KEGG   PATHWAY: arut04210
Entry
arut04210                   Pathway                                
Name
Apoptosis - Acipenser ruthenus (sterlet)
Description
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled by numerous interrelating processes. The 'extrinsic' pathway involves stimulation of members of the tumor necrosis factor (TNF) receptor subfamily, such as TNFRI, CD95/Fas or TRAILR (death receptors), located at the cell surface, by their specific ligands, such as TNF-alpha, FasL or TRAIL, respectively. The 'intrinsic' pathway is activated mainly by non-receptor stimuli, such as DNA damage, ER stress, metabolic stress, UV radiation or growth-factor deprivation. The central event in the 'intrinsic' pathway is the mitochondrial outer membrane permeabilization (MOMP), which leads to the release of cytochrome c. These two pathways converge at the level of effector caspases, such as caspase-3 and caspase-7. The third major pathway is initiated by the constituents of cytotoxic granules (e.g. Perforin and Granzyme B) that are released by CTLs (cytotoxic T-cells) and NK (natural killer) cells. Granzyme B, similarly to the caspases, cleaves its substrates after aspartic acid residues, suggesting that this protease has the ability to activate members of the caspase family directly. It is the balance between the pro-apoptotic and anti-apoptotic signals that eventually determines whether cells will undergo apoptosis, survive or proliferate. TNF family of ligands activates anti-apoptotic or cell-survival signals as well as apoptotic signals. NGF and Interleukin-3 promotes the survival, proliferation and differentiation of neurons or hematopoietic cells, respectively. Withdrawal of these growth factors leads to cell death, as described above.
Class
Cellular Processes; Cell growth and death
Pathway map
arut04210  Apoptosis
arut04210

Other DBs
GO: 0006915
Organism
Acipenser ruthenus (sterlet) [GN:arut]
Gene
117430815  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
117411923  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
117966855  tumor necrosis factor ligand superfamily member 10-like isoform X1 [KO:K04721]
117416691  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
117423082  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
117966494  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
117411359  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
117417998  fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
117415262  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
117435159  FAS-associated death domain protein-like [KO:K02373]
117431917  fadd; FAS-associated death domain protein [KO:K02373]
117965004  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
117433977  lymphotoxin-alpha-like isoform X1 [KO:K03156]
117433981  tumor necrosis factor-like [KO:K03156]
117425211  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117425088  tumor necrosis factor receptor type 1-associated DEATH domain protein-like [KO:K03171]
117424274  tumor necrosis factor receptor type 1-associated DEATH domain protein-like [KO:K03171]
117413297  CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
117426878  LOW QUALITY PROTEIN: caspase-8-like [KO:K04398] [EC:3.4.22.61]
117426351  caspase-8-like [KO:K04398] [EC:3.4.22.61]
117408587  caspase-8-like [KO:K04398] [EC:3.4.22.61]
117426603  caspase-8-like [KO:K04398] [EC:3.4.22.61]
117414260  caspase-8-like [KO:K04398] [EC:3.4.22.61]
117426544  caspase-8-like isoform X1 [KO:K04400] [EC:3.4.22.63]
117408574  caspase-8-like isoform X1 [KO:K04400] [EC:3.4.22.63]
117409471  caspase-6-like [KO:K04396] [EC:3.4.22.59]
117409020  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
117420645  caspase-3-like [KO:K02187] [EC:3.4.22.56]
117420663  caspase-3-like [KO:K02187] [EC:3.4.22.56]
117414465  caspase-7-like [KO:K04397] [EC:3.4.22.60]
117417933  caspase-7-like [KO:K04397] [EC:3.4.22.60]
117968959  caspase-7-like [KO:K04397] [EC:3.4.22.60]
117397812  caspase-7 [KO:K04397] [EC:3.4.22.60]
117420466  caspase-3-like [KO:K04397] [EC:3.4.22.60]
117419929  BH3-interacting domain death agonist-like [KO:K04726]
117415131  BH3-interacting domain death agonist-like [KO:K04726]
117432031  zgc:153993; apoptosis regulator BAX [KO:K02159]
117434851  apoptosis regulator BAX-like [KO:K02159]
117435272  bcl-2 homologous antagonist/killer-like [KO:K14021]
117406675  diablo homolog, mitochondrial-like [KO:K10522]
