KEGG   PATHWAY: tfn05164
Entry
tfn05164                    Pathway                                
Name
Influenza A - Trachypithecus francoisi (Francois's langur)
Description
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class
Human Diseases; Infectious disease: viral
Pathway map
tfn05164  Influenza A
tfn05164

Organism
Trachypithecus francoisi (Francois's langur) [GN:tfn]
Gene
117097868  LOW QUALITY PROTEIN: tryptase delta-like [KO:K01340] [EC:3.4.21.59]
117097870  LOW QUALITY PROTEIN: tryptase beta-2-like [KO:K01340] [EC:3.4.21.59]
117096916  PLG; plasminogen [KO:K01315] [EC:3.4.21.7]
117090595  complement C1s subcomponent-like [KO:K01312] [EC:3.4.21.4]
117073407  trypsin-like [KO:K01312] [EC:3.4.21.4]
117095813  TMPRSS2; transmembrane protease serine 2 isoform X1 [KO:K09633] [EC:3.4.21.122]
117080547  TMPRSS4; transmembrane protease serine 4 [KO:K09635] [EC:3.4.21.-]
117085551  TMPRSS11D; transmembrane protease serine 11D [KO:K09641] [EC:3.4.21.-]
117087485  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117089372  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
117089373  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
117089374  OAS1; 2'-5'-oligoadenylate synthase 1 isoform X1 [KO:K14216] [EC:2.7.7.84]
117074768  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
117076185  DNAJB1; dnaJ homolog subfamily B member 1 isoform X1 [KO:K09507]
117094183  LOW QUALITY PROTEIN: dnaJ homolog subfamily B member 1-like [KO:K09507]
117063596  DNAJC3; dnaJ homolog subfamily C member 3 isoform X1 [KO:K09523]
117062468  EIF2AK2; LOW QUALITY PROTEIN: interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
117069444  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
117067272  TRIM25; E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:2.3.2.27]
117098707  DDX58; probable ATP-dependent RNA helicase DDX58 isoform X1 [KO:K12646] [EC:5.6.2.6]
117094941  IFIH1; interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]
117079934  NLRX1; NLR family member X1 isoform X1 [KO:K12653]
117068514  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
117068535  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
117095630  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
117078341  IKBKG; LOW QUALITY PROTEIN: NF-kappa-B essential modulator [KO:K07210]
117092495  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
117069810  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
117085710  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
117081405  RELA; transcription factor p65 [KO:K04735]
117067175  CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348]
117086222  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
117076533  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
117071333  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
117089816  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
117074249  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
117091591  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
117096425  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
117097726  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
117098762  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
117077597  TLR7; LOW QUALITY PROTEIN: toll-like receptor 7 [KO:K05404]
117083885  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
117090258  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
117079841  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
117062187  IL1A; interleukin-1 alpha [KO:K04383]
117062188  IL1B; interleukin-1 beta [KO:K04519]
117072793  IL6; interleukin-6 isoform X1 [KO:K05405]
117079203  IL12A; interleukin-12 subunit alpha [KO:K05406]
117065537  IL12B; interleukin-12 subunit beta [KO:K05425]
117086926  TNF; tumor necrosis factor isoform X1 [KO:K03156]
117085498  CXCL8; interleukin-8 [KO:K10030]
117067528  CCL2; C-C motif chemokine 2 [KO:K14624]
117067484  CCL5; C-C motif chemokine 5 [KO:K12499]
117085463  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
117076602  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
117098645  interferon alpha-4-like [KO:K05414]
117098649  interferon alpha-6 [KO:K05414]
117098650  interferon alpha-1/13 [KO:K05414]
117098651  interferon alpha-1/13-like [KO:K05414]
117098652  IFNA2; interferon alpha-2 [KO:K05414]
117099353  interferon alpha-4 [KO:K05414]
117099354  interferon alpha-14 [KO:K05414]
117099355  IFNA8; interferon alpha-8 [KO:K05414]
117099357  interferon alpha-1/13 [KO:K05414]
117098642  IFNB1; interferon beta [KO:K05415]
117095712  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
117095709  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
117092033  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
117076194  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
117066771  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
117094713  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
117089929  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
117069921  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
117095809  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
117095810  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
117075904  ADAR; double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
117070383  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
117089783  IFNG; interferon gamma [KO:K04687]
117097473  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
117095714  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
117098543  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
117097653  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
117087006  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DQ beta 1 chain [KO:K06752]
117087014  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
117087019  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
117087020  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
117087023  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
117087025  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
117087026  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
117089150  HLA class II histocompatibility antigen, DR beta 5 chain isoform X1 [KO:K06752]
117086946  HLA class II histocompatibility antigen, DR beta 5 chain-like isoform X1 [KO:K06752]
117086957  HLA class II histocompatibility antigen, DRB1 beta chain-like isoform X1 [KO:K06752]
