KEGG PATHWAY: cclu04622

KEGG

PATHWAY: cclu04622

Entry

cclu04622                   Pathway

Name

RIG-I-like receptor signaling pathway - Coregonus clupeaformis (lake whitefish)

Description

Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.

Class

Organismal Systems; Immune system

Pathway map

RIG-I-like receptor signaling pathway

Organism

Coregonus clupeaformis (lake whitefish) [GN:cclu]

Gene

ddx58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]

ifih1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]

NFX1-type zinc finger-containing protein 1 [KO:K27391]

NFX1-type zinc finger-containing protein 1 [KO:K27391]

LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DHX58 [KO:K12649] [EC:5.6.2.6]

probable ATP-dependent RNA helicase DHX58 [KO:K12649] [EC:5.6.2.6]

TNF receptor-associated factor 3-like [KO:K03174]

TNF receptor-associated factor 3-like isoform X1 [KO:K03174]

uncharacterized protein LOC121551997 [KO:K12650]

TRAF family member-associated NF-kappa-B activator [KO:K12650]

5-azacytidine-induced protein 2-like [KO:K12651]

5-azacytidine-induced protein 2 [KO:K12651]

tbkbp1; TANK-binding kinase 1-binding protein 1 [KO:K12652]

TANK-binding kinase 1-binding protein 1-like [KO:K12652]

TANK-binding kinase 1-binding protein 1-like [KO:K12652]

TANK-binding kinase 1-binding protein 1-like isoform X1 [KO:K12652]

NF-kappa-B essential modulator isoform X1 [KO:K07210]

NF-kappa-B essential modulator [KO:K07210]

tbk1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]

inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]

inhibitor of nuclear factor kappa-B kinase subunit epsilon-like [KO:K07211] [EC:2.7.11.10]

irf3; interferon regulatory factor 3 [KO:K05411]

interferon regulatory factor 3-like [KO:K09447]

interferon regulatory factor 7 [KO:K09447]

interferon a3-like [KO:K05414]

interferon a3 isoform X1 [KO:K05414]

interferon alpha-1-like [KO:K05414]

interferon beta-like [KO:K05414]

interferon beta-like [KO:K05414]

interferon alpha-1-like [KO:K05414]

interferon alpha-1-like [KO:K05414]

interferon alpha-1-like [KO:K05414]

interferon alpha-1-like [KO:K05414]

interferon a3-like isoform X1 [KO:K05414]

interferon alpha-1-like [KO:K05414]

interferon alpha-1-like [KO:K05414]

LOW QUALITY PROTEIN: interferon alpha-4-like [KO:K05414]

interferon beta-like [KO:K05414]

interferon beta-like [KO:K05414]

interferon a3-like [KO:K05414]

interferon alpha-B-like [KO:K05414]

interferon a3-like [KO:K05414]

interferon a3-like [KO:K05414]

interferon a3-like [KO:K05414]

interferon a3-like [KO:K05414]

interferon a3-like isoform X1 [KO:K05414]

tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]

FAS-associated death domain protein-like [KO:K02373]

FAS-associated death domain protein-like [KO:K02373]

receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]

receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]

caspase-8 [KO:K04398] [EC:3.4.22.61]

casp10; caspase-8 [KO:K04398] [EC:3.4.22.61]

LOW QUALITY PROTEIN: caspase-8 [KO:K04398] [EC:3.4.22.61]

caspase-8 [KO:K04398] [EC:3.4.22.61]

inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]

inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]

inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]

inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]

NF-kappa-B inhibitor alpha-like [KO:K04734]

NF-kappa-B inhibitor alpha-like [KO:K04734]

NF-kappa-B inhibitor alpha [KO:K04734]

NF-kappa-B inhibitor alpha [KO:K04734]

nuclear factor NF-kappa-B p105 subunit [KO:K02580]

nuclear factor NF-kappa-B p105 subunit [KO:K02580]

transcription factor p65 [KO:K04735]

transcription factor p65 [KO:K04735]

traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]

TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]

TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]

TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]

TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]

mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]

mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]

mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]

mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]

traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]

map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]

mitogen-activated protein kinase kinase kinase 1-like isoform X1 [KO:K04416] [EC:2.7.11.25]

mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]

mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]

mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]

mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]

mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]

mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]

mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]

mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]

mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]

mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]

mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]

mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]

mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]

mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]

mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]

mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]

mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]

mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]

mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]

mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]

mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]

mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]

interleukin-8 [KO:K10030]

interleukin-8 [KO:K10030]

permeability factor 2 [KO:K10030]

interleukin-8-like [KO:K10030]

tumor necrosis factor-like [KO:K03156]

tumor necrosis factor-like [KO:K03156]

tumor necrosis factor-like [KO:K03156]

tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K03156]

interleukin-12 subunit alpha-like [KO:K05406]

uncharacterized protein LOC121568492 [KO:K05406]

si:dkey-88e18.2; interleukin-12 subunit beta [KO:K05425]

interleukin-12 subunit beta-like isoform X1 [KO:K05425]

interleukin-12 subunit beta-like [KO:K05425]

interleukin-12 subunit beta-like [KO:K05425]

interleukin-12 subunit beta-like [KO:K05425]

permeability factor 2-like [KO:K12671]

adar; double-stranded RNA-specific adenosine deaminase isoform X2 [KO:K12968] [EC:3.5.4.37]

