KEGG   PATHWAY: pprl04020
Entry
pprl04020                   Pathway                                
Name
Calcium signaling pathway - Poeciliopsis prolifica (blackstripe livebearer)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
pprl04020  Calcium signaling pathway
pprl04020

Other DBs
GO: 0019722
Organism
Poeciliopsis prolifica (blackstripe livebearer) [GN:pprl]
Gene
129373210  slc8a4b; solute carrier family 8 member 4b isoform X1 [KO:K05849]
129368392  slc8a4a; solute carrier family 8 member 4a isoform X1 [KO:K05849]
129358998  slc8a2b; sodium/calcium exchanger 2b [KO:K05849]
129359583  slc8a1b; sodium/calcium exchanger 1b isoform X1 [KO:K05849]
129365099  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
129370693  slc8a2a; sodium/calcium exchanger 2a isoform X1 [KO:K05849]
129358462  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
129375498  atp2b1a; plasma membrane calcium-transporting ATPase 1a isoform X1 [KO:K05850] [EC:7.2.2.10]
129353388  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
129354620  LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 2-like [KO:K05850] [EC:7.2.2.10]
129371688  atp2b3b; plasma membrane calcium-transporting ATPase 3b isoform X1 [KO:K05850] [EC:7.2.2.10]
129352295  muscarinic acetylcholine receptor M1-like [KO:K04129]
129359947  chrm3a; muscarinic acetylcholine receptor M3 [KO:K04131]
129375396  chrm5b; muscarinic acetylcholine receptor M5b [KO:K04133]
129365199  chrm5a; muscarinic acetylcholine receptor M5a [KO:K04133]
129366282  adora2ab; adenosine A2a receptor b [KO:K04266]
129372909  adora2aa; adenosine A2a receptor a [KO:K04266]
129368498  adora2b; LOW QUALITY PROTEIN: adenosine receptor A2b [KO:K04267]
129353357  adrb1; beta-1 adrenergic receptor [KO:K04141]
129373485  beta-2 adrenergic receptor-like [KO:K04142]
129362846  adrb2a; adrenoceptor beta 2, surface a [KO:K04142]
129372102  adrb3a; adrenoceptor beta 3a isoform X1 [KO:K04143]
129373612  drd1b; dopamine receptor D1b [KO:K04144]
129362934  D(1) dopamine receptor-like [KO:K04144]
129368160  D(5)-like dopamine receptor [KO:K05840]
129358124  drd5a; D(1B) dopamine receptor [KO:K05840]
129368688  hrh2b; histamine receptor H2b [KO:K04150]
129360515  htr4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
129366281  si:dkey-247m21.3; 5-hydroxytryptamine receptor 4 [KO:K04160]
129367192  5-hydroxytryptamine receptor 4 [KO:K04160]
129364820  htr5ab; 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate b isoform X1 [KO:K04161]
129371704  htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
129373153  htr7c; 5-hydroxytryptamine receptor 7 [KO:K04163]
129372313  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
129357494  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
129378015  guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
129356761  guanine nucleotide-binding protein G(olf) subunit alpha-like [KO:K04633]
129362301  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
129377558  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
129367614  adcy2a; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
129376322  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
129369253  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
129353749  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
129364417  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
129351152  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
129351773  LOW QUALITY PROTEIN: adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
129352689  adcy8; LOW QUALITY PROTEIN: adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
129354678  adenylate cyclase type 8-like isoform X1 [KO:K08048] [EC:4.6.1.1]
129367296  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
129363211  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
129366903  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
129363168  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
129365798  cAMP-dependent protein kinase catalytic subunit beta-like [KO:K04345] [EC:2.7.11.11]
129371377  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
129355437  pln; cardiac phospholamban [KO:K05852]
129359399  sarcolipin [KO:K22642]
129366303  atp2a2b; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 2b [KO:K05853] [EC:7.2.2.10]
129372982  atp2a2a; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
129356355  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like isoform X1 [KO:K05853] [EC:7.2.2.10]
129368488  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
129363363  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
129377679  atp2a1l; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like isoform X1 [KO:K05853] [EC:7.2.2.10]
129369780  stromal interaction molecule 1-like isoform X1 [KO:K16059]
129370679  stromal interaction molecule 1-like isoform X1 [KO:K16059]
129379456  stim2b; stromal interaction molecule 2 isoform X1 [KO:K18196]
129366379  orai1b; calcium release-activated calcium channel protein 1 [KO:K16056]
129373046  calcium release-activated calcium channel protein 1-like isoform X1 [KO:K16056]