117405299  diablo homolog, mitochondrial-like [KO:K10522]
117429617  septin-5 isoform X1 [KO:K16943]
117962709  septin-5-like isoform X1 [KO:K16943]
117409633  serine protease HTRA2, mitochondrial-like [KO:K08669] [EC:3.4.21.108]
117420941  serine protease HTRA2, mitochondrial-like [KO:K08669] [EC:3.4.21.108]
117400603  cytochrome c [KO:K08738]
117426640  cytochrome c-like [KO:K08738]
117412329  cytochrome c [KO:K08738]
117416074  apoptotic protease-activating factor 1-like isoform X1 [KO:K02084]
117419459  apoptotic protease-activating factor 1-like isoform X1 [KO:K02084]
117968643  caspase-9-like isoform X1 [KO:K04399] [EC:3.4.22.62]
117972138  caspase-9-like [KO:K04399] [EC:3.4.22.62]
117425431  caspase-9-like isoform X2 [KO:K04399] [EC:3.4.22.62]
117426078  caspase-9-like isoform X1 [KO:K04399] [EC:3.4.22.62]
117399009  perforin-1-like [KO:K07818]
117399015  LOW QUALITY PROTEIN: perforin-1-like [KO:K07818]
117406489  mast cell protease 1A-like [KO:K01353] [EC:3.4.21.79]
117428865  mast cell protease 1A-like [KO:K01353] [EC:3.4.21.79]
117428982  duodenase-1 [KO:K01353] [EC:3.4.21.79]
117966147  duodenase-1-like [KO:K01353] [EC:3.4.21.79]
117428840  mast cell protease 1A-like [KO:K01353] [EC:3.4.21.79]
117966222  mast cell protease 1A-like [KO:K01353] [EC:3.4.21.79]
117401433  mast cell protease 1A-like [KO:K01353] [EC:3.4.21.79]
117972677  tubulin alpha-8 chain-like [KO:K07374]
117962580  tubulin alpha-8 chain-like [KO:K07374]
117966953  tubulin alpha chain-like [KO:K07374]
117966964  tubulin alpha-1C chain [KO:K07374]
117966966  tubulin alpha chain-like [KO:K07374]
117405916  tubulin alpha chain-like [KO:K07374]
117967084  tubulin alpha chain-like isoform X1 [KO:K07374]
117416255  tubulin alpha chain [KO:K07374]
117407556  tubulin alpha chain-like [KO:K07374]
117407588  tubulin alpha-1A chain-like [KO:K07374]
117408004  tubulin alpha-1A chain-like [KO:K07374]
117408357  tubulin alpha-1A chain-like isoform X1 [KO:K07374]
117400950  tubulin alpha chain [KO:K07374]
117400951  tubulin alpha chain-like isoform X1 [KO:K07374]
117401080  tubulin alpha chain-like [KO:K07374]
117401081  tubulin alpha-1C chain-like [KO:K07374]
117409337  tubulin alpha-8 chain-like [KO:K07374]
117427935  tubulin alpha-8 chain-like isoform X1 [KO:K07374]
117964479  tubulin alpha-8 chain-like isoform X1 [KO:K07374]
117401772  tubulin alpha chain, testis-specific [KO:K07374]
117402664  tubulin alpha-1A chain-like [KO:K07374]
117402673  tubulin alpha chain-like [KO:K07374]
117421146  tubulin alpha-8 chain-like [KO:K07374]
117421148  tubulin alpha-8 chain-like [KO:K07374]
117404226  tubulin alpha chain, testis-specific-like [KO:K07374]
117395593  induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
117424565  actin, cytoplasmic type 5 [KO:K05692]
117418240  actin, cytoplasmic 2 [KO:K05692]
117431529  actb1; actin, cytoplasmic 1 [KO:K05692]
117423427  actin, cytoplasmic type 5 [KO:K05692]
117422341  spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
117396909  spectrin alpha chain, non-erythrocytic 1 isoform X2 [KO:K06114]
117965150  lamin-A-like [KO:K12641]
117395483  lamin-A [KO:K12641]
117408729  lamin-B1 [KO:K07611]
117427827  lamin-L(III)-like isoform X1 [KO:K07611]
117401255  LOW QUALITY PROTEIN: lamin-B2 [KO:K07611]
117429913  lamin-L(III)-like isoform X1 [KO:K07611]
117966187  LOW QUALITY PROTEIN: lamin-B2-like [KO:K07611]
117418280  lamin-B1-like isoform X1 [KO:K07611]
117411586  parp1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
117972033  protein mono-ADP-ribosyltransferase PARP4-like isoform X1 [KO:K10798] [EC:2.4.2.30]
117398129  parp2; poly [ADP-ribose] polymerase 2 isoform X1 [KO:K10798] [EC:2.4.2.30]
117429603  protein mono-ADP-ribosyltransferase PARP4-like isoform X1 [KO:K10798] [EC:2.4.2.30]
117414142  LOW QUALITY PROTEIN: protein mono-ADP-ribosyltransferase PARP3-like [KO:K10798] [EC:2.4.2.30]
117963527  LOW QUALITY PROTEIN: protein mono-ADP-ribosyltransferase PARP3-like [KO:K10798] [EC:2.4.2.30]
117425538  DNA fragmentation factor subunit alpha-like isoform X1 [KO:K02310]
117432196  DNA fragmentation factor subunit alpha-like isoform X1 [KO:K02310]
117425761  DNA fragmentation factor subunit beta [KO:K02311] [EC:3.-.-.-]
117962462  DNA fragmentation factor subunit beta-like isoform X2 [KO:K02311] [EC:3.-.-.-]
117396722  endog; endonuclease G, mitochondrial [KO:K01173]
117430314  apoptosis-inducing factor 1, mitochondrial-like isoform X3 [KO:K04727] [EC:1.-.-.-]
