KEGG   PATHWAY: dro05165
Entry
dro05165                    Pathway                                
Name
Human papillomavirus infection - Desmodus rotundus (common vampire bat)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
dro05165  Human papillomavirus infection
dro05165

Organism
Desmodus rotundus (common vampire bat) [GN:dro]
Gene
112318261  WNT1; LOW QUALITY PROTEIN: proto-oncogene Wnt-1 [KO:K03209]
112300214  WNT2; protein Wnt-2 [KO:K00182]
112314027  WNT2B; protein Wnt-2b [KO:K00182]
112316534  WNT3; proto-oncogene Wnt-3 [KO:K00312]
112304943  WNT3A; protein Wnt-3a [KO:K00312]
112299558  WNT4; protein Wnt-4 [KO:K00408]
112301279  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
112300408  WNT5B; protein Wnt-5b [KO:K00444]
112308052  WNT6; protein Wnt-6 [KO:K00445]
112320683  WNT7A; protein Wnt-7a [KO:K00572]
112322077  WNT7B; protein Wnt-7b [KO:K00572]
112300327  WNT8B; protein Wnt-8b [KO:K00714]
112318177  WNT8A; protein Wnt-8a [KO:K00714]
112316510  WNT9B; protein Wnt-9b [KO:K01064]
112304972  WNT9A; protein Wnt-9a [KO:K01064]
112308080  WNT10A; protein Wnt-10a [KO:K01357]
112318480  WNT10B; protein Wnt-10b [KO:K01357]
112315988  WNT11; protein Wnt-11 [KO:K01384]
112299924  WNT16; protein Wnt-16 [KO:K01558]
112319832  frizzled-1 [KO:K02432]
112319843  LOW QUALITY PROTEIN: frizzled-1-like [KO:K02432]
112308037  FZD7; frizzled-7 [KO:K02432]
112298874  FZD2; frizzled-2 [KO:K02235]
112312643  FZD3; frizzled-3 [KO:K02329]
112316049  FZD4; frizzled-4 isoform X1 [KO:K02354]
112317861  FZD8; frizzled-8 [KO:K02375]
112307880  FZD5; frizzled-5 [KO:K02375]
112315458  FZD6; frizzled-6 [KO:K02376]
112310340  FZD10; frizzled-10 [KO:K02842]
112314758  FZD9; frizzled-9 [KO:K02842]
112299028  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
112308629  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
112307915  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
112320540  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
112298256  AXIN1; axin-1 isoform X1 [KO:K02157]
112316324  AXIN2; axin-2 isoform X1 [KO:K04385]
112312489  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
112307214  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
112309496  CTNNB1; catenin beta-1 [KO:K02105]
112319746  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
112310549  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
112315334  LOW QUALITY PROTEIN: casein kinase I-like [KO:K08957] [EC:2.7.11.1]
112321116  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
112318180  TCF7; transcription factor 7 isoform X1 [KO:K02620]
112302951  TCF7L1; transcription factor 7-like 1 [KO:K04490]
112300313  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
112305886  UBE3A; ubiquitin-protein ligase E3A [KO:K10587] [EC:2.3.2.26]
112306726  TLR3; toll-like receptor 3 [KO:K05401]
112312662  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
112311693  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
112318201  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
112319039  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
112310089  IRF3; interferon regulatory factor 3 [KO:K05411]
112300024  IFNB1; interferon beta [KO:K05415]
112321623  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
112298356  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
112301132  TADA3; transcriptional adapter 3 [KO:K11315]
112308825  TP53; cellular tumor antigen p53 [KO:K04451]
112301206  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
112307354  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112317737  PARD3; partitioning defective 3 homolog [KO:K04237]
112323008  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
112300669  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
112304180  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
112307394  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
112299039  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
112299195  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
112315649  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
112320513  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
112316026  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
112300117  DLG3; disks large homolog 3 [KO:K21098]
112308485  LLGL1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
112298650  LLGL2; lethal(2) giant larvae protein homolog 2 isoform X1 [KO:K06094]
112312573  CRB3; protein crumbs homolog 3 [KO:K06090]
112309168  PATJ; inaD-like protein isoform X1 [KO:K06092]
112311893  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
112321736  VWF; von Willebrand factor [KO:K03900]
112311111  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
112307475  THBS4; thrombospondin-4 [KO:K04659]
112316816  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
112305111  COMP; cartilage oligomeric matrix protein [KO:K04659]
112297305  THBS2; thrombospondin-2 [KO:K04659]
112307828  FN1; fibronectin isoform X1 [KO:K05717]
112319841  COL1A2; collagen alpha-2(I) chain [KO:K06236]
112316389  COL1A1; collagen alpha-1(I) chain [KO:K06236]
112318365  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
112321420  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
112321451  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
112296845  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
112296867  COL4A6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
112307731  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
112307910  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
112308001  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
112309881  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
112309556  collagen alpha-4(VI) chain-like [KO:K06238]
112309687  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
112306524  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
112306535  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
112299197  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
112319309  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
112303890  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
112322610  LAMA1; laminin subunit alpha-1 [KO:K05637]
112297058  LAMA2; laminin subunit alpha-2 [KO:K05637]
112322675  laminin subunit alpha-3-like [KO:K06240]
112303887  LAMA5; laminin subunit alpha-5 [KO:K06240]
112302957  LAMB1; laminin subunit beta-1 [KO:K05636]
112309635  LAMB2; laminin subunit beta-2 [KO:K06243]
112309774  LOW QUALITY PROTEIN: laminin subunit beta-2-like [KO:K06243]
112297463  LAMB3; laminin subunit beta-3 [KO:K06244]
112302299  LAMB4; laminin subunit beta-4 [KO:K06245]
112297926  LAMC1; laminin subunit gamma-1 [KO:K05635]
112296770  LAMC2; laminin subunit gamma-2 [KO:K06246]
112306548  LAMC3; laminin subunit gamma-3 [KO:K06247]
112316447  CHAD; chondroadherin [KO:K06248]
112301870  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
112317813  SPP1; osteopontin [KO:K06250]
112308898  VTN; vitronectin [KO:K06251]
112296964  TNR; tenascin-R [KO:K06252]
112296971  TNN; tenascin-N [KO:K06252]
112306301  TNC; tenascin isoform X1 [KO:K06252]
112302461  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
112317872  IBSP; bone sialoprotein 2 [KO:K06253]
112315280  ITGA1; integrin alpha-1 [KO:K06480]
112315265  ITGA2; integrin alpha-2 [KO:K06481]
