KEGG   PATHWAY: cclu04120
Entry
cclu04120                   Pathway                                
Name
Ubiquitin mediated proteolysis - Coregonus clupeaformis (lake whitefish)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
cclu04120  Ubiquitin mediated proteolysis
cclu04120

Other DBs
GO: 0016567
Organism
Coregonus clupeaformis (lake whitefish) [GN:cclu]
Gene
121530678  [KO:K10601] [EC:2.3.2.27]
121530744  ppil2; RING-type E3 ubiquitin-protein ligase PPIL2 [KO:K10598] [EC:5.2.1.8]
121530749  pias2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
121530757  [KO:K04552] [EC:2.3.2.23]
121530809  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
121530825  uba1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
121530902  [KO:K06689] [EC:2.3.2.23]
121531457  [KO:K04706] [EC:2.3.2.-]
121531572  [KO:K10582] [EC:2.3.2.23]
121531767  [KO:K10571]
121531775  [KO:K10685] [EC:6.2.1.45]
121531803  [KO:K05630] [EC:2.3.2.26]
121531842  siah1; E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
121532178  [KO:K10576] [EC:2.3.2.23]
121532253  [KO:K10580] [EC:2.3.2.23]
121532478  [KO:K06689] [EC:2.3.2.23]
121532526  [KO:K10599] [EC:2.3.2.27]
121532634  [KO:K04649] [EC:2.3.2.23]
121532713  [KO:K03362]
121533312  anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
121533389  [KO:K03364]
121533498  [KO:K02207] [EC:2.3.2.23]
121533525  pias4a; E3 SUMO-protein ligase PIAS4-A isoform X1 [KO:K16065] [EC:2.3.2.27]
121533579  [KO:K06689] [EC:2.3.2.23]
121533665  [KO:K02927]
121534006  anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
121534017  [KO:K10581] [EC:2.3.2.24]
121534182  [KO:K10587] [EC:2.3.2.26]
121534788  aire; autoimmune regulator [KO:K10603]
121534853  [KO:K10610]
121535063  [KO:K02927]
121535136  cul4b; cullin-4B [KO:K10609]
121535211  [KO:K10143] [EC:2.3.2.27]
121535270  cul1a; cullin-1a [KO:K03347]
121535452  [KO:K03869]
121535493  [KO:K03364]
121535509  pias4b; E3 SUMO-protein ligase PIAS4b isoform X1 [KO:K16065] [EC:2.3.2.27]
121535515  [KO:K02207] [EC:2.3.2.23]
121535581  fzr1b; fizzy-related protein homolog [KO:K03364]
121535774  [KO:K10599] [EC:2.3.2.27]
121535969  [KO:K08285] [EC:2.3.2.27]
121535981  [KO:K10614] [EC:2.3.2.26]
121536068  [KO:K10587] [EC:2.3.2.26]
121536461  [KO:K08285] [EC:2.3.2.27]
121536486  [KO:K04725] [EC:2.3.2.27]
121536496  [KO:K10573] [EC:2.3.2.23]
121536616  [KO:K03353]
121536689  [KO:K10687] [EC:2.3.2.34]
121536884  si:rp71-68n21.9; kelch-like protein 9 [KO:K10447]
121536978  [KO:K20217] [EC:2.3.2.23]
121537222  [KO:K10573] [EC:2.3.2.23]
121537559  [KO:K16061]
121537768  cul5b; cullin-5 isoform X1 [KO:K10612]
121537875  [KO:K10592] [EC:2.3.2.26]
121538387  ube4b; ubiquitin conjugation factor E4 B isoform X2 [KO:K10597] [EC:2.3.2.27]
121538457  [KO:K05632] [EC:2.3.2.26]
121538490  [KO:K10686] [EC:6.2.1.64]
121538596  [KO:K10601] [EC:2.3.2.27]
121539527  [KO:K04725] [EC:2.3.2.27]
121539835  ube2d2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
121540101  ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
121540288  [KO:K10573] [EC:2.3.2.23]
121540333  [KO:K02207] [EC:2.3.2.23]
121540360  [KO:K16065] [EC:2.3.2.27]
121540387  [KO:K10609]
