KEGG   PATHWAY: pyu05225
Entry
pyu05225                    Pathway                                
Name
Hepatocellular carcinoma - Herpailurus yagouaroundi (jaguarundi)
Description
Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neoplasms etiologically linked to viral factors. It has been shown that, after HBV/HCV infection and alcohol or aflatoxin B1 exposure, genetic and epigenetic changes occur. The recurrent mutated genes were found to be highly enriched in multiple key driver signaling processes, including telomere maintenance, TP53, cell cycle regulation, the Wnt/beta-catenin pathway (CTNNB1 and AXIN1), the phosphatidylinositol-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway. Recent studies using whole-exome sequencing have revealed recurrent mutations in new driver genes involved in the chromatin remodelling (ARID1A and ARID2) and the oxidative stress (NFE2L2) pathways.
Class
Human Diseases; Cancer: specific types
Pathway map
pyu05225  Hepatocellular carcinoma
pyu05225

Disease
H00048  Hepatocellular carcinoma
Organism
Herpailurus yagouaroundi (jaguarundi) [GN:pyu]
Gene
121009727  NQO1; NAD(P)H dehydrogenase [quinone] 1 isoform X1 [KO:K00355] [EC:1.6.5.2]
121009974  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
121010047  BRD7; bromodomain-containing protein 7 [KO:K11723]
121010113  GSTT2B; LOW QUALITY PROTEIN: glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]
121010163  [KO:K00799] [EC:2.5.1.18]
121010164  [KO:K00799] [EC:2.5.1.18]
121010165  [KO:K00799] [EC:2.5.1.18]
121010702  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
121010888  WNT8A; protein Wnt-8a [KO:K00714]
121011002  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121011286  SMARCC1; SWI/SNF complex subunit SMARCC1 [KO:K11649]
121011444  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121011518  DPF1; zinc finger protein neuro-d4 isoform X1 [KO:K22198]
121011897  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
121012039  E2F1; transcription factor E2F1 [KO:K17454]
121012188  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
121012341  BCL2L1; bcl-2-like protein 1 [KO:K04570]
121012950  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
121013170  PHF10; PHD finger protein 10 isoform X1 [KO:K22197]
121013262  ARID1B; AT-rich interactive domain-containing protein 1B isoform X1 [KO:K11653]
121013545  SMARCA2; probable global transcription activator SNF2L2 [KO:K11647] [EC:5.6.2.-]
121013551  SHC3; SHC-transforming protein 3 [KO:K17448]
121013741  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
121013978  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
121013987  SMARCA4; transcription activator BRG1 isoform X1 [KO:K11647] [EC:5.6.2.-]
121014378  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
121014548  FZD8; frizzled-8 [KO:K02375]
121014969  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121015111  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121015261  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
121015308  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
121015318  AXIN2; axin-2 [KO:K04385]
121015654  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
121015982  TP53; cellular tumor antigen p53 [KO:K04451]
121016029  DVL2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
121016570  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121016685  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
121016686  WNT3A; protein Wnt-3a [KO:K00312]
121016831  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
121016859  PBRM1; protein polybromo-1 isoform X1 [KO:K11757]
121017018  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
121017536  ACTB; actin, cytoplasmic 1 [KO:K05692]
121017637  ACTL6B; actin-like protein 6B [KO:K11652]
121017718  FZD9; frizzled-9 [KO:K02842]
121017912  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
121017928  GSTM4; glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
121018052  ACTG1; actin, cytoplasmic 2 [KO:K05692]
121018482  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
121018751  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
121018827  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
121019071  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
121019121  TCF7L1; transcription factor 7-like 1 [KO:K04490]
121019131  TGFA; protransforming growth factor alpha [KO:K08774]
121019369  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
121019790  AXIN1; axin-1 isoform X1 [KO:K02157]
121020143  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
121020160  WNT9B; protein Wnt-9b [KO:K01064]
121020536  E2F3; transcription factor E2F3 [KO:K06620]
121020585  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121020862  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
121020936  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
121021042  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
121021383  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
121021432  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
121021465  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
121021890  SHC2; SHC-transforming protein 2 [KO:K17447]
121022123  WNT5B; protein Wnt-5b [KO:K00444]
121022226  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121022256  TXNRD3; thioredoxin reductase 3 [KO:K22182] [EC:1.8.1.9]
121022826  HRAS; GTPase HRas isoform X1 [KO:K02833]
121022836  WNT4; protein Wnt-4 [KO:K00408]
121022961  SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform X1 [KO:K11650]
121023018  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121023030  E2F2; transcription factor E2F2 [KO:K09389]
121023038  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
