KEGG   PATHWAY: lve05203
Entry
lve05203                    Pathway                                
Name
Viral carcinogenesis - Lipotes vexillifer (Yangtze River dolphin)
Description
There is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and Kaposi's associated sarcoma virus (KSHV) contribute to 10-15% of the cancers worldwide. Via expression of many potent oncoproteins, these tumor viruses promote an aberrant cell-proliferation via modulating cellular cell-signaling pathways and escape from cellular defense system such as blocking apoptosis. Human tumor virus oncoproteins can also disrupt pathways that are necessary for the maintenance of the integrity of host cellular genome. Viruses that encode such activities can contribute to initiation as well as progression of human cancers.
Class
Human Diseases; Cancer: overview
Pathway map
lve05203  Viral carcinogenesis
lve05203

Organism
Lipotes vexillifer (Yangtze River dolphin) [GN:lve]
Gene
103072342  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103076043  HRAS; GTPase HRas isoform X1 [KO:K02833]
103077579  KRAS; GTPase KRas [KO:K07827]
103068734  NRAS; GTPase NRas [KO:K07828]
103070260  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103075543  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103075978  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
103089070  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
103083306  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
103086171  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
103085711  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
103087008  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
103091030  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
103071696  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
103081811  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
103069101  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
103088040  DDB1; DNA damage-binding protein 1 [KO:K10610]
103086266  YWHAQ; 14-3-3 protein theta [KO:K16197]
103074001  LOW QUALITY PROTEIN: 14-3-3 protein zeta-like [KO:K16197]
103078303  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
103085559  YWHAZ; 14-3-3 protein zeta/delta isoform X1 [KO:K16197]
103088362  YWHAE; 14-3-3 protein epsilon [KO:K06630]
103082303  YWHAH; 14-3-3 protein eta [KO:K16198]
103084836  YWHAG; LOW QUALITY PROTEIN: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma [KO:K16198]
103084253  14-3-3 protein gamma-like [KO:K16198]
103072682  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103086495  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
103082535  STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
103082258  STAT5B; LOW QUALITY PROTEIN: signal transducer and activator of transcription 5B [KO:K11224]
103073819  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
103089245  HPN; serine protease hepsin [KO:K08665] [EC:3.4.21.106]
103089257  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103088756  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103085303  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103070370  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103078725  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103083960  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103087304  RELA; transcription factor p65 isoform X1 [KO:K04735]
103082973  REL; proto-oncogene c-Rel [KO:K09254]
103076968  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
103068644  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103089875  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
103087546  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
103078168  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
103089138  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
103085295  EGR2; E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
103072642  EGR3; early growth response protein 3 isoform X1 [KO:K12497]
103087912  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
103074386  LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159]
103088206  SP100; LOW QUALITY PROTEIN: SP100 nuclear antigen [KO:K15413]
103071429  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
103080733  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
103082221  DDX3X; ATP-dependent RNA helicase DDX3X-like isoform X1 [KO:K11594] [EC:5.6.2.7]
103075964  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
103077464  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103074112  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
103068403  histone H2B type W-T-like [KO:K11252]
103068676  histone H2B type W-T-like [KO:K11252]
103070340  histone H2B type 1-like [KO:K11252]
103076624  histone H2B type 1-like [KO:K11252]
103076894  histone H2B type 1-like [KO:K11252]
103078258  histone H2B type 1-M-like [KO:K11252]
103079101  histone H2B type 1-like [KO:K11252]
103080666  histone H2B type 1-B-like [KO:K11252]
103082925  histone H2B type 1-like [KO:K11252]
103085965  histone H2B type 1-J-like [KO:K11252]
103086798  histone H2B type 1-K-like [KO:K11252]
103088169  histone H2B type 1-A-like [KO:K11252]
103071163  histone H2B type 1-like [KO:K11252]
103071989  histone H2B type 1-N-like [KO:K11252]
