KEGG   PATHWAY: mlx05208
Entry
mlx05208                    Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Mirounga leonina (Southern elephant seal)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
mlx05208  Chemical carcinogenesis - reactive oxygen species
mlx05208

Organism
Mirounga leonina (Southern elephant seal) [GN:mlx]
Gene
118025668  AS3MT; arsenite methyltransferase isoform X1 [KO:K07755] [EC:2.1.1.137]
118022303  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
118000608  LOW QUALITY PROTEIN: glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
118001526  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
118001535  glutathione S-transferase A2 isoform X1 [KO:K00799] [EC:2.5.1.18]
118009589  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
118025611  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
118025932  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
118025941  glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
118019026  glutathione S-transferase Mu 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
117997904  microsomal glutathione S-transferase 2-like [KO:K00799] [EC:2.5.1.18]
118020160  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
118014047  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
117999757  glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
117999839  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
117999840  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
117999843  glutathione S-transferase theta-3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
4355870  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
4355871  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
4355872  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
4355873  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
4355874  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
4355875  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
4355876  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
118016140  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
118016431  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
118026972  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
118024594  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
118005005  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
118012420  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
118006077  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
117999192  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
118006627  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
118016727  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
118008941  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
118026286  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
117997916  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
118013193  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
118000306  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118008679  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
118017566  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118011073  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118025972  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118004320  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118019915  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118013652  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118013723  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118020809  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
118021900  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118000958  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
118021036  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
117998612  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
118005969  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
118009157  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8-like [KO:K03952]
118016476  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8-like [KO:K03952]
118017734  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
118025758  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
118011878  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
117999128  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
118005738  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
117997521  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12-like [KO:K11352]
117998878  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
118005260  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
118009264  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
118002675  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
118025455  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
118021161  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
118012157  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
118007053  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
118006688  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
118018036  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
118005924  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
118025000  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
118015199  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
118026254  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9-like [KO:K03965]
118021712  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
118009645  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
118012110  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
118014015  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
118015844  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
118006687  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
118006809  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
118021333  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial-like [KO:K03937]
118027278  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
118019589  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
117998200  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
117999059  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
118006183  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
118005112  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
118016147  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
118022312  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
118023788  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial-like [KO:K03967]
118008977  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial-like [KO:K03967]
118004305  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
118006277  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
118019953  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
118001049  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
118014021  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
118013236  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
118022759  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
4355869  CYTB; cytochrome b [KO:K00412]
118015299  cytochrome c1, heme protein, mitochondrial [KO:K00413]
118005048  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
117999153  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
118019464  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
118015043  cytochrome b-c1 complex subunit 7 [KO:K00417]
118008962  cytochrome b-c1 complex subunit 7-like [KO:K00417]
118009132  cytochrome b-c1 complex subunit 7-like [KO:K00417]
118014721  cytochrome b-c1 complex subunit 7-like [KO:K00417]
118016628  cytochrome b-c1 complex subunit 8 [KO:K00418]
118018636  cytochrome b-c1 complex subunit 9 [KO:K00419]
118006000  cytochrome b-c1 complex subunit 10 [KO:K00420]
4355868  COX3; cytochrome c oxidase subunit III [KO:K02262]
4355866  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
4355867  COX2; cytochrome c oxidase subunit II [KO:K02261]
118023493  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
118001502  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
118011354  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
118003100  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
118008215  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
118009813  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
118002938  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
118018546  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
117999554  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
118022877  cytochrome c oxidase subunit 6B1 [KO:K02267]
118001264  cytochrome c oxidase subunit 6B1-like [KO:K02267]
118003073  cytochrome c oxidase subunit 6B1-like [KO:K02267]
117997912  cytochrome c oxidase subunit 6B2 isoform X1 [KO:K02267]
118012351  cytochrome c oxidase subunit 6B1-like [KO:K02267]
118025026  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6C [KO:K02268]
118005417  cytochrome c oxidase subunit 6C-like [KO:K02268]
118007814  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
118022879  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
118008635  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
118001468  LOW QUALITY PROTEIN: uncharacterized protein LOC118001468 [KO:K02270]
118015405  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
118010248  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
118026049  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
118016969  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
118013136  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
118014377  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
118009891  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117998533  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
118015981  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
118023545  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
118010255  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
118025936  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
117998506  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
118004416  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
118012585  LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
118008699  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
118014290  LOW QUALITY PROTEIN: ATP synthase subunit gamma, mitochondrial-like [KO:K02136]
