KEGG   PATHWAY: vvp05168
Entry
vvp05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Vulpes vulpes (red fox)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
vvp05168  Herpes simplex virus 1 infection
vvp05168

Organism
Vulpes vulpes (red fox) [GN:vvp]
Gene
112913802  LTA; lymphotoxin-alpha [KO:K05468]
112911825  TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477]
112924719  TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152]
112906881  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
112907150  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
112916156  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
112914804  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
112911512  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
112935347  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
112908352  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112924254  RELA; transcription factor p65 isoform X1 [KO:K04735]
112925935  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
112925936  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
112918107  C-C motif chemokine 2 [KO:K14624]
112920316  NECTIN1; nectin-1 [KO:K06081]
112931233  NECTIN2; nectin-2 isoform X1 [KO:K06531]
112912824  paired immunoglobulin-like type 2 receptor beta [KO:K15411]
112935680  PILRA; paired immunoglobulin-like type 2 receptor alpha [KO:K15411]
112935721  paired immunoglobulin-like type 2 receptor beta [KO:K15411]
112926139  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
112935165  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
112911311  ITGA5; integrin alpha-5 [KO:K06484]
112920636  ITGB3; integrin beta-3 [KO:K06493]
112928171  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
112908642  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
112906963  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
112931284  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
112921940  IFNB1; interferon beta [KO:K05415]
112924853  TP53; cellular tumor antigen p53 [KO:K04451]
112911820  C3; complement C3 isoform X1 [KO:K03990]
112923109  C5; complement C5 isoform X1 [KO:K03994]
112907275  CFP; properdin [KO:K15412]
112933419  TLR2; toll-like receptor 2 [KO:K10159]
112908648  TLR9; toll-like receptor 9 [KO:K10161]
112921656  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
112914606  IRF7; interferon regulatory factor 7 [KO:K09447]
112934769  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
112935599  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
112921061  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
112911496  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
112930471  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
112923157  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
112933980  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
112919509  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
112916797  IL1B; interleukin-1 beta [KO:K04519]
112918099  CCL5; C-C motif chemokine 5 [KO:K12499]
112915865  IL6; interleukin-6 [KO:K05405]
112913803  TNF; tumor necrosis factor [KO:K03156]
112933314  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
112928651  IL12B; interleukin-12 subunit beta [KO:K05425]
112927563  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
112916461  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
112930079  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
112930285  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
112914364  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
112922304  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
112911635  interferon alpha-1/2-like [KO:K05414]
112911642  interferon alpha-3-like [KO:K05414]
112911646  interferon alpha-1/2 [KO:K05414]
112911647  interferon alpha-1/2-like [KO:K05414]
112911648  interferon alpha-1/2 [KO:K05414]
112911649  interferon alpha-1/2-like [KO:K05414]
112921941  interferon alpha-1/2-like [KO:K05414]
112921942  interferon alpha-1/2-like [KO:K05414]