103073911  histone H2B type 2-E-like [KO:K11252]
103090141  histone H2B type 3-B-like [KO:K11252]
103090400  histone H2B type 3-B-like [KO:K11252]
103074679  histone H2B type 1-A-like [KO:K11252]
103080157  histone H2B type 2-E-like [KO:K11252]
103080427  histone H2B type 2-E-like [KO:K11252]
103081255  histone H2B type 2-F-like isoform X1 [KO:K11252]
103081704  histone H2B type 2-E-like [KO:K11252]
103080941  histone H4-like isoform X1 [KO:K11254]
103074048  histone H4 variant TH091-like [KO:K11254]
103074978  histone H4-like [KO:K11254]
103076354  histone H4-like [KO:K11254]
103081667  histone H4-like [KO:K11254]
103082659  histone H4-like [KO:K11254]
103086526  histone H4-like [KO:K11254]
103089247  histone H4-like [KO:K11254]
103080975  histone H4-like [KO:K11254]
103084066  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103079766  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103070103  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
103091065  CDK1; cyclin-dependent kinase 1-like isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
103083522  TBP; TATA-box-binding protein isoform X1 [KO:K03120]
103077940  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
103073021  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
103075423  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
103081431  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
103077598  RBPJ; LOW QUALITY PROTEIN: recombination signal binding protein for immunoglobulin kappa J region [KO:K06053]
103080331  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
103069389  SNW1; SNW domain-containing protein 1 isoform X1 [KO:K06063]
103068296  GTF2H1; general transcription factor IIH subunit 1 [KO:K03141]
103088908  GTF2H2; general transcription factor IIH subunit 2 isoform X1 [KO:K03142]
103076867  GTF2H3; general transcription factor IIH subunit 3 isoform X1 [KO:K03143]
103078718  GTF2H4; general transcription factor IIH subunit 4 [KO:K03144]
103071817  GTF2E1; general transcription factor IIE subunit 1 [KO:K03136]
103088940  general transcription factor IIE subunit 2-like isoform X1 [KO:K03137]
103086399  SND1; staphylococcal nuclease domain-containing protein 1 [KO:K15979]
103079020  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
103070724  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
103090005  GTF2B; transcription initiation factor IIB [KO:K03124]
103090612  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103077970  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
103072491  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
103081338  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103071139  CCNA1; cyclin-A1 [KO:K06627]
103073434  CCNA2; cyclin-A2 [KO:K06627]
103090160  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
103084091  MRPS18B; 28S ribosomal protein S18b, mitochondrial [KO:K16174]
103085868  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
103088738  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103084510  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
103075051  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
103081519  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
103074440  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
103079796  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
103088910  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
103076568  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
103071664  UBE3A; ubiquitin-protein ligase E3A [KO:K10587] [EC:2.3.2.26]
103079722  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
103083796  SCRIB; LOW QUALITY PROTEIN: protein scribble homolog [KO:K16175]
103078515  PXN; paxillin-like isoform X1 [KO:K05760]
103069848  putative Bcl-2 homologous antagonist/killer 2-like [KO:K14021]
103070943  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
103081489  PSMC1; 26S protease regulatory subunit 4 isoform X1 [KO:K03062]
103072166  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
103073545  RBL1; retinoblastoma-like protein 1 [KO:K04681]
103074426  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
103070701  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
103074147  UBR4; E3 ubiquitin-protein ligase UBR4 [KO:K10691] [EC:2.3.2.27]
103071861  JUN; transcription factor AP-1 [KO:K04448]
103071816  CHD4; chromodomain-helicase-DNA-binding protein 4 [KO:K11643] [EC:5.6.2.-]
103070274  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
103070161  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
103082097  HDAC3; histone deacetylase 3 [KO:K11404] [EC:3.5.1.98]
103070550  HDAC5; histone deacetylase 5 isoform X1 [KO:K11406] [EC:3.5.1.98]
103079661  HDAC4; LOW QUALITY PROTEIN: histone deacetylase 4 [KO:K11406] [EC:3.5.1.98]
103074668  HDAC6; histone deacetylase 6 [KO:K11407] [EC:3.5.1.98]
103079886  HDAC7; histone deacetylase 7 isoform X1 [KO:K11408] [EC:3.5.1.98]
103078231  HDAC8; histone deacetylase 8-like isoform X1 [KO:K11405] [EC:3.5.1.98]
103068824  HDAC9; histone deacetylase 9-like isoform X1 [KO:K11409] [EC:3.5.1.98]
103077804  HDAC10; histone deacetylase 10 [KO:K18671] [EC:3.5.1.98]
103069141  HDAC11; histone deacetylase 11 [KO:K11418] [EC:3.5.1.98]
