Entry
Name
Cytokine-cytokine receptor interaction - Manis javanica (Malayan pangolin)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
mjv04060 Cytokine-cytokine receptor interaction
Organism
Manis javanica (Malayan pangolin) [GN:
mjv ]
Gene
108383372 TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X3 [KO:K04721 ]
108383720 TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375 ]
108383807 TNFSF4; tumor necrosis factor ligand superfamily member 4 isoform X1 [KO:K05469 ]
108383809 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
108384676 TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160 ]
108385416 EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162 ]
108385695 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
108387107 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151 ]
108387576 TNFRSF21; tumor necrosis factor receptor superfamily member 21 isoform X2 [KO:K05157 ]
108387605 LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159 ]
108387612 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158 ]
108387644 TNFRSF18; tumor necrosis factor receptor superfamily member 18 isoform X1 [KO:K05154 ]
108387646 TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X1 [KO:K05142 ]
108388270 RELT; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156 ]
108389002 IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737 ]
108390189 IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
108391063 NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583 ]
108391156 TNFRSF9; tumor necrosis factor receptor superfamily member 9 isoform X2 [KO:K05146 ]
108392655 CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738 ]
108392662 IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
108392857 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
108392900 CD40; tumor necrosis factor receptor superfamily member 5 isoform X3 [KO:K03160 ]
108393156 CLCF1; cardiotrophin-like cytokine factor 1 isoform X2 [KO:K05421 ]
108393228 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
108393946 IL6R; interleukin-6 receptor subunit alpha isoform X2 [KO:K05055 ]
108394072 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
108394461 IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076 ]
108394464 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
108395488 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
108397803 TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
108399298 IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
108399719 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
108399808 IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X2 [KO:K05077 ]
108400801 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
108400987 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
108401017 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
108401018 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
108401438 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
108401571 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
108401747 TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
108401797 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
108403151 TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376 ]
108403518 IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598 ]
108404275 TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475 ]
108404560 CXCL12; LOW QUALITY PROTEIN: stromal cell-derived factor 1 [KO:K10031 ]
108405149 IL4R; interleukin-4 receptor subunit alpha isoform X2 [KO:K05071 ]
108405578 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B isoform X1 [KO:K05150 ]
108406858 IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072 ]
108407315 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
108407553 IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway