KEGG   PATHWAY: tmu05164
Entry
tmu05164                    Pathway                                
Name
Influenza A - Trichechus manatus latirostris (Florida manatee)
Description
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class
Human Diseases; Infectious disease: viral
Pathway map
tmu05164  Influenza A
tmu05164

Organism
Trichechus manatus latirostris (Florida manatee) [GN:tmu]
Gene
101342891  plasminogen isoform X2 [KO:K01315] [EC:3.4.21.7]
101342021  trypsin-2 [KO:K01312] [EC:3.4.21.4]
101342267  trypsin-like [KO:K01312] [EC:3.4.21.4]
101342773  trypsin-like [KO:K01312] [EC:3.4.21.4]
101343274  cationic trypsin-like [KO:K01312] [EC:3.4.21.4]
101343023  LOW QUALITY PROTEIN: trypsin-like [KO:K01312] [EC:3.4.21.4]
101349908  transmembrane protease serine 2 [KO:K09633] [EC:3.4.21.122]
101360701  transmembrane protease serine 4 [KO:K09635] [EC:3.4.21.-]
101354103  transmembrane protease serine 11D [KO:K09641] [EC:3.4.21.-]
101356454  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101347429  2'-5'-oligoadenylate synthase 2 isoform X1 [KO:K14216] [EC:2.7.7.84]
101344304  2'-5'-oligoadenylate synthase 1 isoform X2 [KO:K14216] [EC:2.7.7.84]
101344040  2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
101358385  2-5A-dependent ribonuclease [KO:K01165]
101349931  dnaJ homolog subfamily B member 1 [KO:K09507]
101349263  dnaJ homolog subfamily C member 3 isoform X1 [KO:K09523]
101359071  interferon-induced, double-stranded RNA-activated protein kinase isoform X2 [KO:K16195] [EC:2.7.11.1]
101356436  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101344128  E3 ubiquitin/ISG15 ligase TRIM25 isoform X1 [KO:K10652] [EC:2.3.2.27]
101340796  probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
101341398  interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]
101343372  NLR family member X1 isoform X1 [KO:K12653]
101358775  mitochondrial antiviral-signaling protein [KO:K12648]
101341290  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101351256  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101347574  NF-kappa-B essential modulator isoform X1 [KO:K07210]
101357924  NF-kappa-B inhibitor beta [KO:K02581]
101355353  NF-kappa-B inhibitor alpha [KO:K04734]
101351866  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101361706  transcription factor p65 [KO:K04735]
101361776  calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348]
101357653  toll-like receptor 3 isoform X1 [KO:K05401]
101358234  TIR domain-containing adapter molecule 1 [KO:K05842]
101347503  TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101345902  serine/threonine-protein kinase TBK1 isoform X3 [KO:K05410] [EC:2.7.11.10]
101344779  inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
101348880  interferon regulatory factor 3 [KO:K05411]
101344282  CREB-binding protein [KO:K04498] [EC:2.3.1.48]
101349614  histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
101353470  toll-like receptor 4 [KO:K10160]
101348713  toll-like receptor 7 isoform X2 [KO:K05404]
101341326  myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
101349224  interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101352078  interferon regulatory factor 7 [KO:K09447]
101359155  interleukin-1 alpha isoform X1 [KO:K04383]
101359415  IL1B; interleukin-1 beta [KO:K04519]
101351590  interleukin-6 [KO:K05405]
101353752  interleukin-12 subunit alpha [KO:K05406]
101344352  interleukin-12 subunit beta [KO:K05425]
101342656  TNF; tumor necrosis factor [KO:K03156]
101358515  interleukin-8 [KO:K10030]
101358871  C-C motif chemokine 2 [KO:K14624]
101352479  C-C motif chemokine 5 [KO:K12499]
101352998  C-X-C motif chemokine 10 [KO:K12671]
101343257  intercellular adhesion molecule 1 [KO:K06490]
101341058  interferon alpha-5-like [KO:K05414]
101341314  interferon alpha-5-like [KO:K05414]
101341564  interferon alpha-5-like [KO:K05414]
101343075  interferon alpha-5-like [KO:K05414]
101342581  interferon alpha-5-like [KO:K05414]
101342828  interferon alpha-5-like [KO:K05414]
101350125  interferon alpha-5-like [KO:K05414]
101344616  interferon alpha-5-like [KO:K05414]
101343586  interferon alpha-5-like [KO:K05414]
101345099  interferon alpha-5-like [KO:K05414]
101349610  interferon beta [KO:K05415]
101361715  interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
101354122  interferon alpha/beta receptor 2 [KO:K05131]
101346613  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101357635  non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
101348420  suppressor of cytokine signaling 3 [KO:K04696]
101357916  signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101348948  signal transducer and activator of transcription 2 [KO:K11221]
101354811  interferon regulatory factor 9 [KO:K04693]
101361136  interferon-induced GTP-binding protein Mx2 [KO:K14754]
101360020  double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
101356208  protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
101346429  interferon gamma [KO:K04687]
101345582  interferon gamma receptor 1 isoform X1 [KO:K05132]
101361970  interferon gamma receptor 2 [KO:K05133]
101354918  tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
101355081  MHC class II transactivator [KO:K08060] [EC:2.7.11.1]
101343312  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