103073555  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
103069880  IRF9; interferon regulatory factor 9 [KO:K04693]
103091280  DNAJA3; dnaJ homolog subfamily A member 3, mitochondrial isoform X1 [KO:K09504]
103085599  KAT2B; histone acetyltransferase KAT2B [KO:K06062] [EC:2.3.1.48]
103080529  KAT2A; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
103090766  GTF2A1L; LOW QUALITY PROTEIN: general transcription factor IIA, 1-like [KO:K03122]
103074764  GTF2A1; transcription initiation factor IIA subunit 1 isoform X1 [KO:K03122]
103091215  GTF2A2; transcription initiation factor IIA subunit 2 [KO:K03123]
103083410  SRF; serum response factor [KO:K04378]
103074882  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103069029  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103085645  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
103088294  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
103074749  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
103074732  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
103083293  GSN; gelsolin isoform X1 [KO:K05768]
103091591  SCIN; adseverin [KO:K05768]
103070717  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
103088628  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
103084826  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103072667  CDKN2A; cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 [KO:K06621]
103089606  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
103073805  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
103081104  CDC20; cell division cycle protein 20 homolog [KO:K03363]
103072712  mitotic spindle assembly checkpoint protein MAD1-like [KO:K06679]
103091432  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
103085911  VAC14; protein VAC14 homolog [KO:K15305]
103082774  RANBP1; ran-specific GTPase-activating protein isoform X1 [KO:K15306]
103088370  POLB; DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
103077222  IRF7; interferon regulatory factor 7 [KO:K09447]
103075698  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
103081662  CCR5; c-C chemokine receptor type 5 [KO:K04180]
103074832  CCR8; c-C chemokine receptor type 8 [KO:K04183]
103081393  CCR3; c-C chemokine receptor type 3 [KO:K04178]
103080618  CCR4; c-C chemokine receptor type 4 [KO:K04179]
103082742  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
103077054  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
103083608  BAD; bcl2 antagonist of cell death [KO:K02158]
103083690  C3; complement C3 [KO:K03990]
103085165  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
103083060  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
103076235  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
103086977  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
Reference
PMID:18201576
  Authors
McLaughlin-Drubin ME, Munger K
  Title
Viruses associated with human cancer.
  Journal
Biochim Biophys Acta 1782:127-50 (2008)
DOI:10.1016/j.bbadis.2007.12.005
Reference
PMID:21102637
  Authors
Moore PS, Chang Y
  Title
Why do viruses cause cancer? Highlights of the first century of human tumour virology.
  Journal
Nat Rev Cancer 10:878-89 (2010)
DOI:10.1038/nrc2961
Reference
PMID:19400863
  Authors
Kalland KH, Ke XS, Oyan AM
  Title
Tumour virology--history, status and future challenges.
  Journal
APMIS 117:382-99 (2009)
DOI:10.1111/j.1600-0463.2009.02452.x
Reference
PMID:17979705
  Authors
Boccardo E, Villa LL
  Title
Viral origins of human cancer.
  Journal
Curr Med Chem 14:2526-39 (2007)
DOI:10.2174/092986707782023316
Reference
PMID:21084867
  Authors
Saha A, Kaul R, Murakami M, Robertson ES
  Title
Tumor viruses and cancer biology: Modulating signaling pathways for therapeutic intervention.
  Journal
Cancer Biol Ther 10:961-78 (2010)
DOI:10.4161/cbt.10.10.13923
Reference
PMID:21152115
  Authors
Zheng ZM
  Title
Viral oncogenes, noncoding RNAs, and RNA splicing in human tumor viruses.
  Journal
Int J Biol Sci 6:730-55 (2010)
DOI:10.7150/ijbs.6.730
Reference
PMID:19956178
  Authors
Martin D, Gutkind JS
  Title
Human tumor-associated viruses and new insights into the molecular mechanisms of cancer.
  Journal
Oncogene 27 Suppl 2:S31-42 (2008)
DOI:10.1038/onc.2009.351
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:21647825
  Authors
Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:21966251
  Authors
Nishida N, Goel A
  Title
Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review.
  Journal
Curr Genomics 12:130-7 (2011)
DOI:10.2174/138920211795564359
Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
PMID:9343405
  Authors
Klein NP, Schneider RJ
  Title
Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras.
  Journal
Mol Cell Biol 17:6427-36 (1997)
DOI:10.1128/MCB.17.11.6427
Reference
PMID:16039586
  Authors
Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, Hung MC
  Title
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
  Journal
Mol Cell 19:159-70 (2005)
DOI:10.1016/j.molcel.2005.06.009
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:10824878
  Authors
Arbuthnot P, Capovilla A, Kew M
  Title
Putative role of hepatitis B virus X protein in hepatocarcinogenesis: effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK/STAT pathways.