121023288  TXNRD2; thioredoxin reductase 2, mitochondrial isoform X1 [KO:K22182] [EC:1.8.1.9]
121023683  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
121023699  [KO:K23790]
121023737  GSTP1; glutathione S-transferase P [KO:K23790]
121023741  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
121023839  ARID1A; AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653]
121023852  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
121023947  BAD; bcl2-associated agonist of cell death [KO:K02158]
121023964  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
121024259  FZD10; frizzled-10 [KO:K02842]
121024748  FZD3; frizzled-3 isoform X1 [KO:K02329]
121026094  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
121026171  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
121027050  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
121027286  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
121027638  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
121027695  WNT2B; protein Wnt-2b [KO:K00182]
121027738  NRAS; GTPase NRas [KO:K07828]
121027988  FZD1; frizzled-1 [KO:K02432]
121028241  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
121028423  WNT16; protein Wnt-16 [KO:K01558]
121028442  WNT2; protein Wnt-2 [KO:K00182]
121028446  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
121028738  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
121028796  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
121029177  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
121029294  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
121029363  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
121029481  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
121029583  [KO:K00799] [EC:2.5.1.18]
121029585  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
121029586  [KO:K00799] [EC:2.5.1.18]
121029587  [KO:K00799] [EC:2.5.1.18]
121030749  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
121030921  FZD7; frizzled-7 isoform X1 [KO:K02432]
121030981  FZD5; frizzled-5 [KO:K02375]
121031082  WNT10A; protein Wnt-10a [KO:K01357]
121031083  WNT6; protein Wnt-6 [KO:K00445]
121031433  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
121031737  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
121032005  DPF3; zinc finger protein DPF3 isoform X1 [KO:K22198]
121032078  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
121032358  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121032920  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
121032957  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
121033506  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
121033562  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
121033733  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
121034018  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121034024  ACTL6A; actin-like protein 6A isoform X1 [KO:K11340]
121034071  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
121034522  [KO:K06621]
121034732  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
121036286  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
121037198  GSTO1; glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
121037199  GSTO2; glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
121037238  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
121037465  FRAT1; proto-oncogene FRAT1 [KO:K03069]
121037466  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
121037468  WNT8B; protein Wnt-8b [KO:K00714]
121038593  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 isoform X1 [KO:K11650]
121038637  WNT1; proto-oncogene Wnt-1 [KO:K03209]
121038640  WNT10B; protein Wnt-10b [KO:K01357]
121038809  KRAS; GTPase KRas isoform X1 [KO:K07827]
121038866  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
121038918  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
121039018  ARID2; AT-rich interactive domain-containing protein 2 [KO:K11765]
121039303  WNT11; protein Wnt-11 [KO:K01384]
121039382  FZD4; frizzled-4 isoform X1 [KO:K02354]
121039645  [KO:K11651]
121040175  WNT7B; protein Wnt-7b [KO:K00572]
121040433  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
121040502  TXNRD1; thioredoxin reductase 1, cytoplasmic isoform X1 [KO:K22182] [EC:1.8.1.9]
121040857  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
121040936  SMARCC2; SWI/SNF complex subunit SMARCC2 isoform X1 [KO:K11649]
121041205  WNT7A; protein Wnt-7a [KO:K00572]
121041241  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121041673  SHC4; SHC-transforming protein 4 [KO:K17449]
121041863  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
121041878  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
121042092  TERT; LOW QUALITY PROTEIN: telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
121042474  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121042823  FZD6; frizzled-6 [KO:K02376]
121042977  MYC; myc proto-oncogene protein [KO:K04377]
121043455  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
121044367  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
121044690  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
121044888  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
121044946  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X1 [KO:K11651]
121045102  FZD2; frizzled-2 [KO:K02235]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06793  Vinyl chloride
C06800  Aflatoxin B1
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
PMID:20639898
  Authors
Whittaker S, Marais R, Zhu AX
  Title
The role of signaling pathways in the development and treatment of hepatocellular carcinoma.