101343065  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
101344101  LOW QUALITY PROTEIN: boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
101345015  boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
101361245  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
101342567  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
101342817  HLA class II histocompatibility antigen, DP alpha 1 chain isoform X2 [KO:K06752]
101342571  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
101343573  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
101345267  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
101345522  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
101348755  HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
101343031  NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
101357919  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
101359297  caspase-1 [KO:K01370] [EC:3.4.22.36]
101348624  interleukin-18 [KO:K05482]
101356715  interleukin-33 [KO:K12967]
101351035  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101343804  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101347746  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101358678  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101346849  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101359658  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
101360493  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101356099  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101350197  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101351688  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101355276  cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
101359129  tumor necrosis factor ligand superfamily member 10 isoform X2 [KO:K04721]
101348450  tumor necrosis factor receptor superfamily member 10A [KO:K04722]
101344408  tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
101346704  tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
101341867  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101341635  tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101352734  FAS-associated death domain protein [KO:K02373]
101344302  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101356396  BH3-interacting domain death agonist [KO:K04726]
101356564  apoptosis regulator BAX [KO:K02159]
101341201  bcl-2 homologous antagonist/killer [KO:K14021]
101351096  voltage-dependent anion-selective channel protein 1 [KO:K05862]
101351885  ADP/ATP translocase 3 [KO:K05863]
101350620  ADP/ATP translocase 4 [KO:K05863]
101341492  ADP/ATP translocase 2 [KO:K05863]
101354695  ADP/ATP translocase 1 [KO:K05863]
101355182  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
101354940  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
101340375  cytochrome c [KO:K08738]
101351271  cytochrome c-like [KO:K08738]
101349393  apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
101355103  caspase-9 [KO:K04399] [EC:3.4.22.62]
101354307  caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101358918  putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404]
101349392  cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404]
101348094  embryonic polyadenylate-binding protein 2 [KO:K14396]
111819095  polyadenylate-binding protein 2 [KO:K14396]
101342572  nuclear RNA export factor 2-like [KO:K14284]
101345001  nuclear RNA export factor 2-like [KO:K14284]
101362056  nuclear RNA export factor 1 isoform X1 [KO:K14284]
101342413  nuclear RNA export factor 3-like [KO:K14284]
101341638  nuclear RNA export factor 3 [KO:K14284]
101342657  nuclear RNA export factor 2-like [KO:K14284]
101343412  nuclear RNA export factor 3-like [KO:K14284]
101343677  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
101352883  NTF2-related export protein 1 [KO:K14285]
101351071  NTF2-related export protein 2 isoform X4 [KO:K14285]
101341958  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4 [KO:K15047]
101350684  mRNA export factor isoform X2 [KO:K14298]
101348698  nuclear pore complex protein Nup98-Nup96 isoform X3 [KO:K14297]
101359700  radical S-adenosyl methionine domain-containing protein 2 [KO:K15045]
101349919  farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
101348250  protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
101357840  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101343332  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101341078  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101340589  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101358526  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101358156  actin, cytoplasmic 1 [KO:K05692]
101344372  actin, cytoplasmic 2 [KO:K05692]
101342403  ras-related protein Rab-11A [KO:K07904]
101348686  ras-related protein Rab-11B [KO:K07905]
101356593  exportin-1 isoform X1 [KO:K14290]
101343325  importin subunit alpha-5 isoform X2 [KO:K23940]
101350882  importin subunit alpha-1 [KO:K15043]
101346406  importin subunit alpha-8 [KO:K15043]
101359786  importin subunit alpha-7 [KO:K15042]
Compound
C00027  Hydrogen peroxide
C00080  H+
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24225499
  Authors
Edinger TO, Pohl MO, Stertz S
  Title
Entry of influenza A virus: host factors and antiviral targets.
