KEGG   PATHWAY: mmu05415
Entry
mmu05415                    Pathway                                
Name
Diabetic cardiomyopathy - Mus musculus (house mouse)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
mmu05415  Diabetic cardiomyopathy
mmu05415

Disease
H02498  Diabetic cardiomyopathy
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100041273  Ndufb4c; NADH:ubiquinone oxidoreductase subunit B4C [KO:K03960]
100042503  Ndufb4b; NADH:ubiquinone oxidoreductase subunit B4B [KO:K03960]
100502727  Gm19340; predicted gene, 19340 [KO:K03949]
102631912  Ndufb1; NADH:ubiquinone oxidoreductase subunit B1 [KO:K03957]
102633050  Gm6293; predicted pseudogene 6293 [KO:K00419]
102633230  Gm11633; predicted gene 11633 [KO:K02264]
102634451  Ndufab1-ps; NADH:ubiquinone oxidoreductase subunit AB1b [KO:K03955]
104130  Ndufb11; NADH:ubiquinone oxidoreductase subunit B11 [KO:K11351]
105675  Ppif; peptidylprolyl isomerase F (cyclophilin F) [KO:K09565] [EC:5.2.1.8]
108058  Camk2d; calcium/calmodulin-dependent protein kinase II, delta [KO:K04515] [EC:2.7.11.17]
110323  Cox6b1; cytochrome c oxidase, subunit 6B1 [KO:K02267]
110854  Ptpa; protein phosphatase 2 protein activator [KO:K17605]
11421  Ace; angiotensin I converting enzyme [KO:K01283] [EC:3.4.15.1]
11545  Parp1; poly (ADP-ribose) polymerase family, member 1 [KO:K24070]
115487111  Gm29667; predicted gene 29667 [KO:K00134] [EC:1.2.1.12]
11596  Ager; advanced glycosylation end product-specific receptor [KO:K19722]
11606  Agt; angiotensinogen [KO:K09821]
11607  Agtr1a; angiotensin II receptor, type 1a [KO:K04166]
11608  Agtr1b; angiotensin II receptor, type 1b [KO:K04166]
11651  Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652  Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
11739  Slc25a4; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 [KO:K05863]
11740  Slc25a5; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 [KO:K05863]
11937  Atp2a1; ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 [KO:K05853] [EC:7.2.2.10]
11938  Atp2a2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 [KO:K05853] [EC:7.2.2.10]
11946  Atp5f1a; ATP synthase F1 subunit alpha [KO:K02132]
11947  Atp5f1b; ATP synthase F1 subunit beta [KO:K02133] [EC:7.1.2.2]
11949  Atp5f1c; ATP synthase F1 subunit gamma [KO:K02136]
11950  Atp5pb; ATP synthase peripheral stalk-membrane subunit b [KO:K02127]
11951  Atp5mc1; ATP synthase membrane subunit c locus 1 [KO:K02128]
11957  Atp5pf; ATP synthase peripheral stalk subunit F6 [KO:K02131]
12322  Camk2a; calcium/calmodulin-dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
12323  Camk2b; calcium/calmodulin-dependent protein kinase II, beta [KO:K04515] [EC:2.7.11.17]
12325  Camk2g; calcium/calmodulin-dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
12491  Cd36; CD36 molecule [KO:K06259]
12825  Col3a1; collagen, type III, alpha 1 [KO:K19720]
12842  Col1a1; collagen, type I, alpha 1 [KO:K06236]
12843  Col1a2; collagen, type I, alpha 2 [KO:K06236]
12857  Cox4i1; cytochrome c oxidase subunit 4I1 [KO:K02263]
12858  Cox5a; cytochrome c oxidase subunit 5A [KO:K02264]
12859  Cox5b; cytochrome c oxidase subunit 5B [KO:K02265]
12861  Cox6a1; cytochrome c oxidase subunit 6A1 [KO:K02266]
12862  Cox6a2; cytochrome c oxidase subunit 6A2 [KO:K02266]