117411826  apoptosis-inducing factor 1, mitochondrial-like isoform X1 [KO:K04727] [EC:1.-.-.-]
117963438  apoptosis-inducing factor 1, mitochondrial-like isoform X1 [KO:K04727] [EC:1.-.-.-]
117424652  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
117417930  ern2; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
117423116  serine/threonine-protein kinase/endoribonuclease IRE1-like isoform X2 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
117962289  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
117962309  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
117396690  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
117396934  TNF receptor-associated factor 2-like isoform X2 [KO:K03173] [EC:2.3.2.27]
117411749  itpr1a; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
117412304  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
117419457  inositol 1,4,5-trisphosphate receptor type 2-like [KO:K04959]
117415087  inositol 1,4,5-trisphosphate receptor type 2-like [KO:K04959]
117396958  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
117430810  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
117962701  LOW QUALITY PROTEIN: calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
117968954  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
117410781  calpain-14-like [KO:K01367] [EC:3.4.22.52]
117429789  calpain-A-like [KO:K01367] [EC:3.4.22.52]
117411200  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
117430547  calpain-A-like [KO:K01367] [EC:3.4.22.52]
117402957  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
117410849  zgc:136872; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
117411201  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117410845  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117410846  calpain-2 catalytic subunit-like isoform X2 [KO:K03853] [EC:3.4.22.53]
117402852  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117403231  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117403377  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117408518  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
117421266  eukaryotic translation initiation factor 2-alpha kinase 3-like isoform X1 [KO:K08860] [EC:2.7.11.1]
117421495  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
117422066  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
117966972  DNA damage-inducible transcript 3 protein-like isoform X1 [KO:K04452]
117401063  DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
117411196  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
117403126  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
117973058  dipeptidyl peptidase 1-like [KO:K01275] [EC:3.4.14.1]
117405993  dipeptidyl peptidase 1 [KO:K01275] [EC:3.4.14.1]
117421652  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
117966750  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
117431943  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
117434446  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
117398711  LOW QUALITY PROTEIN: cathepsin F [KO:K01373] [EC:3.4.22.41]
117967865  LOW QUALITY PROTEIN: cathepsin F-like [KO:K01373] [EC:3.4.22.41]
117427928  pro-cathepsin H-like [KO:K01366] [EC:3.4.22.16]
117429312  pro-cathepsin H-like [KO:K01366] [EC:3.4.22.16]
117971318  cathepsin K-like [KO:K01371] [EC:3.4.22.38]
117395492  cathepsin K-like [KO:K01371] [EC:3.4.22.38]
117428809  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
117428939  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
117401373  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
117401374  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
117401377  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
117394528  cts12; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
117410991  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
117403776  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
117404126  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
117413506  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
117966330  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
117428941  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
117414262  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
117428940  cathepsin L1-like isoform X2 [KO:K01365] [EC:3.4.22.15]
117408796  ctso; cathepsin O [KO:K01374] [EC:3.4.22.42]
117971317  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