112298771  ITGA2B; integrin alpha-IIb [KO:K06476]
112316285  ITGA3; integrin alpha-3 [KO:K06482]
112305817  ITGA4; integrin alpha-4 [KO:K06483]
112318448  ITGA5; integrin alpha-5 [KO:K06484]
112305805  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
112319154  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
112320534  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
112309728  ITGA9; integrin alpha-9 [KO:K06585]
112314615  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
112311545  ITGA11; integrin alpha-11 [KO:K06587]
112305765  ITGAV; integrin alpha-V [KO:K06487]
112317701  ITGB1; integrin beta-1 [KO:K05719]
112316322  ITGB3; integrin beta-3 [KO:K06493]
112298656  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
112320641  ITGB5; integrin beta-5 [KO:K06588]
112322244  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
112318624  ITGB7; integrin beta-7 [KO:K06590]
112306853  ITGB8; integrin beta-8 [KO:K06591]
112310483  PXN; paxillin [KO:K05760]
112302067  TNF; tumor necrosis factor isoform X1 [KO:K03156]
112321955  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
112300831  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
112297049  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
112307358  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
112317320  FADD; FAS-associated death domain protein [KO:K02373]
112307787  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
112306749  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
112298631  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
112318081  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
112306709  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
112303160  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
112314247  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
112305238  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
112319536  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
112300238  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
112316681  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
112309842  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
112313320  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
112296522  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
112311482  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
112311490  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
112297593  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
112317077  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
112302106  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
112306281  TSC1; hamartin [KO:K07206]
112298303  TSC2; tuberin isoform X1 [KO:K07207]
112308268  RHEB; GTP-binding protein Rheb [KO:K07208]
112299108  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
112306701  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
112316527  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
112317229  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
112302219  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
112317275  BAD; bcl2-associated agonist of cell death [KO:K02158]
112319577  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
112310002  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112299448  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
112307667  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112321016  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112305224  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112314466  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112311458  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112318919  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112320130  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112312153  FOXO1; forkhead box protein O1 [KO:K07201]
112318485  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
112302262  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
112317273  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
112312821  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
112302074  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
112319119  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
112319896  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
112296785  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
112315543  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
112319068  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
112313044  RB1; retinoblastoma-associated protein [KO:K06618]
112304047  RBL1; retinoblastoma-like protein 1 [KO:K04681]
112296681  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
112311308  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
112303722  E2F1; transcription factor E2F1 [KO:K17454]
112312522  CCNA2; cyclin-A2 [KO:K06627]
112311852  CCNA1; cyclin-A1 [KO:K06627]
112314280  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
112320668  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
112302143  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
112300474  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
112321547  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
112296261  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
112317867  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112317202  RELA; transcription factor p65 [KO:K04735]
112319061  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
112304333  NFX1; transcriptional repressor NF-X1 [KO:K12236]
112299318  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
112297024  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
112321666  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
112318138  IRF1; interferon regulatory factor 1 [KO:K09444]
112297176  TBP; TATA-box-binding protein isoform X1 [KO:K03120]
112311996  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
112297070  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
112297492  RLA class I histocompatibility antigen, alpha chain 11/11-like [KO:K06751]
112313872  patr class I histocompatibility antigen, alpha chain E-like [KO:K06751]
112313873  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
112313875  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
112313876  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
112313879  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-39 alpha chain-like [KO:K06751]
112313880  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
112314045  HLA class I histocompatibility antigen, A-36 alpha chain-like isoform X1 [KO:K06751]
112314059  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
112314061  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
112314062  HLA class I histocompatibility antigen, B-48 alpha chain-like [KO:K06751]
112314063  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
112314064  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
112302342  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
112302447  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
112302469  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
112296339  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
112320533  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
112297842  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147]
112305088  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
