KEGG   PATHWAY: oro04151
Entry
oro04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Odobenus rosmarus divergens (Pacific walrus)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
oro04151  PI3K-Akt signaling pathway
oro04151

Other DBs
GO: 0043491
Organism
Odobenus rosmarus divergens (Pacific walrus) [GN:oro]
Gene
101377629  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
101384783  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
101367107  EREG; proepiregulin isoform X2 [KO:K09784]
101367396  AREG; amphiregulin isoform X1 [KO:K09782]
101363195  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101369428  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
101377940  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
101370946  FGF4; fibroblast growth factor 4 [KO:K04358]
101379461  FGF18; fibroblast growth factor 18 [KO:K04358]
101379943  FGF20; fibroblast growth factor 20 [KO:K04358]
101382345  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101366748  FGF10; fibroblast growth factor 10 [KO:K04358]
101385349  FGF3; fibroblast growth factor 3 [KO:K04358]
101382205  FGF22; fibroblast growth factor 22 [KO:K04358]
101366655  FGF16; fibroblast growth factor 16 [KO:K04358]
101373546  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
101379430  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101381072  FGF9; fibroblast growth factor 9 [KO:K04358]
101364070  FGF6; fibroblast growth factor 6 [KO:K04358]
101385649  FGF19; fibroblast growth factor 19 [KO:K22603]
101373782  FGF21; fibroblast growth factor 21 [KO:K22429]
101363779  FGF23; fibroblast growth factor 23 [KO:K22428]
101384791  NGF; beta-nerve growth factor [KO:K02582]
101372507  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
101386733  NTF3; neurotrophin-3 [KO:K04356]
101369695  NTF4; neurotrophin-4 [KO:K12457]
101383590  INS; insulin [KO:K04526]
101386334  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
101384061  IGF2; LOW QUALITY PROTEIN: insulin-like growth factor II [KO:K13769]
101386160  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
101370194  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
101363701  PDGFD; platelet-derived growth factor D [KO:K05450]
101378889  PDGFC; platelet-derived growth factor C [KO:K05450]
101365427  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
101378811  KITLG; kit ligand isoform X1 [KO:K05461]
101383895  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
101363442  VEGFA; vascular endothelial growth factor A [KO:K05448]
101377548  VEGFB; vascular endothelial growth factor B [KO:K16858]
101369724  PGF; placenta growth factor [KO:K16859]
101372364  FIGF; vascular endothelial growth factor D [KO:K05449]
101375487  VEGFC; vascular endothelial growth factor C [KO:K05449]
101373766  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101373650  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
101366974  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
101371627  ANGPT4; angiopoietin-4 [KO:K05467]
101362498  EFNA5; ephrin-A5 [KO:K05462]
101374175  EFNA2; ephrin-A2 [KO:K05462]
101369919  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
101370418  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
101370908  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
101379435  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
101365865  NRTN; LOW QUALITY PROTEIN: neurturin [KO:K25414]
101378458  ARTN; LOW QUALITY PROTEIN: artemin [KO:K25415]
101363290  PSPN; persephin [KO:K25416]
101386858  EGFR; epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]
101364161  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
101385903  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101371484  receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
101364849  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
101381278  FGFR2; fibroblast growth factor receptor 2 isoform X2 [KO:K05093] [EC:2.7.10.1]
101381434  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101381264  FGFR4; fibroblast growth factor receptor 4 isoform X2 [KO:K05095] [EC:2.7.10.1]
101365058  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101374117  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
101364921  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101363371  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
101386211  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101372359  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101374793  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101374504  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101372059  KIT; mast/stem cell growth factor receptor Kit isoform X7 [KO:K05091] [EC:2.7.10.1]
101382975  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
101383542  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101382368  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101371459  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101365730  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101367636  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
101383361  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101372117  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101362094  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101385114  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101369947  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101367134  GTPase HRas-like [KO:K02833]
101372786  HRAS; GTPase HRas isoform X1 [KO:K02833]
101370458  KRAS; GTPase KRas isoform X2 [KO:K07827]
101363525  NRAS; GTPase NRas [KO:K07828]
101372149  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101365373  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101376586  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101372573  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
101382213  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101367978  IRS1; insulin receptor substrate 1 [KO:K16172]
101363280  TLR2; toll-like receptor 2 [KO:K10159]
101367407  uncharacterized protein LOC101367407 [KO:K10159]
101371071  TLR4; toll-like receptor 4 [KO:K10160]
101378519  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
101366544  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
101370467  uncharacterized protein LOC101370467 [KO:K06856]
101373095  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
101375348  CD19; B-lymphocyte antigen CD19 isoform X2 [KO:K06465]
101371611  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
101371706  somatotropin isoform X1 [KO:K05438]
101378550  PRL; prolactin [KO:K05439]
101366093  OSM; oncostatin-M [KO:K05418]
101386196  IL2; interleukin-2 [KO:K05429]
101377851  IL6; interleukin-6 isoform X1 [KO:K05405]
101384443  IL4; interleukin-4 [KO:K05430]
101374293  IL7; interleukin-7 isoform X1 [KO:K05431]
101377641  interferon alpha-1/2-like [KO:K05414]
101378214  IFNA5; interferon alpha-5 [KO:K05414]
101374322  interferon alpha-1/2-like [KO:K05414]
101374610  interferon alpha-14-like [KO:K05414]
101379735  interferon beta-like [KO:K05414]
101374900  IFNB1; interferon beta [KO:K05415]
101379507  EPO; erythropoietin isoform X1 [KO:K05437]
101385858  CSF3; granulocyte colony-stimulating factor [KO:K05423]
101370443  GHR; growth hormone receptor [KO:K05080]
101375420  PRLR; prolactin receptor isoform X2 [KO:K05081]
101377508  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
101378506  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
101366322  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
101374379  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
101383763  IL3RA; LOW QUALITY PROTEIN: interleukin-3 receptor subunit alpha [KO:K04737]
