KEGG   PATHWAY: pkl05164
Entry
pkl05164                    Pathway                                
Name
Influenza A - Pipistrellus kuhlii (Kuhl's pipistrelle)
Description
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class
Human Diseases; Infectious disease: viral
Pathway map
pkl05164  Influenza A
pkl05164

Organism
Pipistrellus kuhlii (Kuhl's pipistrelle) [GN:pkl]
Gene
118731552  tryptase-like [KO:K01340] [EC:3.4.21.59]
118731553  tryptase beta-2-like [KO:K01340] [EC:3.4.21.59]
118731556  tryptase beta-2-like [KO:K01340] [EC:3.4.21.59]
118705887  PLG; plasminogen [KO:K01315] [EC:3.4.21.7]
118714134  cationic trypsin-3 [KO:K01312] [EC:3.4.21.4]
118714152  anionic trypsin [KO:K01312] [EC:3.4.21.4]
118723981  TMPRSS2; transmembrane protease serine 2 [KO:K09633] [EC:3.4.21.122]
118713382  TMPRSS4; transmembrane protease serine 4 isoform X1 [KO:K09635] [EC:3.4.21.-]
118710130  transmembrane protease serine 11D-like [KO:K09641] [EC:3.4.21.-]
118731558  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
118719718  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
118719719  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
118725488  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
118703083  2'-5'-oligoadenylate synthase 1-like isoform X1 [KO:K14216] [EC:2.7.7.84]
118721312  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
118706495  DNAJB1; dnaJ homolog subfamily B member 1 [KO:K09507]
118730734  DNAJC3; dnaJ homolog subfamily C member 3 isoform X1 [KO:K09523]
118717741  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
118716512  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
118728033  TRIM25; E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:2.3.2.27]
118716422  DDX58; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
118709529  IFIH1; interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]
118710571  NLRX1; NLR family member X1 [KO:K12653]
118707494  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
118719404  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118728482  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118706407  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118702448  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
118726764  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
118703354  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118706879  RELA; transcription factor p65 isoform X1 [KO:K04735]
118726533  CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348]
118730097  TLR3; toll-like receptor 3 [KO:K05401]
118731340  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
118714100  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
118730716  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
118721500  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
118712200  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
118703341  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
118728280  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
118716098  TLR4; toll-like receptor 4 [KO:K10160]
118719932  TLR7; toll-like receptor 7 [KO:K05404]
118715489  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
118728234  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
118717964  IRF7; LOW QUALITY PROTEIN: interferon regulatory factor 7 [KO:K09447]
118717645  IL1A; interleukin-1 alpha [KO:K04383]
118717646  IL1B; interleukin-1 beta isoform X1 [KO:K04519]
118714203  IL6; interleukin-6 [KO:K05405]
118722291  IL12A; interleukin-12 subunit alpha [KO:K05406]
118710699  IL12B; interleukin-12 subunit beta [KO:K05425]
118716986  TNF; tumor necrosis factor [KO:K03156]
118709059  CXCL8; interleukin-8 [KO:K10030]
118728099  C-C motif chemokine 2-like isoform X1 [KO:K14624]
118728100  C-C motif chemokine 2-like [KO:K14624]
118726321  CCL5; C-C motif chemokine 5 [KO:K12499]
118705071  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
118731218  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
118716770  IFNB1; interferon beta [KO:K05415]
118716063  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
118716053  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
118724308  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
118731195  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
118704555  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
118709492  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
118729130  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
118725866  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
118723199  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
118723200  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
118721102  ADAR; double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
118728971  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
118729249  IFNG; interferon gamma [KO:K04687]
118705949  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
118716064  IFNGR2; interferon gamma receptor 2 [KO:K05133]
118716550  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
118703428  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
118705668  SLA class II histocompatibility antigen, DQ haplotype D alpha chain isoform X1 [KO:K06752]
118705669  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X1 [KO:K06752]
118705670  DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752]
118705671  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
118705672  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
118705673  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
118705674  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
118705675  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
