KEGG   PATHWAY: sara05208
Entry
sara05208                   Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Sorex araneus (European shrew)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
sara05208  Chemical carcinogenesis - reactive oxygen species
sara05208

Organism
Sorex araneus (European shrew) [GN:sara]
Gene
101555413  AS3MT; arsenite methyltransferase [KO:K07755] [EC:2.1.1.137]
101548683  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
101545361  glutathione S-transferase Mu 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101545806  glutathione S-transferase Mu 2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101546243  glutathione S-transferase Mu 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101546676  glutathione S-transferase Mu 2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101547102  glutathione S-transferase Mu 2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101547538  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
101539867  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
101558495  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
101559037  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
101559303  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
101546536  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
101548751  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
101552024  GSTO1; glutathione S-transferase omega-1 isoform X3 [KO:K00799] [EC:2.5.1.18]
101551022  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
101557519  LOW QUALITY PROTEIN: glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
101558058  LOW QUALITY PROTEIN: glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
101543479  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
101543744  glutathione S-transferase theta-2B-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101557248  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
101557792  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
101552131  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
101558520  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
101551755  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
101543334  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
101544921  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
101554385  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
101545904  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
101546024  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
105943548  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6-like [KO:K03950]
101553539  NDUFA7; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
101550865  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
101542674  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
101544570  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
101552611  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
101549676  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
101547468  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like [KO:K03956]
101546611  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
101558634  NDUFA13; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
101548133  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
101550944  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
101542801  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
101558498  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
101550923  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
101537479  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial-like [KO:K03961]
101542269  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
101542877  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
101544724  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
101556879  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
101544144  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
101546564  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
101550285  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
101558708  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
101550024  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
101552276  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
101551320  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
101540006  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
101541168  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial-like [KO:K03939]
101559074  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
101553637  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
101552172  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
101538589  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
101551181  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
101554907  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
101554761  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
101538333  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
101555430  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
101555423  cytochrome c1, heme protein, mitochondrial [KO:K00413]
101548951  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
101545563  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
101544373  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
101545363  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
101558821  cytochrome b-c1 complex subunit 7 [KO:K00417]
101540389  cytochrome b-c1 complex subunit 8 [KO:K00418]
101553451  cytochrome b-c1 complex subunit 9 [KO:K00419]
101539972  cytochrome b-c1 complex subunit 10 [KO:K00420]
101546155  uncharacterized protein LOC101546155 [KO:K02263]
101537037  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
101551395  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
101540298  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
101551148  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
101543393  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
101556738  cytochrome c oxidase subunit 6B2 [KO:K02267]
101543526  cytochrome c oxidase subunit 6B1 [KO:K02267]
101555790  LOW QUALITY PROTEIN: uncharacterized protein LOC101555790 [KO:K02270]
101551390  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
101541919  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
101551046  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
101539577  ATP5A1; ATP synthase subunit alpha, mitochondrial isoform X1 [KO:K02132]
101544645  LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
101538160  LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
101550289  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
101554727  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
101538919  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
101553732  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
101547279  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
101552989  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
101546618  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
101540173  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
101544721  ATP5H; ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138]
101557303  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
101543369  ATP synthase subunit O, mitochondrial-like [KO:K02137]
101543863  ATP5J; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
101537605  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
101557440  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101553627  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
101539505  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
101553449  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
101538265  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