129370584  orai2; protein orai-2 [KO:K16057]
129375629  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
129372579  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
129356852  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
129352870  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a [KO:K04851]
129370128  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
129372226  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
129367079  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b isoform X1 [KO:K04344]
129363260  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
129366626  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
129351565  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a [KO:K04849]
129361800  LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
129370740  voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
129377595  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
129363158  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
129363253  voltage-dependent T-type calcium channel subunit alpha-1I-like isoform X1 [KO:K04856]
129376904  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
129367342  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
129362652  chrna8; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
129374954  chrna11; cholinergic receptor, nicotinic, alpha 11 [KO:K04809]
129369472  chrna7a; neuronal acetylcholine receptor subunit alpha-7a isoform X1 [KO:K04809]
129371561  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
129366028  grin1b; glutamate receptor ionotropic, NMDA 1b isoform X1 [KO:K05208]
129366311  grin1a; glutamate receptor ionotropic, NMDA 1a isoform X1 [KO:K05208]
129363328  grin2aa; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
129363377  glutamate receptor ionotropic, NMDA 2B-like [KO:K05210]
129367864  glutamate receptor ionotropic, NMDA 2C-like [KO:K05211]
129373947  grin2ca; glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca [KO:K05211]
129375840  grin2da; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
129371520  glutamate receptor ionotropic, NMDA 2D [KO:K05212]
129366618  grin3a; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
129373726  grin3bb; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
129365506  grin3ba; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
129368450  p2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
129372097  p2rx2; P2X purinoceptor 2 [KO:K05216]
129362942  p2rx3a; P2X purinoceptor 3a [KO:K05217]
129373059  p2rx4b; P2X purinoceptor 4b [KO:K05218]
129368473  p2rx5; P2X purinoceptor 5 [KO:K05219]
129366269  p2rx7; P2X purinoceptor 7 isoform X1 [KO:K05220]
129368545  ryanodine receptor 1-like isoform X1 [KO:K04961]
129359247  ryr1b; ryanodine receptor 1b isoform X1 [KO:K04961]
129352296  ryr2a; ryanodine receptor 2 [KO:K04962]
129359699  ryr2b; ryanodine receptor 2 [KO:K04962]
129375390  ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
129365155  ryanodine receptor 3-like [KO:K04963]
129378187  calsequestrin-1-like isoform X1 [KO:K23468]
129362114  casq1a; calsequestrin-1a [KO:K23468]
129379063  calsequestrin-2-like [KO:K23445]
129361216  calsequestrin-2-like [KO:K23445]
129355495  aspartyl/asparaginyl beta-hydroxylase-like isoform X1 [KO:K00476] [EC:1.14.11.16]
129355257  LOW QUALITY PROTEIN: cysteinyl leukotriene receptor 2-like [KO:K04322]
129362407  cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
129376726  cysteinyl leukotriene receptor 2-like [KO:K04322]
129351484  chrm2a; muscarinic acetylcholine receptor M2a isoform X1 [KO:K04130]
129363872  muscarinic acetylcholine receptor M4-like [KO:K04130]
129366744  adra1ab; alpha-1A adrenergic receptor [KO:K04135]
129373154  adra1aa; adrenoceptor alpha 1Aa [KO:K04135]
129362475  alpha-1A adrenergic receptor-like [KO:K04136]
129370601  alpha-1A adrenergic receptor-like isoform X1 [KO:K04136]
129367035  adra1d; alpha-1D adrenergic receptor [KO:K04137]
129364494  agtr1b; type-1 angiotensin II receptor [KO:K04166]
129351284  endothelin receptor type B-like isoform X1 [KO:K04197]
129361279  ednrbb; endothelin receptor type B [KO:K04198]
129362209  ednrba; endothelin receptor Ba [KO:K04198]
129362802  endothelin receptor type B-like [KO:K04198]
129371944  f2r; proteinase-activated receptor 1 [KO:K03914]
129374184  proteinase-activated receptor 1-like [KO:K03914]
129357887  metabotropic glutamate receptor 1-like [KO:K04603]
129352436  grm1a; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
129368632  grm5a; glutamate receptor, metabotropic 5a isoform X1 [KO:K04604]
129358993  grm5b; metabotropic glutamate receptor 5b [KO:K04604]
129361385  gastrin-releasing peptide receptor-like [KO:K04169]
129369605  grpr; gastrin-releasing peptide receptor [KO:K04169]
129367537  dopamine D2-like receptor [KO:K04149]
129358468  hrh1; histamine H1 receptor [KO:K04149]
129379117  htr2aa; 5-hydroxytryptamine receptor 2A [KO:K04157]
129375167  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
129352372  htr2cl1; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 [KO:K04157]
