KEGG   PATHWAY: cdk05014
Entry
cdk05014                    Pathway                                
Name
Amyotrophic lateral sclerosis - Camelus dromedarius (Arabian camel)
Description
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a progressive degeneration of motor neurons in the brain and spinal cord. In 90% of patients, ALS is sporadic, with no clear genetic linkage. On the other hand, the remaining 10% of cases show familial inheritance, with mutations in SOD1, TDP43(TARDBP), FUS, or C9orf72 genes being the most frequent causes. In spite of such difference, familial ALS and sporadic ALS have similarities in their pathological features. Proposed disease mechanisms contributing to motor neuron degeneration in ALS are: impaired proteostasis, aberrant RNA processing, mitochondrial disfunction and oxidative stress, microglia activation, and axonal dysfunction.
Class
Human Diseases; Neurodegenerative disease
Pathway map
cdk05014  Amyotrophic lateral sclerosis
cdk05014

Organism
Camelus dromedarius (Arabian camel) [GN:cdk]
Gene
105103011  TP53; cellular tumor antigen p53 [KO:K04451]
105100418  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
105100737  BID; LOW QUALITY PROTEIN: BH3-interacting domain death agonist [KO:K04726]
105088999  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
105100821  BCL2L1; bcl-2-like protein 1 isoform X2 [KO:K04570]
105102890  BAX; apoptosis regulator BAX [KO:K02159]
105101547  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
105097442  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
105098528  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
105095080  cytochrome c [KO:K08738]
105092650  cytochrome c [KO:K08738]
105107056  CASP9; LOW QUALITY PROTEIN: caspase-9 [KO:K04399] [EC:3.4.22.62]
105084433  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105086775  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
105096659  LOW QUALITY PROTEIN: superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
5618953  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
5618961  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
5618962  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
5618958  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
5618955  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
5618957  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
5618963  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
105104414  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
105086491  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
105105846  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
105091110  LOW QUALITY PROTEIN: nucleolin 2-like [KO:K03944]
116150922  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
105098104  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
105105514  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
105088698  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
105098308  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
105085342  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
105091880  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
105087580  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
105104365  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X2 [KO:K03952]
105091332  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
105105383  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
105094828  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
105091762  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
105097420  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
105103723  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
105096144  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
105096996  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
105091662  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
105099177  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
105090315  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
105085920  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
105085566  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
105105974  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
105084324  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
105096438  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
105099726  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
105101950  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
105099258  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
105100106  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
105106884  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
105087155  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
105090973  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
105102170  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
105104129  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
105104408  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
116147839  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial-like [KO:K03941] [EC:7.1.1.2]
116147841  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial-like [KO:K03941] [EC:7.1.1.2]
105087084  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
105097534  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
105102189  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
105107079  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
105100098  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
105094129  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
105089357  cytochrome b-c1 complex subunit Rieske, mitochondrial isoform X1 [KO:K00411] [EC:7.1.1.8]
5618965  CYTB; cytochrome b [KO:K00412]
105105005  cytochrome c1, heme protein, mitochondrial [KO:K00413]
105087919  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
105092293  cytochrome b-c1 complex subunit 2, mitochondrial isoform X1 [KO:K00415]
105092921  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
105090575  cytochrome b-c1 complex subunit 7 [KO:K00417]
105090190  cytochrome b-c1 complex subunit 8 [KO:K00418]
105099458  cytochrome b-c1 complex subunit 9 [KO:K00419]
105106524  cytochrome b-c1 complex subunit 10 [KO:K00420]
5618954  COX3; cytochrome c oxidase subunit III [KO:K02262]
5618956  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
5618959  COX2; cytochrome c oxidase subunit II [KO:K02261]
105098909  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
105100820  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
