KEGG   PATHWAY: oro04024
Entry
oro04024                    Pathway                                
Name
cAMP signaling pathway - Odobenus rosmarus divergens (Pacific walrus)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
oro04024  cAMP signaling pathway
oro04024

Other DBs
GO: 0019933
Organism
Odobenus rosmarus divergens (Pacific walrus) [GN:oro]
Gene
101379269  VIP; VIP peptides isoform X1 [KO:K05264]
101366206  CRH; corticoliberin [KO:K05256]
101375408  CGA; glycoprotein hormones alpha chain [KO:K08522]
101369994  lutropin subunit beta [KO:K08521]
101368390  GPHA2; glycoprotein hormone alpha-2 [KO:K25483]
101378089  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
101385992  TSHB; thyrotropin subunit beta [KO:K05251]
101367412  POMC; pro-opiomelanocortin [KO:K05228]
101380721  GCG; glucagon [KO:K05259]
101364460  GIP; gastric inhibitory polypeptide [KO:K05258]
101369871  follitropin subunit beta [KO:K05250]
101368657  NPPA; natriuretic peptides A [KO:K12334]
101383041  ADCYAP1; pituitary adenylate cyclase-activating polypeptide [KO:K05262]
101365047  ADRB1; beta-1 adrenergic receptor [KO:K04141]
101369132  ADRB2; beta-2 adrenergic receptor [KO:K04142]
101368015  DRD1; D(1A) dopamine receptor [KO:K04144]
101380571  DRD5; D(1B) dopamine receptor [KO:K05840]
101380968  ADORA2A; adenosine receptor A2a [KO:K04266]
101368249  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
101372756  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
101379988  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
101378697  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X2 [KO:K04587]
101372351  VIPR2; vasoactive intestinal polypeptide receptor 2 isoform X1 [KO:K04590]
101373186  CRHR1; corticotropin-releasing factor receptor 1 isoform X1 [KO:K04578]
101380742  CRHR2; corticotropin-releasing factor receptor 2 isoform X2 [KO:K04579]
101372292  LHCGR; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
101370481  TSHR; thyrotropin receptor isoform X1 [KO:K04249]
101377845  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
101366823  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
101370214  GIPR; gastric inhibitory polypeptide receptor [KO:K04580]
101383865  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
101372582  FSHR; follicle-stimulating hormone receptor isoform X1 [KO:K04247]
101384059  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
101364060  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
105757053  neuroendocrine secretory protein 55 [KO:K04632]
101377023  EDN1; endothelin-1 isoform X2 [KO:K16366]
101370530  EDN2; endothelin-2 isoform X1 [KO:K16367]
101367609  EDN3; endothelin-3 [KO:K05227]
101378609  SST; somatostatin [KO:K05237]
101384687  NPY; pro-neuropeptide Y [KO:K05232]
101369258  GHRL; appetite-regulating hormone isoform X1 [KO:K05254]
101386183  OXT; LOW QUALITY PROTEIN: oxytocin-neurophysin 1 [KO:K05243]
101368922  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
101370471  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
101383568  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
101375694  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
101380353  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
101380644  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101386108  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
101363015  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
101374451  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
101378598  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
101374348  ADORA1; adenosine receptor A1 [KO:K04265]
101363432  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
101365852  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
101379420  SSTR1; somatostatin receptor type 1 [KO:K04217]
101368246  SSTR2; somatostatin receptor type 2 [KO:K04218]
101383018  SSTR5; somatostatin receptor type 5 [KO:K04221]
101376108  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
101375818  hydroxycarboxylic acid receptor 2 [KO:K08402]
101370403  FFAR2; free fatty acid receptor 2 [KO:K04328]
101374510  SUCNR1; succinate receptor 1 [KO:K10042]
101371218  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
101367602  OXTR; oxytocin receptor [KO:K04229]
101370855  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
101376186  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
101367568  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
101367936  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
101379158  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101365382  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101368682  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101374313  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
101380824  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
101373816  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
101377421  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
101370350  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101364108  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101363792  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
101379936  ADCY10; adenylate cyclase type 10 isoform X2 [KO:K11265] [EC:4.6.1.1]
101381141  CNGA1; cGMP-gated cation channel alpha-1 [KO:K04948]
101368266  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
101376220  CNGA3; cyclic nucleotide-gated cation channel alpha-3 [KO:K04950]
101382492  CNGA4; cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
101381529  CNGB1; cyclic nucleotide-gated cation channel beta-1 [KO:K04952]
101380553  CNGB3; cyclic nucleotide-gated cation channel beta-3 [KO:K04953]
101373722  calmodulin-alpha-like [KO:K02183]
101384567  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
101376564  CALML5; calmodulin-like protein 5 [KO:K02183]
101370824  CALML6; calmodulin-like protein 6 [KO:K02183]
101376265  CALML3; calmodulin-like protein 3 [KO:K02183]
101371788  CALM3; calmodulin [KO:K02183]
101386691  calmodulin-like [KO:K02183]
101372085  calmodulin-A-like [KO:K02183]
101379187  CALM1; calmodulin isoform X1 [KO:K02183]
101366685  CALM2; calmodulin isoform X1 [KO:K02183]
101375584  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
101375944  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101367567  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2 [KO:K04515] [EC:2.7.11.17]
101384300  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
101369425  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
101383752  BVES; blood vessel epicardial substance [KO:K21108]
101364302  POPDC2; popeye domain-containing protein 2 isoform X1 [KO:K26206]
101384217  POPDC3; popeye domain-containing protein 3 [KO:K26207]
101374381  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
101376484  HCN2; LOW QUALITY PROTEIN: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
101382024  HCN4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
101380131  ABCC4; multidrug resistance-associated protein 4 isoform X1 [KO:K05673]
101371953  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
101382059  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
101385933  RRAS; ras-related protein R-Ras [KO:K07829]
101370485  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
101383564  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
101369263  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101367598  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
101367488  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101374143  MAPK8; mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
101376185  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
101375466  RAP1A; ras-related protein Rap-1A [KO:K04353]
101383971  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
101365424  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
