KEGG   PATHWAY: cmac04010
Entry
cmac04010                   Pathway                                
Name
MAPK signaling pathway - Chlamydotis macqueenii (Macqueen's bustard)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
cmac04010  MAPK signaling pathway
cmac04010

Other DBs
GO: 0000165
Organism
Chlamydotis macqueenii (Macqueen's bustard) [GN:cmac]
Gene
104482992  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
104487032  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
104482547  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
104477589  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
104487021  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
104482868  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
104477078  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
104478656  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
104486589  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
104480524  voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
104487643  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
104484209  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
104478541  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04865]
104483490  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
104483491  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
104477389  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
104474549  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
104477497  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
104475831  GNA12; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
104479325  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
104485953  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
104474009  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
104482876  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104479993  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
104485396  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
104473755  ras guanyl-releasing protein 3 [KO:K12362]
104480251  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
104484610  NF1; neurofibromin [KO:K08052]
104486692  ras GTPase-activating protein 1-like [KO:K04352]
104485395  RASA2; LOW QUALITY PROTEIN: ras GTPase-activating protein 2 [KO:K08053]
104485325  ras-related protein Rap-1A [KO:K04353]
104474756  RAP1B; ras-related protein Rap-1b [KO:K07836]
104484067  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
104478227  proepiregulin-like [KO:K09784]
104483569  AREG; LOW QUALITY PROTEIN: amphiregulin [KO:K09782]
104476880  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
104480529  FGF2; fibroblast growth factor 2 [KO:K18497]
104478936  FGF18; fibroblast growth factor 18 [KO:K04358]
104472979  FGF6; fibroblast growth factor 6 [KO:K04358]
104475253  fibroblast growth factor 9 [KO:K04358]
104479986  fibroblast growth factor 20 [KO:K04358]
104480634  fibroblast growth factor 10-like [KO:K04358]
104481171  FGF7; fibroblast growth factor 7 [KO:K04358]
104481649  fibroblast growth factor 16-like [KO:K04358]
104481855  FGF3; fibroblast growth factor 3 [KO:K04358]
104477576  fibroblast growth factor 5-like [KO:K04358]
104482446  FGF8; fibroblast growth factor 8 [KO:K04358]
104480126  FGF19; fibroblast growth factor 19 [KO:K22603]
104473654  FGF23; fibroblast growth factor 23 [KO:K22428]
104483239  NGF; beta-nerve growth factor [KO:K02582]
104475611  BDNF; brain-derived neurotrophic factor [KO:K04355]
104478497  NTF3; neurotrophin-3 [KO:K04356]
104484558  INS; insulin [KO:K04526]
104477534  IGF1; insulin-like growth factor I [KO:K05459]
104477662  platelet-derived growth factor subunit A-like [KO:K04359]
104482122  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
104479793  PDGFD; LOW QUALITY PROTEIN: platelet-derived growth factor D [KO:K05450]
104481214  PDGFC; platelet-derived growth factor C [KO:K05450]
104477927  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
104479113  KITLG; kit ligand [KO:K05461]
104483226  VEGFA; vascular endothelial growth factor A [KO:K05448]
104475744  FIGF; vascular endothelial growth factor D [KO:K05449]
104482607  VEGFC; vascular endothelial growth factor C [KO:K05449]
104480767  HGF; hepatocyte growth factor [KO:K05460]
104484211  ANGPT2; angiopoietin-2 [KO:K05466]
104480434  uncharacterized protein LOC104480434 [KO:K05462]
104482838  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
104486314  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
104487232  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
104482652  LOW QUALITY PROTEIN: fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
104481337  BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
104478591  LOW QUALITY PROTEIN: insulin receptor-like [KO:K04527] [EC:2.7.10.1]
104485700  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
104485376  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
104479936  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104479937  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
104480516  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
104473346  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
104477618  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
104487718  LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1-like [KO:K05096] [EC:2.7.10.1]
104473483  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
104484700  KDR; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
104479811  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
104481822  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
104479784  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
104478493  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
104481790  SOS2; son of sevenless homolog 2 [KO:K03099]
104487373  HRAS; GTPase HRas [KO:K02833]
104475393  KRAS; GTPase KRas isoform X1 [KO:K07827]
104480086  GTPase NRas [KO:K07828]
104485553  RRAS2; ras-related protein R-Ras2 [KO:K07830]
104477878  MRAS; ras-related protein M-Ras [KO:K07831]
104479333  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
104477214  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104484433  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104480033  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104474865  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
104486553  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104475729  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
104483249  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
104484420  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
104475913  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
104481692  RPS6KA1; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
104478786  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
104476239  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
104480517  SRF; serum response factor [KO:K04378]
104477375  microtubule-associated protein tau-like [KO:K04380]
104476809  STMN1; stathmin [KO:K04381]
104478126  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
104479676  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104479677  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104479783  cytosolic phospholipase A2 beta-like [KO:K16342] [EC:3.1.1.4]
