KEGG   PATHWAY: mun04014
Entry
mun04014                    Pathway                                
Name
Ras signaling pathway - Meriones unguiculatus (Mongolian gerbil)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
mun04014  Ras signaling pathway
mun04014

Other DBs
GO: 0032318
Organism
Meriones unguiculatus (Mongolian gerbil) [GN:mun]
Gene
110553196  Egf; pro-epidermal growth factor [KO:K04357]
110547163  Tgfa; protransforming growth factor alpha [KO:K08774]
110559286  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
110545886  Fgf2; fibroblast growth factor 2 [KO:K18497]
110546548  Fgf4; fibroblast growth factor 4 [KO:K04358]
110549737  Fgf9; fibroblast growth factor 9 [KO:K04358]
110547817  Fgf18; fibroblast growth factor 18 [KO:K04358]
110546441  Fgf3; fibroblast growth factor 3 [KO:K04358]
110548616  Fgf6; fibroblast growth factor 6 [KO:K04358]
110550451  Fgf10; fibroblast growth factor 10 [KO:K04358]
110556776  Fgf8; fibroblast growth factor 8 isoform X4 [KO:K04358]
110551350  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
110550525  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
110560157  Fgf7; fibroblast growth factor 7 isoform X1 [KO:K04358]
110564316  Fgf20; fibroblast growth factor 20 [KO:K04358]
110539533  Fgf16; fibroblast growth factor 16 [KO:K04358]
110546517  Fgf19; fibroblast growth factor 19 [KO:K22603]
110550501  Fgf21; fibroblast growth factor 21 [KO:K22429]
110548635  Fgf23; fibroblast growth factor 23 [KO:K22428]
110564378  Ngf; beta-nerve growth factor [KO:K02582]
110564258  Bdnf; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
110545561  Ntf3; neurotrophin-3 [KO:K04356]
110560656  Ntf4; neurotrophin-4 [KO:K12457]
110547298  Ins; insulin [KO:K04526]
110561622  Igf1; insulin-like growth factor I isoform X5 [KO:K05459]
110546690  Igf2; insulin-like growth factor II isoform X1 [KO:K13769]
110550699  Pdgfa; platelet-derived growth factor subunit A isoform X3 [KO:K04359]
110557819  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
110540260  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
110542507  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
110545505  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
110559281  Kitlg; kit ligand isoform X1 [KO:K05461]
110550366  Vegfa; vascular endothelial growth factor A, long form isoform X3 [KO:K05448]
110551598  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
110546968  Pgf; placenta growth factor [KO:K16859]
110539385  Vegfd; vascular endothelial growth factor D isoform X3 [KO:K05449]
110542126  Vegfc; vascular endothelial growth factor C [KO:K05449]
110565312  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
110552616  Angpt1; angiopoietin-1 isoform X2 [KO:K05465]
110559352  Angpt2; angiopoietin-2 [KO:K05466]
110555822  Angpt4; angiopoietin-4 isoform X1 [KO:K05467]
110550381  ephrin-A3 isoform X1 [KO:K05462]
110551766  Efna5; ephrin-A5 isoform X1 [KO:K05462]
110552024  Efna1; ephrin-A1 isoform X1 [KO:K05462]
110551374  Efna2; ephrin-A2 [KO:K05462]
110539539  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
110563307  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
110554946  Fgfr2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
110557305  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
110549775  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
110551211  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
110564977  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
110565075  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
110547261  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
110558105  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
110546695  Pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
110546688  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
110565064  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
110547372  Flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
110556944  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
110558703  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
110552526  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
110543906  Epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
110547825  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
110555404  Gab1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
110547318  Gab2; GRB2-associated-binding protein 2 [KO:K08091]
110551574  Shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
110551355  Shc2; SHC-transforming protein 2 isoform X4 [KO:K17447]
110559069  Shc3; SHC-transforming protein 3 [KO:K17448]
110550937  Shc4; SHC-transforming protein 4 [KO:K17449]
110546380  Ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
110547073  Sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
110556913  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110552794  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
110550263  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
110565085  Rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350]
110549343  Rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
110562664  Rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
110552560  Rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
110545437  tyrosine-protein kinase ZAP-70 [KO:K07360] [EC:2.7.10.2]
110548013  Lat; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
110545270  Htr7; 5-hydroxytryptamine receptor 7 isoform X2 [KO:K04163]
110559917  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
110556769  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
110548560  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
110556251  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
110545481  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
110557636  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
110557460  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
110558140  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
110540240  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
110555606  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
110552633  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
110557441  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
110565823  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
110545821  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
110558424  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
110548730  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
110565822  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
110553430  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
110545842  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110555016  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
110549494  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
110565729  Rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
110556997  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
110561693  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
110561484  Calm1; calmodulin-1 [KO:K02183]
110562918  Calm2; calmodulin-2 [KO:K02183]
110552646  Calm3; calmodulin-3 [KO:K02183]
110550527  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
110560701  Calml3; calmodulin-like protein 3 [KO:K02183]
110560702  calmodulin-4-like [KO:K02183]
110553931  Hras; GTPase HRas isoform X1 [KO:K02833]
110558913  Kras; GTPase KRas isoform X1 [KO:K07827]
110544642  GTPase NRas [KO:K07828]
110544765  Nras; GTPase NRas [KO:K07828]
110548400  Mras; ras-related protein M-Ras [KO:K07831]
110546864  Rras; ras-related protein R-Ras isoform X1 [KO:K07829]
110556050  Rras2; ras-related protein R-Ras2 [KO:K07830]