121540776  [KO:K10140]
121540782  pias1b; E3 SUMO-protein ligase PIAS1 [KO:K04706] [EC:2.3.2.-]
121540784  [KO:K10582] [EC:2.3.2.23]
121540889  [KO:K10591] [EC:2.3.2.26]
121541398  [KO:K04416] [EC:2.7.11.25]
121541510  [KO:K08770]
121541571  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
121541618  [KO:K10575] [EC:2.3.2.23]
121541686  [KO:K10607] [EC:2.3.2.27]
121541879  [KO:K10447]
121541952  cdc23; cell division cycle protein 23 homolog [KO:K03355]
121542082  [KO:K06689] [EC:2.3.2.23]
121542924  [KO:K10583] [EC:2.3.2.23]
121543381  [KO:K10576] [EC:2.3.2.23]
121543418  [KO:K06689] [EC:2.3.2.23]
121543474  [KO:K10580] [EC:2.3.2.23]
121543515  [KO:K04649] [EC:2.3.2.23]
121543590  [KO:K03362]
121543619  [KO:K10580] [EC:2.3.2.23]
121543750  [KO:K10602] [EC:2.3.2.27]
121544518  [KO:K06689] [EC:2.3.2.23]
121545217  [KO:K10571]
121545593  [KO:K05632] [EC:2.3.2.26]
121545638  [KO:K10686] [EC:6.2.1.64]
121545880  [KO:K10592] [EC:2.3.2.26]
121546010  [KO:K10597] [EC:2.3.2.27]
121546400  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
121546416  [KO:K06689] [EC:2.3.2.23]
121546525  [KO:K16061]
121546680  [KO:K10599] [EC:2.3.2.27]
121547203  [KO:K09561] [EC:2.3.2.27]
121547220  [KO:K10577]
121548029  [KO:K04696]
121548293  [KO:K10591] [EC:2.3.2.26]
121549027  [KO:K10578] [EC:2.3.2.23]
121549775  cul1b; cullin-1b [KO:K03347]
121549935  [KO:K05633] [EC:2.3.2.26]
121549960  [KO:K03870]
121549994  [KO:K10589] [EC:2.3.2.26]
121550064  [KO:K10576] [EC:2.3.2.23]
121550179  [KO:K10608] [EC:2.3.2.27]
121550215  [KO:K03352]
121550236  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
121550247  [KO:K03350]
121550299  [KO:K02207] [EC:2.3.2.23]
121550379  [KO:K10575] [EC:2.3.2.23]
121550438  [KO:K10577]
121550528  [KO:K10588] [EC:2.3.2.26]
121550698  [KO:K10577]
121550723  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
121550817  [KO:K10604] [EC:2.3.2.27]
121550913  [KO:K04707] [EC:2.3.2.27]
121550972  [KO:K03868] [EC:2.3.2.32]
121551031  [KO:K03353]
121551066  [KO:K04678] [EC:2.3.2.26]
121551199  [KO:K04696]
121551587  [KO:K09561] [EC:2.3.2.27]
121552188  [KO:K10578] [EC:2.3.2.23]
121553068  [KO:K08285] [EC:2.3.2.27]
121553180  birc6; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 6 [KO:K10586] [EC:2.3.2.23]
121553211  herc4; probable E3 ubiquitin-protein ligase HERC4 [KO:K10615] [EC:2.3.2.26]
121553251  prkn; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
121553475  [KO:K02977]
121553521  fancl; E3 ubiquitin-protein ligase FANCL isoform X1 [KO:K10606] [EC:2.3.2.27]
121553561  [KO:K06689] [EC:2.3.2.23]
121553643  [KO:K06689] [EC:2.3.2.23]
121553870  [KO:K06643] [EC:2.3.2.27]
121554009  keap1b; kelch-like ECH-associated protein 1B [KO:K10456]
121554494  [KO:K10260]
121554628  anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
121554963  [KO:K10687] [EC:2.3.2.34]
121554967  ube2g2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
121555056  [KO:K20217] [EC:2.3.2.23]
121555304  [KO:K10688] [EC:2.3.2.23 2.3.2.25]
121555308  [KO:K03872]
121555414  [KO:K06643] [EC:2.3.2.27]
121555424  [KO:K03871]
121555472  [KO:K03178] [EC:6.2.1.45]
121556475  [KO:K10583] [EC:2.3.2.23]
121556791  [KO:K10609]