112921945  interferon alpha-2-like [KO:K05414]
112926356  CGAS; cyclic GMP-AMP synthase isoform X1 [KO:K17834] [EC:2.7.7.86]
112933944  TMEM173; stimulator of interferon genes protein isoform X1 [KO:K12654]
112933024  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
112924187  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
112935190  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
112909999  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
112935312  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
112916653  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
112919935  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
112927184  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
112933813  EIF2B1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
112927285  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
112914796  EIF2B3; translation initiation factor eIF-2B subunit gamma isoform X1 [KO:K03241]
112908528  EIF2B4; translation initiation factor eIF-2B subunit delta isoform X1 [KO:K03680]
112926251  EIF2B5; translation initiation factor eIF-2B subunit epsilon isoform X1 [KO:K03240]
112935202  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
112935211  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
112921799  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
112911506  HCFC1; host cell factor 1 isoform X1 [KO:K14966]
112930660  HCFC2; host cell factor 2 [KO:K27390]
112920314  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
112923504  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
112931385  POU2F2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
112909256  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
112909270  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
112920856  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
112907887  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
112909637  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
112922923  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
112922378  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
112926537  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
112929530  ZNF23; zinc finger protein 23 [KO:K09228]
112922724  ZNF133; zinc finger protein 133 isoform X1 [KO:K09228]
112908784  LOW QUALITY PROTEIN: zinc finger protein 551-like [KO:K09228]
112908785  zinc finger protein 211-like isoform X1 [KO:K09228]
112908786  zinc finger protein 154-like [KO:K09228]
112908792  zinc finger protein 324A-like isoform X1 [KO:K09228]
112908796  zinc finger protein 324A-like [KO:K09228]
112909965  LOW QUALITY PROTEIN: zinc finger protein 33B-like [KO:K09228]
112909981  ZNF12; LOW QUALITY PROTEIN: zinc finger protein 12 [KO:K09228]
112912693  zinc finger protein 345-like [KO:K09228]
112912714  zinc finger protein 724-like [KO:K09228]
112912778  zinc finger protein 883-like [KO:K09228]
112929239  ZNF768; zinc finger protein 768 [KO:K09228]
112929240  zinc finger protein 501 isoform X1 [KO:K09228]
112929345  ZNF688; zinc finger protein 688 [KO:K09228]
112929346  LOW QUALITY PROTEIN: zinc finger protein 785-like [KO:K09228]
112929362  RBAK; RB-associated KRAB zinc finger protein [KO:K09228]
112930140  ZNF436; zinc finger protein 436 isoform X1 [KO:K09228]
112931237  ZNF175; zinc finger protein 175 isoform X1 [KO:K09228]
112931279  ZNF229; zinc finger protein 229 isoform X1 [KO:K09228]
112931280  ZNF285; zinc finger protein 285 [KO:K09228]
112931304  ZNF180; zinc finger protein 180 isoform X1 [KO:K09228]
112931307  zinc finger protein 260-like [KO:K09228]
112931316  ZNF112; zinc finger protein 112 isoform X1 [KO:K09228]
112931318  zinc finger protein 227-like [KO:K09228]
112931319  ZNF45; zinc finger protein 45 isoform X1 [KO:K09228]
112931320  ZNF235; LOW QUALITY PROTEIN: zinc finger protein 235 [KO:K09228]
112931321  ZNF283; LOW QUALITY PROTEIN: zinc finger protein 283 [KO:K09228]
112931322  ZNF404; zinc finger protein 404 [KO:K09228]
112931323  zinc finger protein-like [KO:K09228]