101368251  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
101373228  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
101385299  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
101370046  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
101386107  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
101385485  EPOR; erythropoietin receptor [KO:K05079]
101377969  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
101365648  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101375007  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
101369142  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
101368204  COL1A1; collagen alpha-1(I) chain [KO:K06236]
101374645  COL1A2; collagen alpha-2(I) chain [KO:K06236]
105757317  mucin-1-like [KO:K06236]
101370480  COL2A1; collagen alpha-1(II) chain [KO:K19719]
101366517  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
101367094  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
101373882  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
101373537  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
101378777  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
101381103  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
101383410  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
101381689  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
101376308  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
101384542  collagen alpha-4(VI) chain-like [KO:K06238]
101386561  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
101371920  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
101362257  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
101385065  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
101378050  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
101383157  LAMA2; laminin subunit alpha-2 [KO:K05637]
101364310  LAMA1; laminin subunit alpha-1 [KO:K05637]
101370639  LAMA5; laminin subunit alpha-5 [KO:K06240]
101386047  LAMA3; laminin subunit alpha-3 [KO:K06240]
101369714  laminin subunit alpha-4 [KO:K06241]
101382657  LAMB1; laminin subunit beta-1 isoform X2 [KO:K05636]
101380776  LAMB2; laminin subunit beta-2 [KO:K06243]
101368738  LAMB3; laminin subunit beta-3 [KO:K06244]
101382364  LAMB4; laminin subunit beta-4 [KO:K06245]
101384210  LAMC1; laminin subunit gamma-1 [KO:K05635]
101384487  LAMC2; laminin subunit gamma-2 [KO:K06246]
101369468  LAMC3; laminin subunit gamma-3 [KO:K06247]
101370869  CHAD; chondroadherin [KO:K06248]
101384714  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
101376329  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
101379820  COMP; cartilage oligomeric matrix protein [KO:K04659]
101367458  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
101379053  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
101381226  THBS2; thrombospondin-2 [KO:K04659]
101365197  FN1; fibronectin isoform X1 [KO:K05717]
101386416  SPP1; osteopontin isoform X1 [KO:K06250]
101384418  VTN; LOW QUALITY PROTEIN: vitronectin [KO:K06251]
101386461  TNC; tenascin isoform X1 [KO:K06252]
101386939  TNXB; tenascin-X [KO:K06252]
101364666  TNN; tenascin-N [KO:K06252]
101365272  TNR; tenascin-R [KO:K06252]
101385961  VWF; von Willebrand factor isoform X1 [KO:K03900]
101384653  IBSP; bone sialoprotein 2 [KO:K06253]
101375017  ITGA1; integrin alpha-1 isoform X2 [KO:K06480]
101375601  ITGA2; integrin alpha-2 [KO:K06481]
101369639  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
101366550  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
101363662  ITGA4; integrin alpha-4 [KO:K06483]
101380023  ITGA5; integrin alpha-5 [KO:K06484]
101383404  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
101378058  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
101377347  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
101365247  ITGA9; integrin alpha-9 [KO:K06585]
101379997  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
101385440  ITGA11; integrin alpha-11 [KO:K06587]
101368762  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
101385291  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
101369957  ITGB3; integrin beta-3 [KO:K06493]
101384197  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
101376952  ITGB5; integrin beta-5 [KO:K06588]
101366733  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
101371307  ITGB7; integrin beta-7 [KO:K06590]
101374393  ITGB8; integrin beta-8 [KO:K06591]
101371010  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101370689  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101385241  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101385267  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101374787  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101370100  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101371800  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101364644  F2R; proteinase-activated receptor 1 [KO:K03914]
101380644  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101386108  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
101371767  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
101363634  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
101363176  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
101363180  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
101377363  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
101386667  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
101381482  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1 [KO:K04536]
101378633  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1 [KO:K04537]
101371845  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101369300  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101362117  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
101366315  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101376879  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101369684  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101365462  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
101363588  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
101371482  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
101370001  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
101375712  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101379027  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101374080  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101368814  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
101382152  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101375999  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
101386155  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101362272  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
101374579  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
101375062  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
101378353  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
101376688  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
101379000  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
101372712  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
101367999  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
101363167  TSC1; hamartin isoform X2 [KO:K07206]
101371494  TSC2; tuberin isoform X1 [KO:K07207]
101363732  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
101373648  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
101363844  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101384799  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
101386736  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
101370155  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