129359506  lutropin-choriogonadotropic hormone receptor-like [KO:K04248]
129359737  lhcgr; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
129371873  ntsr1; neurotensin receptor type 1 [KO:K04211]
129355762  oxtra; oxytocin receptor [KO:K04229]
129358423  isotocin receptor-like [KO:K04229]
129366190  avpr1aa; arginine vasopressin receptor 1Aa [KO:K04226]
129352899  arg8-vasotocin receptor-like [KO:K04226]
129377962  leukotriene B4 receptor 1-like [KO:K04297]
129356787  leukotriene B4 receptor 1-like [KO:K04297]
129374735  ptafr; platelet-activating factor receptor [KO:K04279]
129367038  ptger1a; prostaglandin E receptor 1a (subtype EP1) [KO:K04258]
129363555  ptger1c; prostaglandin E receptor 1c (subtype EP1) [KO:K04258]
129363939  prostaglandin E2 receptor EP1 subtype-like isoform X1 [KO:K04258]
129375126  ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
129374371  ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
129374756  B2 bradykinin receptor-like [KO:K03916]
129374757  bdkrb1; B1 bradykinin receptor [KO:K03916]
129374758  B2 bradykinin receptor-like [KO:K03916]
129374787  bdkrb2; B2 bradykinin receptor [KO:K03916]
129379727  substance-P receptor-like [KO:K04222]
129373024  tacr1a; tachykinin receptor 1a [KO:K04222]
129364201  tacr2; substance-K receptor [KO:K04223]
129366969  tacr3l; tachykinin receptor 3-like [KO:K04224]
129366984  tacr3a; tachykinin receptor 3a [KO:K04224]
129376410  tbxa2r; thromboxane A2 receptor isoform X1 [KO:K04264]
129367694  trhra; thyrotropin-releasing hormone receptor [KO:K04282]
129362552  trhr2; thyrotropin releasing hormone receptor 2 [KO:K04282]
129375818  trhrb; thyrotropin-releasing hormone receptor b [KO:K04282]
129370367  thyrotropin-releasing hormone receptor-like [KO:K04282]
129360983  cckbrb; cholecystokinin receptor type A [KO:K04194]
129379101  cckbra; cholecystokinin receptor-like [KO:K04194]
129379459  cckar; cholecystokinin receptor type A [KO:K04194]
129361541  C-X-C chemokine receptor type 4-like [KO:K04189]
129362049  C-X-C chemokine receptor type 4-like [KO:K04189]
129371935  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
129374344  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04634]
129365136  gna11b; guanine nucleotide-binding protein subunit alpha-11b isoform X1 [KO:K04634]
129371651  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04635]
129371936  gna14a; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
129375288  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04637]
129360254  pro-epidermal growth factor-like [KO:K04357]
129360259  pro-epidermal growth factor-like [KO:K04357]
129358454  tgfa; LOW QUALITY PROTEIN: protransforming growth factor alpha [KO:K08774]
129367366  platelet-derived growth factor subunit A-like [KO:K04359]
129363603  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
129367152  si:ch211-79m20.1; uncharacterized protein si:ch211-79m20.1 [KO:K17386]
129360778  platelet-derived growth factor C-like [KO:K05450]
129360781  platelet-derived growth factor C-like [KO:K05450]
129359460  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
129373597  putative fibroblast growth factor 1 [KO:K18496]
129362454  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
129360495  fibroblast growth factor 2-like [KO:K18497]
129360508  fibroblast growth factor 2-like [KO:K18497]
129360493  fibroblast growth factor 18-like isoform X1 [KO:K04358]
129360506  fibroblast growth factor 18-like isoform X1 [KO:K04358]
129365949  fgf10b; fibroblast growth factor 10b [KO:K04358]
129366100  fgf5; fibroblast growth factor 5 [KO:K04358]
129366473  fgf10a; fibroblast growth factor 10a [KO:K04358]
129366883  fgf8b; fibroblast growth factor 8b [KO:K04358]
129367028  fibroblast growth factor 9-like [KO:K04358]
129362506  fgf16; fibroblast growth factor 16 [KO:K04358]
129362896  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
129362973  fgf20b; fibroblast growth factor 20b [KO:K04358]
129356816  fgf6b; fibroblast growth factor 6b [KO:K04358]
129374779  fgf22; fibroblast growth factor 22 [KO:K04358]
129351573  fgf17; fibroblast growth factor 17 [KO:K04358]
129369388  fgf7; fibroblast growth factor 7 [KO:K04358]
129352780  fibroblast growth factor 4-like [KO:K04358]
129353215  fgf3; fibroblast growth factor 3 [KO:K04358]
129353231  fgf4; LOW QUALITY PROTEIN: fibroblast growth factor 4 [KO:K04358]
129359985  fgf8a; fibroblast growth factor 8 [KO:K04358]
129353175  fgf19; fibroblast growth factor 19 [KO:K22603]
129377852  fgf21; fibroblast growth factor 21 [KO:K22429]
129356236  fibroblast growth factor 23-like [KO:K22428]
129356820  fgf23; fibroblast growth factor 23 [KO:K22428]
129360078  fibroblast growth factor 23-like [KO:K22428]
129362754  vegfba; vascular endothelial growth factor A [KO:K05448]
129369036  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
129378645  vegfc; vascular endothelial growth factor C [KO:K05449]
129369592  vegfd; vascular endothelial growth factor D [KO:K05449]
129372351  ngfa; neurotrophin-7 [KO:K02582]
129372835  ngfb; nerve growth factor [KO:K02582]
