KEGG   PATHWAY: fca05144
Entry
fca05144                    Pathway                                
Name
Malaria - Felis catus (domestic cat)
Description
Plasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop into the merozoite form.
Sporozoite invasion of hepatocytes is mediated by parasite surface protein like CSP. Subsequent infection into red blood cells (RBCs) by merozoites causes malaria disease via aberrant cytokine production and sequestration of parasite-infected red blood cells (pRBCs) to host endothelium. Microvasculature sequestration in the brain brings about cerebral malaria that can results in death or persisting neurological impairment. PfEMP1 has been suggested as the key adhesive molecule of pRBCs.
Class
Human Diseases; Infectious disease: parasitic
Pathway map
fca05144  Malaria
fca05144

Organism
Felis catus (domestic cat) [GN:fca]
Gene
101101459  SDC1; syndecan-1 [KO:K06257]
101092416  SDC2; syndecan-2 [KO:K16336]
101090780  LRP1; prolow-density lipoprotein receptor-related protein 1 isoform X2 [KO:K04550]
101093144  CD81; CD81 antigen [KO:K06508]
493705  HGF; hepatocyte growth factor precursor [KO:K05460]
493669  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
101094569  ACKR1; atypical chemokine receptor 1 [KO:K06574]
109498956  GYPA; glycophorin-A isoform X1 [KO:K06575]
101097411  GYPC; glycophorin-C [KO:K06576]
101089822  hemoglobin subunit alpha-like [KO:K13822]
111558266  hemoglobin subunit alpha [KO:K13822]
101091307  hemoglobin subunit beta-A/B [KO:K13823]
101098159  hemoglobin subunit beta-1 [KO:K13823]
493839  TLR9; toll-like receptor 9 precursor [KO:K10161]
101087092  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
493797  TLR2; toll-like receptor 2 [KO:K10159]
493698  TLR4; toll-like receptor 4 precursor [KO:K10160]
493683  IL10; interleukin-10 precursor [KO:K05443]
768263  TGFB1; transforming growth factor beta-1 isoform X2 [KO:K13375]
101093414  TGFB2; transforming growth factor beta-2 isoform X2 [KO:K13376]
101098469  TGFB3; transforming growth factor beta-3 isoform X1 [KO:K13377]
493836  CXCL8; interleukin-8 precursor [KO:K10030]
493687  IL6; interleukin-6 precursor [KO:K05405]
100127112  MCP-1; C-C motif chemokine 2 [KO:K14624]
493700  CSF3; granulocyte colony-stimulating factor precursor [KO:K05423]
768274  IL1B; interleukin-1 beta precursor [KO:K04519]
493755  TNF; tumor necrosis factor precursor [KO:K03156]
493741  IL12A; interleukin-12 subunit alpha precursor [KO:K05406]
493688  IL18; interleukin-18 precursor [KO:K05482]
101081737  KLRB1; killer cell lectin-like receptor subfamily B member 1 [KO:K06543]
101086984  NKG2-D type II integral membrane protein [KO:K06728]
111559549  uncharacterized protein LOC111559549 [KO:K10785]
493965  IFNG; interferon gamma precursor [KO:K04687]
101093842  CD36; platelet glycoprotein 4 [KO:K06259]
102899461  CR1L; complement component receptor 1-like protein [KO:K04011]
101084403  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
101088865  VCAM1; vascular cell adhesion protein 1 isoform X1 [KO:K06527]
101092689  THBS1; thrombospondin-1 [KO:K16857]
101087199  THBS4; thrombospondin-4 [KO:K04659]
101088820  COMP; cartilage oligomeric matrix protein [KO:K04659]
101100567  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
101093580  THBS3; LOW QUALITY PROTEIN: thrombospondin-3 [KO:K04659]
101085520  SELE; E-selectin [KO:K06494]
101085940  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
101087258  ITGB2; integrin beta-2 [KO:K06464]
101089421  ICAM1; intercellular adhesion molecule 1 isoform X1 [KO:K06490]
493850  CD40LG; CD40 ligand [KO:K03161]
101085363  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
101083565  SELP; P-selectin isoform X1 [KO:K06496]
Compound
C00533  Nitric oxide
C00634  Chondroitin 4-sulfate
G00052  Type II B antigen
G00054  Type II A antigen
G10505  Hyaluronic acid
Reference
  Authors
Morahan BJ, Wang L, Coppel RL
  Title
No TRAP, no invasion.
  Journal
Trends Parasitol 25:77-84 (2009)
DOI:10.1016/j.pt.2008.11.004
Reference
PMID:8920859
  Authors
Shakibaei M, Frevert U
  Title
Dual interaction of the malaria circumsporozoite protein with the low density lipoprotein receptor-related protein (LRP) and heparan sulfate proteoglycans.