117965122  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
117395491  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
117965129  cathepsin L1-like [KO:K01368] [EC:3.4.22.27]
117965168  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
117395567  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
117432598  cathepsin Z-like [KO:K08568] [EC:3.4.18.1]
117423512  cathepsin Z-like [KO:K08568] [EC:3.4.18.1]
117972988  inhibitor of apoptosis protein-like [KO:K16060]
117405623  inhibitor of apoptosis protein isoform X1 [KO:K16060]
117430831  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase XIAP-like [KO:K04725] [EC:2.3.2.27]
117400943  birc5b; baculoviral IAP repeat-containing protein 5b [KO:K08731]
117424092  birc5a; baculoviral IAP repeat-containing protein 5a [KO:K08731]
117410460  bcl2l11; bcl-2-like protein 11 isoform X1 [KO:K16341]
117420711  bcl-2-like protein 1 [KO:K04570]
117434069  bcl-2-like protein 1 [KO:K04570]
117399761  apoptosis regulator Bcl-2-like [KO:K02161]
117394930  apoptosis regulator Bcl-2-like isoform X1 [KO:K02161]
117434177  death domain-associated protein 6 [KO:K02308]
117964846  death domain-associated protein 6-like [KO:K02308]
117394623  ripk1l; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
117422477  LOW QUALITY PROTEIN: disabled homolog 2-interacting protein-like [KO:K19901]
117396975  LOW QUALITY PROTEIN: disabled homolog 2-interacting protein-like [KO:K19901]
117410928  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
117402892  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
117413367  mitogen-activated protein kinase kinase kinase 5-like isoform X1 [KO:K04426] [EC:2.7.11.25]
117414092  mitogen-activated protein kinase kinase kinase 5-like isoform X1 [KO:K04426] [EC:2.7.11.25]
117409061  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117415548  LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
117962527  mitogen-activated protein kinase 10 isoform X7 [KO:K04440] [EC:2.7.11.24]
117418084  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117431535  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
117413208  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
117398525  bcl2-associated agonist of cell death-like [KO:K02158]
117967845  bcl2-associated agonist of cell death-like [KO:K02158]
117963780  transcription factor AP-1-like [KO:K04448]
117421449  transcription factor AP-1-like [KO:K04448]
117416589  transcription factor AP-1-like [KO:K04448]
117401403  transcription factor AP-1 [KO:K04448]
117422116  proto-oncogene c-Fos-like isoform X1 [KO:K04379]
117417438  proto-oncogene c-Fos-like isoform X1 [KO:K04379]
117409032  proto-oncogene c-Fos-like [KO:K04379]
117422027  proto-oncogene c-Fos-like [KO:K04379]
117970978  cellular tumor antigen p53-like isoform X1 [KO:K04451]
117404615  cellular tumor antigen p53 [KO:K04451]
117427187  mitogen-activated protein kinase kinase kinase 14-like isoform X1 [KO:K04466] [EC:2.7.11.25]
117433487  map3k14a; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
117416037  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
117397678  inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
117962689  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
117404249  NF-kappa-B essential modulator [KO:K07210]
117401606  NF-kappa-B essential modulator-like [KO:K07210]
117421916  NF-kappa-B inhibitor alpha-like [KO:K04734]
117404215  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
117408542  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
117421210  nuclear factor NF-kappa-B p105 subunit-like isoform X1 [KO:K02580]
117962714  putative transcription factor p65 homolog isoform X1 [KO:K04735]
117967842  putative transcription factor p65 homolog [KO:K04735]
117398684  putative transcription factor p65 homolog isoform X1 [KO:K04735]
117409269  tyrosine-protein phosphatase non-receptor type 13 isoform X1 [KO:K02374]
117963590  tyrosine-protein phosphatase non-receptor type 13-like isoform X1 [KO:K02374]
117400851  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117971933  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117971936  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117971940  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117416935  LOW QUALITY PROTEIN: growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