12864  Cox6c; cytochrome c oxidase subunit 6C [KO:K02268]
12865  Cox7a1; cytochrome c oxidase subunit 7A1 [KO:K02270]
12866  Cox7a2; cytochrome c oxidase subunit 7A2 [KO:K02270]
12867  Cox7c; cytochrome c oxidase subunit 7C [KO:K02272]
12868  Cox8a; cytochrome c oxidase subunit 8A [KO:K02273]
12869  Cox8b; cytochrome c oxidase subunit 8B [KO:K02273]
12895  Cpt1b; carnitine palmitoyltransferase 1b, muscle [KO:K19523] [EC:2.3.1.21]
12896  Cpt2; carnitine palmitoyltransferase 2 [KO:K08766] [EC:2.3.1.21]
13033  Ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
13057  Cyba; cytochrome b-245, alpha polypeptide [KO:K08009]
13058  Cybb; cytochrome b-245, beta polypeptide [KO:K21421] [EC:1.-.-.-]
14380  G6pd2; glucose-6-phosphate dehydrogenase 2 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
14381  G6pdx; glucose-6-phosphate dehydrogenase X-linked [KO:K00036] [EC:1.1.1.49 1.1.1.363]
14433  Gapdh; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
14583  Gfpt1; glutamine fructose-6-phosphate transaminase 1 [KO:K00820] [EC:2.6.1.16]
14584  Gfpt2; glutamine fructose-6-phosphate transaminase 2 [KO:K00820] [EC:2.6.1.16]
14782  Gsr; glutathione reductase [KO:K00383] [EC:1.8.1.7]
14936  Gys1; glycogen synthase 1, muscle [KO:K00693] [EC:2.4.1.11]
16333  Ins1; insulin I [KO:K04526]
16334  Ins2; insulin II [KO:K04526]
16337  Insr; insulin receptor [KO:K04527] [EC:2.7.10.1]
16367  Irs1; insulin receptor substrate 1 [KO:K16172]
17126  Smad2; SMAD family member 2 [KO:K04500]
17127  Smad3; SMAD family member 3 [KO:K23605]
17227  Mcpt4; mast cell protease 4 [KO:K01329] [EC:3.4.21.39]
17228  Cma1; chymase 1, mast cell [KO:K01329] [EC:3.4.21.39]
17390  Mmp2; matrix metallopeptidase 2 [KO:K01398] [EC:3.4.24.24]
17395  Mmp9; matrix metallopeptidase 9 [KO:K01403] [EC:3.4.24.35]
17705  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
17706  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
17708  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
17709  COX2; cytochrome c oxidase subunit II [KO:K02261]
17710  COX3; cytochrome c oxidase subunit III [KO:K02262]
17711  CYTB; cytochrome b [KO:K00412]
17716  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
17717  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
17718  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
17719  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
17720  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
17721  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
17722  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
17969  Ncf1; neutrophil cytosolic factor 1 [KO:K08011]
17970  Ncf2; neutrophil cytosolic factor 2 [KO:K08010]
17972  Ncf4; neutrophil cytosolic factor 4 [KO:K08012]
17991  Ndufa2; NADH:ubiquinone oxidoreductase subunit A2 [KO:K03946]
17992  Ndufa4; Ndufa4, mitochondrial complex associated [KO:K03948]
17993  Ndufs4; NADH:ubiquinone oxidoreductase core subunit S4 [KO:K03937]
17995  Ndufv1; NADH:ubiquinone oxidoreductase core subunit V1 [KO:K03942] [EC:7.1.1.2]
18033  Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580]
18127  Nos3; nitric oxide synthase 3, endothelial cell [KO:K13242] [EC:1.14.13.39]
18597  Pdha1; pyruvate dehydrogenase E1 alpha 1 [KO:K00161] [EC:1.2.4.1]
18598  Pdha2; pyruvate dehydrogenase E1 alpha 2 [KO:K00161] [EC:1.2.4.1]