112908803  ZNF484; zinc finger protein 484 [KO:K09228]
112908822  ZNF132; zinc finger protein 132 [KO:K09228]
112908823  zinc finger protein 850-like isoform X1 [KO:K09228]
112908825  zinc finger protein 418-like [KO:K09228]
112908826  putative uncharacterized zinc finger protein 814 [KO:K09228]
112908827  zinc finger protein 256-like [KO:K09228]
112908828  ZNF606; zinc finger protein 606 [KO:K09228]
112908829  zinc finger protein 345-like isoform X1 [KO:K09228]
112908830  ZNF135; zinc finger protein 135 [KO:K09228]
112908833  ZNF8; zinc finger protein 8 [KO:K09228]
112908837  zinc finger protein OZF-like [KO:K09228]
112908843  ZNF671; zinc finger protein 671 isoform X1 [KO:K09228]
112908845  zinc finger protein 132-like [KO:K09228]
112908846  ZNF584; zinc finger protein 584 isoform X1 [KO:K09228]
112908861  ZNF544; LOW QUALITY PROTEIN: zinc finger protein 544 [KO:K09228]
112908870  ZNF169; zinc finger protein 169 isoform X1 [KO:K09228]
112910015  ZNF853; zinc finger protein 853 [KO:K09228]
112910016  ZNF316; zinc finger protein 316 [KO:K09228]
112912810  zinc finger protein 324A-like [KO:K09228]
112915670  ZFP1; zinc finger protein 1 homolog isoform X1 [KO:K09228]
112931413  ZNF677; zinc finger protein 677 [KO:K09228]
112931414  zinc finger protein 268-like isoform X1 [KO:K09228]
112931415  ZNF613; zinc finger protein 613 isoform X1 [KO:K09228]
112908069  LOW QUALITY PROTEIN: zinc finger protein 791-like [KO:K09228]
112908077  ZNF333; zinc finger protein 333 isoform X1 [KO:K09228]
112908090  LOW QUALITY PROTEIN: zinc finger protein 709-like [KO:K09228]
112911911  zinc finger protein OZF-like isoform X1 [KO:K09228]
112911912  ZNF550; zinc finger protein 550 [KO:K09228]
112911917  ZNF304; zinc finger protein 304 [KO:K09228]
112911918  zinc finger protein 883-like [KO:K09228]
112911919  ZNF772; zinc finger protein 772 [KO:K09228]
112911920  zinc finger protein 773-like isoform X1 [KO:K09228]
112911926  LOW QUALITY PROTEIN: zinc finger protein with KRAB and SCAN domains 7-like [KO:K09228]
112911928  zinc finger protein 549-like [KO:K09228]
112916238  ZNF777; zinc finger protein 777 [KO:K09228]
112916239  ZNF282; LOW QUALITY PROTEIN: zinc finger protein 282 [KO:K09228]
112916240  ZNF212; zinc finger protein 212 isoform X1 [KO:K09228]
112916242  ZNF398; zinc finger protein 398 isoform X1 [KO:K09228]
112916243  ZNF425; zinc finger protein 425 isoform X1 [KO:K09228]
112916244  ZNF786; zinc finger protein 786 [KO:K09228]
112916257  ZNF746; zinc finger protein 746 [KO:K09228]
112916258  ZNF783; protein ZNF783 [KO:K09228]
112923256  ZNF597; zinc finger protein 597 [KO:K09228]
112930816  ZNF189; zinc finger protein 189 isoform X1 [KO:K09228]
112931418  zinc finger protein 347-like [KO:K09228]
112931419  zinc finger protein 677-like isoform X1 [KO:K09228]
112931420  zinc finger protein 84-like [KO:K09228]
112931421  zinc finger protein 677-like [KO:K09228]
112931422  ZNF577; zinc finger protein 577 [KO:K09228]
112931430  LOW QUALITY PROTEIN: zinc finger protein 432-like [KO:K09228]
112931455  ZNF473; zinc finger protein 473 isoform X1 [KO:K09228]
112931488  uncharacterized protein LOC112931488 [KO:K09228]
112931489  LOW QUALITY PROTEIN: zinc finger protein 84-like [KO:K09228]
112931545  zinc finger protein 226-like [KO:K09228]
112931941  ZNF334; zinc finger protein 334 [KO:K09228]
112907541  zinc finger protein 883-like isoform X1 [KO:K09228]
112907542  ZNF74; zinc finger protein 74 isoform X1 [KO:K09228]
112911470  ZFP92; zinc finger protein 92 homolog isoform X1 [KO:K09228]
112912880  zinc finger protein 420-like [KO:K09228]
112932474  zinc finger protein 354B isoform X1 [KO:K09228]
112932475  zinc finger protein 454-like isoform X1 [KO:K09228]
112908148  zinc finger protein 709-like [KO:K09228]
112908157  zinc finger protein 709-like [KO:K09228]
112909428  ZNF331; zinc finger protein 331 [KO:K09228]
112909435  zinc finger protein 471 isoform X1 [KO:K09228]
112909437  ZNF470; zinc finger protein 470 isoform X1 [KO:K09228]