110550150  Nf1; neurofibromin isoform X1 [KO:K08052]
110564462  Rasa1; ras GTPase-activating protein 1 [KO:K04352]
110555293  Rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
110562003  Rasa3; ras GTPase-activating protein 3 isoform X2 [KO:K12380]
110557246  Rasa4b; ras GTPase-activating protein 4B isoform X2 [KO:K17630]
110543624  Syngap1; ras/Rap GTPase-activating protein SynGAP isoform X1 [KO:K17631]
110546401  Rasal1; rasGAP-activating-like protein 1 isoform X1 [KO:K17632]
110551815  Rasal2; ras GTPase-activating protein nGAP isoform X1 [KO:K17633]
110548905  Rasal3; RAS protein activator like-3 isoform X2 [KO:K17634]
110564633  Rassf1; ras association domain-containing protein 1 isoform X2 [KO:K09850]
110550325  Rassf5; ras association domain-containing protein 5 isoform X4 [KO:K08015]
110548224  Stk4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
110557645  Tiam1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
110557417  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110548466  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
110548820  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
110547315  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
110553293  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
110541384  Pak3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
110552542  Pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
110540522  Pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
110550597  Pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
110540728  transforming protein RhoA-like isoform X1 [KO:K04513]
110565123  Rhoa; transforming protein RhoA isoform X2 [KO:K04513]
110565112  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110556252  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110548394  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110553683  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110549145  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110563512  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110556719  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110558966  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110564898  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110562528  Ikbkg; NF-kappa-B essential modulator isoform X3 [KO:K07210]
110552966  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
110544653  LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
110556613  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
110558602  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
110549347  Rela; transcription factor p65 isoform X1 [KO:K04735]
110551603  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
110550083  Bcl2l1; bcl-2-like protein 1 isoform X1 [KO:K04570]
110564659  Foxo4; forkhead box protein O4 [KO:K12358]
110556827  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
110545460  Ralgapa2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
110559550  Ralgapa1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
110566014  Ralgapb; ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
110549995  Ralgds; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
110546193  Rgl1; ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
110543519  Rgl2; ral guanine nucleotide dissociation stimulator-like 2 [KO:K17636]
110545330  Rala; ras-related protein Ral-A [KO:K07834]
110546412  Ralb; ras-related protein Ral-B [KO:K07835]
110553679  Pld1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
110557322  Pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
110558158  Exoc2; exocyst complex component 2 [KO:K17637]
110549049  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
110539751  Rel; proto-oncogene c-Rel isoform X1 [KO:K09254]
110552285  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110557386  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110562875  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110558555  Ralbp1; ralA-binding protein 1 [KO:K08773]
110545010  Cdc42; cell division control protein 42 homolog isoform X2 [KO:K04393]
110552572  Afdn; afadin isoform X15 [KO:K05702]
110555628  Shoc2; leucine-rich repeat protein SHOC-2 [KO:K19613]
110550814  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
110559000  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110555605  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
110553796  Mapk1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
110547978  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110555393  Pla1a; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
110545600  Pla2g1b; phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
110553222  Pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110544978  Pla2g2c; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110544979  Pla2g2f; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110544980  Pla2g2d; group IID secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
110544988  Pla2g2a; phospholipase A2, membrane associated isoform X3 [KO:K01047] [EC:3.1.1.4]
110544989  Pla2g5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
110556844  group 10 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
110557689  Pla2g3; group 3 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
110566324  Pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
110544984  Pla2g2e; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110553491  Pla2g4a; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
110554759  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X2 [KO:K16342] [EC:3.1.1.4]
110554765  Pla2g4d; LOW QUALITY PROTEIN: cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
110554773  Pla2g4f; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
110554755  Pla2g4b; cytosolic phospholipase A2 beta isoform X2 [KO:K16342] [EC:3.1.1.4]
110566433  Pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
110551614  phospholipase A and acyltransferase 3 isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
110543001  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
110557309  Ets1; protein C-ets-1 isoform X2 [KO:K02678]
110562473  Ets2; protein C-ets-2 [KO:K21932]
110546393  Brap; BRCA1-associated protein isoform X1 [KO:K10632] [EC:2.3.2.27]
110550133  Ksr1; kinase suppressor of Ras 1 isoform X2 [KO:K14958]
110551892  Ksr2; kinase suppressor of Ras 2 isoform X1 [KO:K18529] [EC:2.7.11.1]
110551808  Rapgef5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
110549551  Rap1a; ras-related protein Rap-1A [KO:K04353]
110562151  Rap1b; ras-related protein Rap-1b [KO:K07836]
110566524  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
110555335  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110559612  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
110556016  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
110556482  Rin1; ras and Rab interactor 1 isoform X1 [KO:K17638]
110558915  Abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
110563282  Abl2; tyrosine-protein kinase ABL2 isoform X2 [KO:K08887] [EC:2.7.10.2]
110565695  Rab5a; ras-related protein Rab-5A isoform X1 [KO:K07887]
110559387  Rab5b; ras-related protein Rab-5B [KO:K07888]
110550900  Rab5c; ras-related protein Rab-5C [KO:K07889]
110556916  Arf6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
mun04010  MAPK signaling pathway
mun04015  Rap1 signaling pathway
mun04020  Calcium signaling pathway
mun04144  Endocytosis
mun04151  PI3K-Akt signaling pathway
mun04660  T cell receptor signaling pathway
mun04720  Long-term potentiation
mun04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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