  Journal
Oncogene 29:4989-5005 (2010)
DOI:10.1038/onc.2010.236
Reference
PMID:26099527
  Authors
Zucman-Rossi J, Villanueva A, Nault JC, Llovet JM
  Title
Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.
  Journal
Gastroenterology 149:1226-1239.e4 (2015)
DOI:10.1053/j.gastro.2015.05.061
Reference
PMID:17295177
  Authors
Villanueva A, Newell P, Chiang DY, Friedman SL, Llovet JM.
  Title
Genomics and signaling pathways in hepatocellular carcinoma.
  Journal
Semin Liver Dis 27:55-76 (2007)
DOI:10.1055/s-2006-960171
Reference
PMID:16799620
  Authors
Breuhahn K, Longerich T, Schirmacher P
  Title
Dysregulation of growth factor signaling in human hepatocellular carcinoma.
  Journal
Oncogene 25:3787-800 (2006)
DOI:10.1038/sj.onc.1209556
Reference
PMID:19387255
  Authors
Minguez B, Tovar V, Chiang D, Villanueva A, Llovet JM
  Title
Pathogenesis of hepatocellular carcinoma and molecular therapies.
  Journal
Curr Opin Gastroenterol 25:186-94 (2009)
DOI:10.1097/MOG.0b013e32832962a1
Reference
PMID:21829020
  Authors
Kudo M
  Title
Signaling pathway and molecular-targeted therapy for hepatocellular carcinoma.
  Journal
Dig Dis 29:289-302 (2011)
DOI:10.1159/000327562
Reference
PMID:23994386
  Authors
Nault JC, Zucman-Rossi J
  Title
Genetics of hepatocellular carcinoma: the next generation.
  Journal
J Hepatol 60:224-6 (2014)
DOI:10.1016/j.jhep.2013.08.019
Reference
PMID:11935086
  Authors
Rocken C, Carl-McGrath S.
  Title
Pathology and pathogenesis of hepatocellular carcinoma.
  Journal
Dig Dis 19:269-78 (2001)
DOI:10.1159/000050693
Reference
PMID:21303380
  Authors
Cornella H, Alsinet C, Villanueva A
  Title
Molecular pathogenesis of hepatocellular carcinoma.
  Journal
Alcohol Clin Exp Res 35:821-5 (2011)
DOI:10.1111/j.1530-0277.2010.01406.x
Reference
PMID:27895396
  Authors
Niu ZS, Niu XJ, Wang WH
  Title
Genetic alterations in hepatocellular carcinoma: An update.
  Journal
World J Gastroenterol 22:9069-9095 (2016)
DOI:10.3748/wjg.v22.i41.9069
Reference
PMID:11956813
  Authors
Tannapfel A, Wittekind C
  Title
Genes involved in hepatocellular carcinoma: deregulation in cell cycling and apoptosis.
  Journal
Virchows Arch 440:345-52 (2002)
DOI:10.1007/s00428-002-0617-x
Reference
PMID:23426905
  Authors
Shiraha H, Yamamoto K, Namba M
  Title
Human hepatocyte carcinogenesis (review).
