KEGG   PATHWAY: cjc04621
Entry
cjc04621                    Pathway                                
Name
NOD-like receptor signaling pathway - Callithrix jacchus (white-tufted-ear marmoset)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
cjc04621  NOD-like receptor signaling pathway
cjc04621

Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100389449  NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
100404956  RIPK2; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
100390258  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100393096  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
100408512  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
100402266  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100415321  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100388493  RELA; transcription factor p65 isoform X1 [KO:K04735]
100406769  IL1B; interleukin-1 beta isoform X1 [KO:K04519]
100396804  IL18; interleukin-18 [KO:K05482]
100393440  IL6; interleukin-6 precursor [KO:K05405]
100397484  TNF; tumor necrosis factor [KO:K03156]
100390587  CXCL8; interleukin-8 [KO:K10030]
100389870  CXCL2; C-X-C motif chemokine 2 [KO:K05505]
100400489  C-X-C motif chemokine 2 [KO:K05505]
100401955  CXCL1; growth-regulated alpha protein [KO:K05505]
100387612  CCL2; C-C motif chemokine 2 [KO:K14624]
100389780  CCL5; C-C motif chemokine 5 [KO:K12499]
100409435  CAMP; cathelicidin antimicrobial peptide [KO:K13916]
100386936  defensin alpha 5-like [KO:K05230]
100407125  neutrophil defensin 1-like [KO:K05230]
100415641  DEFA4; defensin alpha 4 [KO:K05230]
100407484  beta-defensin 103A isoform X1 [KO:K23126]
100414962  NOD2; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165]
100403175  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100398947  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
100414129  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
100401610  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
100400700  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100404815  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100392721  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100387686  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100390109  MAPK10; mitogen-activated protein kinase 10 isoform X7 [KO:K04440] [EC:2.7.11.24]
100396611  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100396967  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100404377  MAPK14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
100405093  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
100400411  JUN; transcription factor Jun [KO:K04448]
100400405  ATG16L1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
100404382  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
100396359  ATG12; ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
100404267  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
100393860  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
100399942  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
100410093  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
100411187  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
100400974  MAP1LC3C; LOW QUALITY PROTEIN: microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
100399550  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A isoform X1 [KO:K10435]
100410303  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
100409060  SUGT1; protein SGT1 homolog isoform X2 [KO:K12795]
100392136  SHARPIN; sharpin isoform X3 [KO:K20894]
100411512  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
100407708  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
100402341  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
100409569  CARD6; caspase recruitment domain-containing protein 6 isoform X1 [KO:K12797]
100393238  TRIP6; thyroid receptor-interacting protein 6 [KO:K12792]
100394092  ERBIN; erbin isoform X1 [KO:K12796]
100394418  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
100399118  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
100404226  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100388423  TRAF5; TNF receptor-associated factor 5 isoform X3 [KO:K09849]
100395364  TRAF6; TNF receptor-associated factor 6 isoform X2 [KO:K03175] [EC:2.3.2.27]
100399254  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
100397002  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X2 [KO:K11859] [EC:3.4.19.12]
100410549  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
100387401  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100399701  TBK1; serine/threonine-protein kinase TBK1 isoform X6 [KO:K05410] [EC:2.7.11.10]
100392518  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
100395103  TANK; TRAF family member-associated NF-kappa-B activator isoform X4 [KO:K12650]
100414132  IRF3; interferon regulatory factor 3 isoform X4 [KO:K05411]
100405036  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
100414516  interferon alpha-1/13-like [KO:K05414]
100390201  interferon alpha-5-like [KO:K05414]
100406098  interferon alpha-5-like [KO:K05414]
100406466  interferon alpha-14 [KO:K05414]
100387372  interferon alpha-5-like [KO:K05414]
103793369  interferon alpha-5-like [KO:K05414]
128928158  interferon alpha-14-like [KO:K05414]
128932203  interferon alpha-5-like [KO:K05414]
100388391  IFNB1; interferon beta [KO:K05415]
100407954  NLRX1; NLR family member X1 isoform X2 [KO:K12653]
100405331  ANTXR2; anthrax toxin receptor 2 [KO:K20909]
100410030  ANTXR1; anthrax toxin receptor 1 isoform X1 [KO:K20909]
100412129  NLRP1; NACHT, LRR and PYD domains-containing protein 1 [KO:K12798]
100395878  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
100385618  caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
100408947  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100401978  BCL2L1; bcl-2-like protein 1 [KO:K04570]
100389833  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
100392399  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
100412396  PANX1; pannexin-1 [KO:K03443]
100393329  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