104486295  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
104487005  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104487006  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104477947  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104477948  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104482028  LOW QUALITY PROTEIN: interleukin-1 beta-like [KO:K04519]
104483848  TGFB2; transforming growth factor beta-2 [KO:K13376]
104482520  TGFB3; transforming growth factor beta-3 [KO:K13377]
104479955  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
104473405  interleukin-1 receptor type 1-like [KO:K04386]
104480365  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
104484193  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
104478544  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
104477160  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
104477426  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
104476724  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
104479316  CD14; LOW QUALITY PROTEIN: monocyte differentiation antigen CD14 [KO:K04391]
104478734  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104477102  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
104475947  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
104476901  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104484025  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
104485519  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104475837  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
104487033  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
104473787  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
104480420  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
104474687  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
104487556  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
104478097  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
104484103  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
104476145  mitogen-activated protein kinase kinase kinase kinase 4-like [KO:K04407] [EC:2.7.11.1]
104486696  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
104480440  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
104472916  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
104487282  STK4; serine/threonine-protein kinase 4 [KO:K04411]
104478361  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
104486221  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
104479327  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
104485993  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
104487253  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
104483201  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
104487356  mitogen-activated protein kinase kinase kinase MLK4 [KO:K17534] [EC:2.7.11.25]
104477127  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
104484632  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
104482240  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
104479593  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
104478587  serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
104481075  serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
104487044  serine/threonine-protein kinase TAO3-like [KO:K04429] [EC:2.7.11.1]
104478299  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
104482374  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
104476633  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
104478554  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
104473094  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
104480072  CRKL; crk-like protein [KO:K04438]
104475944  LOW QUALITY PROTEIN: adapter molecule crk-like [KO:K04438]
104480682  LOW QUALITY PROTEIN: beta-arrestin-1-like [KO:K04439]
104483661  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104476736  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
104482156  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104484690  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
104484691  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
104476042  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104481863  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104477257  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
104486084  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
104474108  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
104479013  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
104474545  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
104478878  JUND; LOW QUALITY PROTEIN: transcription factor jun-D [KO:K04448]
104476630  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
104487157  MEF2C; myocyte-specific enhancer factor 2C [KO:K04454]
104485389  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104481650  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104478304  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
104480756  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
104482109  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
104485259  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
104479077  DUSP4; LOW QUALITY PROTEIN: dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104480396  DUSP16; LOW QUALITY PROTEIN: dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104476704  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104477222  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104485071  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
104483485  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
104475396  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
104475164  protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
104473763  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
104482501  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
104485723  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
104478148  MAP3K14; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
104482587  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
104484702  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104482234  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
104473653  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
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Toxicol Lett 143:323-30 (2003)
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Cell 141:1117-34 (2010)
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Chu WM
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Cancer Lett 328:222-5 (2013)
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Trends Immunol 34:307-16 (2013)
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Biochim Biophys Acta 1843:2563-2582 (2014)
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Related
pathway
cmac04070  Phosphatidylinositol signaling system
cmac04110  Cell cycle
cmac04115  p53 signaling pathway
cmac04210  Apoptosis
cmac04310  Wnt signaling pathway
KO pathway
ko04010   
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