18604  Pdk2; pyruvate dehydrogenase kinase, isoenzyme 2 [KO:K00898] [EC:2.7.11.2]
18706  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
18707  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
18708  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
18709  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
18710  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
18750  Prkca; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
18751  Prkcb; protein kinase C, beta [KO:K19662] [EC:2.7.11.13]
18752  Prkcg; protein kinase C, gamma [KO:K19663] [EC:2.7.11.13]
18753  Prkcd; protein kinase C, delta [KO:K06068] [EC:2.7.11.13]
18762  Prkcz; protein kinase C, zeta [KO:K18952] [EC:2.7.11.13]
18795  Plcb1; phospholipase C, beta 1 [KO:K05858] [EC:3.1.4.11]
18796  Plcb2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
18797  Plcb3; phospholipase C, beta 3 [KO:K05858] [EC:3.1.4.11]
18798  Plcb4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
18821  Pln; phospholamban [KO:K05852]
19013  Ppara; peroxisome proliferator activated receptor alpha [KO:K07294]
19045  Ppp1ca; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
19046  Ppp1cb; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
19047  Ppp1cc; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
19094  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
19211  Pten; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
19353  Rac1; Rac family small GTPase 1 [KO:K04392]
19354  Rac2; Rac family small GTPase 2 [KO:K07860]
19697  Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
19701  Ren1; renin 1 structural [KO:K01380] [EC:3.4.23.15]
19702  Ren2; renin 2 tandem duplication of Ren1 [KO:K01380] [EC:3.4.23.15]
20191  Ryr2; ryanodine receptor 2, cardiac [KO:K04962]
20463  Cox7a2l; cytochrome c oxidase subunit 7A2 like [KO:K02270]
20525  Slc2a1; solute carrier family 2 (facilitated glucose transporter), member 1 [KO:K07299]
20528  Slc2a4; solute carrier family 2 (facilitated glucose transporter), member 4 [KO:K07191]
20683  Sp1; trans-acting transcription factor 1 [KO:K04684]
210789  Tbc1d4; TBC1 domain family, member 4 [KO:K17902]
217246  Ace3; angiotensin I converting enzyme 3 [KO:K01283] [EC:3.4.15.1]
21803  Tgfb1; transforming growth factor, beta 1 [KO:K13375]
21808  Tgfb2; transforming growth factor, beta 2 [KO:K13376]
21809  Tgfb3; transforming growth factor, beta 3 [KO:K13377]
21812  Tgfbr1; transforming growth factor, beta receptor I [KO:K04674] [EC:2.7.11.30]
21813  Tgfbr2; transforming growth factor, beta receptor II [KO:K04388] [EC:2.7.11.30]
21954  Tnni3; troponin I, cardiac 3 [KO:K12044]
22272  Uqcrq; ubiquinol-cytochrome c reductase, complex III subunit VII [KO:K00418]
22273  Uqcrc1; ubiquinol-cytochrome c reductase core protein 1 [KO:K00414]
22333  Vdac1; voltage-dependent anion channel 1 [KO:K05862]
22334  Vdac2; voltage-dependent anion channel 2 [KO:K15040]
22335  Vdac3; voltage-dependent anion channel 3 [KO:K15041]
225887  Ndufs8; NADH:ubiquinone oxidoreductase core subunit S8 [KO:K03941] [EC:7.1.1.2]
226646  Ndufs2; NADH:ubiquinone oxidoreductase core subunit S2 [KO:K03935] [EC:7.1.1.2]
227197  Ndufs1; NADH:ubiquinone oxidoreductase core subunit S1 [KO:K03934] [EC:7.1.1.2]