105092495  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
105087250  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
105092680  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
105101997  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
105089718  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
105088048  cytochrome c oxidase subunit 6B1 [KO:K02267]
105098744  cytochrome c oxidase subunit 6B2 [KO:K02267]
105090541  cytochrome c oxidase subunit 6C [KO:K02268]
105088079  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
105105462  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
105103545  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
105096479  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
105095562  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
116151966  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
116152083  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
105095183  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
105086351  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
105091350  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
105104113  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
116147347  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
5618964  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
105102044  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
105094601  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
105095776  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
105097572  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
105104626  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
105089856  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
105086808  ATP5PF; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
5618960  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
105090242  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
105100100  TOMM40L; mitochondrial import receptor subunit TOM40B [KO:K11518]
105095467  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
105092475  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
105088855  PINK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
105086287  PRKN; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
105100651  OPTN; optineurin isoform X1 [KO:K19946]
105100630  SQSTM1; sequestosome-1 [KO:K14381]
105084948  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
105104671  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
105089261  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
105093693  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
105084819  WDR41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
105100568  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
105093608  C9orf72; guanine nucleotide exchange C9orf72 homolog [KO:K23609]
105101820  RAB8A; ras-related protein Rab-8A [KO:K07901]
105096835  ras-related protein Rab-39B [KO:K07925]
105088948  RAB1A; ras-related protein Rab-1A [KO:K07874]
105107024  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
105094622  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
105085092  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
105100387  ATG101; autophagy-related protein 101 isoform X1 [KO:K19730]
105106863  ATG13; autophagy-related protein 13 isoform X3 [KO:K08331]
105097068  RB1CC1; LOW QUALITY PROTEIN: RB1-inducible coiled-coil protein 1 [KO:K17589]
105106861  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
105099268  BECN2; beclin-2 [KO:K08334]
105090478  BECN1; beclin-1 isoform X1 [KO:K08334]
105088768  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
105091474  ATG14; beclin 1-associated autophagy-related key regulator isoform X1 [KO:K17889]
105093862  NRBF2; nuclear receptor-binding factor 2 [KO:K21246]
105085253  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
105095494  ATG2B; autophagy-related protein 2 homolog B [KO:K17906]
105102629  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
105085704  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
105104243  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
105098965  ALS2; alsin isoform X1 [KO:K04575]
105085148  RAB5A; ras-related protein Rab-5A [KO:K07887]
105087769  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
105097108  FIG4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
105101702  SPG11; spatacsin isoform X1 [KO:K19026]
105102643  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105092463  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105089593  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116152568  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
116157512  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
105100490  UBQLN1; ubiquilin-1 isoform X1 [KO:K04523]
105093069  UBQLN2; ubiquilin-2 [KO:K04523]
105105661  UBQLN4; ubiquilin-4 [KO:K04523]
105097938  UBQLN3; ubiquilin-3 [KO:K04523]
105102312  VCP; transitional endoplasmic reticulum ATPase [KO:K13525]
105098327  DERL1; derlin-1 isoform X1 [KO:K11519]
105094163  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
105092322  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
105087216  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
105086586  PSMA8; proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
105095668  PSMA7; proteasome subunit alpha type-7 isoform X1 [KO:K02731] [EC:3.4.25.1]
105085640  PSMA5; proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
105086687  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
105086238  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
105101478  PSMB6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
105092636  PSMB7; proteasome subunit beta type-7 isoform X1 [KO:K02739] [EC:3.4.25.1]
105106941  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
105086959  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
105096978  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
105093880  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
105103219  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
105093016  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
105096017  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
105093331  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
105091425  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
105106880  PSMC3; 26S proteasome regulatory subunit 6A isoform X1 [KO:K03065]
105090405  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
