KEGG   PATHWAY: oro04510
Entry
oro04510                    Pathway                                
Name
Focal adhesion - Odobenus rosmarus divergens (Pacific walrus)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
oro04510  Focal adhesion
oro04510

Other DBs
GO: 0005925
Organism
Odobenus rosmarus divergens (Pacific walrus) [GN:oro]
Gene
101362094  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101362115  MYL5; myosin light chain 5 [KO:K12753]
101362244  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
101362257  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
101362541  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
101362594  PAK7; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
101362788  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
101363175  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
101363193  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101363254  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101363442  VEGFA; vascular endothelial growth factor A [KO:K05448]
101363662  ITGA4; integrin alpha-4 [KO:K06483]
101363701  PDGFD; platelet-derived growth factor D [KO:K05450]
101363849  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
101363974  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
101364161  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
101364310  LAMA1; laminin subunit alpha-1 [KO:K05637]
101364349  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
101364547  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
101364638  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101364666  TNN; tenascin-N [KO:K06252]
101364900  DOCK1; dedicator of cytokinesis protein 1 isoform X2 [KO:K13708]
101365197  FN1; fibronectin isoform X1 [KO:K05717]
101365239  EMP1; epithelial membrane protein 1 [KO:K26255]
101365247  ITGA9; integrin alpha-9 [KO:K06585]
101365272  TNR; tenascin-R [KO:K06252]
101365373  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101365642  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101365718  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101365730  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101365904  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
101366038  CAV1; caveolin-1 isoform X1 [KO:K06278]
101366509  CAV2; caveolin-2 [KO:K12958]
101366517  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
101366544  [KO:K04392]
101366550  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
101366733  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
101366888  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
101367094  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
101367134  [KO:K02833]
101367150  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
101367308  CAV3; caveolin-3 [KO:K12959]
101367385  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101367458  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
101367488  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101367825  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
101367883  RAPGEF1; rap guanine nucleotide exchange factor 1 [KO:K06277]
101367940  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
101368004  PARVA; alpha-parvin [KO:K06275]
101368074  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
101368204  COL1A1; collagen alpha-1(I) chain [KO:K06236]
101368207  JUN; transcription factor AP-1 isoform X1 [KO:K04448]
101368668  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
101368696  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
101368738  LAMB3; laminin subunit beta-3 [KO:K06244]
101368762  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
101368899  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform isoform X1 [KO:K12758]
101369015  CRKL; crk-like protein [KO:K04438]
101369017  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
101369067  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101369468  LAMC3; laminin subunit gamma-3 [KO:K06247]
101369639  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
101369700  PXN; paxillin [KO:K05760]
101369714  [KO:K06241]
101369724  PGF; placenta growth factor [KO:K16859]
101369772  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X3 [KO:K12329]
101369947  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101369957  ITGB3; integrin beta-3 [KO:K06493]
101370048  VCL; vinculin isoform X1 [KO:K05700]
101370100  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101370194  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
101370480  COL2A1; collagen alpha-1(II) chain [KO:K19719]
101370639  LAMA5; laminin subunit alpha-5 [KO:K06240]
101370689  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101370711  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
101370869  CHAD; chondroadherin [KO:K06248]
101371010  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101371074  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
101371237  TLN2; talin-2 isoform X2 [KO:K06271]
101371307  ITGB7; integrin beta-7 [KO:K06590]
101371459  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101371532  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101371800  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101371920  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
101372149  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101372267  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101372346  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101372359  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101372364  FIGF; vascular endothelial growth factor D [KO:K05449]
101372573  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
101372786  HRAS; GTPase HRas isoform X1 [KO:K02833]
101372845  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
101372891  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101372971  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
101373139  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
101373249  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
101373422  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101373537  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
101373766  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101373821  SHC1; SHC-transforming protein 1 isoform X2 [KO:K06279]
101373882  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
101374128  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101374143  MAPK8; mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
