KEGG   PATHWAY: tpai04020
Entry
tpai04020                   Pathway                                
Name
Calcium signaling pathway - Tympanuchus pallidicinctus (lesser prairie-chicken)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
tpai04020  Calcium signaling pathway
tpai04020

Other DBs
GO: 0019722
Organism
Tympanuchus pallidicinctus (lesser prairie-chicken) [GN:tpai]
Gene
128077212  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
128085790  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
128073504  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
128087985  plasma membrane calcium-transporting ATPase 4-like isoform X1 [KO:K05850] [EC:7.2.2.10]
128078316  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
128081623  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
128086614  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
128084158  ADORA2A; adenosine receptor A2a [KO:K04266]
128083594  ADORA2B; adenosine receptor A2b [KO:K04267]
128077971  ADRB1; beta-1 adrenergic receptor isoform X1 [KO:K04141]
128081664  ADRB2; beta-2 adrenergic receptor [KO:K04142]
128089996  ADRB3; beta-3 adrenergic receptor [KO:K04143]
128081634  DRD1; D(1A) dopamine receptor [KO:K04144]
128078001  D(1)-like dopamine receptor [KO:K05840]
128079945  DRD5; D(1B) dopamine receptor [KO:K05840]
128080656  octopamine receptor-like isoform X1 [KO:K04150]
128081526  HRH2; histamine H2 receptor [KO:K04150]
128081345  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
128085378  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
128084989  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
128080048  5-hydroxytryptamine receptor 7-like isoform X1 [KO:K04163]
128077813  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
128081238  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
128091460  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
128087769  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
128091036  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
128084684  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
128082547  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
128091225  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
128078941  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
128072854  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
128074908  SLN; sarcolipin [KO:K22642]
128075723  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
128083469  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
128084774  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
128088583  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
128080108  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
128084704  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
128083520  ORAI2; protein orai-2 [KO:K16057]
128073122  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
128078544  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
128090290  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
128073142  voltage-dependent N-type calcium channel subunit alpha-1B-like isoform X1 [KO:K04849]
128072523  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
128083117  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
128078918  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
128073578  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
128075101  neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
128089596  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
128079654  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
128079156  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
128073998  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
128082975  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
128089434  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
128072041  GRIN3B; glutamate receptor ionotropic, NMDA 3B isoform X1 [KO:K05214]
128083615  P2RX1; P2X purinoceptor 1 [KO:K05215]
128083831  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
128085501  LOW QUALITY PROTEIN: bone marrow proteoglycan-like [KO:K05217]
128086341  P2RX3; P2X purinoceptor 3 isoform X1 [KO:K05217]
128084638  P2RX4; P2X purinoceptor 4 isoform X1 [KO:K05218]
128083671  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
128084033  P2RX6; P2X purinoceptor 6 [KO:K05221]
128084635  P2RX7; P2X purinoceptor 7 [KO:K05220]
128087003  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
128086612  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
128077860  TRDN; triadin isoform X1 [KO:K23449]
128072423  CASQ2; calsequestrin-2 [KO:K23445]
128091391  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
128076203  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
128071658  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
128073119  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
128090184  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
128081610  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
128080363  ADRA1D; alpha-1D adrenergic receptor isoform X1 [KO:K04137]
128082574  AGTR1; type-1 angiotensin II receptor [KO:K04166]
128084311  EDNRA; endothelin-1 receptor [KO:K04197]
128076236  endothelin receptor type B-like isoform X1 [KO:K04198]
128092235  EDNRB; endothelin receptor type B [KO:K04198]
128074670  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
128074784  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
128073999  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
128076555  GRPR; gastrin-releasing peptide receptor [KO:K04169]
128078320  HRH1; histamine H1 receptor [KO:K04149]
128082612  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
128075792  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
128071647  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
128088112  lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
128081056  NTSR1; neurotensin receptor type 1 [KO:K04211]
128078307  OXTR; oxytocin receptor [KO:K04229]
128073869  AVPR1A; vasopressin V1a receptor [KO:K04226]
128088127  AVPR1B; vasopressin V1b receptor [KO:K04227]
128088547  PTAFR; platelet-activating factor receptor [KO:K04279]
128072760  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
128072627  PTGFR; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
128086289  BDKRB1; B1 bradykinin receptor [KO:K03915]
128086288  BDKRB2; B2 bradykinin receptor [KO:K03916]
128071865  TACR1; substance-P receptor [KO:K04222]
128078115  TACR2; substance-K receptor isoform X1 [KO:K04223]
128080643  TACR3; neuromedin-K receptor [KO:K04224]
128090142  TBXA2R; thromboxane A2 receptor isoform X1 [KO:K04264]
128080900  thyrotropin-releasing hormone receptor-like [KO:K04282]
128091357  TRHR; thyrotropin-releasing hormone receptor isoform X1 [KO:K04282]
128080123  CCKAR; cholecystokinin receptor type A [KO:K04194]
128088608  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
128076754  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
128089400  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
128090368  GNA11; guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
128080350  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
128090190  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
128079041  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
128073591  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
128074814  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
128084384  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
128083930  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
128080445  FGF2; fibroblast growth factor 2 [KO:K18497]
