KEGG   PATHWAY: mcal04015
Entry
mcal04015                   Pathway                                
Name
Rap1 signaling pathway - Mus caroli (Ryukyu mouse)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
mcal04015  Rap1 signaling pathway
mcal04015

Other DBs
GO: 0007264
Organism
Mus caroli (Ryukyu mouse) [GN:mcal]
Gene
110290796  Rap1a; ras-related protein Rap-1A [KO:K04353]
110303320  Rap1b; ras-related protein Rap-1b [KO:K07836]
110300983  Mras; ras-related protein M-Ras isoform X1 [KO:K07831]
110307233  Rapgef5; rap guanine nucleotide exchange factor 5 [KO:K08019]
110306465  Dock4; dedicator of cytokinesis protein 4 isoform X1 [KO:K17697]
110285719  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
110311574  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
110296148  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
110286675  calmodulin-alpha-like [KO:K02183]
110308577  Calml3; calmodulin-like protein 3 [KO:K02183]
110308601  calmodulin-4 [KO:K02183]
110286582  calmodulin [KO:K02183]
110306434  Calm1; calmodulin-1 [KO:K02183]
110302040  Calml4; calmodulin-like protein 4 isoform X2 [KO:K02183]
110297869  Calm3; calmodulin-3 [KO:K02183]
110294847  calmodulin-like [KO:K02183]
110312637  Calm2; calmodulin-2 [KO:K02183]
110308051  F2r; proteinase-activated receptor 1 [KO:K03914]
110300734  F2rl3; proteinase-activated receptor 4 [KO:K04236]
110291425  P2ry1; P2Y purinoceptor 1 [KO:K04270]
110284264  Fpr1; fMet-Leu-Phe receptor [KO:K04172]
110292580  Lpar1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
110300387  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
110291198  Lpar3; lysophosphatidic acid receptor 3 [KO:K04294]
110287196  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
110297038  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
110303741  Adora2a; adenosine receptor A2a [KO:K04266]
110305306  Adora2b; adenosine receptor A2b [KO:K04267]
110308282  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
110308334  neuroendocrine secretory protein 55 [KO:K04632]
110305998  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
110307661  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
110306494  Adcy3; adenylate cyclase type 3 isoform X2 [KO:K08043] [EC:4.6.1.1]
110309267  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
110311373  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
110310126  Adcy6; adenylate cyclase type 6 isoform X5 [KO:K08046] [EC:4.6.1.1]
110299719  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
110310371  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
110311555  Adcy9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
110310170  Rapgef3; rap guanine nucleotide exchange factor 3 isoform X2 [KO:K08014]
110289761  Rapgef4; rap guanine nucleotide exchange factor 4 isoform X3 [KO:K04351]
110285306  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
110285320  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
110290514  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
110286326  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
110308867  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
110312642  Rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
110285321  Rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
110291005  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
110284837  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
110291557  Fgf2; fibroblast growth factor 2 [KO:K18497]
110300580  Fgf20; fibroblast growth factor 20 [KO:K04358]
110295342  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
110285629  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
110287226  Fgf16; fibroblast growth factor 16 [KO:K04358]
110305760  Fgf18; fibroblast growth factor 18 [KO:K04358]
110308847  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
110303818  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
110309422  Fgf9; fibroblast growth factor 9 [KO:K04358]
110289950  Fgf7; fibroblast growth factor 7 [KO:K04358]
110296943  Fgf6; fibroblast growth factor 6 [KO:K04358]
110299316  Fgf4; fibroblast growth factor 4 [KO:K04358]
110299386  Fgf3; fibroblast growth factor 3 [KO:K04358]
110308330  Fgf10; fibroblast growth factor 10 [KO:K04358]
110299450  Fgf19; fibroblast growth factor 19 [KO:K22603]
110299358  Fgf21; fibroblast growth factor 21 [KO:K22429]
110297028  Fgf23; fibroblast growth factor 23 [KO:K22428]
110291584  Ngf; beta-nerve growth factor [KO:K02582]
110299132  insulin-2 [KO:K04526]
110286053  insulin-1 [KO:K04526]
110304009  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
110294651  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
110310626  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
110290924  Pdgfc; platelet-derived growth factor C [KO:K05450]
