KEGG   PATHWAY: mna05165
Entry
mna05165                    Pathway                                
Name
Human papillomavirus infection - Miniopterus natalensis (Natal long-fingered bat)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
mna05165  Human papillomavirus infection
mna05165

Organism
Miniopterus natalensis (Natal long-fingered bat) [GN:mna]
Gene
107523880  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
107523913  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
107523936  ITGB6; integrin beta-6 [KO:K06589]
107524098  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
107524266  CTNNB1; catenin beta-1 [KO:K02105]
107524451  WNT11; protein Wnt-11 [KO:K01384]
107524532  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
107524632  TSC1; hamartin [KO:K07206]
107524677  LAMC3; laminin subunit gamma-3 [KO:K06247]
107524712  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
107524716  FZD5; frizzled-5 [KO:K02375]
107524737  FN1; fibronectin isoform X1 [KO:K05717]
107524769  WNT6; protein Wnt-6 [KO:K00445]
107524821  WNT10A; protein Wnt-10a [KO:K01357]
107524863  WNT2; protein Wnt-2 [KO:K00182]
107524898  RHEB; GTP-binding protein Rheb [KO:K07208]
107525061  IRF1; interferon regulatory factor 1 [KO:K09444]
107525073  ITGB1; integrin beta-1 [KO:K05719]
107525076  FZD8; frizzled-8 [KO:K02375]
107525082  PARD3; partitioning defective 3 homolog [KO:K04237]
107525165  CCNA1; cyclin-A1 [KO:K06627]
107525258  KRAS; GTPase KRas [KO:K07827]
107525363  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
107525394  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
107525397  TCF7; transcription factor 7 isoform X1 [KO:K02620]
107525529  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
107525530  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
107525658  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
107525695  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
107525737  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
107525750  CRB3; protein crumbs homolog 3 [KO:K06090]
107525813  [KO:K06751]
107525841  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
107525851  SOS2; son of sevenless homolog 2 [KO:K03099]
107525977  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
107525996  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
107526032  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
107526046  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
107526093  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
107526271  [KO:K06480]
107526501  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
107526557  FZD9; frizzled-9 [KO:K02842]
107526620  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
107526629  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
107526728  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
107526759  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
107526860  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
107527094  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
107527140  ITGA2; integrin alpha-2 [KO:K06481]
107527219  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
107527282  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
107527350  ITGB5; integrin beta-5 [KO:K06588]
107527413  HES1; transcription factor HES-1 [KO:K06054]
107527450  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
107527747  E2F1; transcription factor E2F1 [KO:K17454]
107527883  UBE3A; ubiquitin-protein ligase E3A [KO:K10587] [EC:2.3.2.26]
107528223  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
107528238  WNT10B; protein Wnt-10b [KO:K01357]
107528239  WNT1; proto-oncogene Wnt-1 [KO:K03209]
107528299  ITGB7; integrin beta-7 [KO:K06590]
107528315  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
107528331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107528407  MAML1; mastermind-like protein 1 [KO:K06061]
107528441  [KO:K06751]
107528451  CCNA2; cyclin-A2 [KO:K06627]
107528477  OASL; 2'-5'-oligoadenylate synthase-like protein isoform X1 [KO:K14608]
107528505  PXN; paxillin isoform X1 [KO:K05760]
107528616  TCF7L1; transcription factor 7-like 1 [KO:K04490]
107528641  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
107528756  VTN; vitronectin [KO:K06251]
107528834  FZD2; frizzled-2 [KO:K02235]
107528854  ITGA2B; integrin alpha-IIb [KO:K06476]
107528930  TUBG2; tubulin gamma-2 chain isoform X1 [KO:K10389]
107528932  [KO:K10389]
107528935  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
107529098  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
107529178  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
107529232  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
107529317  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107529329  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X1 [KO:K04632]
107529353  [KO:K04632]
107529446  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
107529447  [KO:K06243]
107529477  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
107529541  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
107529572  LAMA5; laminin subunit alpha-5 [KO:K06240]
107529641  FZD10; frizzled-10 [KO:K02842]
107529651  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
107529842  CHAD; chondroadherin [KO:K06248]
107529865  WNT9A; protein Wnt-9a [KO:K01064]
107529884  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
107529919  WNT3A; protein Wnt-3a [KO:K00312]
107530003  HES6; transcription cofactor HES-6 [KO:K09087]
107530028  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
107530082  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
107530103  WNT8A; protein Wnt-8a [KO:K00714]
107530219  WNT3; proto-oncogene Wnt-3 [KO:K00312]
107530252  ITGA8; integrin alpha-8 [KO:K06584]
107530327  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
107530370  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
107530382  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
107530384  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
107530451  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107530635  WNT5A; protein Wnt-5a [KO:K00444]
107530883  ITGB3; integrin beta-3 [KO:K06493]
107530895  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
107530914  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
107530937  LAMA2; laminin subunit alpha-2 [KO:K05637]
107530990  WNT9B; protein Wnt-9b [KO:K01064]
107530996  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