118021601  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
118005812  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
118024015  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
118013637  LOW QUALITY PROTEIN: ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
118013662  ATP synthase subunit epsilon, mitochondrial [KO:K02135]
4355864  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
118019006  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
118000847  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
118023337  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
118008780  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
118016240  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
118024792  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
118026484  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
118012240  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
118012306  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
118021108  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
118024289  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
118010299  ATP synthase subunit d, mitochondrial-like [KO:K02138]
118017147  ATP synthase subunit d, mitochondrial-like [KO:K02138]
118026298  ATP synthase subunit d, mitochondrial-like [KO:K02138]
117999517  ATP synthase subunit d, mitochondrial-like [KO:K02138]
118014376  ATP synthase subunit d, mitochondrial-like [KO:K02138]
118001601  ATP synthase subunit O, mitochondrial-like [KO:K02137]
118004098  ATP synthase subunit O, mitochondrial-like [KO:K02137]
118018842  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
118000514  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
118018060  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
118018787  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
118019306  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
118019784  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
118020828  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
118020909  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
118014566  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
118021844  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
4355865  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
118001859  superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
118001985  superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
118016634  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
118004524  voltage-dependent anion-selective channel protein 1-like [KO:K05862]
118021936  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
118009917  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
118012526  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
118022338  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
118010066  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
118026668  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
118012355  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
118022199  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
118018817  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
118015754  CAT; catalase [KO:K03781] [EC:1.11.1.6]
118010812  SLC26A1; sulfate anion transporter 1 [KO:K14700]
118006625  sulfate transporter [KO:K14701]
118006756  sulfate transporter [KO:K14701]
118005129  SLC26A6; solute carrier family 26 member 6 isoform X1 [KO:K14704]
118014133  SLC26A9; solute carrier family 26 member 9 [KO:K14706]
118002935  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
117998120  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
118022900  cytochrome P450 2F5 [KO:K07416] [EC:1.14.14.1]
118003748  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
118007783  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
118013009  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
118022112  EPHX2; bifunctional epoxide hydrolase 2 isoform X1 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
118005711  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
118020183  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
118019480  AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
118021623  LOW QUALITY PROTEIN: aldo-keto reductase family 1 member C15-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
118021905  aldo-keto reductase family 1 member C4-like isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
118023616  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
118018856  carbonyl reductase [NADPH] 1 isoform X1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
118020835  AHR; aryl hydrocarbon receptor [KO:K09093]
118024706  LPO; lactoperoxidase isoform X1 [KO:K12550] [EC:1.11.1.7]
118013457  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
118023475  cytochrome b-245 light chain isoform X1 [KO:K08009]
118023514  NOX1; LOW QUALITY PROTEIN: NADPH oxidase 1 [KO:K08008]
117999511  NCF1; neutrophil cytosol factor 1 [KO:K08011]
118014374  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
118027092  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
118024535  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
118020685  HGF; hepatocyte growth factor [KO:K05460]
118021010  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
118024273  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
118007794  SOS1; son of sevenless homolog 1 [KO:K03099]
118002069  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
118016228  HRAS; GTPase HRas isoform X1 [KO:K02833]
118025572  KRAS; GTPase KRas isoform X1 [KO:K07827]
118000495  NRAS; GTPase NRas [KO:K07828]
118009801  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
118021159  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118005431  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118003336  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
118004882  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
117999637  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
117999826  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
118000829  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
118000083  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
118005180  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
118022776  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118010368  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118026506  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118001095  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118001265  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
117997742  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
117997743  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
118019356  JUN; transcription factor AP-1 [KO:K04448]
118002212  FOS; proto-oncogene c-Fos [KO:K04379]
118016863  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118019468  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
118006042  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118004424  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
118020028  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118006556  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118018155  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
117999338  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
118021736  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
118022658  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118002024  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118014553  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118001573  FOXO3; forkhead box protein O3 [KO:K09408]
118016000  BAD; bcl2-associated agonist of cell death [KO:K02158]
118023969  PTPN1; tyrosine-protein phosphatase non-receptor type 1 isoform X1 [KO:K05696] [EC:3.1.3.48]
118012969  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118024839  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118009921  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118014480  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118002835  NF-kappa-B inhibitor alpha [KO:K04734]
118002880  NF-kappa-B inhibitor alpha [KO:K04734]
118016059  RELA; transcription factor p65 [KO:K04735]
118027047  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118005176  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
118015850  PTPRJ; receptor-type tyrosine-protein phosphatase eta isoform X1 [KO:K05698] [EC:3.1.3.48]
118007276  low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
118007329  low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
118018488  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
118020136  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
118011463  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
118017579  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
118014417  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
118007768  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
118002976  PRKD1; serine/threonine-protein kinase D1 [KO:K06070] [EC:2.7.11.13]
117998180  PRKD2; serine/threonine-protein kinase D2 isoform X1 [KO:K06070] [EC:2.7.11.13]
118015244  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
117999965  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
118006301  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
118024997  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
118002352  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
118000312  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
118001628  VEGFA; vascular endothelial growth factor A [KO:K05448]
118006049  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
118012291  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
117998752  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Related
pathway
mlx00190  Oxidative phosphorylation
mlx00980  Metabolism of xenobiotics by cytochrome P450
mlx04010  MAPK signaling pathway
mlx04064  NF-kappa B signaling pathway
mlx04066  HIF-1 signaling pathway
mlx04151  PI3K-Akt signaling pathway
mlx04370  VEGF signaling pathway
mlx05207  Chemical carcinogenesis - receptor activation
mlx05211  Renal cell carcinoma
mlx05215  Prostate cancer
mlx05219  Bladder cancer
mlx05221  Acute myeloid leukemia
mlx05222  Small cell lung cancer
mlx05223  Non-small cell lung cancer
mlx05224  Breast cancer
mlx05225  Hepatocellular carcinoma
KO pathway
ko05208   
LinkDB

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