KEGG   PATHWAY: mmf04062
Entry
mmf04062                    Pathway                                
Name
Chemokine signaling pathway - Molossus molossus (Pallas's mastiff bat)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
mmf04062  Chemokine signaling pathway
mmf04062

Other DBs
GO: 0070098
Organism
Molossus molossus (Pallas's mastiff bat) [GN:mmf]
Gene
118626364  growth-regulated protein homolog gamma-like [KO:K05505]
118643206  growth-regulated protein homolog [KO:K05505]
118643274  growth-regulated protein homolog gamma-like [KO:K05505]
118626277  CXCL5; C-X-C motif chemokine 5 [KO:K05506]
118630872  platelet basic protein isoform X1 [KO:K10029]
118626319  C-X-C motif chemokine 15-like [KO:K10030]
118636257  interleukin-8-like [KO:K10030]
118643469  CXCL8; interleukin-8 [KO:K10030]
118620671  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
118618117  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
118618109  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
118632498  CXCL12; stromal cell-derived factor 1 [KO:K10031]
118642807  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
118634667  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
118630882  platelet factor 4-like isoform X1 [KO:K05407]
118615647  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
118637888  lymphotactin-like [KO:K05507]
118639024  CX3CL1; fractalkine [KO:K05508]
118633759  CCL1; C-C motif chemokine 1 [KO:K05514]
118634634  C-C motif chemokine 2-like [KO:K14624]
118634314  C-C motif chemokine 3-like [KO:K05408]
118634427  C-C motif chemokine 3 [KO:K05408]
118634379  C-C motif chemokine 4 [KO:K12964]
118634535  C-C motif chemokine 4-like [KO:K12964]
118634388  CCL5; C-C motif chemokine 5 [KO:K12499]
118634834  C-C motif chemokine 8-like [KO:K16596]
118634641  eotaxin-like [KO:K16597]
118634851  C-C motif chemokine 13-like [KO:K16595]
118634315  C-C motif chemokine 14-like [KO:K21092]
118634313  C-C motif chemokine 15-like isoform X1 [KO:K05511]
118634927  C-C motif chemokine 9-like [KO:K05511]
118639602  CCL17; C-C motif chemokine 17 [KO:K21083]
118630091  CCL19; C-C motif chemokine 19 [KO:K05512]
118625758  CCL20; C-C motif chemokine 20 [KO:K14625]
118630085  C-C motif chemokine 21-like [KO:K16062]
118639603  CCL22; C-C motif chemokine 22 [KO:K21095]
118642108  CCL24; C-C motif chemokine 24 [KO:K21097]
118643791  CCL25; C-C motif chemokine 25 [KO:K13072]
118642760  CCL26; C-C motif chemokine 26 [KO:K21096]
118630036  uncharacterized protein LOC118630036 [KO:K16598]
118630231  CCL27; LOW QUALITY PROTEIN: C-C motif chemokine 27 [KO:K16598]
118641536  CCL28; LOW QUALITY PROTEIN: C-C motif chemokine 28 [KO:K05513]
118625201  C-X-C chemokine receptor type 2-like [KO:K05050]
118636502  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
118625406  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
118628178  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
118633080  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
118632885  XCR1; chemokine XC receptor 1 [KO:K04193]
118633603  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
118633459  CCR8; C-C chemokine receptor type 8 [KO:K04183]
118620807  CCR6; C-C chemokine receptor type 6 [KO:K04181]
118633434  CCR9; C-C chemokine receptor type 9 [KO:K04184]
118633375  CCR4; C-C chemokine receptor type 4 [KO:K04179]
118634399  CCR7; C-C chemokine receptor type 7 [KO:K04182]
118633395  CCR2; C-C chemokine receptor type 2 [KO:K04177]
118633424  C-C chemokine receptor type 5-like [KO:K04180]
118633353  C-C chemokine receptor type 1-like [KO:K04176]
118633347  C-C chemokine receptor type 3-like [KO:K04178]
118634688  CCR10; C-C chemokine receptor type 10 [KO:K04185]
118629676  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
118615617  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
118625659  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
118623876  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
118634787  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
118634401  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
118632994  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
118620140  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
118637975  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
118620164  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
118642779  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
118630645  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
118631458  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
118617134  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
118623920  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
118639510  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
118631528  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
118642221  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
118626166  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
118615793  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118631367  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
118618187  HCK; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
118626506  FGR; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
118618720  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
118637475  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
118615745  SHC2; SHC-transforming protein 2 [KO:K17447]
118629877  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
118631532  SHC4; SHC-transforming protein 4 [KO:K17449]
118633806  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
118630966  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
118616724  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
118643162  HRAS; GTPase HRas isoform X1 [KO:K02833]
118624619  KRAS; GTPase KRas isoform X1 [KO:K07827]
118637822  NRAS; GTPase NRas [KO:K07828]
118633343  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118619570  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118628434  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
118640210  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118642307  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
118632927  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118626944  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118617106  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118626685  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118642883  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118616460  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118619840  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
118634593  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
118634929  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
118643394  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
118640620  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118619617  LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
118630299  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118638405  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118621858  FOXO3; forkhead box protein O3 [KO:K09408]
118632312  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118622317  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118635619  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118617230  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
118638716  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
118624789  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118628367  RELA; transcription factor p65 [KO:K04735]
118627989  BAD; bcl2-associated agonist of cell death [KO:K02158]
118639101  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
118617870  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
118615153  ITK; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
118629384  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
118643718  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
118637802  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
118616519  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
118624097  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
118634237  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
118627562  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
118626070  CDC42; cell division control protein 42 homolog [KO:K04393]
118638912  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
118635814  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
118632939  RHOA; transforming protein RhoA [KO:K04513]
118618764  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
118630612  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
118643409  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
118641555  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
118624402  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
118616885  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
118617165  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
118629739  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
118627522  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
118640651  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
118626418  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
118638371  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
118615888  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
118639405  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
118621254  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
118629801  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
118619968  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
118626713  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
118616113  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
118642671  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
118620007  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
118634527  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
118618940  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
118620171  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
118615340  DOCK2; dedicator of cytokinesis protein 2 [KO:K12367]
118631501  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
118639815  PXN; paxillin isoform X1 [KO:K05760]
118639462  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
118639914  CRKL; crk-like protein [KO:K04438]
118633933  CRK; adapter molecule crk [KO:K04438]
118615360  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
118629502  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
118618293  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
118618784  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
118628278  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
118632151  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
118618299  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
118639621  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
118628048  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
118637043  RAP1A; ras-related protein Rap-1A [KO:K04353]
118624733  RAP1B; ras-related protein Rap-1b [KO:K07836]
118616553  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
118617355  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
118641370  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
118633138  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
118641800  NCF1; neutrophil cytosol factor 1 [KO:K08011]
118633542  GRK7; LOW QUALITY PROTEIN: rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
118622775  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
118639875  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
118627698  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
118643634  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
118632060  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
118638950  GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
118634043  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
118627946  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
mmf04010  MAPK signaling pathway
mmf04060  Cytokine-cytokine receptor interaction
mmf04120  Ubiquitin mediated proteolysis
mmf04630  JAK-STAT signaling pathway
mmf04670  Leukocyte transendothelial migration
mmf04810  Regulation of actin cytoskeleton
KO pathway
ko04062   
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