107531189  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
107531280  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
107531299  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
107531399  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
107531433  IFNB1; interferon beta [KO:K05415]
107531583  PSMC1; 26S protease regulatory subunit 4 [KO:K03062]
107531724  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
107531752  PATJ; inaD-like protein [KO:K06092]
107531880  IRF3; interferon regulatory factor 3 [KO:K05411]
107531901  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
107532425  MAML2; mastermind-like protein 2 isoform X1 [KO:K06061]
107532452  FZD4; frizzled-4 isoform X1 [KO:K02354]
107532464  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
107532628  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107532901  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
107532931  LAMB3; laminin subunit beta-3 [KO:K06244]
107533168  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
107533206  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
107533300  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
107533366  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
107533380  TSC2; tuberin isoform X1 [KO:K07207]
107533468  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
107533544  RELA; transcription factor p65 [KO:K04735]
107533585  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
107533604  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
107533801  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107533927  FZD7; frizzled-7 [KO:K02432]
107533931  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
107534103  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
107534117  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
107534199  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107534276  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
107534373  EGF; pro-epidermal growth factor [KO:K04357]
107534581  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
107534729  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
107534753  TADA3; transcriptional adapter 3 [KO:K11315]
107534839  WNT7B; protein Wnt-7b [KO:K00572]
107534924  [KO:K06061]
107535067  THBS4; thrombospondin-4 [KO:K04659]
107535229  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
107535230  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
107535234  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
107535325  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
107535388  COMP; cartilage oligomeric matrix protein [KO:K04659]
107535436  ATP6V1B2; V-type proton ATPase subunit B, brain isoform isoform X1 [KO:K02147]
107535445  TNC; tenascin [KO:K06252]
107535447  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
107535531  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
107535740  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
107535753  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
107535781  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
107535865  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
107535878  LAMA1; laminin subunit alpha-1 [KO:K05637]
107535921  [KO:K06240]
107535922  [KO:K06240]
107536231  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
107536232  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
107536358  JAG1; protein jagged-1 [KO:K06052]
107536455  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
107536477  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
107536493  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
107536618  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
107536630  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
107536644  LLGL2; lethal(2) giant larvae protein homolog 2 [KO:K06094]
107536679  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
107536886  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
107536896  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
107536901  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
107537025  THBS2; thrombospondin-2 [KO:K04659]
107537027  TBP; TATA-box-binding protein [KO:K03120]
107537045  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
107537047  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
107537112  IBSP; bone sialoprotein 2 [KO:K06253]
107537117  SPP1; osteopontin [KO:K06250]
107537379  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
107537386  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
107537406  TCIRG1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
107537414  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
107537434  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
107537477  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
107537536  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
107537551  FOXO1; forkhead box protein O1 [KO:K07201]
107537725  ATP6V1E1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
107537768  FZD3; frizzled-3 isoform X1 [KO:K02329]
107537979  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
107537987  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
107538223  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
107538226  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
107538237  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
107538303  AXIN2; axin-2 isoform X1 [KO:K04385]
107538391  HES3; transcription factor HES-3 [KO:K09088]
107538392  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
107538414  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
107538446  WNT4; protein Wnt-4 [KO:K00408]
107538463  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
107538488  [KO:K06751]
107538601  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
107538811  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
107538830  [KO:K04451]
107538891  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
107538904  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
107538942  NOTCH4; neurogenic locus notch homolog protein 4 [KO:K20996]
107538944  TNXB; tenascin-X [KO:K06252]
107538961  [KO:K06751]
107538974  TNF; tumor necrosis factor [KO:K03156]
107539005  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
107539057  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
107539175  ITGA3; integrin alpha-3 [KO:K06482]
107539184  COL1A1; collagen alpha-1(I) chain [KO:K06236]
