Entry Name MicroRNAs in cancer - Peromyscus leucopus (white-footed mouse)
Description MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer. The upregulation (overexpression) of specific miRNAs could lead to the repression of tumor suppressor gene expression, and conversely the downregulation of specific miRNAs could result in an increase of oncogene expression; both these situations induce subsequent malignant effects on cell proliferation, differentiation, and apoptosis that lead to tumor growth and progress. The miRNA signatures of cancer observed in various studies differ significantly. These inconsistencies occur due to the differences in the study populations and methodologies used. This pathway map shows the summarized results from various studies in 9 cancers, each of which is presented in a review article.
Class Human Diseases; Cancer: overviewBRITE hierarchy
Pathway map Organism Peromyscus leucopus (white-footed mouse) [GN:
pleu ]
Gene 114680595 Rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204 ]
114682383 Mcl1; LOW QUALITY PROTEIN: induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539 ]
114682786 Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
114683897 Shc4; LOW QUALITY PROTEIN: SHC-transforming protein 4 [KO:K17449 ]
114684032 Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
114684081 Apc2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085 ]
114684840 Dicer1; endoribonuclease Dicer isoform X1 [KO:K11592 ] [EC:3.1.26.-]
114686138 Notch3; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 3 [KO:K20995 ]
114686260 Notch2; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 2 [KO:K20994 ]
114688602 Hnrnpk; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886 ]
114688966 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649 ]
114692821 Notch1; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1 [KO:K02599 ]
114692977 Igf2bp1; insulin-like growth factor 2 mRNA-binding protein 1 isoform X1 [KO:K17391 ]
114693559 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
114694276 Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386 ]
114695335 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
114695568 Zeb1; zinc finger E-box-binding homeobox 1 isoform X1 [KO:K09299 ]
114696876 Marcks; LOW QUALITY PROTEIN: myristoylated alanine-rich C-kinase substrate [KO:K12561 ]
114698210 Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376 ]
114699141 Slc7a1; high affinity cationic amino acid transporter 1 [KO:K13863 ]
114700972 Zeb2; zinc finger E-box-binding homeobox 2 isoform X1 [KO:K23560 ]
114703850 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
114705300 Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448 ]
114706924 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
114710959 Rassf1; ras association domain-containing protein 1 isoform X1 [KO:K09850 ]
Reference Authors Lee YS, Dutta A
Title MicroRNAs in cancer.
Journal Reference Authors Babashah S, Soleimani M
Title The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis.
Journal Reference Authors Garzon R, Calin GA, Croce CM
Title MicroRNAs in Cancer.
Journal Reference Authors Chen PS, Su JL, Hung MC
Title Dysregulation of microRNAs in cancer.
Journal Reference Authors Ling H, Zhang W, Calin GA
Title Principles of microRNA involvement in human cancers.
Journal Reference Authors Iorio MV, Croce CM
Title MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review.
Journal Reference Authors Sayed D, Abdellatif M
Title MicroRNAs in development and disease.
Journal Reference Authors Wang Q, Wang S, Wang H, Li P, Ma Z
Title MicroRNAs: novel biomarkers for lung cancer diagnosis, prediction and treatment.
Journal Reference Authors Song JH, Meltzer SJ
Title MicroRNAs in pathogenesis, diagnosis, and treatment of gastroesophageal cancers.
Journal Reference Authors Chu Y, Zhu H, Lv L, Zhou Y, Huo J
Title MiRNA s in oesophageal squamous cancer.
Journal Neth J Med 71:69-75 (2013)
Reference Authors Kan T, Meltzer SJ
Title MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma.
Journal Reference Authors Smith CM, Watson DI, Michael MZ, Hussey DJ
Title MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma.
Journal Reference Authors Song S, Ajani JA
Title The role of microRNAs in cancers of the upper gastrointestinal tract.
Journal Reference Authors Liu WH, Yeh SH, Chen PJ
Title Role of microRNAs in hepatitis B virus replication and pathogenesis.
Journal Reference Authors Hrasovec S, Glavac D
Title MicroRNAs as Novel Biomarkers in Colorectal Cancer.
Journal Reference Authors Liu H
Title MicroRNAs in breast cancer initiation and progression.
Journal Reference Authors Li SD, Zhang JR, Wang YQ, Wan XP
Title The role of microRNAs in ovarian cancer initiation and progression.
Journal Reference Authors Zabolotneva AA, Zhavoronkov A, Garazha AV, Roumiantsev SA, Buzdin AA
Title Characteristic patterns of microRNA expression in human bladder cancer.
Journal Reference Authors Saini S, Majid S, Dahiya R
Title Diet, microRNAs and prostate cancer.
Journal Related KO pathway