128080113  FGF20; fibroblast growth factor 20 [KO:K04358]
128086511  FGF3; fibroblast growth factor 3 [KO:K04358]
128086513  FGF4; fibroblast growth factor 4 [KO:K04358]
128080591  FGF5; fibroblast growth factor 5 [KO:K04358]
128074443  FGF10; fibroblast growth factor 10 [KO:K04358]
128081569  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
128074883  FGF9; fibroblast growth factor 9 [KO:K04358]
128075567  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
128076008  FGF16; fibroblast growth factor 16 isoform X1 [KO:K04358]
128090350  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
128077678  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
128084483  FGF6; fibroblast growth factor 6 [KO:K04358]
128086510  FGF19; fibroblast growth factor 19 [KO:K22603]
128084481  FGF23; fibroblast growth factor 23 [KO:K22428]
128076240  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
128080166  VEGFC; LOW QUALITY PROTEIN: vascular endothelial growth factor C [KO:K05449]
128076448  VEGFD; vascular endothelial growth factor D [KO:K05449]
128087993  NGF; beta-nerve growth factor [KO:K02582]
128079558  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
128078764  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
128074489  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
128088438  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
128089037  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
128074177  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
128076846  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
128080542  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
128081597  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
128089959  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
128077633  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
128080206  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
128081672  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
128074996  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
128075754  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
128081503  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
128080541  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
128090579  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
128089796  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
128075412  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
128073475  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
128078755  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
128077909  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
128091911  M1-specific T cell receptor beta chain-like isoform X1 [KO:K10785]
128087322  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
128088755  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
128077279  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
128086570  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
128087418  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
128075392  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
128081205  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
128091181  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like isoform X1 [KO:K01116] [EC:3.1.4.11]
128082052  PLCG2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
128078078  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
128073560  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
128078344  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
128084490  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
128088141  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
128080133  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like isoform X1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
128083820  TPCN1; two pore channel protein 1 isoform X1 [KO:K16896]
128086507  TPCN2; two pore channel protein 2 [KO:K14077]
128079428  MCOLN1; mucolipin-1 [KO:K04992]
128072486  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
128072631  MCOLN3; mucolipin-3 [KO:K04994]
128083264  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
128077896  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
128083973  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
128077551  VDAC2; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2 [KO:K15040]
128071876  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
128079964  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
128076055  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
128071781  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
128078144  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
128078780  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
128080884  TNNC2; troponin C, skeletal muscle isoform X1 [KO:K12042]
128075286  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
128078959  CALM2; calmodulin-2 [KO:K02183]
128085815  CALM1; calmodulin-1 [KO:K02183]
128079715  calmodulin, striated muscle [KO:K02183]
128083704  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
128081883  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
128076114  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
128076396  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
128080942  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
128087741  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
128081886  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
128088754  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
128076624  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
128088075  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
128079737  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
128078665  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
128081602  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
128090212  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
128078211  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
128079887  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
128088935  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
128089507  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
128090046  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
128078201  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
128079870  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
128078635  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
128088144  TFEB; transcription factor EB isoform X1 [KO:K15590]
128087895  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
128080796  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
128081918  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
128084048  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
128083623  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
128085808  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
128077210  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
128085391  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
128091835  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
128084692  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
128082763  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
128085331  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
128083108  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
128078963  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
tpai04010  MAPK signaling pathway
tpai04070  Phosphatidylinositol signaling system
tpai04210  Apoptosis
KO pathway
ko04020   
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