KEGG   PATHWAY: nvs04020
Entry
nvs04020                    Pathway                                
Name
Calcium signaling pathway - Neogale vison (American mink)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
nvs04020  Calcium signaling pathway
nvs04020

Other DBs
GO: 0019722
Organism
Neogale vison (American mink) [GN:nvs]
Gene
122889097  FGF20; fibroblast growth factor 20 [KO:K04358]
122889193  C11H4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
122889210  FGF5; fibroblast growth factor 5 [KO:K04358]
122889234  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
122889250  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
122889261  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
122889317  TACR3; neuromedin-K receptor [KO:K04224]
122889339  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122889471  CCKAR; cholecystokinin receptor type A [KO:K04194]
122889497  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
122889603  EDNRA; endothelin-1 receptor [KO:K04197]
122889629  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
122889648  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
122889778  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122889792  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
122889854  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
122889876  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
122889883  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
122889940  DRD5; D(1B) dopamine receptor [KO:K05840]
122889978  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
122890020  VEGFC; vascular endothelial growth factor C [KO:K05449]
122890114  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
122890116  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
122890262  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
122890459  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
122890843  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
122890844  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
122891087  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
122891387  AVPR1A; vasopressin V1a receptor [KO:K04226]
122891453  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
122891466  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
122891509  [KO:K02183]
122891596  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
122891745  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
122891793  CALML3; calmodulin-like protein 3 [KO:K02183]
122891954  FGF6; fibroblast growth factor 6 [KO:K04358]
122892167  FGF23; fibroblast growth factor 23 [KO:K22428]
122892168  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
122892214  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
122892381  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
122892461  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
122892544  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
122892576  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
122892614  DRD1; D(1A) dopamine receptor [KO:K04144]
122892906  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
122893040  [KO:K05101] [EC:2.7.10.1]
122893099  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
122893102  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03916]
122893253  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
122893404  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
122893445  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
122893622  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
122893638  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
122893729  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
122893739  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
122893809  [KO:K04809]
122893865  CALML4; calmodulin-like protein 4 [KO:K02183]
122893885  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
122894107  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
122894113  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
122894275  ADRB2; beta-2 adrenergic receptor [KO:K04142]
122894282  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
122894399  CALM1; calmodulin-1 [KO:K02183]
122894561  [KO:K10784]
122895287  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
122895321  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
122895385  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
122895607  [KO:K16058]
122895627  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
122895824  ORAI2; protein orai-2 isoform X1 [KO:K16057]
122895879  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
122895969  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
122896073  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
122896088  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
122896190  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
122896262  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
122896928  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
122897099  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
122897132  GRPR; gastrin-releasing peptide receptor [KO:K04169]
122897137  FGF16; fibroblast growth factor 16 [KO:K04358]
122897292  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
122897329  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
122897535  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
122897554  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
122897566  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
122897658  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
122897958  [KO:K05857] [EC:3.1.4.11]
122898670  CALML6; calmodulin-like protein 6 [KO:K02183]
122898999  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
122899079  HTR6; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 6 [KO:K04162]
122899273  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
122899646  PTAFR; platelet-activating factor receptor [KO:K04279]
122900086  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
122900117  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
122900129  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
122900139  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
122900141  MCOLN3; mucolipin-3 [KO:K04994]
122900266  TRDN; LOW QUALITY PROTEIN: triadin [KO:K23449]
122900317  [KO:K05862]
122900366  NGF; beta-nerve growth factor [KO:K02582]
122900368  CASQ2; calsequestrin-2 isoform X1 [KO:K23445]
122900634  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
122900636  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
122900746  TACR2; substance-K receptor [KO:K04223]
122900781  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
122900795  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122900805  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
122900818  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
122900832  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
122900916  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
122900943  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
122901128  ADRB1; beta-1 adrenergic receptor [KO:K04141]
122901170  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
122901177  VEGFA; vascular endothelial growth factor A [KO:K05448]
122901870  [KO:K04161]
122901990  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
122902004  P2RX6; P2X purinoceptor 6 [KO:K05221]
122902211  FGF10; fibroblast growth factor 10 [KO:K04358]
122902255  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
122902268  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
122902310  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
122902405  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
122902655  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
122902697  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
122902796  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
122903126  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