  Journal
J Gastroenterol Hepatol 15:357-68 (2000)
DOI:10.1046/j.1440-1746.2000.02069.x
Reference
PMID:9837909
  Authors
Gottlob K, Fulco M, Levrero M, Graessmann A
  Title
The hepatitis B virus HBx protein inhibits caspase 3 activity.
  Journal
J Biol Chem 273:33347-53 (1998)
DOI:10.1074/jbc.273.50.33347
Reference
PMID:15614436
  Authors
Zhang JL, Zhao WG, Wu KL, Wang K, Zhang X, Gu CF, Li Y, Zhu Y, Wu JG
  Title
Human hepatitis B virus X protein promotes cell proliferation and inhibits cell apoptosis through interacting with a serine protease Hepsin.
  Journal
Arch Virol 150:721-41 (2005)
DOI:10.1007/s00705-004-0446-0
Reference
PMID:15105524
  Authors
Cooray S
  Title
The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival.
  Journal
J Gen Virol 85:1065-76 (2004)
DOI:10.1099/vir.0.19771-0
Reference
PMID:16939421
  Authors
Mukherji A, Janbandhu VC, Kumar V
  Title
HBx-dependent cell cycle deregulation involves interaction with cyclin E/A-cdk2 complex and destabilization of p27Kip1.
  Journal
Biochem J 401:247-56 (2007)
DOI:10.1042/BJ20061091
Reference
PMID:15173177
  Authors
Yoo YG, Lee MO
  Title
Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.
  Journal
J Biol Chem 279:36242-9 (2004)
DOI:10.1074/jbc.M401290200
Reference
PMID:11604508
  Authors
Waris G, Huh KW, Siddiqui A
  Title
Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress.
  Journal
Mol Cell Biol 21:7721-30 (2001)
DOI:10.1128/MCB.21.22.7721-7730.2001
Reference
PMID:17894800
  Authors
Kasprzak A, Adamek A
  Title
Role of hepatitis C virus proteins (C, NS3, NS5A) in hepatic oncogenesis.
  Journal
Hepatol Res 38:1-26 (2008)
DOI:10.1111/j.1872-034X.2007.00261.x
Reference
PMID:9882379
  Authors
You LR, Chen CM, Lee YH
  Title
Hepatitis C virus core protein enhances NF-kappaB signal pathway triggering by lymphotoxin-beta receptor ligand and tumor necrosis factor alpha.
  Journal
J Virol 73:1672-81 (1999)
DOI:10.1128/JVI.73.2.1672-1681.1999
Reference
PMID:16581947
  Authors
Sato Y, Kato J, Takimoto R, Takada K, Kawano Y, Miyanishi K, Kobune M, Sato Y, Takayama T, Matunaga T, Niitsu Y
  Title
Hepatitis C virus core protein promotes proliferation of human hepatoma cells through enhancement of transforming growth factor alpha expression via activation of nuclear factor-kappaB.
  Journal
Gut 55:1801-8 (2006)
DOI:10.1136/gut.2005.070417
Reference
PMID:14559998
  Authors
Watashi K, Hijikata M, Tagawa A, Doi T, Marusawa H, Shimotohno K
  Title
Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus.
  Journal
Mol Cell Biol 23:7498-509 (2003)
DOI:10.1128/MCB.23.21.7498-7509.2003
Reference
PMID:9651361
  Authors
Hsieh TY, Matsumoto M, Chou HC, Schneider R, Hwang SB, Lee AS, Lai MM
  Title
Hepatitis C virus core protein interacts with heterogeneous nuclear ribonucleoprotein K.
  Journal
J Biol Chem 273:17651-9 (1998)
DOI:10.1074/jbc.273.28.17651
Reference
PMID:10873631
  Authors
Wang F, Yoshida I, Takamatsu M, Ishido S, Fujita T, Oka K, Hotta H
  Title
Complex formation between hepatitis C virus core protein and p21Waf1/Cip1/Sdi1.
  Journal
Biochem Biophys Res Commun 273:479-84 (2000)
DOI:10.1006/bbrc.2000.2970
Reference
PMID:10074132
  Authors
You LR, Chen CM, Yeh TS, Tsai TY, Mai RT, Lin CH, Lee YH
  Title
Hepatitis C virus core protein interacts with cellular putative RNA helicase.
  Journal
J Virol 73:2841-53 (1999)
DOI:10.1128/JVI.73.4.2841-2853.1999
Reference
PMID:10644344
  Authors
Aoki H, Hayashi J, Moriyama M, Arakawa Y, Hino O
  Title
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1.