101374393  ITGB8; integrin beta-8 [KO:K06591]
101374641  [KO:K12757]
101374645  COL1A2; collagen alpha-2(I) chain [KO:K06236]
101374757  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101374787  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101374793  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101375017  ITGA1; integrin alpha-1 isoform X2 [KO:K06480]
101375321  [KO:K12757]
101375328  ACTB; actin, cytoplasmic 1 isoform X2 [KO:K05692]
101375422  BAD; bcl2-associated agonist of cell death [KO:K02158]
101375466  RAP1A; ras-related protein Rap-1A [KO:K04353]
101375473  [KO:K06272] [EC:2.7.11.1]
101375487  VEGFC; vascular endothelial growth factor C [KO:K05449]
101375500  SHC3; SHC-transforming protein 3 [KO:K17448]
101375601  ITGA2; integrin alpha-2 [KO:K06481]
101375729  SHC4; SHC-transforming protein 4 [KO:K17449]
101376185  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
101376308  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
101376329  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
101376952  ITGB5; integrin beta-5 [KO:K06588]
101377347  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
101377381  PARVB; beta-parvin [KO:K06275]
101377465  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
101377548  VEGFB; vascular endothelial growth factor B [KO:K16858]
101377629  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
101377667  PARVG; gamma-parvin [KO:K06275]
101378050  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
101378058  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
101378347  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
101378349  EMP2; epithelial membrane protein 2 [KO:K26256]
101378353  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
101378519  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
101378646  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2 [KO:K00889] [EC:2.7.1.68]
101378737  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
101378777  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
101378889  PDGFC; platelet-derived growth factor C [KO:K05450]
101378973  MYLK; myosin light chain kinase, smooth muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
101379053  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
101379820  COMP; cartilage oligomeric matrix protein [KO:K04659]
101379866  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X2 [KO:K00889] [EC:2.7.1.68]
101379997  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
101380023  ITGA5; integrin alpha-5 [KO:K06484]
101380560  FLNA; filamin-A [KO:K04437]
101380776  LAMB2; laminin subunit beta-2 [KO:K06243]
101380879  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101381103  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
101381226  THBS2; thrombospondin-2 [KO:K04659]
101381609  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
101381689  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
101382213  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101382320  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101382364  LAMB4; laminin subunit beta-4 [KO:K06245]
101382368  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101382657  LAMB1; laminin subunit beta-1 isoform X2 [KO:K05636]
101382867  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101382948  FLNB; filamin-B isoform X1 [KO:K27392]
101383157  LAMA2; laminin subunit alpha-2 [KO:K05637]
101383166  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101383234  TLN1; talin-1 [KO:K06271]
101383404  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
101383410  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
101383468  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
101383534  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
101383542  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101383637  VAV1; proto-oncogene vav isoform X2 [KO:K05730]
101383971  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
101384062  CRK; adapter molecule crk isoform X1 [KO:K04438]
101384064  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
101384118  SHC2; SHC-transforming protein 2 [KO:K17447]
101384125  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
101384197  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
101384210  LAMC1; laminin subunit gamma-1 [KO:K05635]
101384418  VTN; LOW QUALITY PROTEIN: vitronectin [KO:K06251]
101384487  LAMC2; laminin subunit gamma-2 [KO:K06246]
101384536  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X2 [KO:K06270]
101384542  [KO:K06238]
101384653  IBSP; bone sialoprotein 2 [KO:K06253]
101384714  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
101385065  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
101385114  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101385187  MYL10; myosin regulatory light chain 10 [KO:K12756]
101385241  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101385267  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101385291  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
101385359  ZYX; zyxin [KO:K06273]
101385440  ITGA11; integrin alpha-11 [KO:K06587]
101385566  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
101385830  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101385961  VWF; von Willebrand factor isoform X1 [KO:K03900]
101386047  LAMA3; laminin subunit alpha-3 [KO:K06240]
101386053  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101386060  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101386160  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
101386211  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101386230  ROCK1; rho-associated protein kinase 1 isoform X2 [KO:K04514] [EC:2.7.11.39]
101386334  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
101386416  SPP1; osteopontin isoform X1 [KO:K06250]
101386461  TNC; tenascin isoform X1 [KO:K06252]
101386561  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
101386858  EGFR; epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]
101386939  TNXB; tenascin-X [KO:K06252]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
oro04010  MAPK signaling pathway
oro04060  Cytokine-cytokine receptor interaction
oro04070  Phosphatidylinositol signaling system
oro04110  Cell cycle
oro04151  PI3K-Akt signaling pathway
oro04310  Wnt signaling pathway
oro04512  ECM-receptor interaction
oro04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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