121556918  [KO:K10602] [EC:2.3.2.27]
121557107  [KO:K10605] [EC:2.3.2.27]
121557208  [KO:K04694]
121558449  [KO:K16060]
121558519  [KO:K10614] [EC:2.3.2.26]
121559174  [KO:K06643] [EC:2.3.2.27]
121559716  [KO:K16060]
121559813  [KO:K06643] [EC:2.3.2.27]
121560171  keap1a; kelch-like ECH-associated protein 1A isoform X1 [KO:K10456]
121560275  fbxw7; F-box/WD repeat-containing protein 7 isoform X1 [KO:K10260]
121560717  [KO:K10596] [EC:2.3.2.27]
121560841  [KO:K04707] [EC:2.3.2.27]
121561241  [KO:K06643] [EC:2.3.2.27]
121561274  cul3b; cullin-3b [KO:K03869]
121561558  [KO:K20217] [EC:2.3.2.23]
121561559  [KO:K20217] [EC:2.3.2.23]
121561981  [KO:K20217] [EC:2.3.2.23]
121562670  ube2kb; ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast) [KO:K04649] [EC:2.3.2.23]
121563450  [KO:K20217] [EC:2.3.2.23]
121564245  sae1; SUMO-activating enzyme subunit 1 [KO:K10684] [EC:6.2.1.45]
121564406  [KO:K10590] [EC:2.3.2.26]
121564635  rnf7; RING-box protein 2 [KO:K10611]
121567309  [KO:K09561] [EC:2.3.2.27]
121567327  [KO:K03869]
121567354  [KO:K04707] [EC:2.3.2.27]
121567357  [KO:K10596] [EC:2.3.2.27]
121567549  [KO:K10611]
121567553  [KO:K10590] [EC:2.3.2.26]
121567648  ube2ib; SUMO-conjugating enzyme UBC9-A [KO:K10577]
121567818  [KO:K25228]
121567876  [KO:K10612]
121567977  [KO:K04696]
121568702  [KO:K04696]
121568946  elob; elongin-B [KO:K03873]
121568980  [KO:K04678] [EC:2.3.2.26]
121569034  [KO:K03868] [EC:2.3.2.32]
121569103  [KO:K10604] [EC:2.3.2.27]
121569117  [KO:K10577]
121569462  [KO:K10585] [EC:2.3.2.23]
121569483  [KO:K10579] [EC:2.3.2.34]
121569641  [KO:K10579] [EC:2.3.2.34]
121569663  [KO:K10585] [EC:2.3.2.23]
121569717  [KO:K03350]
121569724  [KO:K10577]
121569847  [KO:K10589] [EC:2.3.2.26]
121569964  ube2wb; probable ubiquitin-conjugating enzyme E2 W-B isoform X1 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
121570006  [KO:K03870]
121570187  [KO:K10586] [EC:2.3.2.23]
121571063  [KO:K10260]
121571434  [KO:K04706] [EC:2.3.2.-]
121571626  [KO:K10573] [EC:2.3.2.23]
121571684  [KO:K10447]
121571755  [KO:K02977]
121571865  [KO:K03348]
121571886  [KO:K10582] [EC:2.3.2.23]
121571923  [KO:K20217] [EC:2.3.2.23]
121573290  [KO:K10610]
121573413  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
121573776  fbxw11b; F-box and WD repeat domain-containing 11-B [KO:K03362]
121573859  [KO:K03875]
121573884  [KO:K04552] [EC:2.3.2.23]
121573935  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
121574005  [KO:K03094]
121574082  ube2g1a; ubiquitin-conjugating enzyme E2 G1a [KO:K10575] [EC:2.3.2.23]
121574428  [KO:K10574] [EC:2.3.2.23]
121574509  [KO:K10594] [EC:2.3.2.26]
121574698  [KO:K04554] [EC:2.3.2.23]
121574881  uba7; ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
121575505  [KO:K02207] [EC:2.3.2.23]
121575574  [KO:K05632] [EC:2.3.2.26]
121575928  vhl; von Hippel-Lindau disease tumor suppressor [KO:K03871]
121576030  [KO:K06688] [EC:2.3.2.23]
121576376  [KO:K10576] [EC:2.3.2.23]
121576413  [KO:K10587] [EC:2.3.2.26]
121576670  [KO:K04506] [EC:2.3.2.27]
121576712  wwp2; NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1 [KO:K05630] [EC:2.3.2.26]
121576736  [KO:K10685] [EC:6.2.1.45]