100393989  TRPM2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977] [EC:3.6.1.13]
100401153  TRPM7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
100413307  TRPV2; transient receptor potential cation channel subfamily V member 2 isoform X1 [KO:K04971]
100406413  CASR; extracellular calcium-sensing receptor [KO:K04612]
100412340  GPRC6A; G-protein coupled receptor family C group 6 member A [KO:K04622]
100400803  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
100386921  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100409716  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100410075  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
100385763  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
118144170  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
100390843  inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
100399873  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
100399481  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100398162  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100395618  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
100385368  OAS1; 2'-5'-oligoadenylate synthase 1 isoform X1 [KO:K14216] [EC:2.7.7.84]
100392459  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
103795420  OAS2; 2'-5'-oligoadenylate synthase 2 isoform X2 [KO:K14216] [EC:2.7.7.84]
100405212  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
100399669  DHX33; ATP-dependent RNA helicase DHX33 isoform X1 [KO:K17820] [EC:5.6.2.6]
100394906  MFN1; mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
100412019  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
100415562  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
100398268  RIPK3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
100390533  DNM1L; dynamin-1-like protein isoform X6 [KO:K17065] [EC:3.6.5.5]
100393546  NAMPT; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
100402410  LOW QUALITY PROTEIN: nicotinamide phosphoribosyltransferase-like [KO:K03462] [EC:2.4.2.12]
100415466  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
100414967  CYBA; cytochrome b-245 light chain isoform X2 [KO:K08009]
100397837  TXNIP; thioredoxin-interacting protein [KO:K20910]
100413131  TXN; thioredoxin [KO:K03671]
100392009  TXN2; thioredoxin, mitochondrial [KO:K03671]
108587771  thioredoxin-like [KO:K03671]
100387933  NEK7; serine/threonine-protein kinase Nek7 isoform X1 [KO:K20876] [EC:2.7.11.34]
100395464  BRCC3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
100409130  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
100409403  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
100411012  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
100392924  heat shock protein HSP 90-beta-like [KO:K04079]
100403265  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
100415462  CARD8; caspase recruitment domain-containing protein 8 isoform X1 [KO:K12801]
100386566  pyrin domain-containing protein 1 [KO:K12802]
100388608  PYDC1; pyrin domain-containing protein 1 [KO:K12802]
100387055  MEFV; pyrin isoform X1 [KO:K12803]
100406340  PSTPIP1; proline-serine-threonine phosphatase-interacting protein 1 isoform X3 [KO:K12804]
100395220  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100410616  FADD; FAS-associated death domain protein [KO:K02373]
118145584  CARD18; caspase recruitment domain-containing protein 18 [KO:K12806]
100414562  NLRP6; NACHT, LRR and PYD domains-containing protein 6 isoform X1 [KO:K20863]
100386387  NLRP7; NACHT, LRR and PYD domains-containing protein 7 isoform X1 [KO:K20864]
100415673  NAIP; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 1 [KO:K12807]
100395399  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
100405150  guanylate-binding protein 2 [KO:K20897]
100404432  guanylate-binding protein 2 [KO:K20897]
128930985  guanylate-binding protein 2-like [KO:K20897]
100405878  GBP5; guanylate-binding protein 5 isoform X2 [KO:K20898]
100396986  AIM2; interferon-inducible protein AIM2 isoform X1 [KO:K12966]
100396626  IFI16; gamma-interferon-inducible protein 16 [KO:K20914]
100392591  TP53BP1; TP53-binding protein 1 isoform X1 [KO:K20915]
108589048  PYDC5; LOW QUALITY PROTEIN: pyrin domain-containing protein 5 [KO:K20916]
100393236  RHOA; transforming protein RhoA [KO:K04513]
100404129  transforming protein RhoA-like [KO:K04513]
100401855  PKN1; serine/threonine-protein kinase N1 isoform X5 [KO:K06071] [EC:2.7.11.13]
100390164  PKN2; serine/threonine-protein kinase N2 isoform X2 [KO:K23691] [EC:2.7.11.13]
100390011  uncharacterized protein LOC100390011 [KO:K06630]
100400280  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
100404789  GBP4; guanylate-binding protein 4 isoform X1 [KO:K20899]
100404066  LOW QUALITY PROTEIN: guanylate-binding protein 1 [KO:K20899]
100405506  guanylate-binding protein 4 isoform X2 [KO:K20899]
108592425  LOW QUALITY PROTEIN: guanylate-binding protein 7-like [KO:K20899]
100385257  caspase-4 isoform X1 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
100412430  GSDMD; gasdermin-D [KO:K20917]
100410306  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
128928024  IFNAR2; interferon alpha/beta receptor 2 isoform X2 [KO:K05131]
100385835  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100405583  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
100401630  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100393190  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
100399012  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
100405343  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
100413151  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
100402978  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X3 [KO:K04733] [EC:2.7.11.1]
100403981  STING1; stimulator of interferon genes protein [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
cjc04010  MAPK signaling pathway
cjc04064  NF-kappa B signaling pathway
cjc04140  Autophagy - animal
cjc04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
LinkDB

DBGET integrated database retrieval system