107539496  HEY1; LOW QUALITY PROTEIN: hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
107539654  AXIN1; axin-1 isoform X1 [KO:K02157]
107539805  BAD; bcl2-associated agonist of cell death [KO:K02158]
107540144  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
107540244  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
107540259  ATP6V1E2; V-type proton ATPase subunit E 2 isoform X1 [KO:K02150]
107540309  ITGB8; integrin beta-8 [KO:K06591]
107540441  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
107540521  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
107540693  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
107540705  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
107540819  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
107540891  [KO:K04393]
107540994  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
107541067  ITGA5; integrin alpha-5 [KO:K06484]
107541106  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107541116  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
107541208  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
107541226  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
107541504  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
107541559  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
107541604  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
107541653  FZD1; frizzled-1 [KO:K02432]
107541691  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
107541704  COL1A2; collagen alpha-2(I) chain [KO:K06236]
107541780  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
107541819  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
107542012  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
107542095  RBL1; retinoblastoma-like protein 1 [KO:K04681]
107542171  FADD; FAS-associated death domain protein [KO:K02373]
107542305  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
107542351  HRAS; GTPase HRas isoform X1 [KO:K02833]
107542383  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107542524  WNT8B; protein Wnt-8b [KO:K00714]
107542599  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
107542619  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
107542884  PARD6A; partitioning defective 6 homolog alpha [KO:K06093]
107542898  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
107542931  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
107543012  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
107543188  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107543257  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
107543303  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107543411  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
107543484  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
107543537  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
107543696  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
107543726  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
107543746  TNN; tenascin-N [KO:K06252]
107543769  TNR; tenascin-R [KO:K06252]
107543787  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
107543851  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
107543873  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
107544039  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
107544058  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
107544091  VWF; von Willebrand factor [KO:K03900]
107544136  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
107544152  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
107544156  IKBKG; NF-kappa-B essential modulator [KO:K07210]
107544221  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
107544336  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
107544390  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
107544475  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
107544485  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
107544496  HES7; transcription factor HES-7 [KO:K09087]
107544572  TP53; cellular tumor antigen p53 [KO:K04451]
107544933  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
107544968  NFX1; transcriptional repressor NF-X1 isoform X1 [KO:K12236]
107545056  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
107545227  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
107545234  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
107545293  WNT2B; protein Wnt-2b [KO:K00182]
107545296  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
107545303  NRAS; GTPase NRas [KO:K07828]
107545508  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
107545578  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
107545671  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
107545672  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
107545675  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
107545909  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
107546030  FZD6; frizzled-6 isoform X1 [KO:K02376]
107546034  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
107546062  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
107546063  [KO:K06238]
107546091  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
107546119  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
107546126  [KO:K06751]
107546127  [KO:K06751]
107546189  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
107546223  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
107546245  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
107546249  LAMC2; laminin subunit gamma-2 [KO:K06246]
107546271  LAMC1; laminin subunit gamma-1 [KO:K05635]
107546464  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
107546495  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
107546708  ITGA4; integrin alpha-4 [KO:K06483]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Reference
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Related
pathway
mna04064  NF-kappa B signaling pathway
mna04110  Cell cycle
mna04115  p53 signaling pathway
mna04150  mTOR signaling pathway
mna04151  PI3K-Akt signaling pathway
mna04210  Apoptosis
mna04310  Wnt signaling pathway
mna04330  Notch signaling pathway
mna04510  Focal adhesion
mna04520  Adherens junction
mna04530  Tight junction
mna04612  Antigen processing and presentation
mna04620  Toll-like receptor signaling pathway
mna04630  JAK-STAT signaling pathway
KO pathway
ko05165   

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