110301590  Pdgfd; platelet-derived growth factor D isoform X2 [KO:K05450]
110291496  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
110302981  Kitlg; kit ligand isoform X1 [KO:K05461]
110284402  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
110285510  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
110307029  Pgf; placenta growth factor [KO:K16859]
110287326  Vegfd; vascular endothelial growth factor D [KO:K05449]
110300171  Vegfc; vascular endothelial growth factor C [KO:K05449]
110294216  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
110310421  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
110300338  Angpt2; angiopoietin-2 [KO:K05466]
110290227  Angpt4; angiopoietin-4 [KO:K05467]
110303946  Efna2; ephrin-A2 [KO:K05462]
110291707  Efna1; ephrin-A1 [KO:K05462]
110283991  Efna5; ephrin-A5 isoform X1 [KO:K05462]
110291641  Efna3; ephrin-A3 isoform X1 [KO:K05462]
110291542  Efna4; ephrin-A4 isoform X2 [KO:K05462]
110304228  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
110299550  Fgfr1; fibroblast growth factor receptor 1 isoform X2 [KO:K04362] [EC:2.7.10.1]
110299396  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
110293909  Fgfr3; fibroblast growth factor receptor 3 isoform X8 [KO:K05094] [EC:2.7.10.1]
110307648  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
110305182  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
110300622  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
110297825  Igf1r; insulin-like growth factor 1 receptor isoform X2 [KO:K05087] [EC:2.7.10.1]
110295292  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
110284880  Pdgfrb; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
110285184  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
110294693  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
110294038  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
110304471  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
110294607  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
110295947  Met; hepatocyte growth factor receptor isoform X2 [KO:K05099] [EC:2.7.10.1]
110293136  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
110292090  Epha2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
110305233  Crk; adapter molecule crk isoform X1 [KO:K04438]
110311596  Crkl; crk-like protein [KO:K04438]
110309132  Rapgef1; rap guanine nucleotide exchange factor 1 isoform X2 [KO:K06277]
110299902  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform X2 [KO:K05726]
110300286  Cdh1; cadherin-1 [KO:K05689]
110301052  Ctnnb1; catenin beta-1 [KO:K02105]
110295719  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
110294002  Magi2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
110291899  Magi3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 [KO:K06112]
110290848  Rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
110304183  Rapgef6; rap guanine nucleotide exchange factor 6 isoform X4 [KO:K08020]
110298793  Lat; linker for activation of T-cells family member 1 [KO:K07362]
110310521  Fyb1; FYN-binding protein 1 isoform X1 [KO:K17698]
110305428  Lcp2; lymphocyte cytosolic protein 2 [KO:K07361]
110305536  Skap1; src kinase-associated phosphoprotein 1 isoform X2 [KO:K17699]
110290454  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
110304357  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110297826  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
110297763  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
110284070  Prkd3; serine/threonine-protein kinase D3 isoform X1 [KO:K06070] [EC:2.7.11.13]
110297421  Prkd2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
110306947  Prkd1; serine/threonine-protein kinase D1 [KO:K06070] [EC:2.7.11.13]
110301511  Drd2; D(2) dopamine receptor isoform X2 [KO:K04145]
110293089  Cnr1; cannabinoid receptor 1 [KO:K04277]
110290775  Gnai3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
110294623  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
110301809  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
110299754  Gnao1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
110292249  Rap1gap; rap1 GTPase-activating protein 1 isoform X4 [KO:K17700]
110306472  Sipa1l1; signal-induced proliferation-associated 1-like protein 1 isoform X1 [KO:K17701]
110285384  Sipa1; signal-induced proliferation-associated protein 1 [KO:K08013]
110299766  Sipa1l2; signal-induced proliferation-associated 1-like protein 2 isoform X1 [KO:K17702]
110297441  Sipa1l3; signal-induced proliferation-associated 1-like protein 3 [KO:K17703]
110289711  Id1; DNA-binding protein inhibitor ID-1 isoform X1 [KO:K04680]
110310932  Thbs1; thrombospondin-1 isoform X2 [KO:K16857]
110286147  Ralgds; ral guanine nucleotide dissociation stimulator isoform X6 [KO:K08732]