  Journal
J Gen Virol 95:263-77 (2014)
DOI:10.1099/vir.0.059477-0
Reference
PMID:19565019
  Authors
Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
  Title
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
  Journal
J Mol Genet Med 3:167-75 (2008)
Reference
PMID:27751627
  Authors
Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
  Title
A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
  Journal
Trends Microbiol 24:933-943 (2016)
DOI:10.1016/j.tim.2016.09.003
Reference
PMID:18588994
  Authors
Thanh TT, van Doorn HR, de Jong MD
  Title
Human H5N1 influenza: current insight into pathogenesis.
  Journal
Int J Biochem Cell Biol 40:2671-4 (2008)
DOI:10.1016/j.biocel.2008.05.019
Reference
PMID:23977434
  Authors
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
  Title
Influenza A induced cellular signal transduction pathways.
  Journal
J Thorac Dis 5 Suppl 2:S132-41 (2013)
DOI:10.3978/j.issn.2072-1439.2013.07.42
Reference
PMID:20020828
  Authors
Hale BG, Albrecht RA, Garcia-Sastre A
  Title
Innate immune evasion strategies of influenza viruses.
  Journal
Future Microbiol 5:23-41 (2010)
DOI:10.2217/fmb.09.108
Reference
PMID:21698289
  Authors
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
  Title
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
  Journal
PLoS One 6:e20215 (2011)
DOI:10.1371/journal.pone.0020215
Reference
PMID:19782761
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
DOI:10.1016/j.micinf.2009.09.007
Reference
PMID:23170167
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
PMID:30487536
  Authors
Long JS, Mistry B, Haslam SM, Barclay WS
  Title
Host and viral determinants of influenza A virus species specificity.
  Journal
Nat Rev Microbiol 17:67-81 (2019)
DOI:10.1038/s41579-018-0115-z
Reference
PMID:29556226
  Authors
Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
  Title
Host Immune Response to Influenza A Virus Infection.
  Journal
Front Immunol 9:320 (2018)
DOI:10.3389/fimmu.2018.00320
Reference
PMID:20130137
  Authors
Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
  Title
The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
  Journal
J Gen Virol 91:1439-49 (2010)
DOI:10.1099/vir.0.018465-0
Reference
PMID:18980544
  Authors
Ichinohe T, Iwasaki A, Hasegawa H
  Title
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
  Journal
Expert Rev Vaccines 7:1435-45 (2008)
DOI:10.1586/14760584.7.9.1435
Reference
PMID:27231932
  Authors
Le Sage V, Cinti A, Amorim R, Mouland AJ
  Title
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
  Journal
Viruses 8:E152 (2016)
DOI:10.3390/v8060152
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:21971186
  Authors
Varga ZT, Palese P
  Title
The influenza A virus protein PB1-F2: killing two birds with one stone?
  Journal
Virulence 2:542-6 (2011)
DOI:10.4161/viru.2.6.17812
Reference
PMID:30254192
  Authors
Atkin-Smith GK, Duan M, Chen W, Poon IKH
  Title
The induction and consequences of Influenza A virus-induced cell death.
  Journal
Cell Death Dis 9:1002 (2018)
DOI:10.1038/s41419-018-1035-6
Reference
PMID:30545063
  Authors
Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
  Title
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
  Journal
Viruses 10:E708 (2018)
DOI:10.3390/v10120708
Reference
PMID:21253874
  Authors
Dai X, Zhang L, Hong T
  Title
Host cellular signaling induced by influenza virus.
  Journal
Sci China Life Sci 54:68-74 (2011)
DOI:10.1007/s11427-010-4116-z
Reference
PMID:26008706
  Authors
Li J, Yu M, Zheng W, Liu W
  Title
Nucleocytoplasmic shuttling of influenza A virus proteins.
  Journal
Viruses 7:2668-82 (2015)
DOI:10.3390/v7052668
Reference
PMID:30079062
  Authors
Dou D, Revol R, Ostbye H, Wang H, Daniels R
  Title
Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
  Journal
Front Immunol 9:1581 (2018)
DOI:10.3389/fimmu.2018.01581
Reference
PMID:23236273
  Authors
Paterson D, Fodor E
  Title
Emerging roles for the influenza A virus nuclear export protein (NEP).
  Journal
PLoS Pathog 8:e1003019 (2012)
DOI:10.1371/journal.ppat.1003019
Related
pathway
tmu00900  Terpenoid backbone biosynthesis
tmu03013  Nucleocytoplasmic transport
tmu03015  mRNA surveillance pathway
tmu04010  MAPK signaling pathway
tmu04110  Cell cycle
tmu04144  Endocytosis
tmu04210  Apoptosis
tmu04620  Toll-like receptor signaling pathway
tmu04621  NOD-like receptor signaling pathway
tmu04622  RIG-I-like receptor signaling pathway
tmu04630  JAK-STAT signaling pathway
tmu05416  Viral myocarditis
KO pathway
ko05164   
LinkDB

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