117408484  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117400855  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117400856  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117409183  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117409625  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117409629  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117428915  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
117401312  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
117404259  growth arrest and DNA damage-inducible protein GADD45 alpha-like isoform X1 [KO:K04402]
117422408  TNF receptor-associated factor 1-like [KO:K03172]
117433548  TNF receptor-associated factor 1-like [KO:K03172]
117433702  TNF receptor-associated factor 2-like [KO:K03172]
117433751  TNF receptor-associated factor 1-like [KO:K03172]
117433946  TNF receptor-associated factor 2-like [KO:K03172]
117396680  TNF receptor-associated factor 1-like [KO:K03172]
117405719  serine-protein kinase ATM-like isoform X1 [KO:K04728] [EC:2.7.11.1]
117407051  serine-protein kinase ATM-like isoform X1 [KO:K04728] [EC:2.7.11.1]
117434910  pidd1; p53-induced death domain-containing protein 1 [KO:K10130]
117403657  pmaip1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
117425205  casp2; caspase-2 [KO:K02186] [EC:3.4.22.55]
117965946  venom nerve growth factor-like [KO:K02582]
117433907  venom nerve growth factor [KO:K02582]
117970830  high affinity nerve growth factor receptor-like isoform X1 [KO:K03176] [EC:2.7.10.1]
117395629  high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
117432590  cytokine receptor common subunit beta-like [KO:K04738]
117433124  cytokine receptor common subunit beta-like [KO:K04738]
117417151  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
117425425  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
117432219  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
117417457  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117423098  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
117423331  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117407471  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
117417119  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
117428991  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
117401370  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
117403662  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117404001  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
117418593  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
117431063  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
117416317  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
117398601  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
117423438  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117415905  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117400209  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
117411324  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
117403056  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117412568  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
117414362  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
117422488  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
117397139  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
117431924  GTPase HRas [KO:K02833]
117434435  GTPase HRas [KO:K02833]
117419957  GTPase KRas isoform X1 [KO:K07827]
117962512  GTPase HRas-like [KO:K07827]
117415640  GTPase KRas isoform X1 [KO:K07827]
117407743  GTPase HRas-like [KO:K07827]
117428047  GTPase NRas [KO:K07828]
117962404  GTPase NRas [KO:K07828]
117414023  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
117412241  LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
117428255  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117964269  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117401470  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
117966151  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
117973328  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117398123  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
117426782  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00319  Sphingosine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Related
pathway
arut04010  MAPK signaling pathway
arut04020  Calcium signaling pathway
arut04115  p53 signaling pathway
arut04141  Protein processing in endoplasmic reticulum
KO pathway
ko04210   
LinkDB

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