
108388270  RELT; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156]
108388277  [KO:K05414]
108388382  ACVR2B; activin receptor type-2B isoform X1 [KO:K13596] [EC:2.7.11.30]
108388693  IL11; interleukin-11 isoform X1 [KO:K05417]
108389002  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
108389086  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
108389334  [KO:K16622]
108389764  [KO:K14624]
108389768  [KO:K05066]
108389965  [KO:K05066]
108390063  IL13; interleukin-13 [KO:K05435]
108390065  IL4; interleukin-4 [KO:K05430]
108390150  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
108390168  BMP7; bone morphogenetic protein 7 isoform X1 [KO:K16621]
108390189  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
108390374  IL31; interleukin-31 [KO:K22631]
108390628  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
108391039  CCL28; C-C motif chemokine 28 isoform X1 [KO:K05513]
108391063  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
108391156  TNFRSF9; tumor necrosis factor receptor superfamily member 9 isoform X2 [KO:K05146]
108391238  IL9; interleukin-9 [KO:K05432]
108391240  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
108391479  BMP6; bone morphogenetic protein 6 [KO:K16620]
108391544  IL17A; interleukin-17A [KO:K05489]
108391859  TGFBR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
108391910  ACVR2A; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
108391987  [KO:K05447]
108392349  GDF9; growth/differentiation factor 9 [KO:K22673]
108392510  ACVR1; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
108392567  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
108392655  CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738]
108392662  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
108392856  [KO:K04736]
108392857  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
108392900  CD40; tumor necrosis factor receptor superfamily member 5 isoform X3 [KO:K03160]
108393000  [KO:K05174]
108393001  IL1RL1; interleukin-1 receptor-like 1 [KO:K05171]
108393007  IL18R1; interleukin-18 receptor 1 isoform X1 [KO:K05173]
108393034  IL1B; interleukin-1 beta [KO:K04519]
108393156  CLCF1; cardiotrophin-like cytokine factor 1 isoform X2 [KO:K05421]
108393208  [KO:K04722]
108393228  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
108393352  CXCL17; C-X-C motif chemokine 17 [KO:K22627]
108393599  CCL26; C-C motif chemokine 26 [KO:K21096]
108393600  CCL24; C-C motif chemokine 24 [KO:K21097]
108393724  BMP10; bone morphogenetic protein 10 [KO:K22670]
108393777  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
108393946  IL6R; interleukin-6 receptor subunit alpha isoform X2 [KO:K05055]
108394072  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
108394105  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
108394148  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
108394461  IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076]
108394464  TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
108394700  [KO:K05447]
108394778  IL17B; interleukin-17B isoform X2 [KO:K05490]
108394781  AMHR2; anti-Muellerian hormone type-2 receptor isoform X1 [KO:K04672] [EC:2.7.11.30]
108395274  THPO; thrombopoietin isoform X1 [KO:K06854]
108395315  [KO:K05424]
108395349  CCL27; LOW QUALITY PROTEIN: C-C motif chemokine 27 [KO:K16598]
108395358  [KO:K16598]
108395366  CCL19; C-C motif chemokine 19 [KO:K05512]
108395488  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
108395518  GDF6; growth/differentiation factor 6 [KO:K20012]
108395551  [KO:K05056]
108395594  [KO:K16062]
108395850  GDF2; growth/differentiation factor 2 [KO:K05503]
108395853  GDF10; growth/differentiation factor 10 [KO:K22674]
108395934  GDF11; growth/differentiation factor 11 [KO:K22679]
108396586  BMP3; bone morphogenetic protein 3 [KO:K05496]
108396772  INHA; inhibin alpha chain isoform X2 [KO:K05500]
108396861  LIF; leukemia inhibitory factor isoform X3 [KO:K05419]
108396879  OSM; oncostatin-M [KO:K05418]
108397080  IL34; interleukin-34 isoform X1 [KO:K22633]
108397407  [KO:K05440]
108397408  [KO:K05440]
108397409  [KO:K05414]
108397673  [KO:K05505]
108397803  TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152]
108397876  LTB; lymphotoxin-beta isoform X1 [KO:K03157]
108397877  TNF; tumor necrosis factor [KO:K03156]
108397878  LTA; lymphotoxin-alpha [KO:K05468]
108398074  CNTF; ciliary neurotrophic factor [KO:K05420]
108398270  [KO:K13594] [EC:2.7.11.30]
108398274  ACVR1B; activin receptor type-1B isoform X2 [KO:K13567] [EC:2.7.11.30]
108398622  IL6; interleukin-6 [KO:K05405]
108398727  [KO:K10030]
108398928  IL7; interleukin-7 isoform X1 [KO:K05431]
108398989  EPOR; erythropoietin receptor [KO:K05079]
108399024  RELL1; RELT-like protein 1 isoform X1 [KO:K26541]
108399095  IFNK; interferon kappa [KO:K05441]
108399139  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
108399294  [KO:K05486]
108399298  IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481]
108399299  IL36G; interleukin-36 gamma [KO:K05487]
108399300  IL36RN; interleukin-36 receptor antagonist protein [KO:K05483]
108399351  [KO:K05507]
108399719  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
108399808  IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X2 [KO:K05077]
108399939  [KO:K12967]
108400020  IL25; interleukin-25 [KO:K05493]
108400493  GHR; growth hormone receptor [KO:K05080]
108400628  CCR2; C-C chemokine receptor type 2 isoform X1 [KO:K04177]
108400629  [KO:K04180]
108400801  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