112315457  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
112297717  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
112311894  ATP6V1D; LOW QUALITY PROTEIN: V-type proton ATPase subunit D [KO:K02149]
112311685  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
112298088  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
112299881  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
112302070  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
112318916  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
112306428  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
112320762  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
112310801  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
112298564  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
112317092  TCIRG1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
112299776  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
112300822  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
112320856  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
112308345  V-type proton ATPase subunit e 2 [KO:K02153]
112308346  V-type proton ATPase subunit e 2 [KO:K02153]
112319542  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
112298316  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
112314545  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
112296333  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
112296254  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
112306912  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
112298645  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
112297971  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
112310995  SOS2; son of sevenless homolog 2 [KO:K03099]
112317099  HRAS; GTPase HRas isoform X1 [KO:K02833]
112318275  KRAS; LOW QUALITY PROTEIN: GTPase KRas [KO:K07827]
112304041  LOW QUALITY PROTEIN: GTPase KRas-like [KO:K07827]
112313707  NRAS; GTPase NRas [KO:K07828]
112301126  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112311345  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112312483  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112304801  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
112301746  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112296707  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
112320979  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
112303826  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
112303827  neuroendocrine secretory protein 55-like [KO:K04632]
112309395  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
112301523  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
112310132  BAX; apoptosis regulator BAX [KO:K02159]
112307981  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
112304550  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
112303463  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
112299769  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
112312688  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
112316383  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
112306927  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
112299153  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
112298567  TUBG1; tubulin gamma-1 chain [KO:K10389]
112298758  tubulin gamma-2 chain [KO:K10389]
112301834  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
112297048  interferon alpha-4-like [KO:K05414]
112302798  interferon alpha-4-like [KO:K05414]
112302800  interferon alpha-4-like [KO:K05414]
112305552  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
112305536  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
112309187  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
112301524  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
112307780  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
112319116  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
112301148  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
112298045  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
112310735  OASL; 2'-5'-oligoadenylate synthase-like protein isoform X1 [KO:K14608]
112305998  interferon-induced GTP-binding protein Mx1-like [KO:K14754]
112304175  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
112299549  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
112304129  JAG1; protein jagged-1 [KO:K06052]
112306567  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
112314013  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
112305046  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
112302312  NOTCH4; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 4 [KO:K20996]
112311152  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
112319527  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
112298814  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
112321833  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
112312382  MAML3; mastermind-like protein 3 [KO:K06061]
112317549  MAML2; mastermind-like protein 2 [KO:K06061]
112296405  MAML1; mastermind-like protein 1 [KO:K06061]
112304053  RBPJL; recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053]
112316917  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
112301010  HES1; LOW QUALITY PROTEIN: transcription factor HES-1 [KO:K06054]
112299641  HES2; transcription factor HES-2 [KO:K09087]
112307886  HES6; transcription cofactor HES-6 isoform X1 [KO:K09087]
112308945  HES7; transcription factor HES-7 isoform X1 [KO:K09087]
112299597  HES4; transcription factor HES-4 [KO:K09089]
112299624  HES5; transcription factor HES-5 [KO:K06055]
112297358  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
112299577  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
112320814  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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The molecular biology of cervical cancer.
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The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
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Pathogens 5:E8 (2016)
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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Reference
PMID:15175323
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Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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J Biol Chem 279:35664-70 (2004)
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Reference
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Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Mol Cell Biol 28:4819-28 (2008)
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Reference
PMID:23536685
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Related
pathway
dro04064  NF-kappa B signaling pathway
dro04110  Cell cycle
dro04115  p53 signaling pathway
dro04150  mTOR signaling pathway
dro04151  PI3K-Akt signaling pathway
dro04210  Apoptosis
dro04310  Wnt signaling pathway
dro04330  Notch signaling pathway
dro04510  Focal adhesion
dro04520  Adherens junction
dro04530  Tight junction
dro04612  Antigen processing and presentation
dro04620  Toll-like receptor signaling pathway
dro04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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