129375657  hepatocyte growth factor-like isoform X1 [KO:K05460]
129359042  hepatocyte growth factor [KO:K05460]
129358401  mst1; hepatocyte growth factor-like protein [KO:K23441]
129366494  gdnfa; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
129372125  glial cell line-derived neurotrophic factor-like [KO:K05452]
129362259  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
129354379  LOW QUALITY PROTEIN: melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
129377813  erbb2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
129372373  erbb3b; receptor tyrosine-protein kinase erbB-3b isoform X1 [KO:K05084] [EC:2.7.10.1]
129358381  erbb3a; receptor tyrosine-protein kinase erbB-3a isoform X1 [KO:K05084] [EC:2.7.10.1]
129361272  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
129378661  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
129369979  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
129362573  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
129370750  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
129379807  fgfr1b; fibroblast growth factor receptor 1b isoform X1 [KO:K04362] [EC:2.7.10.1]
129373089  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
129369845  si:ch211-167j9.5; tyrosine kinase receptor Cad96Ca isoform X1 [KO:K05093] [EC:2.7.10.1]
129359558  fibroblast growth factor receptor 2-like isoform X1 [KO:K05093] [EC:2.7.10.1]
129377229  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
129373566  LOW QUALITY PROTEIN: fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
129360552  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
129360563  LOW QUALITY PROTEIN: vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
129364817  flt1; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
129362873  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
129375414  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
129370914  ntrk1; LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
129374151  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
129365724  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
129366167  NT-3 growth factor receptor-like [KO:K05101] [EC:2.7.10.1]
129369507  ntrk3b; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
129353366  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
129355348  mst1rb; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
129358446  macrophage-stimulating protein receptor-like [KO:K05100] [EC:2.7.10.1]
129352639  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
129377239  M1-specific T cell receptor beta chain-like [KO:K10785]
129377391  T cell receptor beta chain MC.7.G5-like [KO:K10785]
129363471  Ig heavy chain Mem5-like [KO:K06856]
129362128  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1-like isoform X1 [KO:K05857] [EC:3.1.4.11]
129373999  plcd3a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A [KO:K05857] [EC:3.1.4.11]
129356457  plcd4a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
129352293  plcd3b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A isoform X1 [KO:K05857] [EC:3.1.4.11]
129364530  plcd1a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1a isoform X1 [KO:K05857] [EC:3.1.4.11]
129373219  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
129369013  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
129369014  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
129353933  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
129365596  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
129371997  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like [KO:K01116] [EC:3.1.4.11]
129370252  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
129359838  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
129353334  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
129360685  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1-like isoform X1 [KO:K05861] [EC:3.1.4.11]
129353093  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
129353750  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
129364907  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
129352937  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
129354427  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
129352091  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
129352097  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
129352104  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
129371978  tpcn1; two pore channel protein 1 isoform X1 [KO:K16896]
129353203  tpcn2; two pore channel protein 2 isoform X1 [KO:K14077]
129363129  mucolipin-1-like isoform X1 [KO:K04992]
129372812  mcoln2; mucolipin-2 isoform X1 [KO:K04993]
129373045  mcoln3b; mucolipin-3 [KO:K04994]
129362263  mucolipin-3-like isoform X1 [KO:K04994]
129363644  sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
129371091  sphk2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
129359747  mcu; calcium uniporter protein, mitochondrial [KO:K20858]
129373421  vdac1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