121576744  [KO:K10571]
121576998  [KO:K10580] [EC:2.3.2.23]
121577684  fbxo2; F-box only protein 2 [KO:K10099]
121577895  [KO:K04554] [EC:2.3.2.23]
121577972  ube2c; ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
121577985  [KO:K05632] [EC:2.3.2.26]
121578052  [KO:K02207] [EC:2.3.2.23]
121578473  [KO:K10686] [EC:6.2.1.64]
121578492  rhobtb1; rho-related BTB domain-containing protein 1 isoform X1 [KO:K07868]
121579150  [KO:K10575] [EC:2.3.2.23]
121579236  [KO:K03094]
121579238  [KO:K10574] [EC:2.3.2.23]
121579312  [KO:K10699] [EC:6.2.1.45]
121579371  [KO:K04707] [EC:2.3.2.27]
121579388  [KO:K10608] [EC:2.3.2.27]
121579517  [KO:K10447]
121579588  [KO:K03355]
121579594  [KO:K06689] [EC:2.3.2.23]
121579738  cblb; E3 ubiquitin-protein ligase CBL-B-B [KO:K22517] [EC:2.3.2.27]
121579887  [KO:K03362]
121580194  [KO:K12456]
121580667  [KO:K10584] [EC:2.3.2.23]
121580773  [KO:K02927]
121580912  [KO:K10143] [EC:2.3.2.27]
121580962  [KO:K03347]
121580972  [KO:K03363]
121581191  [KO:K02207] [EC:2.3.2.23]
121581203  [KO:K03364]
121581296  [KO:K03869]
121581855  ercc8; DNA excision repair protein ERCC-8 [KO:K10570]
121581892  [KO:K10600] [EC:2.3.2.27]
121581971  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
121582186  [KO:K03875]
121582227  [KO:K04552] [EC:2.3.2.23]
121582271  [KO:K10582] [EC:2.3.2.23]
121582282  [KO:K10582] [EC:2.3.2.23]
121582488  [KO:K10607] [EC:2.3.2.27]
121582529  anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
121582578  [KO:K10575] [EC:2.3.2.23]
121582686  [KO:K04551]
121582732  [KO:K13305] [EC:2.3.2.26]
121583248  [KO:K06689] [EC:2.3.2.23]
121583601  herc1; LOW QUALITY PROTEIN: probable E3 ubiquitin-protein ligase HERC1 [KO:K10594] [EC:2.3.2.26]
121583952  [KO:K10575] [EC:2.3.2.23]
121584320  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
121584432  [KO:K07868]
121584458  ube2l3b; ubiquitin-conjugating enzyme E2 L3b [KO:K04552] [EC:2.3.2.23]
121584471  [KO:K16063] [EC:2.3.2.-]
121584525  [KO:K10588] [EC:2.3.2.26]
121584553  [KO:K02207] [EC:2.3.2.23]
121584734  [KO:K03354]
121584822  [KO:K07868]
121584850  [KO:K06689] [EC:2.3.2.23]
121585113  [KO:K10600] [EC:2.3.2.27]
121585133  fbxo4; F-box only protein 4 [KO:K10291]
121585220  fbxw8; F-box/WD repeat-containing protein 8 [KO:K10264]
121586042  [KO:K10593] [EC:2.3.2.26]
121586159  cblc; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
121586204  ubr5; E3 ubiquitin-protein ligase UBR5 isoform X16 [KO:K10593] [EC:2.3.2.26]
121586552  [KO:K20217] [EC:2.3.2.23]
121586554  [KO:K20217] [EC:2.3.2.23]
121586590  ube2ql1; uncharacterized protein ube2ql1 isoform X1 [KO:K10582] [EC:2.3.2.23]
121587346  [KO:K07868]
121587520  [KO:K07868]
123480955  [KO:K06689] [EC:2.3.2.23]
123481193  [KO:K10612]
123481296  [KO:K09561] [EC:2.3.2.27]
123483521  [KO:K10612]
123485655  [KO:K10609]
123486365  [KO:K10699] [EC:6.2.1.45]
123487349  [KO:K10573] [EC:2.3.2.23]
123487864  [KO:K04649] [EC:2.3.2.23]
123489621  [KO:K10580] [EC:2.3.2.23]
123491260  [KO:K03871]
123492007  [KO:K02927]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
cclu03050  Proteasome
KO pathway
ko04120   

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