117087000  mamu class II histocompatibility antigen, DR alpha chain [KO:K06752]
117087003  HLA class II histocompatibility antigen, DR beta 5 chain-like isoform X1 [KO:K06752]
117087004  DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752]
117087005  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
117074712  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
117087696  PYCARD; apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
117080358  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
117080362  caspase-1-like isoform X1 [KO:K01370] [EC:3.4.22.36]
117098563  IL33; interleukin-33 isoform X1 [KO:K12967]
117065206  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117092662  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
117075022  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
117083761  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117084122  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
117093348  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117071286  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117091956  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117076331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117087209  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
117089862  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
117073473  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
117083738  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
117093403  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
117093430  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
117074605  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
117086221  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
117090649  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117087931  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
117079989  FADD; FAS-associated death domain protein [KO:K02373]
117094661  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
117096070  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
117091541  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
117087056  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
117096195  bcl-2 homologous antagonist/killer-like [KO:K14021]
117098307  voltage-dependent anion-selective channel protein 1-like [KO:K05862]
117065867  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
117077936  ADP/ATP translocase 2-like [KO:K05863]
117076189  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
117085890  SLC25A31; ADP/ATP translocase 4 isoform X1 [KO:K05863]
117086204  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
117077276  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
117078921  cytochrome c-like [KO:K08738]
117078953  cytochrome c-like [KO:K08738]
117096842  cytochrome c-like [KO:K08738]
117079868  cytochrome c-like [KO:K08738]
117097957  cytochrome c-like [KO:K08738]
117098492  cytochrome c-like [KO:K08738]
117080718  cytochrome c-like [KO:K08738]
117072525  cytochrome c [KO:K08738]
117072825  cytochrome c-like [KO:K08738]
117081557  cytochrome c-like [KO:K08738]
117083033  cytochrome c-like [KO:K08738]
117093380  cytochrome c-like [KO:K08738]
117089565  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
117093253  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
117083313  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
117075139  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
117086196  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
117072018  CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404]
117066618  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404]
117096666  embryonic polyadenylate-binding protein 2-like isoform X1 [KO:K14396]
117069968  polyadenylate-binding protein 2 isoform X1 [KO:K14396]
117088796  PABPN1L; embryonic polyadenylate-binding protein 2 isoform X1 [KO:K14396]
117086632  LOW QUALITY PROTEIN: polyadenylate-binding protein 2-like [KO:K14396]
117077701  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
117077918  NXF3; nuclear RNA export factor 3 [KO:K14284]
117080437  NXF1; nuclear RNA export factor 1 [KO:K14284]
117083531  nuclear RNA export factor 2 [KO:K14284]
117075301  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
117085246  nuclear RNA export factor 2 isoform X1 [KO:K14284]
117077594  NXT2; LOW QUALITY PROTEIN: NTF2-related export protein 2 [KO:K14285]
117068368  NXT1; NTF2-related export protein 1 [KO:K14285]
117076000  HNRNPUL1; heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1 [KO:K15047]
117068971  RAE1; mRNA export factor isoform X1 [KO:K14298]
117080550  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
117062774  RSAD2; radical S-adenosyl methionine domain-containing protein 2 isoform X1 [KO:K15045]
117074566  FDPS; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
117067396  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117083269  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
117084479  LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
117070473  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117076490  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
117087606  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
117096627  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117072721  ACTB; actin, cytoplasmic 1 [KO:K05692]
117081956  actin, cytoplasmic 1-like [KO:K05692]
117083152  actin [KO:K05692]
117066827  ACTG1; actin, cytoplasmic 2 [KO:K05692]
117094375  LOW QUALITY PROTEIN: actin-like [KO:K05692]
117070480  RAB11A; ras-related protein Rab-11A [KO:K07904]
117076167  RAB11B; ras-related protein Rab-11B [KO:K07905]
117099696  XPO1; exportin-1 isoform X1 [KO:K14290]
117083414  KPNA1; importin subunit alpha-5 [KO:K23940]
117087929  LOW QUALITY PROTEIN: importin subunit alpha-1-like [KO:K15043]
117072655  KPNA7; importin subunit alpha-8 [KO:K15043]
117083132  importin subunit alpha-1 isoform X1 [KO:K15043]
117083953  LOW QUALITY PROTEIN: importin subunit alpha-1-like [KO:K15043]
117067377  KPNA2; importin subunit alpha-1 [KO:K15043]
117096975  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
117092958  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
Compound
C00027  Hydrogen peroxide
C00080  H+
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24225499
  Authors
Edinger TO, Pohl MO, Stertz S
  Title
Entry of influenza A virus: host factors and antiviral targets.