105085877  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
105093755  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
105099032  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
105102519  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X2 [KO:K06693]
105092316  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
105088223  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
105094369  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
105088390  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
105105733  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X2 [KO:K03039]
105103211  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
105093692  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X2 [KO:K03030]
105096924  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
105095674  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
105103305  HDAC6; histone deacetylase 6 isoform X1 [KO:K11407] [EC:3.5.1.98]
105107018  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
105106644  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
105098495  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
105101008  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741]
105102130  HNRNPA2B1; heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1 [KO:K13158]
105102480  ATXN2; LOW QUALITY PROTEIN: ataxin-2 [KO:K23625]
105102777  ATXN2L; ataxin-2-like protein isoform X1 [KO:K23625]
105090797  MATR3; matrin-3 isoform X1 [KO:K13213]
105097678  ANG; angiogenin [KO:K16631] [EC:3.1.27.-]
105102246  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
105106390  ALYREF; LOW QUALITY PROTEIN: THO complex subunit 4 [KO:K12881]
105101332  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
105103649  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
105091509  NXF1; nuclear RNA export factor 1 [KO:K14284]
105106281  NXT1; NTF2-related export protein 1 isoform X1 [KO:K14285]
105093186  NXT2; NTF2-related export protein 2 isoform X2 [KO:K14285]
105092571  GLE1; nucleoporin GLE1 isoform X1 [KO:K18723]
105099284  TPR; nucleoprotein TPR isoform X2 [KO:K09291]
105091850  NUP50; nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
105089110  NUP153; nuclear pore complex protein Nup153 isoform X2 [KO:K14296]
105096580  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
105098845  RAE1; mRNA export factor [KO:K14298]
105093113  SEC13; protein SEC13 homolog [KO:K14004]
105086469  SEH1L; nucleoporin SEH1 [KO:K14299]
105097352  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
105101088  NUP107; nuclear pore complex protein Nup107 isoform X2 [KO:K14301]
105097464  NUP37; nucleoporin Nup37 [KO:K14302]
105106891  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
105104636  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
105100912  NUP43; nucleoporin Nup43 [KO:K14305]
105100183  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
105095432  NUP62CL; nucleoporin-62 C-terminal-like protein [KO:K14306]
105096414  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
105091570  NUP54; nucleoporin p54 isoform X4 [KO:K14308]
105102675  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
105091613  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
105092554  NUP188; nucleoporin NUP188 homolog [KO:K14311]
105086989  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
105098933  nucleoporin NUP35 [KO:K14313]
116152953  nucleoporin NUP35-like [KO:K14313]
105089305  NUP210L; nuclear pore membrane glycoprotein 210-like [KO:K14314]
105101678  NUP210; nuclear pore membrane glycoprotein 210 isoform X1 [KO:K14314]
105090782  NDC1; nucleoporin NDC1 isoform X1 [KO:K14315]
105089661  POM121C; nuclear envelope pore membrane protein POM 121C [KO:K14316]
105097844  nuclear envelope pore membrane protein POM 121C-like [KO:K14316]
105106213  POM121L2; POM121-like protein 2 [KO:K14316]
116149904  nuclear envelope pore membrane protein POM 121C-like [KO:K14316]
116153315  nuclear envelope pore membrane protein POM 121C-like [KO:K14316]
105085163  NUP214; nuclear pore complex protein Nup214 isoform X6 [KO:K14317]
105104777  NUP88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
105099086  RGPD4; ranBP2-like and GRIP domain-containing protein 4 isoform X1 [KO:K12172] [EC:2.3.2.-]
105085172  SETX; probable helicase senataxin isoform X1 [KO:K10706] [EC:5.6.2.-]
105095208  CHCHD10; coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial [KO:K22759]
105092624  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
105098863  VAPB; vesicle-associated membrane protein-associated protein B/C isoform X1 [KO:K10707]
105092786  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
105100346  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
105092320  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
105099473  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
105106196  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
105092037  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
105104181  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
105086172  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105091928  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105101373  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
105085597  SIGMAR1; sigma non-opioid intracellular receptor 1 isoform X1 [KO:K20719]
105087473  TNF; tumor necrosis factor [KO:K03156]
105098228  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
105107099  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
105101430  DAXX; death domain-associated protein 6 [KO:K02308]
105100607  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
105085694  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
105101337  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
105101338  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105090355  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
105090356  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
105104911  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
105104450  CCS; copper chaperone for superoxide dismutase [KO:K04569]
105087146  GPX8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
105088187  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
105084546  GPX6; glutathione peroxidase 6 isoform X2 [KO:K00432] [EC:1.11.1.9]
105084547  GPX5; epididymal secretory glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
105086185  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