  Journal
J Virol 74:1736-41 (2000)
DOI:10.1128/JVI.74.4.1736-1741.2000
Reference
PMID:17267064
  Authors
Yan XB, Battaglia S, Boucreux D, Chen Z, Brechot C, Pavio N
  Title
Mapping of the interacting domains of hepatitis C virus core protein and the double-stranded RNA-activated protein kinase PKR.
  Journal
Virus Res 125:79-87 (2007)
DOI:10.1016/j.virusres.2006.12.010
Reference
PMID:9060639
  Authors
Borowski P, Oehlmann K, Heiland M, Laufs R
  Title
Nonstructural protein 3 of hepatitis C virus blocks the distribution of the free catalytic subunit of cyclic AMP-dependent protein kinase.
  Journal
J Virol 71:2838-43 (1997)
DOI:10.1128/JVI.71.4.2838-2843.1997
Reference
PMID:10405893
  Authors
Borowski P, Kuhl R, Laufs R, Schulze zur Wiesch J, Heiland M
  Title
Identification and characterization of a histone binding site of the non-structural protein 3 of hepatitis C virus.
  Journal
J Clin Virol 13:61-9 (1999)
DOI:10.1016/S1386-6532(99)00007-4
Reference
PMID:12101418
  Authors
Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD
  Title
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
  Journal
Oncogene 21:4801-11 (2002)
DOI:10.1038/sj.onc.1205589
Reference
PMID:12925958
  Authors
Chung YL, Sheu ML, Yen SH
  Title
Hepatitis C virus NS5A as a potential viral Bcl-2 homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma.
  Journal
Int J Cancer 107:65-73 (2003)
DOI:10.1002/ijc.11303
Reference
PMID:10400746
  Authors
Gale M Jr, Kwieciszewski B, Dossett M, Nakao H, Katze MG
  Title
Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase.
  Journal
J Virol 73:6506-16 (1999)
DOI:10.1128/JVI.73.8.6506-6516.1999
Reference
PMID:12186904
  Authors
He Y, Nakao H, Tan SL, Polyak SJ, Neddermann P, Vijaysri S, Jacobs BL, Katze MG
  Title
Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase.
  Journal
J Virol 76:9207-17 (2002)
DOI:10.1128/JVI.76.18.9207-9217.2002
Reference
PMID:15795286
  Authors
Street A, Macdonald A, McCormick C, Harris M
  Title
Hepatitis C virus NS5A-mediated activation of phosphoinositide 3-kinase results in stabilization of cellular beta-catenin and stimulation of beta-catenin-responsive transcription.
  Journal
J Virol 79:5006-16 (2005)
DOI:10.1128/JVI.79.8.5006-5016.2005
Reference
PMID:11886269
  Authors
Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB
  Title
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.
  Journal
Virology 294:94-105 (2002)
DOI:10.1006/viro.2001.1309
Reference
PMID:11278402
  Authors
Arima N, Kao CY, Licht T, Padmanabhan R, Sasaguri Y, Padmanabhan R
  Title
Modulation of cell growth by the hepatitis C virus nonstructural protein NS5A.
  Journal
J Biol Chem 276:12675-84 (2001)
DOI:10.1074/jbc.M008329200
Reference
PMID:21250384
  Authors
He Y, Staschke KA, Tan SL
  Title
HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
  Journal
Hepatitis C Viruses: Genomes and Molecular Biology (2006)
Reference
PMID:12379483
  Authors
Qadri I, Iwahashi M, Simon F
  Title
Hepatitis C virus NS5A protein binds TBP and p53, inhibiting their DNA binding and p53 interactions with TBP and ERCC3.
  Journal
Biochim Biophys Acta 1592:193-204 (2002)
DOI:10.1016/S0167-4889(02)00315-4
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:20494113
  Authors
Klein G, Klein E, Kashuba E
  Title
Interaction of Epstein-Barr virus (EBV) with human B-lymphocytes.
  Journal
Biochem Biophys Res Commun 396:67-73 (2010)
DOI:10.1016/j.bbrc.2010.02.146
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:11160754
  Authors
Harada S, Yalamanchili R, Kieff E
  Title
Epstein-Barr virus nuclear protein 2 has at least two N-terminal domains that mediate self-association.
  Journal
J Virol 75:2482-7 (2001)
DOI:10.1128/JVI.75.5.2482-2487.2001
Reference
PMID:15452270
  Authors
Peng CW, Zhao B, Kieff E
  Title
Four EBNA2 domains are important for EBNALP coactivation.