  Journal
J Gen Virol 95:263-77 (2014)
DOI:10.1099/vir.0.059477-0
Reference
PMID:19565019
  Authors
Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
  Title
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
  Journal
J Mol Genet Med 3:167-75 (2008)
Reference
PMID:27751627
  Authors
Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
  Title
A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
  Journal
Trends Microbiol 24:933-943 (2016)
DOI:10.1016/j.tim.2016.09.003
Reference
PMID:18588994
  Authors
Thanh TT, van Doorn HR, de Jong MD
  Title
Human H5N1 influenza: current insight into pathogenesis.
  Journal
Int J Biochem Cell Biol 40:2671-4 (2008)
DOI:10.1016/j.biocel.2008.05.019
Reference
PMID:23977434
  Authors
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
  Title
Influenza A induced cellular signal transduction pathways.
  Journal
J Thorac Dis 5 Suppl 2:S132-41 (2013)
DOI:10.3978/j.issn.2072-1439.2013.07.42
Reference
PMID:20020828
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
Reference
PMID:21698289
  Authors
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
  Title
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
  Journal
PLoS One 6:e20215 (2011)
DOI:10.1371/journal.pone.0020215
Reference
PMID:19782761
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
DOI:10.1016/j.micinf.2009.09.007
Reference
PMID:23170167
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
PMID:30487536
  Authors
Long JS, Mistry B, Haslam SM, Barclay WS
  Title
Host and viral determinants of influenza A virus species specificity.
  Journal
Nat Rev Microbiol 17:67-81 (2019)
DOI:10.1038/s41579-018-0115-z
Reference
PMID:29556226
  Authors
Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
  Title
Host Immune Response to Influenza A Virus Infection.
  Journal
Front Immunol 9:320 (2018)
DOI:10.3389/fimmu.2018.00320
Reference
PMID:20130137
  Authors
Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
  Title
The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
  Journal
J Gen Virol 91:1439-49 (2010)
DOI:10.1099/vir.0.018465-0
Reference
PMID:18980544
  Authors
Ichinohe T, Iwasaki A, Hasegawa H
  Title
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
  Journal
Expert Rev Vaccines 7:1435-45 (2008)
DOI:10.1586/14760584.7.9.1435
Reference
PMID:27231932
  Authors
Le Sage V, Cinti A, Amorim R, Mouland AJ
  Title
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
  Journal
Viruses 8:E152 (2016)
DOI:10.3390/v8060152
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:21971186
  Authors
Varga ZT, Palese P
  Title
The influenza A virus protein PB1-F2: killing two birds with one stone?
  Journal
Virulence 2:542-6 (2011)
DOI:10.4161/viru.2.6.17812
Reference
PMID:30254192
  Authors
Atkin-Smith GK, Duan M, Chen W, Poon IKH
  Title
The induction and consequences of Influenza A virus-induced cell death.
  Journal
Cell Death Dis 9:1002 (2018)
DOI:10.1038/s41419-018-1035-6
Reference
PMID:30545063
  Authors
Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
  Title
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
  Journal
Viruses 10:E708 (2018)
DOI:10.3390/v10120708
Reference
PMID:21253874
  Authors
Dai X, Zhang L, Hong T
  Title
Host cellular signaling induced by influenza virus.
  Journal
Sci China Life Sci 54:68-74 (2011)
DOI:10.1007/s11427-010-4116-z
Reference
PMID:26008706
  Authors
Li J, Yu M, Zheng W, Liu W
  Title
Nucleocytoplasmic shuttling of influenza A virus proteins.
  Journal
Viruses 7:2668-82 (2015)
DOI:10.3390/v7052668
Reference
PMID:30079062
  Authors
Dou D, Revol R, Ostbye H, Wang H, Daniels R
  Title
Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
  Journal
Front Immunol 9:1581 (2018)
DOI:10.3389/fimmu.2018.01581
Reference
PMID:23236273
  Authors
Paterson D, Fodor E
  Title
Emerging roles for the influenza A virus nuclear export protein (NEP).
  Journal
PLoS Pathog 8:e1003019 (2012)
DOI:10.1371/journal.ppat.1003019
Related
pathway
tfn00900  Terpenoid backbone biosynthesis
tfn03013  Nucleocytoplasmic transport
tfn03015  mRNA surveillance pathway
tfn04010  MAPK signaling pathway
tfn04110  Cell cycle
tfn04144  Endocytosis
tfn04210  Apoptosis
tfn04620  Toll-like receptor signaling pathway
tfn04621  NOD-like receptor signaling pathway
tfn04622  RIG-I-like receptor signaling pathway
tfn04630  JAK-STAT signaling pathway
tfn05416  Viral myocarditis
KO pathway
ko05164   
LinkDB

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