  Journal
Int J Oncol 42:1133-8 (2013)
DOI:10.3892/ijo.2013.1829
Reference
PMID:23887712
  Authors
Nault JC, Mallet M, Pilati C, Calderaro J, Bioulac-Sage P, Laurent C, Laurent A, Cherqui D, Balabaud C, Zucman-Rossi J
  Title
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
  Journal
Nat Commun 4:2218 (2013)
DOI:10.1038/ncomms3218
Reference
PMID:22561517
  Authors
Guichard C, Amaddeo G, Imbeaud S, Ladeiro Y, Pelletier L, Maad IB, Calderaro J, Bioulac-Sage P, Letexier M, Degos F, Clement B, Balabaud C, Chevet E, Laurent A, Couchy G, Letouze E, Calvo F, Zucman-Rossi J
  Title
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma.
  Journal
Nat Genet 44:694-8 (2012)
DOI:10.1038/ng.2256
Reference
  Authors
Praslicka BJ, Kerins MJ, Ooi A
  Title
The complex role of NRF2 in cancer: a genomic view
  Journal
Curr Opin Toxicol 1:37-45 (2016)
DOI:10.1016/j.cotox.2016.09.003
Reference
PMID:24024136
  Authors
Kansanen E, Kuosmanen SM, Leinonen H, Levonen AL
  Title
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer.
  Journal
Redox Biol 1:45-9 (2013)
DOI:10.1016/j.redox.2012.10.001
Reference
PMID:21251164
  Authors
Taguchi K, Motohashi H, Yamamoto M
  Title
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution.
  Journal
Genes Cells 16:123-40 (2011)
DOI:10.1111/j.1365-2443.2010.01473.x
Reference
PMID:20019356
  Authors
Klaunig JE, Kamendulis LM, Hocevar BA
  Title
Oxidative stress and oxidative damage in carcinogenesis.
  Journal
Toxicol Pathol 38:96-109 (2010)
DOI:10.1177/0192623309356453
Reference
PMID:11193292
  Authors
Krupp G, Bonatz G, Parwaresch R
  Title
Telomerase, immortality and cancer.
  Journal
Biotechnol Annu Rev 6:103-40 (2000)
DOI:10.1016/S1387-2656(00)06020-8
Reference
PMID:27323951
  Authors
Jafri MA, Ansari SA, Alqahtani MH, Shay JW
  Title
Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies.
  Journal
Genome Med 8:69 (2016)
DOI:10.1186/s13073-016-0324-x
Reference
PMID:27029895
  Authors
Shay JW
  Title
Role of Telomeres and Telomerase in Aging and Cancer.
  Journal
Cancer Discov 6:584-93 (2016)
DOI:10.1158/2159-8290.CD-16-0062
Reference
PMID:27508192
  Authors
Granito A, Guidetti E, Gramantieri L
  Title
c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma.
  Journal
J Hepatocell Carcinoma 2:29-38 (2015)
DOI:10.2147/JHC.S77038
Reference
PMID:16934487
  Authors
Vita M, Henriksson M
  Title
The Myc oncoprotein as a therapeutic target for human cancer.
  Journal
Semin Cancer Biol 16:318-30 (2006)
DOI:10.1016/j.semcancer.2006.07.015
Reference
PMID:24096051
  Authors
Qu A, Jiang C, Cai Y, Kim JH, Tanaka N, Ward JM, Shah YM, Gonzalez FJ
  Title
Role of Myc in hepatocellular proliferation and hepatocarcinogenesis.
  Journal
J Hepatol 60:331-8 (2014)
DOI:10.1016/j.jhep.2013.09.024
Related
pathway
pyu04010  MAPK signaling pathway
pyu04020  Calcium signaling pathway
pyu04110  Cell cycle
pyu04115  p53 signaling pathway
pyu04151  PI3K-Akt signaling pathway
pyu04310  Wnt signaling pathway
pyu04350  TGF-beta signaling pathway
pyu04932  Non-alcoholic fatty liver disease
pyu04936  Alcoholic liver disease
pyu05160  Hepatitis C
pyu05161  Hepatitis B
KO pathway
ko05225   

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