118705676  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
118706033  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
118706034  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
118726063  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
118704942  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
118712991  IL18; interleukin-18 isoform X1 [KO:K05482]
118716565  IL33; LOW QUALITY PROTEIN: interleukin-33 [KO:K12967]
118703803  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118722550  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
118725879  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
118722506  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118715291  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118731984  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118727672  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118714856  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118702383  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118705228  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
118730275  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
118714298  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
118722395  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
118721567  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
118719270  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
118728672  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
118713371  FADD; FAS-associated death domain protein [KO:K02373]
118709494  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
118728790  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
118712174  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
118705679  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
118710789  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
118722102  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
118714365  ADP/ATP translocase 3-like [KO:K05863]
118714494  ADP/ATP translocase 2-like [KO:K05863]
118730509  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
118711361  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
118727795  cytochrome c [KO:K08738]
118717745  cytochrome c-like [KO:K08738]
118729137  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
118724633  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
118729116  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
118702155  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404]
118703240  CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404]
118720864  PABPN1L; LOW QUALITY PROTEIN: embryonic polyadenylate-binding protein 2 [KO:K14396]
118725335  polyadenylate-binding protein 2 isoform X1 [KO:K14396]
118720236  nuclear RNA export factor 2-like [KO:K14284]
118720237  NXF3; nuclear RNA export factor 3 [KO:K14284]
118720243  nuclear RNA export factor 2-like [KO:K14284]
118720245  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
118720246  nuclear RNA export factor 2-like [KO:K14284]
118707227  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
118728189  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
118707471  NXT1; NTF2-related export protein 1 [KO:K14285]
118702300  HNRNPUL1; heterogeneous nuclear ribonucleoprotein U-like protein 1 [KO:K15047]
118707785  RAE1; mRNA export factor isoform X1 [KO:K14298]
118713430  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
118714851  RSAD2; radical S-adenosyl methionine domain-containing protein 2 [KO:K15045]
118721633  FDPS; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
118726595  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118715231  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118731837  LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
118719104  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
118731359  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
118704886  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
118725266  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
118704529  ACTG1; actin, cytoplasmic 2 [KO:K05692]
118710780  ACTB; actin, cytoplasmic 1 [KO:K05692]
118719424  RAB11A; ras-related protein Rab-11A isoform X1 [KO:K07904]
118725836  RAB11B; ras-related protein Rab-11B isoform X1 [KO:K07905]
118717401  XPO1; exportin-1 isoform X1 [KO:K14290]
118724389  KPNA1; importin subunit alpha-5 isoform X1 [KO:K23940]
118726317  KPNA2; importin subunit alpha-1 isoform X1 [KO:K15043]
118710753  KPNA7; importin subunit alpha-8 [KO:K15043]
118705277  KPNA5; importin subunit alpha-6 [KO:K15042]
118723750  KPNA6; importin subunit alpha-7 [KO:K15042]
Compound
C00027  Hydrogen peroxide
C00080  H+
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24225499
  Authors
Edinger TO, Pohl MO, Stertz S
  Title
Entry of influenza A virus: host factors and antiviral targets.
  Journal
J Gen Virol 95:263-77 (2014)
DOI:10.1099/vir.0.059477-0
Reference
PMID:19565019
  Authors
Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
  Title
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
  Journal
J Mol Genet Med 3:167-75 (2008)
Reference
PMID:27751627
  Authors
Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
  Title
A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
  Journal
Trends Microbiol 24:933-943 (2016)
DOI:10.1016/j.tim.2016.09.003
Reference
PMID:18588994
  Authors
Thanh TT, van Doorn HR, de Jong MD
  Title
Human H5N1 influenza: current insight into pathogenesis.
  Journal
Int J Biochem Cell Biol 40:2671-4 (2008)
DOI:10.1016/j.biocel.2008.05.019
Reference
PMID:23977434
  Authors
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
  Title
Influenza A induced cellular signal transduction pathways.