105092970  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
105098466  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
105106806  CAT; catalase [KO:K03781] [EC:1.11.1.6]
105103776  PRPH; peripherin isoform X1 [KO:K07607]
105102417  NEFL; neurofilament light polypeptide [KO:K04572]
105102423  NEFM; neurofilament medium polypeptide [KO:K04573]
105099464  NEFH; neurofilament heavy polypeptide isoform X1 [KO:K04574]
105107141  profilin-2-like [KO:K05759]
105101469  PFN1; profilin-1 [KO:K05759]
105099591  PFN3; profilin-3 [KO:K05759]
105100025  PFN4; profilin-4 [KO:K05759]
105089494  PFN2; profilin-2 isoform X1 [KO:K05759]
105105716  actin, cytoplasmic 2 [KO:K05692]
105104247  ACTB; actin, cytoplasmic 1 [KO:K05692]
116150665  actin, cytoplasmic 1-like [KO:K05692]
105104077  actin-like [KO:K05692]
105092465  ANXA7; annexin A7 isoform X3 [KO:K17095]
105092425  ANXA11; annexin A11 [KO:K17095]
105084640  KIF5C; LOW QUALITY PROTEIN: kinesin heavy chain [KO:K10396]
105100340  KIF5A; kinesin heavy chain isoform X3 [KO:K10396]
105086860  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
105088615  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
105102569  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
105105985  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
105095455  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
105096109  TUBA4A; tubulin alpha-4A chain [KO:K07374]
105095310  tubulin alpha-1A chain-like [KO:K07374]
105100732  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
105091377  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
105095227  tubulin alpha-3 chain-like isoform X1 [KO:K07374]
116150045  tubulin alpha-3 chain [KO:K07374]
105095224  tubulin alpha-3 chain [KO:K07374]
116150047  tubulin alpha-3 chain-like [KO:K07374]
105089297  tubulin alpha-1A chain-like [KO:K07374]
116147140  tubulin alpha-1C chain-like [KO:K07374]
105096135  tubulin alpha-1D chain isoform X1 [KO:K07374]
105103777  TUBA1C; LOW QUALITY PROTEIN: tubulin alpha-1C chain [KO:K07374]
105103779  LOW QUALITY PROTEIN: tubulin alpha-1B chain [KO:K07374]
105087494  TUBB; tubulin beta chain isoform X2 [KO:K07375]
105087583  LOW QUALITY PROTEIN: tubulin beta-2A chain [KO:K07375]
105098536  tubulin beta-2B chain [KO:K07375]
105086496  TUBB6; LOW QUALITY PROTEIN: tubulin beta-6 chain [KO:K07375]
105104555  TUBB4A; tubulin beta-4A chain [KO:K07375]
105105754  tubulin beta-2A chain [KO:K07375]
105104356  TUBB3; tubulin beta-3 chain [KO:K07375]
105105106  TUBB4B; LOW QUALITY PROTEIN: tubulin beta-4B chain [KO:K07375]
105095658  TUBB1; tubulin beta-1 chain [KO:K07375]
116151533  tubulin beta chain-like [KO:K07375]
116151371  tubulin beta chain-like [KO:K07375]
105105900  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
105100341  DCTN2; dynactin subunit 2 isoform X5 [KO:K10424]
105085596  DCTN3; dynactin subunit 3 [KO:K10425]
105098474  DCTN4; dynactin subunit 4 [KO:K10426]
105094830  DCTN5; dynactin subunit 5 [KO:K10427]
105095796  DCTN6; dynactin subunit 6 [KO:K10428]
105084357  ACTR1A; alpha-centractin [KO:K16575]
105092669  ACTR1B; beta-centractin isoform X1 [KO:K16575]
105086239  ACTR10; actin-related protein 10 isoform X1 [KO:K16576]
105094074  HAP1; huntingtin-associated protein 1 isoform X1 [KO:K04647]
105088795  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
105086725  DNAH8; dynein heavy chain 8, axonemal isoform X1 [KO:K10408]
105091121  DNAH3; dynein heavy chain 3, axonemal [KO:K10408]
105094335  DNAH10; dynein heavy chain 10, axonemal [KO:K10408]
105090647  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
105100268  DNAH14; dynein heavy chain 14, axonemal [KO:K10408]
105095914  DNAH9; LOW QUALITY PROTEIN: dynein heavy chain 9, axonemal [KO:K10408]
105089794  DNAH12; dynein heavy chain 12, axonemal [KO:K10408]
105105809  DNAH17; LOW QUALITY PROTEIN: dynein heavy chain 17, axonemal [KO:K10408]
105103071  DNAH2; dynein heavy chain 2, axonemal [KO:K10408]
105097268  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
105093452  DNAH1; dynein heavy chain 1, axonemal isoform X1 [KO:K10408]
105092900  DNAH11; dynein heavy chain 11, axonemal isoform X1 [KO:K10408]
105086932  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
105085591  DNAI1; dynein intermediate chain 1, axonemal [KO:K10409]
105104948  DNAI2; dynein intermediate chain 2, axonemal isoform X1 [KO:K11143]
105086123  DNAL1; dynein light chain 1, axonemal [KO:K10411]
105091939  DNAL4; dynein light chain 4, axonemal isoform X2 [KO:K10412]
105106813  SLC1A2; excitatory amino acid transporter 2 isoform X1 [KO:K05613]
105088198  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
105095156  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
105101175  GRIA2; glutamate receptor 2 isoform X3 [KO:K05198]
105106183  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
105089056  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
105096536  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
105104658  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
105098957  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
105095803  NRG1; pro-neuregulin-1, membrane-bound isoform isoform X1 [KO:K05455]
105098149  NRG2; LOW QUALITY PROTEIN: pro-neuregulin-2, membrane-bound isoform [KO:K05456]
105092410  NRG3; pro-neuregulin-3, membrane-bound isoform isoform X8 [KO:K05457]
105087221  NRG4; pro-neuregulin-4, membrane-bound isoform isoform X1 [KO:K05458]
105099620  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X2 [KO:K05085] [EC:2.7.10.1]
Compound
C00001  H2O
C00008  ADP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00039  DNA
C00046  RNA
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C16844  Hydroxyl radical
C16845  Peroxynitrite
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PMID:23361386
  Authors
Millecamps S, Julien JP
  Title
Axonal transport deficits and neurodegenerative diseases.
  Journal
Nat Rev Neurosci 14:161-76 (2013)
DOI:10.1038/nrn3380
Related
pathway
cdk00190  Oxidative phosphorylation
cdk03013  Nucleocytoplasmic transport
cdk03050  Proteasome
cdk04010  MAPK signaling pathway
cdk04012  ErbB signaling pathway
cdk04020  Calcium signaling pathway
cdk04115  p53 signaling pathway
cdk04137  Mitophagy - animal
cdk04140  Autophagy - animal
cdk04141  Protein processing in endoplasmic reticulum
cdk04210  Apoptosis
cdk04724  Glutamatergic synapse
cdk04810  Regulation of actin cytoskeleton
KO pathway
ko05014   
LinkDB

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