KEGG   PATHWAY: fca04620
Entry
fca04620                    Pathway                                
Name
Toll-like receptor signaling pathway - Felis catus (domestic cat)
Description
Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK.
Class
Organismal Systems; Immune system
Pathway map
fca04620  Toll-like receptor signaling pathway
fca04620

Organism
Felis catus (domestic cat) [GN:fca]
Gene
100142682  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
100142683  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100142684  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100271864  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100302540  [KO:K05408]
100302541  [KO:K12964]
100499544  AKT2; RAC-beta serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
101081091  [KO:K05408]
101081371  [KO:K05414]
101081387  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X3 [KO:K04368] [EC:2.7.12.2]
101082202  TLR5; toll-like receptor 5 [KO:K10168]
101082274  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101082480  IRF5; interferon regulatory factor 5 [KO:K09446]
101082884  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
101083606  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
101084060  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
101084377  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101084561  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101084765  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101085363  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
101086282  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
101086432  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101086544  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101087092  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
101087614  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101087663  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
101087871  FADD; FAS-associated death domain protein [KO:K02373]
101087931  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101087958  MAPK3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
101088440  [KO:K05414]
101088688  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X2 [KO:K05403]
101089813  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
101090171  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
101090285  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
101090324  [KO:K05409]
101090500  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
101090622  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101090624  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
101091310  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101091536  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
101091762  TLR8; toll-like receptor 8 [KO:K10170]
101091892  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101091955  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
101092535  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
101092818  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
101093286  [KO:K02649]
101093379  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
101093586  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101093854  [KO:K10030]
101094264  SPP1; osteopontin isoform X1 [KO:K06250]
101094274  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101095157  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101095614  TOLLIP; toll-interacting protein [KO:K05402]
101095617  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101095899  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101095934  IRF3; interferon regulatory factor 3 isoform X3 [KO:K05411]
101096132  CD14; monocyte differentiation antigen CD14 [KO:K04391]
101096604  RELA; transcription factor p65 [KO:K04735]
101096739  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101097261  JUN; transcription factor AP-1 [KO:K04448]
101097413  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101097963  [KO:K05399]
101098714  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101099224  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
101099750  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101099880  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
101100131  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
101100225  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101100281  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101100388  CXCL9; C-X-C motif chemokine 9 isoform X1 [KO:K05416]
101100862  LY96; lymphocyte antigen 96 isoform X1 [KO:K05400]
101100970  IRF9; interferon regulatory factor 9 [KO:K04693]
101101135  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101101277  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101101463  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
105260786  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
109498011  [KO:K05399]
111556320  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
111557596  [KO:K05414]
123381775  [KO:K05414]
493648  IFNA8; interferon alpha-8 precursor [KO:K05414]
493653  IFNA7; interferon alpha precursor [KO:K05414]
493660  TLR1; toll-like receptor 1 [KO:K05398]
493661  TLR3; toll-like receptor 3 precursor [KO:K05401]
493662  TLR6; toll-like receptor 6 [KO:K10169]
493685  TLR7; toll-like receptor 7 [KO:K05404]
493687  IL6; interleukin-6 precursor [KO:K05405]
493689  CCL5; C-C motif chemokine 5 precursor [KO:K12499]
493698  TLR4; toll-like receptor 4 precursor [KO:K10160]
493704  CD86; T-lymphocyte activation antigen CD86 precursor [KO:K05413]
493741  IL12A; interleukin-12 subunit alpha precursor [KO:K05406]
493755  TNF; tumor necrosis factor precursor [KO:K03156]
493786  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
493797  TLR2; toll-like receptor 2 [KO:K10159]
493836  CXCL8; interleukin-8 precursor [KO:K10030]
493839  TLR9; toll-like receptor 9 precursor [KO:K10161]
493840  IFNA5; interferon alpha-5 [KO:K05414]
493849  IFNB1; interferon beta precursor [KO:K05415]
493935  FOS; proto-oncogene c-Fos [KO:K04379]
768273  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
768274  IL1B; interleukin-1 beta [KO:K04519]
Reference
PMID:17275323
  Authors
Kawai T, Akira S.
  Title
TLR signaling.
  Journal
Semin Immunol 19:24-32 (2007)
DOI:10.1016/j.smim.2006.12.004
Reference
PMID:17457343
  Authors
O'Neill LA, Bowie AG.
  Title
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.
  Journal
Nat Rev Immunol 7:353-64 (2007)
DOI:10.1038/nri2079
Reference
PMID:16932750
  Authors
Honda K, Taniguchi T.
  Title
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.
  Journal
Nat Rev Immunol 6:644-58 (2006)
DOI:10.1038/nri1900
Reference
PMID:17395581
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and Type I interferons.
  Journal
J Biol Chem 282:15319-23 (2007)
DOI:10.1074/jbc.R700009200
Reference
PMID:16497588
  Authors
Akira S, Uematsu S, Takeuchi O.
  Title
Pathogen recognition and innate immunity.
  Journal
Cell 124:783-801 (2006)
DOI:10.1016/j.cell.2006.02.015
Reference
PMID:14698224
  Authors
Yamamoto M, Takeda K, Akira S.
  Title
TIR domain-containing adaptors define the specificity of TLR signaling.
  Journal
Mol Immunol 40:861-8 (2004)
DOI:10.1016/j.molimm.2003.10.006
Reference
PMID:12734364
  Authors
Means TK, Hayashi F, Smith KD, Aderem A, Luster AD.
  Title
The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells.
  Journal
J Immunol 170:5165-75 (2003)
DOI:10.4049/jimmunol.170.10.5165
Reference
PMID:14751764
  Authors
Aderem A, Smith KD.
  Title
A systems approach to dissecting immunity and inflammation.
  Journal
Semin Immunol 16:55-67 (2004)
DOI:10.1016/j.smim.2003.10.002
Reference
PMID:17637696
  Authors
Banerjee A, Gerondakis S.
  Title
Coordinating TLR-activated signaling pathways in cells of the immune system.
  Journal
Immunol Cell Biol 85:420-4 (2007)
DOI:10.1038/sj.icb.7100098
Reference
PMID:17507094
  Authors
Loniewski KJ, Patial S, Parameswaran N.
  Title
Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.
  Journal
Mol Immunol 44:3715-23 (2007)
DOI:10.1016/j.molimm.2007.04.002
Reference
PMID:11101877
  Authors
Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG.
  Title
Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway.
  Journal
Nat Immunol 1:533-40 (2000)
DOI:10.1038/82797
Reference
PMID:16924467
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and innate immunity.
  Journal
J Mol Med 84:712-25 (2006)
DOI:10.1007/s00109-006-0084-y
Related
pathway
fca04010  MAPK signaling pathway
fca04060  Cytokine-cytokine receptor interaction
fca04064  NF-kappa B signaling pathway
fca04120  Ubiquitin mediated proteolysis
fca04151  PI3K-Akt signaling pathway
fca04210  Apoptosis
fca04610  Complement and coagulation cascades
fca04630  JAK-STAT signaling pathway
KO pathway
ko04620   

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