E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:2.3.2.27]

ftr86; finTRIM family, member 86 [KO:K10652] [EC:2.3.2.27]

E3 ubiquitin/ISG15 ligase TRIM25-like isoform X1 [KO:K10652] [EC:2.3.2.27]

E3 ubiquitin/ISG15 ligase TRIM25-like [KO:K10652] [EC:2.3.2.27]

E3 ubiquitin/ISG15 ligase TRIM25 isoform X1 [KO:K10652] [EC:2.3.2.27]

E3 ubiquitin/ISG15 ligase TRIM25-like [KO:K10652] [EC:2.3.2.27]

E3 ubiquitin/ISG15 ligase TRIM25-like [KO:K10652] [EC:2.3.2.27]

cyldl; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]

ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]

si:cabz01101003.1; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]

cylda; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]

atg5; autophagy protein 5 [KO:K08339]

ubiquitin-like protein ATG12 [KO:K08336]

ubiquitin-like protein ATG12 [KO:K08336]

NLR family member X1 isoform X1 [KO:K12653]

sting1; stimulator of interferon genes protein isoform X1 [KO:K12654]

OTU domain-containing protein 5-A isoform X1 [KO:K12655] [EC:3.4.19.12]

otud5a; OTU domain-containing protein 5-A isoform X1 [KO:K12655] [EC:3.4.19.12]

sike1; suppressor of IKBKE 1 [KO:K12656]

ddx3xb; DEAD-box helicase 3 X-linked b isoform X4 [KO:K11594] [EC:5.6.2.7]

ATP-dependent RNA helicase DDX3Y isoform X1 [KO:K11594] [EC:5.6.2.7]

ddx3xa; DEAD-box helicase 3 X-linked a isoform X1 [KO:K11594] [EC:5.6.2.7]

peptidyl-prolyl cis-trans isomerase NIMA-interacting 1-like [KO:K09578] [EC:5.2.1.8]

pin1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform X1 [KO:K09578] [EC:5.2.1.8]

tkfc; triokinase/FMN cyclase isoform X1 [KO:K00863] [EC:2.7.1.28 2.7.1.29 4.6.1.15]

Compound

RNA

Reference

Authors

Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T

Title

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.

Journal

Nat Immunol 5:730-7 (2004)
DOI:10.1038/ni1087

Reference

Authors

Takeuchi O, Akira S

Title

MDA5/RIG-I and virus recognition.

Journal

Curr Opin Immunol 20:17-22 (2008)
DOI:10.1016/j.coi.2008.01.002

Reference

Authors

Yoneyama M, Fujita T

Title

RNA recognition and signal transduction by RIG-I-like receptors.

Journal

Immunol Rev 227:54-65 (2009)
DOI:10.1111/j.1600-065X.2008.00727.x

Reference

Authors

Nakhaei P, Genin P, Civas A, Hiscott J

Title

RIG-I-like receptors: sensing and responding to RNA virus infection.

Journal

Semin Immunol 21:215-22 (2009)
DOI:10.1016/j.smim.2009.05.001

Reference

Authors

Moore CB, Ting JP

Title

Regulation of mitochondrial antiviral signaling pathways.

Journal

Immunity 28:735-9 (2008)
DOI:10.1016/j.immuni.2008.05.005

Reference

Authors

Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB

Title

Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.

Journal

Pharmacol Ther 124:219-34 (2009)
DOI:10.1016/j.pharmthera.2009.06.012

Reference

Authors

Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G

Title

Approaching the RNA ligand for RIG-I?

Journal

Immunol Rev 227:66-74 (2009)
DOI:10.1111/j.1600-065X.2008.00724.x

Reference

Authors

Saito T, Gale M Jr

Title

Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.

Journal

J Exp Med 205:1523-7 (2008)
DOI:10.1084/jem.20081210

Reference

Authors

Kawai T, Akira S

Title

Toll-like receptor and RIG-I-like receptor signaling.

Journal

Ann N Y Acad Sci 1143:1-20 (2008)
DOI:10.1196/annals.1443.020

Reference

Authors

Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J

Title

TRADD protein is an essential component of the RIG-like helicase antiviral pathway.

Journal

Immunity 28:651-61 (2008)
DOI:10.1016/j.immuni.2008.03.013

Reference

Authors

Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T

Title

TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.

Journal

J Biol Chem 283:36211-20 (2008)
DOI:10.1074/jbc.M806576200

Reference

Authors

Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR

Title

RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.

Journal

J Biol Chem 284:10774-82 (2009)
DOI:10.1074/jbc.M807272200

Reference

Authors

Liu G, Gack MU

Title

Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity.

Journal

Immunity 53:26-42 (2020)
DOI:10.1016/j.immuni.2020.03.017

Related
pathway

MAPK signaling pathway

Ubiquitin mediated proteolysis

Apoptosis

KO pathway

LinkDB

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