101554026  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
101543714  ADP/ATP translocase 3 [KO:K05863]
101538826  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
101540260  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
101538893  CAT; catalase [KO:K03781] [EC:1.11.1.6]
105943317  SLC26A1; sulfate anion transporter 1 [KO:K14700]
101544308  SLC26A2; sulfate transporter [KO:K14701]
101539180  SLC26A6; solute carrier family 26 member 6 [KO:K14704]
101543577  SLC26A9; solute carrier family 26 member 9 [KO:K14706]
101544097  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
101547636  cytochrome P450 2F5 [KO:K07416] [EC:1.14.14.1]
101550604  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
101541021  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
101537100  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
101555407  EPHX2; LOW QUALITY PROTEIN: bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
101543845  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
101549328  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
101549063  AKR1A1; alcohol dehydrogenase [NADP(+)] [KO:K00002] [EC:1.1.1.2]
101544324  alcohol dehydrogenase [NADP(+)]-like [KO:K00002] [EC:1.1.1.2]
101551999  prostaglandin-E(2) 9-reductase-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101551007  prostaglandin-E(2) 9-reductase-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101543981  prostaglandin-E(2) 9-reductase-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101555320  prostaglandin-E(2) 9-reductase-like isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101555749  prostaglandin-E(2) 9-reductase-like isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101545704  aldo-keto reductase family 1 member C23-like protein [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101542092  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
101540843  CBR1; carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
101556409  AHR; aryl hydrocarbon receptor [KO:K09093]
101554475  LPO; lactoperoxidase [KO:K12550] [EC:1.11.1.7]
101558724  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
101540075  cytochrome b-245 light chain [KO:K08009]
101546517  NCF1; neutrophil cytosol factor 1 [KO:K08011]
101547168  NCF2; neutrophil cytosol factor 2 [KO:K08010]
101541792  EGF; pro-epidermal growth factor [KO:K04357]
101552863  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101546946  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101552331  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
101544020  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101550972  SOS1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
101555769  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101546777  HRAS; GTPase HRas [KO:K02833]
101557531  KRAS; GTPase KRas isoform X1 [KO:K07827]
101559343  NRAS; GTPase NRas [KO:K07828]
101554406  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101550676  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
101545329  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101550720  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101555057  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101559341  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101541587  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
101545848  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
101547499  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101542924  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
101554595  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101538553  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101556557  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101556063  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101536977  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101537598  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101554044  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101545321  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101545059  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
101547106  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101541868  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101540938  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101542917  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101556597  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101548304  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101557373  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101540891  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101538779  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
101543096  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101559009  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101543371  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101556693  FOXO3; forkhead box protein O3 isoform X1 [KO:K09408]
101549930  BAD; bcl2-associated agonist of cell death [KO:K02158]
101553726  PTPN1; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
101558235  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101538389  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101540472  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101536840  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101556810  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101543163  RELA; transcription factor p65 [KO:K04735]
101549580  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
101547708  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
101557473  PTPRJ; receptor-type tyrosine-protein phosphatase eta [KO:K05698] [EC:3.1.3.48]
101556194  ACP1; low molecular weight phosphotyrosine protein phosphatase [KO:K14394] [EC:3.1.3.2 3.1.3.48]
101543226  LOW QUALITY PROTEIN: low molecular weight phosphotyrosine protein phosphatase-like [KO:K14394] [EC:3.1.3.2 3.1.3.48]
101556236  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
101552022  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
101559065  SRC; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
101539877  ABL1; tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
101553006  ABL2; Abelson tyrosine-protein kinase 2 [KO:K08887] [EC:2.7.10.2]
101552210  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
101554512  PRKD1; serine/threonine-protein kinase D1 [KO:K06070] [EC:2.7.11.13]
101556065  PRKD2; serine/threonine-protein kinase D2 isoform X1 [KO:K06070] [EC:2.7.11.13]
101540332  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
101538228  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101550489  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
101549152  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
101538909  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
101553552  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
101548477  VEGFA; vascular endothelial growth factor A isoform X3 [KO:K05448]
101540674  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
101542637  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
101552548  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Related
pathway
sara00190  Oxidative phosphorylation
sara00980  Metabolism of xenobiotics by cytochrome P450
sara04010  MAPK signaling pathway
sara04064  NF-kappa B signaling pathway
sara04066  HIF-1 signaling pathway
sara04151  PI3K-Akt signaling pathway
sara04370  VEGF signaling pathway
sara05207  Chemical carcinogenesis - receptor activation
sara05211  Renal cell carcinoma
sara05215  Prostate cancer
sara05219  Bladder cancer
sara05221  Acute myeloid leukemia
sara05222  Small cell lung cancer
sara05223  Non-small cell lung cancer
sara05224  Breast cancer
sara05225  Hepatocellular carcinoma
KO pathway
ko05208   
LinkDB

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