112909438  ZNF667; zinc finger protein 667 isoform X1 [KO:K09228]
112909439  ZNF583; zinc finger protein 583 isoform X1 [KO:K09228]
112909440  ZNF582; zinc finger protein 582 isoform X1 [KO:K09228]
112924919  zinc finger protein 883-like isoform X1 [KO:K09228]
112924920  ZNF286A; zinc finger protein 286A [KO:K09228]
112924921  ZNF624; zinc finger protein 624 [KO:K09228]
112908200  ZFP69B; zinc finger protein 69 homolog B isoform X1 [KO:K09228]
112908201  ZFP69; zinc finger protein 69 homolog isoform X1 [KO:K09228]
112908244  zinc finger protein 684 isoform X1 [KO:K09228]
112912128  ZFP57; zinc finger protein 57 homolog [KO:K09228]
112925542  zinc finger protein 596-like [KO:K09228]
112925543  ZNF596; zinc finger protein 596 isoform X1 [KO:K09228]
112909647  ZNF557; zinc finger protein 557 isoform X1 [KO:K09228]
112909660  ZNF317; zinc finger protein 317 [KO:K09228]
112916626  zinc finger protein 514-like isoform X1 [KO:K09228]
112927382  LOW QUALITY PROTEIN: zinc finger protein 33B-like [KO:K09228]
112927383  zinc finger protein 2 homolog isoform X1 [KO:K09228]
112927385  ZNF37A; zinc finger protein 37A isoform X1 [KO:K09228]
112927386  ZNF25; zinc finger protein 25 isoform X1 [KO:K09228]
112911505  ZNF275; zinc finger protein 275 [KO:K09228]
112921525  uncharacterized protein LOC112921525 [KO:K09228]
112921602  ZNF662; zinc finger protein 662 isoform X1 [KO:K09228]
112909720  zinc finger protein 699 isoform X1 [KO:K09228]
112909721  zinc finger protein 426-like [KO:K09228]
112909723  ZNF177; zinc finger protein 177 [KO:K09228]
112909724  ZNF846; zinc finger protein 846 isoform X1 [KO:K09228]
112911116  zinc finger protein 252 isoform X1 [KO:K09228]
112911121  zinc finger protein 250-like isoform X1 [KO:K09228]
112911124  ZNF34; zinc finger protein 34 isoform X1 [KO:K09228]
112912457  ZNF248; zinc finger protein 248 isoform X1 [KO:K09228]
112934104  ZNF713; zinc finger protein 713 [KO:K09228]
112909067  ZNF205; zinc finger protein 205 isoform X1 [KO:K09228]
112910269  ZNF311; zinc finger protein 311 isoform X1 [KO:K09228]
112910276  ZNF184; zinc finger protein 184 isoform X1 [KO:K09228]
112911588  zinc finger protein 84 isoform X1 [KO:K09228]
112911590  zinc finger protein 605 isoform X1 [KO:K09228]
112911592  ZNF140; zinc finger protein 140 isoform X1 [KO:K09228]
112911594  ZNF10; LOW QUALITY PROTEIN: zinc finger protein 10 [KO:K09228]
112911613  ZNF891; LOW QUALITY PROTEIN: zinc finger protein 891 [KO:K09228]
112927107  ZNF214; zinc finger protein 214 isoform X1 [KO:K09228]
112927157  ZNF300; zinc finger protein 300 isoform X1 [KO:K09228]
112911133  ZNF623; zinc finger protein 623 [KO:K09228]
112911166  ZNF7; zinc finger protein 7 [KO:K09228]
112921086  ZNF641; zinc finger protein 641 [KO:K09228]
112927903  ZNF79; zinc finger protein 79 isoform X1 [KO:K09228]
112928315  LOW QUALITY PROTEIN: zinc finger protein 345-like [KO:K09228]
112928380  zinc finger protein 780A-like isoform X1 [KO:K09228]
112928428  zinc finger protein 181-like isoform X1 [KO:K09228]
112928509  ZNF383; zinc finger protein 383 [KO:K09228]
112928516  ZNF829; zinc finger protein 829 isoform X1 [KO:K09228]
112928518  ZNF793; zinc finger protein 793 isoform X1 [KO:K09228]
112935538  ZNF555; zinc finger protein 555 [KO:K09228]
112935539  zinc finger protein 556-like [KO:K09228]
112935554  zinc finger protein 77-like isoform X1 [KO:K09228]
112909105  ZNF200; zinc finger protein 200 isoform X1 [KO:K09228]
112907253  ZNF630; zinc finger protein 630 isoform X1 [KO:K09228]
112907263  ZNF41; zinc finger protein 41 [KO:K09228]
112907267  ZNF81; zinc finger protein 81 isoform X1 [KO:K09228]
112907268  ZNF674; zinc finger protein 674 isoform X1 [KO:K09228]
112907270  ZNF182; zinc finger protein 182 isoform X1 [KO:K09228]
112907273  ZNF157; zinc finger protein 157 isoform X1 [KO:K09228]
112908693  ZNF510; zinc finger protein 510 [KO:K09228]
112908694  ZNF782; zinc finger protein 782 [KO:K09228]
112912585  ZNF658; LOW QUALITY PROTEIN: zinc finger protein 658 [KO:K09228]