122903224  ADORA2A; adenosine receptor A2a [KO:K04266]
122903384  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
122903400  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
122903443  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
122903445  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
122903447  P2RX4; P2X purinoceptor 4 [KO:K05218]
122903456  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
122904184  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
122904294  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
122904647  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
122904661  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
122904673  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
122904762  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
122904870  [KO:K05862]
122904963  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
122905007  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
122905107  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
122905198  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
122905528  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
122905689  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
122905958  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
122906063  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
122906123  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
122906299  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
122906574  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
122906802  ADORA2B; adenosine receptor A2b [KO:K04267]
122906818  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
122906819  P2RX1; P2X purinoceptor 1 [KO:K05215]
122906824  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
122906918  FGF9; fibroblast growth factor 9 [KO:K04358]
122906988  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
122907089  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
122907169  EDNRB; endothelin receptor type B [KO:K04198]
122907176  PLN; cardiac phospholamban [KO:K05852]
122907298  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
122907539  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
122907665  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
122907848  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
122907909  TFEB; transcription factor EB isoform X1 [KO:K15590]
122908866  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
122909082  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
122909206  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
122909227  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
122909251  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
122909338  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
122909413  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
122909420  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
122909651  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
122909666  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
122909784  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
122909893  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
122909954  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
122909984  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
122910442  AGTR1; type-1 angiotensin II receptor [KO:K04166]
122910530  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
122910613  HRH1; histamine H1 receptor [KO:K04149]
122910619  OXTR; oxytocin receptor [KO:K04229]
122910653  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
122910692  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
122910823  TBXA2R; thromboxane A2 receptor [KO:K04264]
122910827  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
122911198  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
122911312  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
122911463  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
122911475  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
122911482  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
122911638  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
122911685  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
122911833  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X1 [KO:K23450]
122911860  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
122911876  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
122911896  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
122911918  CALM3; calmodulin-3 [KO:K02183]
122912049  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
122912247  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
122912504  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
122912641  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
122912667  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
122913029  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
122913054  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
122913059  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
122913271  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
122913721  FGF3; fibroblast growth factor 3 [KO:K04358]
122913879  FGF21; fibroblast growth factor 21 [KO:K22429]
122913953  SLN; sarcolipin [KO:K22642]
122914477  P2RX3; P2X purinoceptor 3 [KO:K05217]
122914602  FGF4; fibroblast growth factor 4 [KO:K04358]
122914603  FGF19; fibroblast growth factor 19 [KO:K22603]
122915032  TACR1; substance-P receptor isoform X1 [KO:K04222]
122915128  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
122915263  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
122915444  TGFA; protransforming growth factor alpha [KO:K08774]
122915521  NTSR1; neurotensin receptor type 1 [KO:K04211]
122915547  [KO:K04282]
122915551  TNNC2; troponin C, skeletal muscle [KO:K12042]
122915575  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
122915597  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
122915697  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
122915932  [KO:K04632]
122915933  [KO:K04632]
122915966  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
122916074  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
122916236  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
122916255  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
122916256  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
122916371  CALM2; calmodulin-2 [KO:K02183]
122916928  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
122916940  [KO:K05863]
122917048  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
122917067  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
122917392  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
122917394  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
122917648  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
122917675  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
122917677  GNA14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
122918069  CASQ1; calsequestrin-1 [KO:K23468]
122918201  AVPR1B; vasopressin V1b receptor [KO:K04227]
122918316  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
122918388  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
122918592  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
122918678  ITPKB; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
122918724  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
122918773  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
122918815  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
122919116  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
122919222  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
122919270  [KO:K04143]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
nvs04010  MAPK signaling pathway
nvs04070  Phosphatidylinositol signaling system
nvs04210  Apoptosis
nvs04720  Long-term potentiation
nvs04730  Long-term depression
KO pathway
ko04020   

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