101365198  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
101375246  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
101381996  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
101365998  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101373572  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
101377322  RPS6; 40S ribosomal protein S6 isoform X1 [KO:K02991]
101386060  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101384698  PKN1; serine/threonine-protein kinase N1 isoform X2 [KO:K06071] [EC:2.7.11.13]
101379940  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
101383516  PKN3; serine/threonine-protein kinase N3 [KO:K23692] [EC:2.7.11.13]
101378055  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
101362306  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
101363423  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
101383166  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101382320  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101374757  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101376364  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
101383629  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
101367385  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101365923  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
101376533  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101367482  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101385466  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X2 [KO:K03456]
101362885  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2 [KO:K03456]
101378544  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
101368625  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
101382084  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
101383262  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
101374874  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
101385495  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
101382896  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
101378378  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
101366633  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
101378289  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
101377743  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
101370768  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X2 [KO:K11584]
101365532  HSP90AB1; heat shock protein HSP 90-beta isoform X1 [KO:K04079]
101381301  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
101363592  HSP90AA1; LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha [KO:K04079]
101384762  HSP90B1; endoplasmin isoform X1 [KO:K09487]
101377766  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
101383200  CRTC2; CREB-regulated transcription coactivator 2 isoform X2 [KO:K16333]
101380084  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
101362683  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
101374067  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
101373771  TCL1B; LOW QUALITY PROTEIN: T-cell leukemia/lymphoma protein 1B [KO:K16836]
101371670  MTCP1; protein p13 MTCP-1 [KO:K16837]
101382350  NOS3; nitric oxide synthase, endothelial isoform X2 [KO:K13242] [EC:1.14.13.39]
101362868  BRCA1; breast cancer type 1 susceptibility protein isoform X3 [KO:K10605] [EC:2.3.2.27]
101365718  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101368722  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
101370584  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
101382807  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X2 [KO:K01596] [EC:4.1.1.32]
101374479  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X2 [KO:K01596] [EC:4.1.1.32]
101372257  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
101374429  G6PC3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
101385128  G6PC; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
101369253  MYC; myc proto-oncogene protein [KO:K04377]
101371532  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101375107  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101362774  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
101383299  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
101362330  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
101378405  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101363193  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101372891  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101366323  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
101382136  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
101376741  forkhead box protein O3 [KO:K09408]
101380168  RBL2; retinoblastoma-like protein 2 isoform X2 [KO:K16332]
101381319  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
101378922  BCL2L11; bcl-2-like protein 11 isoform X2 [KO:K16341]
101377965  YWHAQ; 14-3-3 protein theta [KO:K16197]
101381520  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
101384625  YWHAZ; 14-3-3 protein zeta/delta isoform X2 [KO:K16197]
101383486  YWHAE; 14-3-3 protein epsilon isoform X2 [KO:K06630]
101364496  YWHAG; 14-3-3 protein gamma [KO:K16198]
101386284  YWHAH; 14-3-3 protein eta isoform X1 [KO:K16198]
101375422  BAD; bcl2-associated agonist of cell death [KO:K02158]
101380440  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101372267  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101362812  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
101383024  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101374034  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101368122  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101383806  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101385783  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101376293  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X2 [KO:K09048]
101381943  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
101385675  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
101384862  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
101381436  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X2 [KO:K09049]
101368348  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
101376217  induced myeloid leukemia cell differentiation protein Mcl-1 homolog [KO:K02539]
101365135  RXRA; retinoic acid receptor RXR-alpha isoform X2 [KO:K08524]
101375462  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
101384959  IKBKG; NF-kappa-B essential modulator isoform X2 [KO:K07210]
101364103  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101375346  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101381225  RELA; transcription factor p65 [KO:K04735]
101371488  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101380888  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
101385402  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101362427  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
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Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
oro00010  Glycolysis / Gluconeogenesis
oro04010  MAPK signaling pathway
oro04012  ErbB signaling pathway
oro04062  Chemokine signaling pathway
oro04064  NF-kappa B signaling pathway
oro04068  FoxO signaling pathway
oro04110  Cell cycle
oro04115  p53 signaling pathway
oro04150  mTOR signaling pathway
oro04210  Apoptosis
oro04370  VEGF signaling pathway
oro04510  Focal adhesion
oro04620  Toll-like receptor signaling pathway
oro04630  JAK-STAT signaling pathway
oro04662  B cell receptor signaling pathway
oro04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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