101363849  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
101366888  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
101383637  VAV1; proto-oncogene vav isoform X2 [KO:K05730]
101378519  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
101366544  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
101385830  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101374128  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101365642  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101366666  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
101383468  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
101377207  MLLT4; afadin isoform X1 [KO:K05702]
101370689  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101385241  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101385267  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101374787  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101370100  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101371800  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101383166  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101382320  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101374757  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101377465  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
101372149  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101365373  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101376586  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101372573  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
101382213  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101367408  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101383001  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101366549  PPP1R1B; protein phosphatase 1 regulatory subunit 1B [KO:K15494]
101382867  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101372346  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101386053  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101383024  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101383806  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101385783  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101376293  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X2 [KO:K09048]
101381943  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
101385675  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
101384862  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
101362815  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
101386879  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
101372507  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
101366773  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
101368207  JUN; transcription factor AP-1 isoform X1 [KO:K04448]
101379949  GLI3; transcriptional activator GLI3 [KO:K06230]
101379429  GLI1; zinc finger protein GLI1 isoform X1 [KO:K16797]
101379447  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
101382855  HHIP; hedgehog-interacting protein [KO:K06231]
101384149  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101371488  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101381225  RELA; transcription factor p65 [KO:K04735]
101369021  SOX9; transcription factor SOX-9 isoform X1 [KO:K18435]
101366553  AMH; muellerian-inhibiting factor [KO:K04665]
101386061  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
101372647  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
101380271  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
101385449  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101364644  F2R; proteinase-activated receptor 1 [KO:K03914]
101375422  BAD; bcl2-associated agonist of cell death [KO:K02158]
101384261  LIPE; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
101386230  ROCK1; rho-associated protein kinase 1 isoform X2 [KO:K04514] [EC:2.7.11.1]
101372971  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
101384536  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X2 [KO:K06270]
101362788  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
101384802  TNNI3; troponin I, cardiac muscle [KO:K12044]
101379994  PLN; cardiac phospholamban [KO:K05852]
101365162  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X2 [KO:K05853] [EC:7.2.2.10]
101384489  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
101375916  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
101372904  RYR2; ryanodine receptor 2 [KO:K04962]
101368222  ryanodine receptor 2-like [KO:K04962]
101368224  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
101378928  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101365544  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101369978  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
101383267  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
101368398  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
101374464  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
101371613  GRIA1; LOW QUALITY PROTEIN: glutamate receptor 1 [KO:K05197]
101377360  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
101365795  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
101381613  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
101363648  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
101379349  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
101379646  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
101376936  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
101366083  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 isoform X1 [KO:K01539] [EC:7.2.2.13]
101368218  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 isoform X1 [KO:K01540]
101377129  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
101376641  ATP1B4; protein ATP1B4 isoform X2 [KO:K01540]
101362729  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
101382690  FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X2 [KO:K01538]
101373240  FXYD1; phospholemman isoform X1 [KO:K13360]
101369980  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
101368790  ORAI1; LOW QUALITY PROTEIN: calcium release-activated calcium channel protein 1 [KO:K16056]
101374723  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X2 [KO:K05850] [EC:7.2.2.10]
101376015  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X2 [KO:K05850] [EC:7.2.2.10]
101368088  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
101377158  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
101365624  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101383514  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101364481  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
101385947  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
105757534  LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase A-like [KO:K19021] [EC:3.1.4.17]
101384884  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
101371957  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
101383319  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
101372982  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
101367993  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
101367053  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
101372969  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
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Related
pathway
oro00071  Fatty acid degradation
oro04015  Rap1 signaling pathway
oro04020  Calcium signaling pathway
oro04151  PI3K-Akt signaling pathway
oro04210  Apoptosis
oro04260  Cardiac muscle contraction
oro04340  Hedgehog signaling pathway
oro04720  Long-term potentiation
oro04740  Olfactory transduction
oro04972  Pancreatic secretion
oro04976  Bile secretion
KO pathway
ko04024   
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