228033  Atp5mc3; ATP synthase membrane subunit c locus 3 [KO:K02128]
230075  Ndufb6; NADH:ubiquinone oxidoreductase subunit B6 [KO:K03962]
232493  Gys2; glycogen synthase 2 [KO:K00693] [EC:2.4.1.11]
236900  Pdk3; pyruvate dehydrogenase kinase, isoenzyme 3 [KO:K00898] [EC:2.7.11.2]
23797  Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
245347  Gm4984; predicted pseudogene 4984 [KO:K22138]
26414  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
26415  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
26416  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
26419  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
26420  Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
27273  Pdk4; pyruvate dehydrogenase kinase, isoenzyme 4 [KO:K00898] [EC:2.7.11.2]
28080  Atp5po; ATP synthase peripheral stalk subunit OSCP [KO:K02137]
29857  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
333182  Cox6b2; cytochrome c oxidase subunit 6B2 [KO:K02267]
407785  Ndufs6; NADH:ubiquinone oxidoreductase core subunit S6 [KO:K03939]
407790  Ndufa4l2; Ndufa4, mitochondrial complex associated like 2 [KO:K03948]
434233  Ppp1ccb; protein phosphatase 1 catalytic subunit gamma B [KO:K06269] [EC:3.1.3.16]
53313  Atp2a3; ATPase, Ca++ transporting, ubiquitous [KO:K05853] [EC:7.2.2.10]
54405  Ndufa1; NADH:ubiquinone oxidoreductase subunit A1 [KO:K03945]
55951  Mpc1; mitochondrial pyruvate carrier 1 [KO:K22138]
56637  Gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
56717  Mtor; mechanistic target of rapamycin kinase [KO:K07203] [EC:2.7.11.1]
595136  Ndufs5; NADH:ubiquinone oxidoreductase core subunit S5 [KO:K03938]
623286  Ndufs6b; NADH:ubiquinone oxidoreductase subunit S6B [KO:K03939]
66043  Atp5f1d; ATP synthase F1 subunit delta [KO:K02134]
66046  Ndufb5; NADH:ubiquinone oxidoreductase subunit B5 [KO:K03961]
66052  Sdhc; succinate dehydrogenase complex, subunit C, integral membrane protein [KO:K00236]
66091  Ndufa3; NADH:ubiquinone oxidoreductase subunit A3 [KO:K03947]
66108  Ndufa9; NADH:ubiquinone oxidoreductase subunit A9 [KO:K03953]
66142  Cox7b; cytochrome c oxidase subunit 7B [KO:K02271]
66152  Uqcr10; ubiquinol-cytochrome c reductase, complex III subunit X [KO:K00419]
66218  Ndufb9; NADH:ubiquinone oxidoreductase subunit B9 [KO:K03965]
66377  Ndufc1; NADH:ubiquinone oxidoreductase subunit C1 [KO:K03967]
66414  Ndufa12; NADH:ubiquinone oxidoreductase subunit A12 [KO:K11352]
66416  Ndufa7; NADH:ubiquinone oxidoreductase subunit A7 [KO:K03951]
66445  Cyc1; cytochrome c-1 [KO:K00413]
66495  Ndufb3; NADH:ubiquinone oxidoreductase subunit B3 [KO:K03959]
66576  Uqcrh; ubiquinol-cytochrome c reductase hinge protein [KO:K00416]
66594  Uqcr11; ubiquinol-cytochrome c reductase, complex III subunit XI [KO:K00420]
66694  Uqcrfs1; ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 [KO:K00411] [EC:7.1.1.8]
667103  Gm13570; predicted gene 13570 [KO:K22138]
66916  Ndufb7; NADH:ubiquinone oxidoreductase subunit B7 [KO:K03963]
66925  Sdhd; succinate dehydrogenase complex, subunit D, integral membrane protein [KO:K00237]
66945  Sdha; succinate dehydrogenase complex, subunit A, flavoprotein (Fp) [KO:K00234] [EC:1.3.5.1]
67003  Uqcrc2; ubiquinol cytochrome c reductase core protein 2 [KO:K00415]
67126  Atp5f1e; ATP synthase F1 subunit epsilon [KO:K02135]
