KEGG   PATHWAY: lve04062
Entry
lve04062                    Pathway                                
Name
Chemokine signaling pathway - Lipotes vexillifer (Yangtze River dolphin)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
lve04062  Chemokine signaling pathway
lve04062

Other DBs
GO: 0070098
Organism
Lipotes vexillifer (Yangtze River dolphin) [GN:lve]
Gene
103071675  growth-regulated alpha protein-like [KO:K05505]
103071959  growth-regulated protein homolog beta-like [KO:K05505]
103071404  uncharacterized protein LOC103071404 [KO:K05505]
103070856  c-X-C motif chemokine 6-like [KO:K05506]
103070573  PPBP; platelet basic protein [KO:K10029]
103086219  IL8; interleukin-8 [KO:K10030]
103074050  CXCL9; c-X-C motif chemokine 9 [KO:K05416]
103073775  CXCL10; c-X-C motif chemokine 10 [KO:K12671]
103078933  CXCL11; c-X-C motif chemokine 11 [KO:K12672]
103071897  stromal cell-derived factor 1-like isoform X1 [KO:K10031]
103077812  CXCL13; c-X-C motif chemokine 13 [KO:K10032]
103071943  CXCL16; c-X-C motif chemokine 16 [KO:K10035]
103072231  PF4; platelet factor 4 [KO:K05407]
103080787  CXCL14; c-X-C motif chemokine 14 [KO:K10033]
103091022  XCL1; lymphotactin [KO:K05507]
103070424  CX3CL1; fractalkine [KO:K05508]
103069631  c-C motif chemokine 1-like [KO:K05514]
103074707  CCL2; c-C motif chemokine 2 [KO:K14624]
103089570  c-C motif chemokine 3-like [KO:K05408]
103089296  CCL3; LOW QUALITY PROTEIN: chemokine (C-C motif) ligand 3 [KO:K05408]
103089823  CCL4; c-C motif chemokine 4 [KO:K12964]
103088500  CCL5; c-C motif chemokine 5 [KO:K12499]
103075456  c-C motif chemokine 8-like [KO:K16596]
103075002  CCL11; eotaxin isoform X1 [KO:K16597]
103088767  CCL14; LOW QUALITY PROTEIN: c-C motif chemokine 14 [KO:K21092]
103091148  CCL15; LOW QUALITY PROTEIN: c-C motif chemokine 15 [KO:K05511]
103080261  uncharacterized protein LOC103080261 [KO:K21083]
103072823  CCL19; c-C motif chemokine 19 [KO:K05512]
103081295  c-C motif chemokine 20-like isoform X1 [KO:K14625]
103072555  CCL21; c-C motif chemokine 21 [KO:K16062]
103070158  CCL22; c-C motif chemokine 22 [KO:K21095]
103084382  CCL24; c-C motif chemokine 24 [KO:K21097]
103081960  CCL25; c-C motif chemokine 25 [KO:K13072]
103082727  CCL26; c-C motif chemokine 26 [KO:K21096]
103082831  CCL27; LOW QUALITY PROTEIN: chemokine (C-C motif) ligand 27 [KO:K16598]
103085724  CCL28; c-C motif chemokine 28 [KO:K05513]
103068692  CXCR2; c-X-C chemokine receptor type 2 [KO:K05050]
103068417  c-X-C chemokine receptor type 2-like [KO:K04175]
103073320  CXCR3; c-X-C chemokine receptor type 3 [KO:K04188]
103073013  CXCR4; c-X-C chemokine receptor type 4 [KO:K04189]
103089170  CXCR5; c-X-C chemokine receptor type 5 [KO:K04190]
103080007  CXCR6; c-X-C chemokine receptor type 6 [KO:K04191]
103080560  XCR1; chemokine XC receptor 1 [KO:K04193]
103074557  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
103074832  CCR8; c-C chemokine receptor type 8 [KO:K04183]
103080243  CCR6; c-C chemokine receptor type 6 [KO:K04181]
103079746  CCR9; c-C chemokine receptor type 9 [KO:K04184]
103080618  CCR4; c-C chemokine receptor type 4 [KO:K04179]
103084456  CCR7; c-C chemokine receptor type 7 [KO:K04182]
103089757  CCR2; LOW QUALITY PROTEIN: c-C chemokine receptor type 2 [KO:K04177]
103081662  CCR5; c-C chemokine receptor type 5 [KO:K04180]
103080835  CCR1; c-C chemokine receptor type 1 [KO:K04176]
103081393  CCR3; c-C chemokine receptor type 3 [KO:K04178]
103072810  CCR10; c-C chemokine receptor type 10 [KO:K04185]
103076804  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
103081519  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
103069117  LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-like [KO:K11220]
103081732  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
103086495  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
103082258  STAT5B; LOW QUALITY PROTEIN: signal transducer and activator of transcription 5B [KO:K11224]
103080185  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
103077308  GNAI2; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
103081367  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
103081539  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
103084817  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
103076182  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
103075499  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
103091169  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
103075153  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
103078677  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
103085845  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
103070451  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
103077464  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103074112  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
103074440  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
103078130  HCK; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
103079693  FGR; tyrosine-protein kinase Fgr isoform X1 [KO:K08891] [EC:2.7.10.2]
103072342  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103074885  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
103088833  SHC2; SHC-transforming protein 2 [KO:K17447]
103078122  SHC3; SHC-transforming protein 3 [KO:K17448]
103088900  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
103079766  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103079242  SOS1; son of sevenless homolog 1 [KO:K03099]
103081084  SOS2; son of sevenless homolog 2-like [KO:K03099]
103076043  HRAS; GTPase HRas isoform X1 [KO:K02833]
103077579  KRAS; GTPase KRas [KO:K07827]
103068734  NRAS; GTPase NRas [KO:K07828]
103087933  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103079256  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
103082805  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