  Journal
J Thorac Dis 5 Suppl 2:S132-41 (2013)
DOI:10.3978/j.issn.2072-1439.2013.07.42
Reference
PMID:20020828
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
Reference
PMID:21698289
  Authors
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
  Title
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
  Journal
PLoS One 6:e20215 (2011)
DOI:10.1371/journal.pone.0020215
Reference
PMID:19782761
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
DOI:10.1016/j.micinf.2009.09.007
Reference
PMID:23170167
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
PMID:30487536
  Authors
Long JS, Mistry B, Haslam SM, Barclay WS
  Title
Host and viral determinants of influenza A virus species specificity.
  Journal
Nat Rev Microbiol 17:67-81 (2019)
DOI:10.1038/s41579-018-0115-z
Reference
PMID:29556226
  Authors
Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
  Title
Host Immune Response to Influenza A Virus Infection.
  Journal
Front Immunol 9:320 (2018)
DOI:10.3389/fimmu.2018.00320
Reference
PMID:20130137
  Authors
Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
  Title
The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
  Journal
J Gen Virol 91:1439-49 (2010)
DOI:10.1099/vir.0.018465-0
Reference
PMID:18980544
  Authors
Ichinohe T, Iwasaki A, Hasegawa H
  Title
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
  Journal
Expert Rev Vaccines 7:1435-45 (2008)
DOI:10.1586/14760584.7.9.1435
Reference
PMID:27231932
  Authors
Le Sage V, Cinti A, Amorim R, Mouland AJ
  Title
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
  Journal
Viruses 8:E152 (2016)
DOI:10.3390/v8060152
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:21971186
  Authors
Varga ZT, Palese P
  Title
The influenza A virus protein PB1-F2: killing two birds with one stone?
  Journal
Virulence 2:542-6 (2011)
DOI:10.4161/viru.2.6.17812
Reference
PMID:30254192
  Authors
Atkin-Smith GK, Duan M, Chen W, Poon IKH
  Title
The induction and consequences of Influenza A virus-induced cell death.
  Journal
Cell Death Dis 9:1002 (2018)
DOI:10.1038/s41419-018-1035-6
Reference
PMID:30545063
  Authors
Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
  Title
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
  Journal
Viruses 10:E708 (2018)
DOI:10.3390/v10120708
Reference
PMID:21253874
  Authors
Dai X, Zhang L, Hong T
  Title
Host cellular signaling induced by influenza virus.
  Journal
Sci China Life Sci 54:68-74 (2011)
DOI:10.1007/s11427-010-4116-z
Reference
PMID:26008706
  Authors
Li J, Yu M, Zheng W, Liu W
  Title
Nucleocytoplasmic shuttling of influenza A virus proteins.
  Journal
Viruses 7:2668-82 (2015)
DOI:10.3390/v7052668
Reference
PMID:30079062
  Authors
Dou D, Revol R, Ostbye H, Wang H, Daniels R
  Title
Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
  Journal
Front Immunol 9:1581 (2018)
DOI:10.3389/fimmu.2018.01581
Reference
PMID:23236273
  Authors
Paterson D, Fodor E
  Title
Emerging roles for the influenza A virus nuclear export protein (NEP).
  Journal
PLoS Pathog 8:e1003019 (2012)
DOI:10.1371/journal.ppat.1003019
Related
pathway
pkl00900  Terpenoid backbone biosynthesis
pkl03013  Nucleocytoplasmic transport
pkl03015  mRNA surveillance pathway
pkl04010  MAPK signaling pathway
pkl04110  Cell cycle
pkl04144  Endocytosis
pkl04210  Apoptosis
pkl04620  Toll-like receptor signaling pathway
pkl04621  NOD-like receptor signaling pathway
pkl04622  RIG-I-like receptor signaling pathway
pkl04630  JAK-STAT signaling pathway
pkl05416  Viral myocarditis
KO pathway
ko05164   
LinkDB

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