  Journal
J Exp Med 184:1699-711 (1996)
DOI:10.1084/jem.184.5.1699
Reference
  Authors
Silvie O, Franetich JF, Renia L, Mazier D
  Title
Malaria sporozoite: migrating for a living.
  Journal
Trends Mol Med 10:97-100; discussion 100-1 (2004)
DOI:10.1016/j.molmed.2004.01.004
Reference
  Authors
Mota MM, Giordano S, Rodriguez A
  Title
Targeting Plasmodium host cells: survival within hepatocytes.
  Journal
Trends Mol Med 10:487-92 (2004)
DOI:10.1016/j.molmed.2004.08.003
Reference
  Authors
Cowman AF, Crabb BS
  Title
The Plasmodium falciparum genome--a blueprint for erythrocyte invasion.
  Journal
Science 298:126-8 (2002)
DOI:10.1126/science.1078169
Reference
  Authors
O'Donnell RA, Blackman MJ
  Title
The role of malaria merozoite proteases in red blood cell invasion.
  Journal
Curr Opin Microbiol 8:422-7 (2005)
DOI:10.1016/j.mib.2005.06.018
Reference
  Authors
Iyer J, Gruner AC, Renia L, Snounou G, Preiser PR
  Title
Invasion of host cells by malaria parasites: a tale of two protein families.
  Journal
Mol Microbiol 65:231-49 (2007)
DOI:10.1111/j.1365-2958.2007.05791.x
Reference
  Authors
Chitnis CE
  Title
Molecular insights into receptors used by malaria parasites for erythrocyte invasion.
  Journal
Curr Opin Hematol 8:85-91 (2001)
DOI:10.1097/00062752-200103000-00005
Reference
  Authors
Rasti N, Wahlgren M, Chen Q
  Title
Molecular aspects of malaria pathogenesis.
  Journal
FEMS Immunol Med Microbiol 41:9-26 (2004)
DOI:10.1016/j.femsim.2004.01.010
Reference
  Authors
Clark IA, Rockett KA, Cowden WB
  Title
Proposed link between cytokines, nitric oxide and human cerebral malaria.
  Journal
Parasitol Today 7:205-7 (1991)
DOI:10.1016/0169-4758(91)90142-B
Reference
  Authors
Hisaeda H, Tetsutani K, Imai T, Moriya C, Tu L, Hamano S, Duan X, Chou B, Ishida H, Aramaki A, Shen J, Ishii KJ, Coban C, Akira S, Takeda K, Yasutomo K, Torii M, Himeno K
  Title
Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells.
  Journal
J Immunol 180:2496-503 (2008)
DOI:10.4049/jimmunol.180.4.2496
Reference
  Authors
Chen Q, Schlichtherle M, Wahlgren M
  Title
Molecular aspects of severe malaria.
  Journal
Clin Microbiol Rev 13:439-50 (2000)
DOI:10.1128/CMR.13.3.439-450.2000
Reference
  Authors
Miller LH, Baruch DI, Marsh K, Doumbo OK
  Title
The pathogenic basis of malaria.
  Journal
Nature 415:673-9 (2002)
DOI:10.1038/415673a
Reference
  Authors
Faille D, El-Assaad F, Alessi MC, Fusai T, Combes V, Grau GE
  Title
Platelet-endothelial cell interactions in cerebral malaria: the end of a cordial understanding.
  Journal
Thromb Haemost 102:1093-102 (2009)
DOI:10.1160/TH09-05-0337
Reference
  Authors
Schofield L, Grau GE
  Title
Immunological processes in malaria pathogenesis.
  Journal
Nat Rev Immunol 5:722-35 (2005)
DOI:10.1038/nri1686
Reference
  Authors
Ishino T, Yano K, Chinzei Y, Yuda M
  Title
Cell-passage activity is required for the malarial parasite to cross the liver sinusoidal cell layer.
  Journal
PLoS Biol 2:E4 (2004)
DOI:10.1371/journal.pbio.0020004
Reference
  Authors
Kariu T, Ishino T, Yano K, Chinzei Y, Yuda M
  Title
CelTOS, a novel malarial protein that mediates transmission to mosquito and vertebrate hosts.
  Journal
Mol Microbiol 59:1369-79 (2006)
DOI:10.1111/j.1365-2958.2005.05024.x
Reference
  Authors
Cox D, McConkey S
  Title
The role of platelets in the pathogenesis of cerebral malaria.
  Journal
Cell Mol Life Sci 67:557-68 (2010)
DOI:10.1007/s00018-009-0211-3
Related
pathway
fca04210  Apoptosis
fca04514  Cell adhesion molecules
fca04610  Complement and coagulation cascades
fca04620  Toll-like receptor signaling pathway
KO pathway
ko05144   
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