  Journal
J Virol 78:11439-42 (2004)
DOI:10.1128/JVI.78.20.11439-11442.2004
Reference
PMID:15767449
  Authors
Peng R, Moses SC, Tan J, Kremmer E, Ling PD
  Title
The Epstein-Barr virus EBNA-LP protein preferentially coactivates EBNA2-mediated stimulation of latent membrane proteins expressed from the viral divergent promoter.
  Journal
J Virol 79:4492-505 (2005)
DOI:10.1128/JVI.79.7.4492-4505.2005
Reference
PMID:21177815
  Authors
Saha A, Bamidele A, Murakami M, Robertson ES
  Title
EBNA3C attenuates the function of p53 through interaction with inhibitor of growth family proteins 4 and 5.
  Journal
J Virol 85:2079-88 (2011)
DOI:10.1128/JVI.02279-10
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Reference
PMID:15542638
  Authors
Knight JS, Sharma N, Kalman DE, Robertson ES
  Title
A cyclin-binding motif within the amino-terminal homology domain of EBNA3C binds cyclin A and modulates cyclin A-dependent kinase activity in Epstein-Barr virus-infected cells.
  Journal
J Virol 78:12857-67 (2004)
DOI:10.1128/JVI.78.23.12857-12867.2004
Reference
PMID:14747563
  Authors
Knight JS, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C regulates cyclin A/p27 complexes and enhances cyclin A-dependent kinase activity.
  Journal
J Virol 78:1981-91 (2004)
DOI:10.1128/JVI.78.4.1981-1991.2004
Reference
PMID:16352731
  Authors
Knight JS, Sharma N, Robertson ES
  Title
Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase.
  Journal
Proc Natl Acad Sci U S A 102:18562-6 (2005)
DOI:10.1073/pnas.0503886102
Reference
PMID:18391203
  Authors
Kashuba E, Yurchenko M, Yenamandra SP, Snopok B, Isaguliants M, Szekely L, Klein G
  Title
EBV-encoded EBNA-6 binds and targets MRS18-2 to the nucleus, resulting in the disruption of pRb-E2F1 complexes.
  Journal
Proc Natl Acad Sci U S A 105:5489-94 (2008)
DOI:10.1073/pnas.0801053105
Reference
PMID:11091847
  Authors
Young LS, Dawson CW, Eliopoulos AG
  Title
The expression and function of Epstein-Barr virus encoded latent genes.
  Journal
Mol Pathol 53:238-47 (2000)
DOI:10.1136/mp.53.5.238
Reference
PMID:19078975
  Authors
Kuppers R
  Title
The biology of Hodgkin's lymphoma.
  Journal
Nat Rev Cancer 9:15-27 (2009)
DOI:10.1038/nrc2542
Reference
PMID:17049016
  Authors
Pattle SB, Farrell PJ
  Title
The role of Epstein-Barr virus in cancer.
  Journal
Expert Opin Biol Ther 6:1193-205 (2006)
DOI:10.1517/14712598.6.11.1193
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:11766888
  Authors
Dell G, Gaston K
  Title
Human papillomaviruses and their role in cervical cancer.
  Journal
Cell Mol Life Sci 58:1923-42 (2001)
DOI:10.1007/PL00000827
Reference
PMID:10793105
  Authors
zur Hausen H
  Title
Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
  Journal
J Natl Cancer Inst 92:690-8 (2000)
DOI:10.1093/jnci/92.9.690
Reference
PMID:19156753
  Authors
Yugawa T, Kiyono T
  Title
Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.
  Journal
Rev Med Virol 19:97-113 (2009)
DOI:10.1002/rmv.605
Reference
PMID:17645777
  Authors
Narisawa-Saito M, Kiyono T
  Title
Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
  Journal
Cancer Sci 98:1505-11 (2007)
DOI:10.1111/j.1349-7006.2007.00546.x
Reference
PMID:15342967
  Authors
Motoyama S, Ladines-Llave CA, Luis Villanueva S, Maruo T
  Title
The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
  Journal
Kobe J Med Sci 50:9-19 (2004)
Reference
PMID:20592731
  Authors
Moody CA, Laimins LA
  Title
Human papillomavirus oncoproteins: pathways to transformation.
  Journal
Nat Rev Cancer 10:550-60 (2010)
DOI:10.1038/nrc2886
Reference
PMID:15956361
  Authors
McCance DJ
  Title
Human papillomaviruses and cell signaling.
