KEGG   PATHWAY: pflv04510
Entry
pflv04510                   Pathway                                
Name
Focal adhesion - Perca flavescens (yellow perch)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pflv04510  Focal adhesion
pflv04510

Other DBs
GO: 0005925
Organism
Perca flavescens (yellow perch) [GN:pflv]
Gene
114567629  col1a2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
114569989  collagen alpha-1(I) chain-like [KO:K06236]
114548727  collagen alpha-1(I) chain-like [KO:K06236]
114558487  collagen alpha-1(II) chain-like [KO:K19719]
114554015  collagen alpha-1(II) chain [KO:K19719]
114564810  collagen alpha-4(IV) chain-like isoform X1 [KO:K06237]
114564811  collagen alpha-5(IV) chain-like [KO:K06237]
114552971  collagen alpha-4(IV) chain-like [KO:K06237]
114552973  collagen alpha-5(IV) chain-like [KO:K06237]
114546009  col4a6; collagen alpha-6(IV) chain [KO:K06237]
114546010  LOW QUALITY PROTEIN: collagen alpha-5(IV) chain-like [KO:K06237]
114563803  col4a2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
114563804  col4a1; collagen alpha-1(IV) chain [KO:K06237]
114564888  col6a1; collagen alpha-1(VI) chain [KO:K06238]
114564920  collagen alpha-2(VI) chain-like isoform X1 [KO:K06238]
114556521  collagen alpha-6(VI) chain-like [KO:K06238]
114556924  collagen alpha-6(VI) chain-like isoform X1 [KO:K06238]
114556932  collagen alpha-6(VI) chain-like [KO:K06238]
114557016  collagen alpha-6(VI) chain-like isoform X1 [KO:K06238]
114563693  LOW QUALITY PROTEIN: collagen alpha-3(VI) chain-like [KO:K06238]
114563694  col6a3; LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238]
114563800  collagen alpha-2(VI) chain-like [KO:K06238]
114545663  collagen alpha-1(IX) chain-like [KO:K08131]
114567632  col9a2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
114568666  collagen alpha-3(IX) chain-like [KO:K08131]
114572084  col9a1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
114558069  col9a3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
114572804  lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
114551694  LOW QUALITY PROTEIN: laminin subunit alpha-1-like [KO:K05637]
114564806  lama3; laminin subunit alpha-3 isoform X1 [KO:K06240]
114559067  lama5; laminin subunit alpha-5 isoform X1 [KO:K06240]
114572757  lama4; laminin subunit alpha-4 [KO:K06241]
114560593  laminin subunit beta-1-like [KO:K05636]
114549974  laminin subunit beta-1-like [KO:K05636]
114558423  lamb2; laminin subunit beta-2 [KO:K06243]
114559291  laminin subunit beta-2-like [KO:K06243]
114553523  lamb3; laminin subunit beta-3 [KO:K06244]
114560595  LOW QUALITY PROTEIN: laminin subunit beta-4-like [KO:K06245]
114564774  lamc1; laminin subunit gamma-1 [KO:K05635]
114565533  laminin subunit gamma-2-like [KO:K06246]
114570542  laminin subunit gamma-3-like [KO:K06247]
114547849  chad; chondroadherin [KO:K06248]
114559851  reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
114546727  thrombospondin-1-like [KO:K16857]
114573037  thbs1; thrombospondin-1 [KO:K16857]
114570660  thrombospondin-4-B isoform X1 [KO:K04659]
114547869  thrombospondin-2-like [KO:K04659]
114561141  comp; cartilage oligomeric matrix protein [KO:K04659]
114555311  thrombospondin-4-B-like isoform X1 [KO:K04659]
114571758  thbs2; thrombospondin-2 isoform X1 [KO:K04659]
114557861  thbs3; thrombospondin-3 [KO:K04659]
114560228  fibronectin-like isoform X1 [KO:K05717]
114567159  vitronectin-like [KO:K06251]
114553230  vitronectin-like [KO:K06251]
114565490  tnr; tenascin-R [KO:K06252]
114568757  tnxb; tenascin-X isoform X1 [KO:K06252]
114571463  tenascin-like isoform X1 [KO:K06252]
114555529  tenascin-like isoform X1 [KO:K06252]
114565106  tnn; tenascin-N isoform X1 [KO:K06252]
114557355  tenascin-like [KO:K06252]
114560628  LOW QUALITY PROTEIN: von Willebrand factor-like [KO:K03900]
114571113  itga1; integrin alpha-1 [KO:K06480]
114555791  itga2; integrin alpha-2 isoform X1 [KO:K06481]
114568873  integrin alpha-3-like isoform X1 [KO:K06482]
114547839  itga3; integrin alpha-3 [KO:K06482]
114563808  itga4; integrin alpha-4 [KO:K06483]
114554385  integrin alpha-5-like [KO:K06484]
114558301  integrin alpha-5-like [KO:K06484]
114564899  integrin alpha-6-like isoform X1 [KO:K06485]
114563374  integrin alpha-6-like [KO:K06485]
114564317  itga6; integrin alpha-6 isoform X1 [KO:K06485]
114554671  itga7; integrin alpha-7 isoform X1 [KO:K06583]
114557043  itga8; integrin alpha-8 [KO:K06584]
114572101  itga9; integrin alpha-9 isoform X1 [KO:K06585]
114556536  itga10; integrin alpha-10 [KO:K06586]
114559410  itga11; integrin alpha-11 isoform X1 [KO:K06587]
114560121  integrin alpha-11-like [KO:K06587]
114563523  itgav; integrin alpha-V [KO:K06487]
114564940  integrin beta-1-like [KO:K05719]
114548960  itgb1; integrin beta-1 isoform X1 [KO:K05719]
114569063  integrin beta-3-like [KO:K06493]
114548400  itgb3; integrin beta-3 isoform X1 [KO:K06493]
114547778  itgb4; integrin beta-4 [KO:K06525]
114564531  itgb5; integrin beta-5 [KO:K06588]
114552855  itgb6; integrin beta-6 [KO:K06589]
114568626  itgb8; integrin beta-8 [KO:K06591]
114568869  emp2; epithelial membrane protein 2 [KO:K26256]
114564713  platelet-derived growth factor subunit A-like [KO:K04359]
114570050  pdgfa; platelet-derived growth factor subunit A [KO:K04359]
114548096  uncharacterized protein LOC114548096 isoform X1 [KO:K17386]
114549755  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
114562955  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
114563345  egf; pro-epidermal growth factor [KO:K04357]
114559177  insulin-like growth factor I [KO:K05459]
114549943  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
114572978  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
114562277  vegfb; vascular endothelial growth factor B [KO:K05448]
114557256  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
114547115  placenta growth factor-like [KO:K16859]
114573284  vascular endothelial growth factor A-like isoform X1 [KO:K16859]
114558708  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
114550825  vascular endothelial growth factor C-like [KO:K05449]
114564168  vegfc; vascular endothelial growth factor C [KO:K05449]
114560350  hepatocyte growth factor-like [KO:K05460]
