KEGG   PATHWAY: mun04015
Entry
mun04015                    Pathway                                
Name
Rap1 signaling pathway - Meriones unguiculatus (Mongolian gerbil)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
mun04015  Rap1 signaling pathway
mun04015

Other DBs
GO: 0007264
Organism
Meriones unguiculatus (Mongolian gerbil) [GN:mun]
Gene
110549551  Rap1a; ras-related protein Rap-1A [KO:K04353]
110562151  Rap1b; ras-related protein Rap-1b [KO:K07836]
110548400  Mras; ras-related protein M-Ras [KO:K07831]
110551808  Rapgef5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
110562266  Dock4; dedicator of cytokinesis protein 4 isoform X1 [KO:K17697]
110556997  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
110561693  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
110561484  Calm1; calmodulin-1 [KO:K02183]
110562918  Calm2; calmodulin-2 [KO:K02183]
110552646  Calm3; calmodulin-3 [KO:K02183]
110550527  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
110560701  Calml3; calmodulin-like protein 3 [KO:K02183]
110560702  calmodulin-4-like [KO:K02183]
110551097  F2r; proteinase-activated receptor 1 [KO:K03914]
110563537  F2rl3; proteinase-activated receptor 4 [KO:K04236]
110566209  P2ry1; P2Y purinoceptor 1 [KO:K04270]
110554214  Lpar1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
110549164  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
110558300  Lpar3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
110541171  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
110548577  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
110553862  Adora2a; adenosine receptor A2a [KO:K04266]
110549785  Adora2b; adenosine receptor A2b [KO:K04267]
110563608  neuroendocrine secretory protein 55-like [KO:K04632]
110555169  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
110550962  Adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
110555185  Adcy3; adenylate cyclase type 3 isoform X3 [KO:K08043] [EC:4.6.1.1]
110556521  Adcy4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
110547229  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
110559444  Adcy6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
110560723  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
110561696  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
110545944  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
110546167  Rapgef3; rap guanine nucleotide exchange factor 3 [KO:K08014]
110554362  Rapgef4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
110562511  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
110563159  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
110555720  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
110551595  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
110550598  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
110562664  Rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
110549343  Rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
110553196  Egf; pro-epidermal growth factor [KO:K04357]
110559286  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
110545886  Fgf2; fibroblast growth factor 2 [KO:K18497]
110546548  Fgf4; fibroblast growth factor 4 [KO:K04358]
110549737  Fgf9; fibroblast growth factor 9 [KO:K04358]
110547817  Fgf18; fibroblast growth factor 18 [KO:K04358]
110546441  Fgf3; fibroblast growth factor 3 [KO:K04358]
110548616  Fgf6; fibroblast growth factor 6 [KO:K04358]
110550451  Fgf10; fibroblast growth factor 10 [KO:K04358]
110556776  Fgf8; fibroblast growth factor 8 isoform X4 [KO:K04358]
110551350  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
110550525  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
110560157  Fgf7; fibroblast growth factor 7 isoform X1 [KO:K04358]
110564316  Fgf20; fibroblast growth factor 20 [KO:K04358]
110539533  Fgf16; fibroblast growth factor 16 [KO:K04358]
110546517  Fgf19; fibroblast growth factor 19 [KO:K22603]
110550501  Fgf21; fibroblast growth factor 21 [KO:K22429]
110548635  Fgf23; fibroblast growth factor 23 [KO:K22428]
110564378  Ngf; beta-nerve growth factor [KO:K02582]
110547298  Ins; insulin [KO:K04526]
110561622  Igf1; insulin-like growth factor I isoform X5 [KO:K05459]
110550699  Pdgfa; platelet-derived growth factor subunit A isoform X3 [KO:K04359]
110557819  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
110540260  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
110542507  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
110545505  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
110559281  Kitlg; kit ligand isoform X1 [KO:K05461]
110550366  Vegfa; vascular endothelial growth factor A, long form isoform X3 [KO:K05448]
110551598  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
110546968  Pgf; placenta growth factor [KO:K16859]
110539385  Vegfd; vascular endothelial growth factor D isoform X3 [KO:K05449]
110542126  Vegfc; vascular endothelial growth factor C [KO:K05449]
110565312  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
110552616  Angpt1; angiopoietin-1 isoform X2 [KO:K05465]
110559352  Angpt2; angiopoietin-2 [KO:K05466]
110555822  Angpt4; angiopoietin-4 isoform X1 [KO:K05467]
110550381  ephrin-A3 isoform X1 [KO:K05462]
110551766  Efna5; ephrin-A5 isoform X1 [KO:K05462]
110552024  Efna1; ephrin-A1 isoform X1 [KO:K05462]
110551374  Efna2; ephrin-A2 [KO:K05462]
110539539  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
110563307  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
110554946  Fgfr2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
110557305  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
110549775  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
110551211  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
110547261  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
110558105  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
110546695  Pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
110546688  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
110565064  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
110547372  Flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
110556944  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
110558703  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
110552526  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
110543906  Epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
110547367  Crk; adapter molecule crk isoform X1 [KO:K04438]
110559213  Crkl; crk-like protein [KO:K04438]
110552091  Rapgef1; rap guanine nucleotide exchange factor 1 isoform X22 [KO:K06277]
110554744  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform X4 [KO:K05726]
110545977  Cdh1; cadherin-1 [KO:K05689]
110561755  Ctnnb1; catenin beta-1 [KO:K02105]
110545672  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