67130  Ndufa6; NADH:ubiquinone oxidoreductase subunit A6 [KO:K03950]
67184  Ndufa13; NADH:ubiquinone oxidoreductase subunit A13 [KO:K11353]
67264  Ndufb8; NADH:ubiquinone oxidoreductase subunit B8 [KO:K03964]
67273  Ndufa10; NADH:ubiquinone oxidoreductase subunit A10 [KO:K03954]
67530  Uqcrb; ubiquinol-cytochrome c reductase binding protein [KO:K00417]
67680  Sdhb; succinate dehydrogenase complex, subunit B, iron sulfur (Ip) [KO:K00235] [EC:1.3.5.1]
67942  Atp5mc2; ATP synthase membrane subunit c locus 2 [KO:K02128]
68194  Ndufb4; NADH:ubiquinone oxidoreductase subunit B4 [KO:K03960]
68197  Ndufc2; NADH:ubiquinone oxidoreductase subunit C2 [KO:K03968]
68198  Ndufb2; NADH:ubiquinone oxidoreductase subunit B2 [KO:K03958]
68202  Ndufa5; NADH:ubiquinone oxidoreductase subunit A5 [KO:K03949]
68263  Pdhb; pyruvate dehydrogenase (lipoamide) beta [KO:K00162] [EC:1.2.4.1]
68342  Ndufb10; NADH:ubiquinone oxidoreductase subunit B10 [KO:K03966]
68349  Ndufs3; NADH:ubiquinone oxidoreductase core subunit S3 [KO:K03936] [EC:7.1.1.2]
68375  Ndufa8; NADH:ubiquinone oxidoreductase subunit A8 [KO:K03952]
69875  Ndufa11; NADH:ubiquinone oxidoreductase subunit A11 [KO:K03956]
70316  Ndufab1; NADH:ubiquinone oxidoreductase subunit AB1 [KO:K03955]
70456  Mpc2; mitochondrial pyruvate carrier 2 [KO:K22139]
71679  Atp5pd; ATP synthase peripheral stalk subunit d [KO:K02138]
72900  Ndufv2; NADH:ubiquinone oxidoreductase core subunit V2 [KO:K03943] [EC:7.1.1.2]
73333  Slc25a31; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 [KO:K05863]
74769  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
75406  Ndufs7; NADH:ubiquinone oxidoreductase core subunit S7 [KO:K03940] [EC:7.1.1.2]
75483  Cox8c; cytochrome c oxidase subunit 8C [KO:K02273]
78174  Cox7b2; cytochrome c oxidase subunit 7B2 [KO:K02271]
78330  Ndufv3; NADH:ubiquinone oxidoreductase core subunit V3 [KO:K03944]
84682  Cox4i2; cytochrome c oxidase subunit 4I2 [KO:K02263]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
Reference
PMID:30443826
  Authors
Riehle C, Bauersachs J
  Title
Of mice and men: models and mechanisms of diabetic cardiomyopathy.
  Journal
Basic Res Cardiol 114:2 (2018)
DOI:10.1007/s00395-018-0711-0
Reference
PMID:24462787
  Authors
Huynh K, Bernardo BC, McMullen JR, Ritchie RH
  Title
Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.
  Journal
Pharmacol Ther 142:375-415 (2014)
DOI:10.1016/j.pharmthera.2014.01.003
Reference
PMID:28231848
  Authors
Lorenzo-Almoros A, Tunon J, Orejas M, Cortes M, Egido J, Lorenzo O
  Title
Diagnostic approaches for diabetic cardiomyopathy.
  Journal
Cardiovasc Diabetol 16:28 (2017)
DOI:10.1186/s12933-017-0506-x
Reference
PMID:32080423
  Authors
Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L
  Title
Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence.
  Journal
Nat Rev Cardiol 17:585-607 (2020)
DOI:10.1038/s41569-020-0339-2
Reference
PMID:31212580
  Authors
Zamora M, Villena JA
  Title
Contribution of Impaired Insulin Signaling to the Pathogenesis of Diabetic Cardiomyopathy.
  Journal
Int J Mol Sci 20:E2833 (2019)
DOI:10.3390/ijms20112833
Reference
PMID:29605388
  Authors
Palomer X, Pizarro-Delgado J, Vazquez-Carrera M
  Title
Emerging Actors in Diabetic Cardiomyopathy: Heartbreaker Biomarkers or Therapeutic Targets?