  Journal
Sci STKE 2005:pe29 (2005)
DOI:10.1126/stke.2882005pe29
Reference
PMID:18385245
  Authors
Wade R, Brimer N, Vande Pol S
  Title
Transformation by bovine papillomavirus type 1 E6 requires paxillin.
  Journal
J Virol 82:5962-6 (2008)
DOI:10.1128/JVI.02747-07
Reference
PMID:9374493
  Authors
Berezutskaya E, Bagchi S
  Title
The human papillomavirus E7 oncoprotein functionally interacts with the S4 subunit of the 26 S proteasome.
  Journal
J Biol Chem 272:30135-40 (1997)
DOI:10.1074/jbc.272.48.30135
Reference
PMID:16381817
  Authors
Zhang B, Chen W, Roman A
  Title
The E7 proteins of low- and high-risk human papillomaviruses share the ability to target the pRB family member p130 for degradation.
  Journal
Proc Natl Acad Sci U S A 103:437-42 (2006)
DOI:10.1073/pnas.0510012103
Reference
PMID:12970441
  Authors
He W, Staples D, Smith C, Fisher C
  Title
Direct activation of cyclin-dependent kinase 2 by human papillomavirus E7.
  Journal
J Virol 77:10566-74 (2003)
DOI:10.1128/JVI.77.19.10566-10574.2003
Reference
PMID:9349482
  Authors
Massimi P, Pim D, Banks L
  Title
Human papillomavirus type 16 E7 binds to the conserved carboxy-terminal region of the TATA box binding protein and this contributes to E7 transforming activity.
  Journal
J Gen Virol 78 ( Pt 10):2607-13 (1997)
DOI:10.1099/0022-1317-78-10-2607
Reference
PMID:8617242
  Authors
Antinore MJ, Birrer MJ, Patel D, Nader L, McCance DJ
  Title
The human papillomavirus type 16 E7 gene product interacts with and trans-activates the AP1 family of transcription factors.
  Journal
EMBO J 15:1950-60 (1996)
DOI:10.1002/j.1460-2075.1996.tb00546.x
Reference
PMID:9990017
  Authors
Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Durr P
  Title
Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
  Journal
Proc Natl Acad Sci U S A 96:1291-6 (1999)
DOI:10.1073/pnas.96.4.1291
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:15310405
  Authors
Azran I, Schavinsky-Khrapunsky Y, Aboud M
  Title
Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
  Journal
Retrovirology 1:20 (2004)
DOI:10.1186/1742-4690-1-20
Reference
PMID:12910250
  Authors
Matsuoka M
  Title
Human T-cell leukemia virus type I and adult T-cell leukemia.
  Journal
Oncogene 22:5131-40 (2003)
DOI:10.1038/sj.onc.1206551
Reference
PMID:11244044
  Authors
Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
  Journal
Annu Rev Immunol 19:475-96 (2001)
DOI:10.1146/annurev.immunol.19.1.475
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:8223437
  Authors
Caron C, Rousset R, Beraud C, Moncollin V, Egly JM, Jalinot P
  Title
Functional and biochemical interaction of the HTLV-I Tax1 transactivator with TBP.
  Journal
EMBO J 12:4269-78 (1993)
DOI:10.1002/j.1460-2075.1993.tb06111.x
Reference
PMID:8756622
  Authors
Clemens KE, Piras G, Radonovich MF, Choi KS, Duvall JF, DeJong J, Roeder R, Brady JN
  Title
Interaction of the human T-cell lymphotropic virus type 1 tax transactivator with transcription factor IIA.
  Journal
Mol Cell Biol 16:4656-64 (1996)
DOI:10.1128/MCB.16.9.4656
Reference
PMID:16036567
  Authors
Harhaj EW, Harhaj NS
  Title
Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
  Journal
IUBMB Life 57:83-91 (2005)
DOI:10.1080/15216540500078715
Reference
PMID:21743832
  Authors
Qu Z, Xiao G
  Title
Human T-cell lymphotropic virus: a model of NF-kappaB-associated tumorigenesis.
  Journal
Viruses 3:714-49 (2011)
DOI:10.3390/v3060714
Reference
PMID:16155601
  Authors
Kashanchi F, Brady JN
  Title
Transcriptional and post-transcriptional gene regulation of HTLV-1.
  Journal
Oncogene 24:5938-51 (2005)
DOI:10.1038/sj.onc.1208973
Reference
PMID:14530271
  Authors
Wu K, Bottazzi ME, de la Fuente C, Deng L, Gitlin SD, Maddukuri A, Dadgar S, Li H, Vertes A, Pumfery A, Kashanchi F
  Title
Protein profile of tax-associated complexes.