129368095  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
129360141  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
129379756  zgc:56235; voltage-dependent anion-selective channel protein 2-like [KO:K15041]
129366147  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
129367021  slc25a4; ADP/ATP translocase 1 [KO:K05863]
129368778  si:dkey-251i10.1; ADP/ATP translocase 3 [KO:K05863]
129360347  ADP/ATP translocase 2-like [KO:K05863]
129360378  ADP/ATP translocase 2-like [KO:K05863]
129367938  ppifb; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
129360152  ppifa; peptidylprolyl isomerase Fa isoform X1 [KO:K09565] [EC:5.2.1.8]
129370269  tnnc1a; troponin C type 1a (slow) isoform X1 [KO:K05865]
129377047  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
129371630  tnnc2.1; troponin C, skeletal muscle [KO:K12042]
129371632  tnnc2.2; troponin C, skeletal muscle [KO:K12042]
129368957  calm1b; calmodulin-1b [KO:K02183]
129369535  calml4a; calmodulin-like protein 4a [KO:K02183]
129369772  calmodulin-1 isoform X1 [KO:K02183]
129359157  calm3a; calmodulin 3a (phosphorylase kinase, delta) isoform X1 [KO:K02183]
129359826  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
129365528  calmodulin-1 [KO:K02183]
129377787  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
129358836  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform-like [KO:K00871] [EC:2.7.11.19]
129379339  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
129369416  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
129352357  phka1a; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
129372871  mylk4b; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
129361815  mylk4a; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
129368157  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
129374000  mylk5; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
129374533  mylka; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
129358156  camk1b; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
129358312  camk1a; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
129376099  camk1da; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
129353823  calcium/calmodulin-dependent protein kinase type 1D-like [KO:K08794] [EC:2.7.11.17]
129377091  camk1gb; calcium/calmodulin-dependent protein kinase IGb [KO:K08794] [EC:2.7.11.17]
129379744  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
129366123  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
129368016  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
129370564  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
129359527  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
129376807  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
129375845  si:ch73-60h1.1; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
129379730  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
129373016  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
129373234  protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
129362595  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129368452  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129359663  calcineurin subunit B type 1 [KO:K06268]
129358226  tfeb; transcription factor EB isoform X1 [KO:K15590]
129367640  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
129375811  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
129372680  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
129377174  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
129362891  nuclear factor of activated T-cells, cytoplasmic 3-like isoform X1 [KO:K17333]
129364067  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
129378104  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
129365983  nos1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
129379212  pde1a; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
129361886  pde1cb; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
129358148  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B-like [KO:K13755] [EC:3.1.4.17]
129355414  protein-tyrosine kinase 2-beta-like [KO:K05871] [EC:2.7.10.2]
129351157  ptk2bb; protein tyrosine kinase 2 beta, b isoform X1 [KO:K05871] [EC:2.7.10.2]
129362397  si:ch73-22a13.3; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
129369088  itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
129374869  itpka; inositol-trisphosphate 3-kinase A isoform X1 [KO:K00911] [EC:2.7.1.127]
129369791  itpkcb; inositol-trisphosphate 3-kinase Cb [KO:K00911] [EC:2.7.1.127]
129367238  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
129363528  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
129363217  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
129353719  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
129371521  prkcg; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
pprl04010  MAPK signaling pathway
pprl04070  Phosphatidylinositol signaling system
pprl04210  Apoptosis
KO pathway
ko04020   
LinkDB

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