112912649  zinc finger protein 345-like [KO:K09228]
112916849  zinc finger protein 850-like [KO:K09228]
112928472  zinc finger protein 585A isoform X1 [KO:K09228]
112928474  zinc finger protein 850-like [KO:K09228]
112928476  ZNF568; zinc finger protein 568 isoform X1 [KO:K09228]
112928477  zinc finger protein 569 [KO:K09228]
112928479  ZNF571; zinc finger protein 571 [KO:K09228]
112928480  ZNF420; zinc finger protein 420 isoform X1 [KO:K09228]
112928483  ZNF567; zinc finger protein 567 [KO:K09228]
112928484  HKR1; Krueppel-related zinc finger protein 1 isoform X1 [KO:K09228]
112928485  ZNF792; zinc finger protein 792 isoform X1 [KO:K09228]
112928487  ZNF790; zinc finger protein 790 isoform X1 [KO:K09228]
112928491  ZNF461; zinc finger protein 461 isoform X1 [KO:K09228]
112928493  ZNF527; zinc finger protein 527 isoform X1 [KO:K09228]
112928494  ZNF599; zinc finger protein 599 isoform X1 [KO:K09228]
112928495  zinc finger protein 82 homolog isoform X1 [KO:K09228]
112928498  zinc finger protein 570 [KO:K09228]
112928500  ZNF382; zinc finger protein 382 isoform X1 [KO:K09228]
112928503  ZFP30; zinc finger protein 30 homolog isoform X1 [KO:K09228]
112928504  ZNF529; zinc finger protein 529 [KO:K09228]
112928505  ZNF565; zinc finger protein 565 [KO:K09228]
112929329  zinc finger protein 300-like isoform X1 [KO:K09228]
112929456  ZFP90; zinc finger protein 90 homolog [KO:K09228]
112919008  zinc finger protein 419-like [KO:K09228]
112923068  ZFP37; zinc finger protein 37 homolog isoform X1 [KO:K09228]
112932428  ZNF354A; zinc finger protein 354A isoform X1 [KO:K09228]
112932463  ZNF354C; zinc finger protein 354C [KO:K09228]
112932839  zinc finger protein 705A-like isoform X1 [KO:K09228]
112913165  ZNF502; zinc finger protein 502 [KO:K09228]
112909358  zinc finger protein 345-like [KO:K09228]
112909359  zinc finger protein 675-like [KO:K09228]
112911927  zinc finger protein 599-like [KO:K09228]
112913470  ZNF485; zinc finger protein 485 [KO:K09228]
112908147  zinc finger protein 14-like isoform X1 [KO:K09228]
112909708  zinc finger protein 2 homolog [KO:K09228]
112912593  LOW QUALITY PROTEIN: zinc finger protein 420-like [KO:K09228]
112912594  LOW QUALITY PROTEIN: zinc finger protein 678-like [KO:K09228]
112912651  LOW QUALITY PROTEIN: zinc finger protein 493-like [KO:K09228]
112912655  LOW QUALITY PROTEIN: zinc finger protein 493-like [KO:K09228]
112928779  zinc finger protein 33B-like isoform X1 [KO:K09228]
112909988  zinc finger protein OZF-like isoform X1 [KO:K09228]
112908848  zinc finger protein 502-like isoform X1 [KO:K09228]
112912741  zinc finger protein 264-like [KO:K09228]
112913109  BST2; bone marrow stromal antigen 2 [KO:K06731]
112922237  IFNG; interferon gamma [KO:K04687]
112919471  IFNGR1; interferon gamma receptor 1 [KO:K05132]
112909266  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
112922148  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
112913887  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
112925462  nuclear body protein SP140-like protein [KO:K15413]
112918012  PML; protein PML [KO:K10054] [EC:2.3.2.-]
112913865  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
112913862  TAP2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
112913885  TAPBP; tapasin [KO:K08058]
112920006  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
112908141  CALR; calreticulin [KO:K08057]
112913580  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
112913584  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
112913586  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
112912180  HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X1 [KO:K06751]
112913727  DLA class I histocompatibility antigen, A9/A9 alpha chain [KO:K06751]
112920024  B2M; beta-2-microglobulin [KO:K08055]
112914136  LOW QUALITY PROTEIN: RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
112914199  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
112913647  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