  Journal
Trends Pharmacol Sci 39:452-467 (2018)
DOI:10.1016/j.tips.2018.02.010
Reference
PMID:28439258
  Authors
Mishra PK, Ying W, Nandi SS, Bandyopadhyay GK, Patel KK, Mahata SK
  Title
Diabetic Cardiomyopathy: An Immunometabolic Perspective.
  Journal
Front Endocrinol (Lausanne) 8:72 (2017)
DOI:10.3389/fendo.2017.00072
Reference
PMID:28177068
  Authors
Chong CR, Clarke K, Levelt E
  Title
Metabolic Remodeling in Diabetic Cardiomyopathy.
  Journal
Cardiovasc Res 113:422-430 (2017)
DOI:10.1093/cvr/cvx018
Reference
PMID:11742414
  Authors
Brownlee M
  Title
Biochemistry and molecular cell biology of diabetic complications.
  Journal
Nature 414:813-20 (2001)
DOI:10.1038/414813a
Reference
PMID:32821697
  Authors
Gollmer J, Zirlik A, Bugger H
  Title
Established and Emerging Mechanisms of Diabetic Cardiomyopathy.
  Journal
J Lipid Atheroscler 8:26-47 (2019)
DOI:10.12997/jla.2019.8.1.26
Reference
PMID:17592090
  Authors
Boudina S, Abel ED
  Title
Diabetic cardiomyopathy revisited.
  Journal
Circulation 115:3213-23 (2007)
DOI:10.1161/CIRCULATIONAHA.106.679597
Reference
PMID:29109032
  Authors
Varma U, Koutsifeli P, Benson VL, Mellor KM, Delbridge LMD
  Title
Molecular mechanisms of cardiac pathology in diabetes - Experimental insights.
  Journal
Biochim Biophys Acta Mol Basis Dis 1864:1949-1959 (2018)
DOI:10.1016/j.bbadis.2017.10.035
Reference
PMID:23147391
  Authors
Mandavia CH, Aroor AR, Demarco VG, Sowers JR
  Title
Molecular and metabolic mechanisms of cardiac dysfunction in diabetes.
  Journal
Life Sci 92:601-8 (2013)
DOI:10.1016/j.lfs.2012.10.028
Reference
PMID:21626163
  Authors
Falcao-Pires I, Leite-Moreira AF
  Title
Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment.
  Journal
Heart Fail Rev 17:325-44 (2012)
DOI:10.1007/s10741-011-9257-z
Reference
PMID:27148064
  Authors
Westermeier F, Riquelme JA, Pavez M, Garrido V, Diaz A, Verdejo HE, Castro PF, Garcia L, Lavandero S
  Title
New Molecular Insights of Insulin in Diabetic Cardiomyopathy.
  Journal
Front Physiol 7:125 (2016)
DOI:10.3389/fphys.2016.00125
Reference
PMID:33276047
  Authors
Randhawa VK, Dhanvantari S, Connelly K
  Title
How Diabetes and Heart Failure Modulate Each Other and Condition Management.
  Journal
Can J Cardiol S0828-282X(20)31115-6 (2020)
DOI:10.1016/j.cjca.2020.11.014
Reference
PMID:31641426
  Authors
Athithan L, Gulsin GS, McCann GP, Levelt E
  Title
Diabetic cardiomyopathy: Pathophysiology, theories and evidence to date.
  Journal
World J Diabetes 10:490-510 (2019)
DOI:10.4239/wjd.v10.i10.490
Reference
PMID:21111987
  Authors
Murarka S, Movahed MR
  Title
Diabetic cardiomyopathy.
  Journal
J Card Fail 16:971-9 (2010)
DOI:10.1016/j.cardfail.2010.07.249
Reference
PMID:25085967
  Authors
Thomas CM, Yong QC, Rosa RM, Seqqat R, Gopal S, Casarini DE, Jones WK, Gupta S, Baker KM, Kumar R
  Title
Cardiac-specific suppression of NF-kappaB signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system.
