KEGG   PATHWAY: lve05169
Entry
lve05169                    Pathway                                
Name
Epstein-Barr virus infection - Lipotes vexillifer (Yangtze River dolphin)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
lve05169  Epstein-Barr virus infection
lve05169

Disease
H00367  Infectious mononucleosis
Organism
Lipotes vexillifer (Yangtze River dolphin) [GN:lve]
Gene
103068356  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
103068617  [KO:K05414]
103068644  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103068842  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
103068921  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103069029  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103069117  [KO:K11220]
103069127  IFNAR2; LOW QUALITY PROTEIN: interferon alpha/beta receptor 2 [KO:K05131]
103069156  [KO:K08738]
103069181  [KO:K05414]
103069223  ENTPD3; LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
103069389  SNW1; SNW domain-containing protein 1 isoform X1 [KO:K06063]
103069546  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
103069739  [KO:K05414]
103069785  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
103069825  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
103069848  [KO:K14021]
103069880  IRF9; interferon regulatory factor 9 [KO:K04693]
103069944  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
103070103  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
103070161  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
103070274  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
103070290  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
103070370  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103070408  E2F1; transcription factor E2F1 [KO:K17454]
103070666  PSMC6; 26S protease regulatory subunit 10B [KO:K03064]
103070686  B2M; beta-2-microglobulin [KO:K08055]
103070701  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
103070742  SAP30; histone deacetylase complex subunit SAP30 [KO:K19202]
103070943  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
103070953  [KO:K08055]
103070997  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
103071139  CCNA1; cyclin-A1 [KO:K06627]
103071175  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
103071515  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
103071732  SAP30L; histone deacetylase complex subunit SAP30L isoform X1 [KO:K19202]
103071861  JUN; transcription factor AP-1 [KO:K04448]
103072166  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
103072491  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
103072682  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103072764  TAP2; LOW QUALITY PROTEIN: antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
103073037  RUNX3; runt-related transcription factor 3 isoform X1 [KO:K09279]
103073219  [KO:K05414]
103073250  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
103073434  CCNA2; cyclin-A2 [KO:K06627]
103073586  [KO:K06066]
103073772  [KO:K05415]
103073775  CXCL10; c-X-C motif chemokine 10 [KO:K12671]
103073819  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
103073874  TAPBP; LOW QUALITY PROTEIN: tapasin [KO:K08058]
103074114  TAPBPL; tapasin-related protein [KO:K28445]
103074176  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
103074219  PSMC3; 26S protease regulatory subunit 6A [KO:K03065]
103074326  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
103074334  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
103074440  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
103074749  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
103074882  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103075051  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
103075075  [KO:K06856]
103075230  NCOR2; LOW QUALITY PROTEIN: nuclear receptor corepressor 2 [KO:K06065]
103075340  MAP3K7; mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
103075361  [KO:K06856]
103075423  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
103075495  [KO:K08738]
103075864  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
103075964  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
103076235  [KO:K06751]
103076365  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103076558  CD247; T-cell surface glycoprotein CD3 zeta chain [KO:K06453]
103076588  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
103076606  [KO:K12159]
103076910  PSMC5; 26S protease regulatory subunit 8 [KO:K03066]
103076968  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
103077054  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
103077222  IRF7; interferon regulatory factor 7 [KO:K09447]
103077294  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
103077530  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103077598  RBPJ; LOW QUALITY PROTEIN: recombination signal binding protein for immunoglobulin kappa J region [KO:K06053]
103077970  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
103078032  NEDD4; E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
103078049  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
103078168  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
103078463  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
103078531  BID; BH3-interacting domain death agonist [KO:K04726]
103078592  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
103078660  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
103078710  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103078725  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103078792  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103079116  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
103079172  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
103079241  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
103079638  [KO:K08738]
103079671  CR2; complement receptor type 2 isoform X1 [KO:K04012]
103079699  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
103079775  HES1; transcription factor HES-1 [KO:K06054]
103079796  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
103079935  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
103080104  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103080331  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
103080339  FADD; FAS-associated death domain protein [KO:K02373]
103080489  BLNK; B-cell linker protein isoform X1 [KO:K07371]
103080594  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
103080608  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
103080704  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
103080733  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
103080788  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
103080860  RELB; transcription factor RelB [KO:K09253]
103080866  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
103080924  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
103080964  VIM; vimentin [KO:K07606]
103081298  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
103081332  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
103081338  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103081431  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
103081489  PSMC1; 26S protease regulatory subunit 4 isoform X1 [KO:K03062]
103081519  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
103081545  IL6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
103081641  [KO:K04433] [EC:2.7.12.2]
103081732  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
103081780  E2F2; transcription factor E2F2 [KO:K09389]
103081814  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
103082326  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
103082490  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103082498  [KO:K03035]
103082644  CALR; calreticulin [KO:K08057]
103082933  CD19; B-lymphocyte antigen CD19 [KO:K06465]
103083060  [KO:K06751]
103083173  [KO:K08738]
103083209  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103083231  TNF; tumor necrosis factor [KO:K03156]
103083691  [KO:K06752]
103083960  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103084066  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103084128  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
103084510  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
103084615  TAP1; LOW QUALITY PROTEIN: antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
103084630  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103084826  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103084975  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103085165  [KO:K06751]
103085172  [KO:K06752]
103085220  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103085303  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103085308  PSMC2; LOW QUALITY PROTEIN: 26S protease regulatory subunit 7 [KO:K03061]
103085441  [KO:K06752]
103085858  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 isoform X1 [KO:K03028]
103085882  E2F3; transcription factor E2F3 [KO:K06620]
103086000  [KO:K06752]
103086254  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
103086271  PSMC4; 26S protease regulatory subunit 6B isoform X1 [KO:K03063]
103086425  BTK; tyrosine-protein kinase BTK isoform X1 [KO:K07370] [EC:2.7.10.2]
103086495  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
103086745  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
103086789  CIR1; LOW QUALITY PROTEIN: corepressor interacting with RBPJ 1 [KO:K06066]
103086796  [KO:K06752]
103086804  CD58; lymphocyte function-associated antigen 3 [KO:K06492]
103086977  [KO:K06751]
103087297  [KO:K06752]
103087304  RELA; transcription factor p65 isoform X1 [KO:K04735]
103087433  OAS1; 2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
103087452  [KO:K06752]
103087546  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
103087567  [KO:K06752]
103087676  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103087703  OAS2; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
103088205  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
103088633  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103088738  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103088756  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103088795  [KO:K03175] [EC:2.3.2.27]
103089123  DDX58; LOW QUALITY PROTEIN: DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 [KO:K12646] [EC:5.6.2.6]
103089138  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
103089187  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
103089257  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103089793  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
103089875  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
103089962  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
103090160  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
103090179  [KO:K10159]
103090213  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
103090612  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103090661  [KO:K05414]
103091202  [KO:K05414]
103091203  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
103091366  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
103091442  [KO:K03038]
103091499  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
103091597  CD44; CD44 antigen isoform X1 [KO:K06256]
103091611  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
lve03050  Proteasome
lve04010  MAPK signaling pathway
lve04020  Calcium signaling pathway
lve04064  NF-kappa B signaling pathway
lve04110  Cell cycle
lve04115  p53 signaling pathway
lve04210  Apoptosis
lve04612  Antigen processing and presentation
lve04620  Toll-like receptor signaling pathway
lve04622  RIG-I-like receptor signaling pathway
lve04630  JAK-STAT signaling pathway
lve04662  B cell receptor signaling pathway
KO pathway
ko05169   

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