112913648  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
112913861  SLA class II histocompatibility antigen, DQ haplotype C beta chain-like [KO:K06752]
112913864  HLA class II histocompatibility antigen, DO beta chain-like [KO:K06752]
112913867  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
112913868  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
112912663  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
112912664  SLA class II histocompatibility antigen, DQ haplotype C beta chain-like [KO:K06752]
112927272  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
112924665  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
112926217  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112934961  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112914774  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112913170  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112935820  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112928376  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112930303  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112923528  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112928006  TSC1; hamartin isoform X1 [KO:K07206]
112909041  TSC2; tuberin isoform X1 [KO:K07207]
112916202  RHEB; GTP-binding protein Rheb [KO:K07208]
112929738  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
112916127  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
112913929  SRPK1; SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
112917914  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
112920664  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
112913941  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
112927217  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
112931642  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
112920096  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
112935274  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
112932898  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
112924352  NXF1; nuclear RNA export factor 1 [KO:K14284]
112912524  NXF3; nuclear RNA export factor 3 [KO:K14284]
112925667  nuclear RNA export factor 2-like [KO:K14284]
112925669  nuclear RNA export factor 2-like [KO:K14284]
112925705  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
112920580  ALYREF; THO complex subunit 4 [KO:K12881]
112921762  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
112931965  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
112917515  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
112929410  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
112924009  FADD; FAS-associated death domain protein [KO:K02373]
112922873  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
112917438  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
112931372  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
112913897  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
112924315  BAD; bcl2-associated agonist of cell death [KO:K02158]
112919203  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
112909902  BCL2L1; bcl-2-like protein 1 [KO:K04570]
112916549  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
112915706  cytochrome c [KO:K08738]
112930669  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
112929772  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
112934766  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
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Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
vvp03040  Spliceosome
vvp03050  Proteasome
vvp04115  p53 signaling pathway
vvp04151  PI3K-Akt signaling pathway
vvp04210  Apoptosis
vvp04610  Complement and coagulation cascades
vvp04612  Antigen processing and presentation
vvp04620  Toll-like receptor signaling pathway
vvp04622  RIG-I-like receptor signaling pathway
vvp04630  JAK-STAT signaling pathway
KO pathway
ko05168   
LinkDB

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