110558629  Magi2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
110546986  Magi3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1 [KO:K06112]
110564013  Rapgef2; rap guanine nucleotide exchange factor 2 isoform X7 [KO:K08018]
110548013  Lat; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
110563626  Fyb1; FYN-binding protein 1 isoform X2 [KO:K17698]
110545366  Lcp2; lymphocyte cytosolic protein 2 isoform X3 [KO:K07361]
110551428  Skap1; src kinase-associated phosphoprotein 1 isoform X2 [KO:K17699]
110552794  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
110555335  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110559612  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
110556016  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
110547071  Prkd3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
110552643  Prkd2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
110539497  Prkd1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
110546462  Drd2; D(2) dopamine receptor isoform X1 [KO:K04145]
110547363  Cnr1; cannabinoid receptor 1 [KO:K04277]
110539607  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
110545517  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
110564775  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
110561150  Gnao1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
110545006  Rap1gap; rap1 GTPase-activating protein 1 isoform X1 [KO:K17700]
110558715  Sipa1l1; signal-induced proliferation-associated 1-like protein 1 isoform X1 [KO:K17701]
110549335  Sipa1; signal-induced proliferation-associated protein 1 [KO:K08013]
110555273  Sipa1l2; signal-induced proliferation-associated 1-like protein 2 isoform X1 [KO:K17702]
110565542  Id1; DNA-binding protein inhibitor ID-1 [KO:K04680]
110564049  Thbs1; thrombospondin-1 isoform X1 [KO:K16857]
110549995  Ralgds; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
110545330  Rala; ras-related protein Ral-A [KO:K07834]
110546412  Ralb; ras-related protein Ral-B [KO:K07835]
110557417  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110548466  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
110548820  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
110559256  Apbb1ip; LOW QUALITY PROTEIN: amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704]
110561879  Tln1; talin-1 isoform X2 [KO:K06271]
110549282  Tln2; talin-2 isoform X1 [KO:K06271]
110551893  Itga2b; integrin alpha-IIb isoform X1 [KO:K06476]
110545659  Itgb3; integrin beta-3 [KO:K06493]
110549768  Pfn3; profilin-3 [KO:K05759]
110542950  profilin-2-like [KO:K05759]
110553183  Pfn4; profilin-4 [KO:K05759]
110554227  Pfn2; profilin-2 isoform X1 [KO:K05759]
110557321  Pfn1; profilin-1 [KO:K05759]
110551519  Vasp; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
110546662  Enah; protein enabled homolog isoform X7 [KO:K05746]
110551783  Evl; ena/VASP-like protein isoform X2 [KO:K23487]
110548804  Actg1; actin, cytoplasmic 2 [KO:K05692]
110558188  Actb; actin, cytoplasmic 1 [KO:K05692]
110557094  Arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
110540728  transforming protein RhoA-like isoform X1 [KO:K04513]
110565123  Rhoa; transforming protein RhoA isoform X2 [KO:K04513]
110566227  Src; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
110545730  Farp2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1 [KO:K06082]
110545010  Cdc42; cell division control protein 42 homolog isoform X2 [KO:K04393]
110557506  Vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
110545611  Vav1; proto-oncogene vav isoform X1 [KO:K05730]
110547752  Vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
110557645  Tiam1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
110554854  Pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
110548902  Pard6b; partitioning defective 6 homolog beta isoform X2 [KO:K06093]
110550266  Pard6g; partitioning defective 6 homolog gamma isoform X1 [KO:K06093]
110546243  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
110559875  Prkcz; protein kinase C zeta type isoform X3 [KO:K18952] [EC:2.7.11.13]
110545685  Prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
110552572  Afdn; afadin isoform X15 [KO:K05702]
110551976  Ctnnd1; catenin delta-1 isoform X1 [KO:K05690]
110562983  Krit1; krev interaction trapped protein 1 [KO:K17705]
110549764  Rgs14; regulator of G-protein signaling 14 isoform X1 [KO:K17706]
110550325  Rassf5; ras association domain-containing protein 5 isoform X4 [KO:K08015]
110548001  Itgal; integrin alpha-L isoform X1 [KO:K05718]
110564544  Itgam; integrin alpha-M [KO:K06461]
110545086  Itgb2; integrin beta-2 [KO:K06464]
110554841  Itgb1; integrin beta-1 isoform X2 [KO:K05719]
110545779  Braf; serine/threonine-protein kinase B-raf isoform X8 [KO:K04365] [EC:2.7.11.1]
110550814  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
110559000  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110555605  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
110553796  Mapk1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
110547978  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110561677  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
110563015  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
110546562  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
110546585  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
110549680  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
110549673  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
110565112  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110556252  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110548394  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110553683  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110549145  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110563512  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110556719  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110558966  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110564898  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110566524  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
110553931  Hras; GTPase HRas isoform X1 [KO:K02833]
110558913  Kras; GTPase KRas isoform X1 [KO:K07827]
110544642  GTPase NRas [KO:K07828]
110544765  Nras; GTPase NRas [KO:K07828]
110546864  Rras; ras-related protein R-Ras isoform X1 [KO:K07829]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
mun04010  MAPK signaling pathway
mun04014  Ras signaling pathway
mun04020  Calcium signaling pathway
mun04151  PI3K-Akt signaling pathway
mun04510  Focal adhesion
mun04520  Adherens junction
mun04660  T cell receptor signaling pathway
mun04810  Regulation of actin cytoskeleton
KO pathway
ko04015   
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