110308275  Rala; ras-related protein Ral-A [KO:K07834]
110291027  Ralb; ras-related protein Ral-B [KO:K07835]
110293965  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
110310226  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
110305163  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
110289676  Apbb1ip; amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704]
110302359  Tln2; talin-2 [KO:K06271]
110292364  Tln1; talin-1 isoform X4 [KO:K06271]
110304761  Itga2b; integrin alpha-IIb [KO:K06476]
110305072  Itgb3; integrin beta-3 [KO:K06493]
110307436  Pfn4; profilin-4 [KO:K05759]
110308017  Pfn3; profilin-3 [KO:K05759]
110287579  Pfn2; profilin-2 [KO:K05759]
110305574  Pfn1; profilin-1 [KO:K05759]
115030076  profilin-1-like [KO:K05759]
110297879  Vasp; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
110291342  Enah; protein enabled homolog isoform X2 [KO:K05746]
110306431  Evl; ena/VASP-like protein isoform X1 [KO:K23487]
110304283  Actg1; actin, cytoplasmic 2 [KO:K05692]
110295381  Actb; actin, cytoplasmic 1 [KO:K05692]
110284610  Arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X4 [KO:K12490]
110292411  transforming protein RhoA [KO:K04513]
110302438  Rhoa; transforming protein RhoA [KO:K04513]
110310031  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
110298769  Farp2; FERM, ARHGEF and pleckstrin domain-containing protein 2 [KO:K06082]
110292517  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
110310431  Vav2; guanine nucleotide exchange factor VAV2 isoform X2 [KO:K05730]
110312346  Vav1; proto-oncogene vav isoform X1 [KO:K05730]
110290661  Vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
110311394  Tiam1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
110300435  Pard3; partitioning defective 3 homolog isoform X7 [KO:K04237]
110287295  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
110299798  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
110284823  Pard6g; partitioning defective 6 homolog gamma isoform X1 [KO:K06093]
110292460  Prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
110290944  Prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
110284326  Afdn; afadin isoform X17 [KO:K05702]
110306307  Ctnnd1; catenin delta-1 [KO:K05690]
110294033  Krit1; krev interaction trapped protein 1 [KO:K17705]
110308386  Rgs14; regulator of G-protein signaling 14 isoform X1 [KO:K17706]
110293075  Rassf5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
110299482  Itgal; integrin alpha-L isoform X1 [KO:K05718]
110298307  Itgam; integrin alpha-M isoform X2 [KO:K06461]
110311769  integrin beta-2-like protein [KO:K06464]
110303281  Itgb2; integrin beta-2 [KO:K06464]
110299930  Itgb1; integrin beta-1 isoform X2 [KO:K05719]
110295945  Braf; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
110296919  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
110301502  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110303196  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
110297836  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110311382  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110304977  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
110304684  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
110312562  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
110310902  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
110310903  Mapk11; mitogen-activated protein kinase 11 isoform X2 [KO:K04441] [EC:2.7.11.24]
110312437  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
110290798  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110292183  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110301355  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
110308009  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110299855  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
110292624  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
110297609  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110294471  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110307022  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110285551  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5 [KO:K05860] [EC:3.1.4.11]
110297313  Hras; GTPase HRas isoform X2 [KO:K02833]
110296194  Kras; GTPase KRas isoform X1 [KO:K07827]
110290873  Nras; GTPase NRas [KO:K07828]
110298333  Rras; ras-related protein R-Ras [KO:K07829]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
mcal04010  MAPK signaling pathway
mcal04014  Ras signaling pathway
mcal04020  Calcium signaling pathway
mcal04151  PI3K-Akt signaling pathway
mcal04510  Focal adhesion
mcal04520  Adherens junction
mcal04660  T cell receptor signaling pathway
mcal04810  Regulation of actin cytoskeleton
KO pathway
ko04015   
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