KEGG   PATHWAY: nasi04510
Entry
nasi04510                   Pathway                                
Name
Focal adhesion - Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
nasi04510  Focal adhesion
nasi04510

Other DBs
GO: 0005925
Organism
Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise) [GN:nasi]
Gene
112399950  COL1A1; collagen alpha-1(I) chain [KO:K06236]
112414553  COL1A2; collagen alpha-2(I) chain [KO:K06236]
112394308  COL2A1; collagen alpha-1(II) chain [KO:K19719]
112402080  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
112402095  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
112396748  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
112396749  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
112405545  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
112405565  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
112404694  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
112401495  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
112401501  collagen alpha-6(VI) chain [KO:K06238]
112408631  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
112408657  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
112395527  COL9A2; LOW QUALITY PROTEIN: collagen alpha-2(IX) chain [KO:K08131]
112403050  COL9A3; LOW QUALITY PROTEIN: collagen alpha-3(IX) chain [KO:K08131]
112405930  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
112409100  LAMA2; laminin subunit alpha-2 [KO:K05637]
112412147  LAMA1; laminin subunit alpha-1 [KO:K05637]
112402951  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
112408327  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
112396971  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
112397922  LAMB1; laminin subunit beta-1 [KO:K05636]
112394660  LAMB2; laminin subunit beta-2 [KO:K06243]
112403506  LAMB3; laminin subunit beta-3 [KO:K06244]
112391177  LAMC1; laminin subunit gamma-1 [KO:K05635]
112391277  LAMC2; laminin subunit gamma-2 [KO:K06246]
112411540  LAMC3; laminin subunit gamma-3 [KO:K06247]
112400522  CHAD; chondroadherin [KO:K06248]
112395038  RELN; reelin [KO:K06249] [EC:3.4.21.-]
112391175  THBS1; thrombospondin-1 [KO:K16857]
112399630  THBS2; thrombospondin-2 [KO:K04659]
112406748  THBS4; thrombospondin-4 [KO:K04659]
112414728  COMP; cartilage oligomeric matrix protein [KO:K04659]
112401735  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
112411833  FN1; fibronectin isoform X1 [KO:K05717]
112393839  SPP1; osteopontin [KO:K06250]
112394473  VTN; vitronectin [KO:K06251]
112395435  TNXB; tenascin-X isoform X1 [KO:K06252]
112411497  TNC; tenascin isoform X1 [KO:K06252]
112408944  TNR; tenascin-R [KO:K06252]
112408954  TNN; tenascin-N [KO:K06252]
112391767  VWF; von Willebrand factor [KO:K03900]
112393811  IBSP; bone sialoprotein 2 [KO:K06253]
112396545  ITGA1; integrin alpha-1 [KO:K06480]
112396551  ITGA2; integrin alpha-2 [KO:K06481]
112410314  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
112398462  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
112414149  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
112393994  ITGA5; integrin alpha-5 [KO:K06484]
112391504  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
112394129  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
112402880  ITGA8; integrin alpha-8 [KO:K06584]
112407165  ITGA9; integrin alpha-9 [KO:K06585]
112391349  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
112401332  ITGA11; integrin alpha-11 [KO:K06587]
112403267  ITGAV; integrin alpha-V [KO:K06487]
112413437  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
112410352  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
112410370  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
112407275  ITGB5; integrin beta-5 [KO:K06588]
112393605  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
112394105  ITGB7; integrin beta-7 [KO:K06590]
112395332  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
112399169  EMP2; epithelial membrane protein 2 [KO:K26256]
112412068  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
112410849  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
112400383  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
112415757  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
112397683  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
112391070  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
112413893  VEGFA; vascular endothelial growth factor A [KO:K05448]
112401987  VEGFB; vascular endothelial growth factor B [KO:K16858]
112394889  PGF; placenta growth factor isoform X1 [KO:K16859]
112399152  VEGFD; vascular endothelial growth factor D [KO:K05449]
112399668  VEGFC; vascular endothelial growth factor C [KO:K05449]
112404733  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
112400744  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
112391109  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
112390977  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
112400779  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
112412693  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
112406568  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
112413371  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
112408223  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
112398419  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
112391622  EMP1; epithelial membrane protein 1 [KO:K26255]
112398489  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
112415395  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
112397736  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
112395211  RHOA; transforming protein RhoA [KO:K04513]
112404448  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
112408295  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
112394771  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
112408795  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
112399693  MYL5; myosin light chain 5 [KO:K12753]
112399810  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
112398590  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
112399982  MYL10; myosin regulatory light chain 10 [KO:K12756]
112409044  myosin regulatory light polypeptide 9 [KO:K12757]
112409045  myosin regulatory light chain 12B [KO:K12757]
112399355  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
112402102  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