108400940  CCR3; C-C chemokine receptor type 3 [KO:K04178]
108400941  CCR1; C-C chemokine receptor type 1 [KO:K04176]
108400987  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
108401017  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
108401018  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
108401158  GDF7; growth/differentiation factor 7 [KO:K20013]
108401250  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
108401438  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
108401471  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
108401472  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
108401553  IL18; interleukin-18 [KO:K05482]
108401571  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
108401747  TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145]
108401797  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
108402233  IL23A; interleukin-23 subunit alpha isoform X1 [KO:K05426]
108402531  IFNB1; interferon beta [KO:K05415]
108402815  BMP15; bone morphogenetic protein 15 [KO:K05498]
108403017  IL10; interleukin-10 isoform X1 [KO:K05443]
108403018  IL19; interleukin-19 [KO:K05444]
108403021  IL20; interleukin-20 [KO:K22667]
108403056  CXCL13; C-X-C motif chemokine 13 isoform X1 [KO:K10032]
108403151  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
108403155  [KO:K05438]
108403291  IL17D; interleukin-17D isoform X2 [KO:K05492]
108403309  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
108403337  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
108403518  IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598]
108403555  CD4; T-cell surface glycoprotein CD4 isoform X1 [KO:K06454]
108403610  EDA; ectodysplasin-A isoform X1 [KO:K05480]
108403876  BMP2; bone morphogenetic protein 2 [KO:K21283]
108403995  IL17F; interleukin-17F [KO:K05494]
108404025  ACKR4; atypical chemokine receptor 4 [KO:K04186]
108404046  IL5; interleukin-5 isoform X1 [KO:K05428]
108404133  LIFR; leukemia inhibitory factor receptor [KO:K05058]
108404275  TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475]
108404277  [KO:K05474]
108404560  CXCL12; LOW QUALITY PROTEIN: stromal cell-derived factor 1 [KO:K10031]
108404608  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
108404707  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
108404710  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
108404850  CCL22; C-C motif chemokine 22 [KO:K21095]
108404851  CX3CL1; fractalkine [KO:K05508]
108404887  IL23R; interleukin-23 receptor [KO:K05065]
108404889  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
108405031  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
108405149  IL4R; interleukin-4 receptor subunit alpha isoform X2 [KO:K05071]
108405151  IL21R; interleukin-21 receptor isoform X1 [KO:K05075]
108405278  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
108405533  RELL2; LOW QUALITY PROTEIN: RELT-like protein 2 [KO:K26541]
108405578  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B isoform X1 [KO:K05150]
108405634  INHBB; inhibin beta B chain [KO:K22687]
108405848  PRLR; prolactin receptor isoform X1 [KO:K05081]
108406011  GDF15; growth/differentiation factor 15 [KO:K05504]
108406024  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
108406161  LEPR; leptin receptor isoform X1 [KO:K05062]
108406195  CD70; CD70 antigen [KO:K05470]
108406440  CXCL8; interleukin-8 isoform X1 [KO:K10030]
108406572  IL22; interleukin-22 [KO:K05445]
108406573  IL26; interleukin-26 [KO:K05446]
108406710  ACKR3; atypical chemokine receptor 3 [KO:K04304]
108406782  CCR4; C-C chemokine receptor type 4 [KO:K04179]
108406858  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
108406917  CX3CR1; CX3C chemokine receptor 1 isoform X2 [KO:K04192]
108406977  IL16; pro-interleukin-16 isoform X1 [KO:K22628]
108407017  MPL; thrombopoietin receptor [KO:K05082]
108407315  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
108407505  CCL5; C-C motif chemokine 5 [KO:K12499]
108407513  [KO:K05511]
108407514  CCL16; C-C motif chemokine 16 [KO:K21093]
108407553  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
108407621  IL27; interleukin-27 subunit alpha isoform X1 [KO:K22629]
108407678  BMP4; bone morphogenetic protein 4 isoform X2 [KO:K04662]
108407980  [KO:K05436]
108408129  IL17RC; interleukin-17 receptor C isoform X2 [KO:K05166]
108408145  INHBA; inhibin beta A chain [KO:K04667]
108408539  [KO:K05440]
108408540  IFNE; LOW QUALITY PROTEIN: interferon epsilon [KO:K05442]
108409113  IL12A; interleukin-12 subunit alpha [KO:K05406]
108409190  IL12B; interleukin-12 subunit beta [KO:K05425]
108409236  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
108409338  NODAL; nodal homolog [KO:K04666]
108409505  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
108409506  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
108409508  [KO:K10029]
108409509  [KO:K05506]
108409510  [KO:K05407]
108409884  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
108409973  INHBC; inhibin beta C chain [KO:K22688]
108410067  [KO:K12672]
108410086  CD40LG; CD40 ligand [KO:K03161]
108410302  IL20RA; interleukin-20 receptor subunit alpha [KO:K05136]
108410304  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
118966863  INHBE; inhibin beta E chain [KO:K22689]
118967254  [KO:K13594] [EC:2.7.11.30]
118969274  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
118969284  [KO:K05505]
118970094  [KO:K04180]
118973014  [KO:K05447]
Reference
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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