  Journal
Am J Physiol Heart Circ Physiol 307:H1036-45 (2014)
DOI:10.1152/ajpheart.00340.2014
Reference
PMID:28236380
  Authors
Brahma MK, Pepin ME, Wende AR
  Title
My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy.
  Journal
Diabetes Metab J 41:1-9 (2017)
DOI:10.4093/dmj.2017.41.1.1
Reference
PMID:18829990
  Authors
Singh VP, Le B, Khode R, Baker KM, Kumar R
  Title
Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis.
  Journal
Diabetes 57:3297-306 (2008)
DOI:10.2337/db08-0805
Reference
PMID:18296558
  Authors
Singh VP, Baker KM, Kumar R
  Title
Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production.
  Journal
Am J Physiol Heart Circ Physiol 294:H1675-84 (2008)
DOI:10.1152/ajpheart.91493.2007
Reference
PMID:26678809
  Authors
Jia G, DeMarco VG, Sowers JR
  Title
Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy.
  Journal
Nat Rev Endocrinol 12:144-53 (2016)
DOI:10.1038/nrendo.2015.216
Reference
PMID:18309108
  Authors
Kim JA, Wei Y, Sowers JR
  Title
Role of mitochondrial dysfunction in insulin resistance.
  Journal
Circ Res 102:401-14 (2008)
DOI:10.1161/CIRCRESAHA.107.165472
Reference
PMID:30170598
  Authors
Ormazabal V, Nair S, Elfeky O, Aguayo C, Salomon C, Zuniga FA
  Title
Association between insulin resistance and the development of cardiovascular disease.
  Journal
Cardiovasc Diabetol 17:122 (2018)
DOI:10.1186/s12933-018-0762-4
Reference
PMID:31269778
  Authors
Evangelista I, Nuti R, Picchioni T, Dotta F, Palazzuoli A
  Title
Molecular Dysfunction and Phenotypic Derangement in Diabetic Cardiomyopathy.
  Journal
Int J Mol Sci 20:E3264 (2019)
DOI:10.3390/ijms20133264
Reference
PMID:24307101
  Authors
Joshi M, Kotha SR, Malireddy S, Selvaraju V, Satoskar AR, Palesty A, McFadden DW, Parinandi NL, Maulik N
  Title
Conundrum of pathogenesis of diabetic cardiomyopathy: role of vascular endothelial dysfunction, reactive oxygen species, and mitochondria.
  Journal
Mol Cell Biochem 386:233-49 (2014)
DOI:10.1007/s11010-013-1861-x
Reference
PMID:29867137
  Authors
Knapp M, Tu X, Wu R
  Title
Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy.
  Journal
Acta Pharmacol Sin 40:1-8 (2019)
DOI:10.1038/s41401-018-0042-6
Reference
PMID:16487830
  Authors
Asbun J, Villarreal FJ
  Title
The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy.
  Journal
J Am Coll Cardiol 47:693-700 (2006)
DOI:10.1016/j.jacc.2005.09.050
Reference
PMID:32024054
  Authors
Levick SP, Widiapradja A
  Title
The Diabetic Cardiac Fibroblast: Mechanisms Underlying Phenotype and Function.
  Journal
Int J Mol Sci 21:E970 (2020)
DOI:10.3390/ijms21030970
Related
pathway
mmu00010  Glycolysis / Gluconeogenesis
mmu00020  Citrate cycle (TCA cycle)
mmu00190  Oxidative phosphorylation
mmu00520  Amino sugar and nucleotide sugar metabolism
mmu03320  PPAR signaling pathway
mmu04071  Sphingolipid signaling pathway
mmu04150  mTOR signaling pathway
mmu04210  Apoptosis
mmu04260  Cardiac muscle contraction
mmu04350  TGF-beta signaling pathway
mmu04614  Renin-angiotensin system
mmu04910  Insulin signaling pathway
mmu04930  Type II diabetes mellitus
mmu04931  Insulin resistance
mmu04933  AGE-RAGE signaling pathway in diabetic complications
mmu04940  Type I diabetes mellitus
KO pathway
ko05415   

DBGET integrated database retrieval system