112408799  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
112390556  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
112394349  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
112402620  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
112406444  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
112397587  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
112404252  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
112398570  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
112407282  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
112396291  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
112411617  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
112392537  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
112410217  ACTG1; actin, cytoplasmic 2 [KO:K05692]
112412020  ACTB; actin, cytoplasmic 1 [KO:K05692]
112398263  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
112403123  CAPN2; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
112396096  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
112392202  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
112411700  TLN1; talin-1 [KO:K06271]
112393160  TLN2; talin-2 [KO:K06271]
112397759  FLNA; filamin-A isoform X1 [KO:K04437]
112400547  FLNB; filamin-B isoform X1 [KO:K27392]
112397371  PXN; paxillin isoform X1 [KO:K05760]
112407651  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
112408441  ZYX; zyxin [KO:K06273]
112415274  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
112396989  VCL; vinculin isoform X1 [KO:K05700]
112407718  PARVA; alpha-parvin [KO:K06275]
112394666  PARVB; beta-parvin isoform X1 [KO:K06275]
112394670  PARVG; gamma-parvin isoform X1 [KO:K06275]
112409350  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
112405757  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112408453  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112415459  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112415982  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
112405503  CTNNB1; catenin beta-1 [KO:K02105]
112410312  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112399411  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
112397907  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
112397030  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
112402798  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112403325  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112406349  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112404930  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112400438  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112414874  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112399575  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112397808  guanine nucleotide exchange factor VAV3-like [KO:K05730]
112411268  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
112400141  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
112399896  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
112410787  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
112410198  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
112402658  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
112404283  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
112411416  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
112415644  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
112412521  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
112391204  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
112414286  CDC42; cell division control protein 42 homolog [KO:K04393]
112393343  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
112412224  CRKL; crk-like protein [KO:K04438]
112392998  CRK; adapter molecule crk isoform X1 [KO:K04438]
112403852  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
112411538  RAPGEF1; rap guanine nucleotide exchange factor 1 [KO:K06277]
112413011  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
112393952  RAP1B; LOW QUALITY PROTEIN: ras-related protein Rap-1b [KO:K07836]
112407608  ras-related protein Rap-1b-like [KO:K07836]
112395723  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112412478  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112413113  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112407080  JUN; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
112398096  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
112408233  CAV1; caveolin-1 isoform X1 [KO:K06278]
112408234  CAV2; caveolin-2 [KO:K12958]
112396781  CAV3; caveolin-3 [KO:K12959]
112396968  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
112401764  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
112396342  SHC2; SHC-transforming protein 2 [KO:K17447]
112390850  SHC3; SHC-transforming protein 3 [KO:K17448]
112402165  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
112410317  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
112405189  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
112391586  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
112402519  HRAS; GTPase HRas isoform X1 [KO:K02833]
112407243  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112393112  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112412232  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112399342  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
112402600  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
112402178  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
112391672  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
112413996  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
112409959  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
112409963  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
112401089  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
112402326  BAD; bcl2-associated agonist of cell death [KO:K02158]
112406137  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
nasi04010  MAPK signaling pathway
nasi04060  Cytokine-cytokine receptor interaction
nasi04070  Phosphatidylinositol signaling system
nasi04110  Cell cycle
nasi04151  PI3K-Akt signaling pathway
nasi04310  Wnt signaling pathway
nasi04512  ECM-receptor interaction
nasi04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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