114550128  hepatocyte growth factor-like [KO:K05460]
114561192  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
114566403  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
114562615  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
114560454  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
114560702  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
114561463  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
114548913  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
114564973  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
114562330  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
114549359  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
114562616  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
114560667  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
114547884  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
114569709  epithelial membrane protein 2-like [KO:K26255]
114546759  epithelial membrane protein 2-like [KO:K26255]
114554227  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
114558328  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
114553094  arhgap35; rho GTPase-activating protein 35 [KO:K05732]
114567288  rho GTPase-activating protein 35-like [KO:K05732]
114547452  arhgap5; rho GTPase-activating protein 5 [KO:K13709]
114558364  rho-related GTP-binding protein RhoA-D [KO:K04513]
114558365  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
114558700  rho-related GTP-binding protein RhoA-C [KO:K04513]
114558914  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
114553635  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
114553877  rho-related GTP-binding protein RhoA-B [KO:K04513]
114565008  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
114546465  rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
114572998  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.39]
114553906  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
114555838  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
114570867  myosin light chain 5-like [KO:K12753]
114555563  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
114553612  myosin regulatory light polypeptide 9 [KO:K12755]
114549044  myosin regulatory light polypeptide 9 [KO:K12757]
114565181  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
114570417  mylpf; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
114548252  myosin regulatory light chain 2, skeletal muscle isoform-like [KO:K12758]
114546620  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
114569623  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
114547698  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
114555082  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
114573024  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
114573966  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
114549886  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
114559811  protein phosphatase 1 regulatory subunit 12A-like isoform X1 [KO:K17457]
114571436  ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
114565381  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
114568996  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
114561233  mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
114548063  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
114565378  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
114568319  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
114570920  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like isoform X1 [KO:K00889] [EC:2.7.1.68]
114561216  pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
114556070  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
114556635  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
114568982  actb; actin, cytoplasmic 1 [KO:K05692]
114564075  actin, cytoplasmic 2-like isoform X1 [KO:K05692]
114564303  actin, cytoplasmic 2 [KO:K05692]
114556359  actin, non-muscle 6.2 [KO:K05692]
114560574  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
114573460  LOW QUALITY PROTEIN: ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
114566584  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
114572526  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
114556645  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
114556646  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
114556744  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
114563664  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
114563675  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
114557816  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
114557817  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
114557979  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
114557980  calpain-2 catalytic subunit-like isoform X1 [KO:K03853] [EC:3.4.22.53]
114546495  actn1; alpha-actinin-1 isoform X1 [KO:K05699]
114550877  alpha-actinin-4-like isoform X1 [KO:K05699]
114559553  tln2; talin-2 isoform X1 [KO:K06271]
114570531  tln1; talin-1 isoform X1 [KO:K06271]
114550057  talin-2 isoform X1 [KO:K06271]
114559340  filamin-A-like isoform X1 [KO:K04437]
114554717  flnb; filamin-B isoform X1 [KO:K27392]
114553666  pxn; paxillin isoform X1 [KO:K05760]
114555555  verprolin-like isoform X1 [KO:K05760]
114552620  ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
114567223  integrin-linked protein kinase-like [KO:K06272] [EC:2.7.11.1]
114557478  zyx; zyxin [KO:K06273]
114552818  LOW QUALITY PROTEIN: vasodilator-stimulated phosphoprotein-like [KO:K06274]
114566840  vasodilator-stimulated phosphoprotein-like isoform X1 [KO:K06274]
114548129  vcl; vinculin isoform X1 [KO:K05700]
114571921  vinculin-like isoform X1 [KO:K05700]
114559932  parvb; beta-parvin isoform X1 [KO:K06275]
114560159  alpha-parvin [KO:K06275]
114560849  parvg; gamma-parvin [KO:K06275]
114548419  pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
114552505  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114566492  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
114546570  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114548453  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