  Journal
J Biol Chem 279:495-508 (2004)
DOI:10.1074/jbc.M310069200
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:16308315
  Authors
Tabakin-Fix Y, Azran I, Schavinky-Khrapunsky Y, Levy O, Aboud M
  Title
Functional inactivation of p53 by human T-cell leukemia virus type 1 Tax protein: mechanisms and clinical implications.
  Journal
Carcinogenesis 27:673-81 (2006)
DOI:10.1093/carcin/bgi274
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:17457345
  Authors
Coscoy L
  Title
Immune evasion by Kaposi's sarcoma-associated herpesvirus.
  Journal
Nat Rev Immunol 7:391-401 (2007)
DOI:10.1038/nri2076
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16828973
  Authors
Jarviluoma A, Ojala PM
  Title
Cell signaling pathways engaged by KSHV.
  Journal
Biochim Biophys Acta 1766:140-58 (2006)
DOI:10.1016/j.bbcan.2006.05.001
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:19715458
  Authors
Lee HR, Kim MH, Lee JS, Liang C, Jung JU
  Title
Viral interferon regulatory factors.
  Journal
J Interferon Cytokine Res 29:621-7 (2009)
DOI:10.1089/jir.2009.0067
Reference
PMID:22566809
  Authors
Jacobs SR, Damania B
  Title
The Viral Interferon Regulatory Factors of KSHV: Immunosuppressors or Oncogenes?
  Journal
Front Immunol 2:19 (2011)
DOI:10.3389/fimmu.2011.00019
Reference
PMID:19651473
  Authors
Wen KW, Damania B
  Title
Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis.
  Journal
Cancer Lett 289:140-50 (2010)
DOI:10.1016/j.canlet.2009.07.004
Reference
PMID:15967719
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
PMID:15692053
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:12770701
  Authors
Verma SC, Robertson ES
  Title
Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus.
  Journal
FEMS Microbiol Lett 222:155-63 (2003)
DOI:10.1016/S0378-1097(03)00261-1
Reference
PMID:10354594
  Authors
Schulz TF, Moore PS
  Title
Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
  Journal
Trends Microbiol 7:196-200 (1999)
DOI:10.1016/S0966-842X(99)01495-X
Reference
PMID:10855768
  Authors
Schulz TF
  Title
Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8): epidemiology and pathogenesis.
  Journal
J Antimicrob Chemother 45 Suppl T3:15-27 (2000)
DOI:10.1093/jac/45.suppl_4.15
Reference
PMID:9594662
  Authors
Moore PS, Chang Y
  Title
Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.
  Journal
Trends Genet 14:144-50 (1998)
DOI:10.1016/S0168-9525(98)01408-5
Reference
PMID:20534855
  Authors
Pietrek M, Brinkmann MM, Glowacka I, Enlund A, Havemeier A, Dittrich-Breiholz O, Kracht M, Lewitzky M, Saksela K, Feller SM, Schulz TF
  Title
Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation.
  Journal
J Virol 84:8231-40 (2010)
DOI:10.1128/JVI.01696-09
Reference
PMID:21421561
  Authors
Bagneris C, Briggs LC, Savva R, Ebrahimi B, Barrett TE
  Title
Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff.
  Journal
Nucleic Acids Res 39:5744-56 (2011)
DOI:10.1093/nar/gkr111
Reference
PMID:15919895
  Authors
Glaunsinger B, Chavez L, Ganem D
  Title
The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable.
  Journal
J Virol 79:7396-401 (2005)
DOI:10.1128/JVI.79.12.7396-7401.2005
Related
pathway
lve03022  Basal transcription factors
lve03320  PPAR signaling pathway
lve04010  MAPK signaling pathway
lve04062  Chemokine signaling pathway
lve04064  NF-kappa B signaling pathway
lve04110  Cell cycle
lve04115  p53 signaling pathway
lve04142  Lysosome
lve04151  PI3K-Akt signaling pathway
lve04210  Apoptosis
lve04630  JAK-STAT signaling pathway
lve04662  B cell receptor signaling pathway
lve04810  Regulation of actin cytoskeleton
lve05160  Hepatitis C
lve05161  Hepatitis B
lve05165  Human papillomavirus infection
lve05166  Human T-cell leukemia virus 1 infection
lve05167  Kaposi sarcoma-associated herpesvirus infection
lve05169  Epstein-Barr virus infection
KO pathway
ko05203   
LinkDB

DBGET integrated database retrieval system