103070260  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103075543  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103089257  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103088756  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103085303  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103070370  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103078725  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103083960  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103069455  PIK3CG; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
103076917  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
103076642  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
103069979  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
103084975  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103076365  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103068921  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103084467  FOXO3; forkhead box protein O3 [KO:K09408]
103085220  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103088633  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103074882  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103069029  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103075864  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
103068644  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103087304  RELA; transcription factor p65 isoform X1 [KO:K04735]
103083608  BAD; bcl2 antagonist of cell death [KO:K02158]
103071307  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
103074757  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
103068755  ITK; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
103082841  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
103084985  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
103088874  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
103074749  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
103076541  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
103079514  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103072869  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
103088294  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
103073648  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
103074732  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
103082455  rho-associated protein kinase 1-like [KO:K04514] [EC:2.7.11.1]
103081507  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
103069235  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1 [KO:K04536]
103072092  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
103089752  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
103084472  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
103088923  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
103068747  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
103075748  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
103082839  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
103069500  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
103075492  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
103091114  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
103089745  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
103068686  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
103077256  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
103068413  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
103089724  guanine nucleotide-binding protein G(T) subunit gamma-T1-like [KO:K04548]
103068383  LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein-like [KO:K12365]
103074917  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
103078799  DOCK2; dedicator of cytokinesis protein 2 [KO:K12367]
103082438  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
103078515  PXN; paxillin-like isoform X1 [KO:K05760]
103077564  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
103087905  CRK; adapter molecule crk isoform X1 [KO:K04438]
103090463  CRKL; crk-like protein [KO:K04438]
103083166  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
103082420  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
103086280  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
103083884  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
103078639  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
103079287  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
103068930  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
103070997  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
103078201  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
103069239  RAP1A; ras-related protein Rap-1A [KO:K04353]
103088976  ras-related protein Rap-1b-like isoform X1 [KO:K07836]
103083426  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
103072473  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
103073449  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
103090549  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103073166  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
103072544  NCF1; neutrophil cytosol factor 1 [KO:K08011]
103084736  GRK7; LOW QUALITY PROTEIN: G protein-coupled receptor kinase 7 [KO:K00909] [EC:2.7.11.14]
103075679  GRK1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
103076247  ADRBK1; LOW QUALITY PROTEIN: beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
103073421  ADRBK2; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
103071087  GRK5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
103082340  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
103072843  ARRB1; beta-arrestin-1 [KO:K04439]
103072490  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
lve04010  MAPK signaling pathway
lve04060  Cytokine-cytokine receptor interaction
lve04120  Ubiquitin mediated proteolysis
lve04630  JAK-STAT signaling pathway
lve04670  Leukocyte transendothelial migration
lve04810  Regulation of actin cytoskeleton
KO pathway
ko04062   
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