114572548  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114563778  gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114567890  catenin beta-1-like [KO:K02105]
114556866  ctnnb1; catenin beta-1 [KO:K02105]
114565339  prkca; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
114570388  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
114566211  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
114569627  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
114557331  LOW QUALITY PROTEIN: protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
114557222  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
114567908  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
114552427  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
114558791  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
114545581  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
114561210  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
114565044  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114564919  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
114566080  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
114570516  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114561139  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
114561270  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
114555608  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
114572137  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
114548616  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
114564847  guanine nucleotide exchange factor VAV3-like isoform X1 [KO:K05730]
114565577  vav1; proto-oncogene vav isoform X1 [KO:K05730]
114570713  vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
114549401  vav3; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV3 [KO:K05730]
114569702  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
114547620  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
114565746  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
114547780  rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
114552600  pak1; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
114546388  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
114561445  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
114566551  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
114552562  pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
114573558  pak5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
114547068  serine/threonine-protein kinase PAK 4-like [KO:K05735] [EC:2.7.11.1]
114572915  serine/threonine-protein kinase PAK 4-like [KO:K05735] [EC:2.7.11.1]
114559266  cell division control protein 42 homolog isoform X1 [KO:K04393]
114567735  cell division control protein 42 homolog [KO:K04393]
114554917  cell division control protein 42 homolog [KO:K04393]
114557534  cell division control protein 42 homolog [KO:K04393]
114560766  bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
114552699  adapter molecule crk-like [KO:K04438]
114566637  adapter molecule crk-like [KO:K04438]
114571390  crkl; crk-like protein isoform X1 [KO:K04438]
114547823  dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
114570984  rapgef1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
114556397  rap guanine nucleotide exchange factor 1-like [KO:K06277]
114558435  ras-related protein Rap-1A [KO:K04353]
114553888  ras-related protein Rap-1A-like [KO:K04353]
114549955  ras-related protein Rap-1b [KO:K07836]
114570928  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114547944  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
114572302  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
114563046  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
114566085  jun; transcription factor AP-1 [KO:K04448]
114571404  transcription factor AP-1-like [KO:K04448]
114561902  transcription factor AP-1-like [KO:K04448]
114550105  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
114560589  cav1; caveolin-1 [KO:K06278]
114559192  caveolin-2-like [KO:K12958]
114553726  caveolin-2-like [KO:K12958]
114554233  caveolin-2-like [KO:K12958]
114560264  cav2; caveolin-2 [KO:K12958]
114554959  cav3; caveolin-3 [KO:K12959]
114546343  tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
114572774  fyn; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
114556600  shc1; LOW QUALITY PROTEIN: SHC-transforming protein 1 [KO:K06279]
114561987  shc2; SHC-transforming protein 2 isoform X1 [KO:K17447]
114571470  shc3; SHC-transforming protein 3 [KO:K17448]
114556819  shc4; SHC-transforming protein 4 isoform X1 [KO:K17449]
114570079  grb2; growth factor receptor-bound protein 2 [KO:K04364]
114546491  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
114568696  LOW QUALITY PROTEIN: son of sevenless homolog 1-like [KO:K03099]
114559784  hras; GTPase HRas [KO:K02833]
114559447  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114559598  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
114569468  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
114555749  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114558838  ETS domain-containing protein Elk-3-like [KO:K04375]
114552928  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
114560618  G1/S-specific cyclin-D1-like [KO:K04503]
114568885  G1/S-specific cyclin-D2-like [KO:K10151]
114560206  ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
114550465  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
114553865  G1/S-specific cyclin-D2-like [KO:K10152]
114566357  inhibitor of apoptosis protein-like [KO:K16060]
114563007  xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
114545719  bad; bcl2-associated agonist of cell death [KO:K02158]
114565630  apoptosis regulator Bcl-2-like [KO:K02161]
114549636  apoptosis regulator Bcl-2-like [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
pflv04010  MAPK signaling pathway
pflv04060  Cytokine-cytokine receptor interaction
pflv04070  Phosphatidylinositol signaling system
pflv04110  Cell cycle
pflv04310  Wnt signaling pathway
pflv04512  ECM-receptor interaction
pflv04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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