KEGG   PATHWAY: pyu04151
Entry
pyu04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Puma yagouaroundi (jaguarundi)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
pyu04151  PI3K-Akt signaling pathway
pyu04151

Other DBs
GO: 0043491
Organism
Puma yagouaroundi (jaguarundi) [GN:pyu]
Gene
121009751  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
121009985  [KO:K16197]
121010704  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
121010877  IL3; interleukin-3 [KO:K04736]
121010879  IL4; interleukin-4 [KO:K05430]
121010979  FGF18; fibroblast growth factor 18 [KO:K04358]
121010992  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
121011002  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121011033  [KO:K04659]
121011070  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
121011180  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
121011326  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
121011444  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121011574  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
121011719  LAMB3; laminin subunit beta-3 [KO:K06244]
121011754  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
121011824  LAMC1; laminin subunit gamma-1 [KO:K05635]
121011826  LAMC2; laminin subunit gamma-2 [KO:K06246]
121011911  TNR; tenascin-R isoform X1 [KO:K06252]
121011915  TNN; tenascin-N [KO:K06252]
121012144  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
121012171  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
121012211  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
121012341  BCL2L1; bcl-2-like protein 1 [KO:K04570]
121012369  ANGPT4; angiopoietin-4 [KO:K05467]
121012732  FGF9; fibroblast growth factor 9 [KO:K04358]
121012779  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
121012786  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
121012848  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
121012953  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
121013178  THBS2; thrombospondin-2 [KO:K04659]
121013424  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
121013433  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
121013479  LAMA2; laminin subunit alpha-2 [KO:K05637]
121013707  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
121013735  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
121013826  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
121013927  THBS4; thrombospondin-4 [KO:K04659]
121013976  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
121014008  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
121014032  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
121014096  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
121014214  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
121014270  [KO:K03914]
121014377  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
121014419  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
121014479  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
121014480  [KO:K06237]
121014485  IRS1; insulin receptor substrate 1 [KO:K16172]
121014604  ITGA8; integrin alpha-8 [KO:K06584]
121014630  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
121014860  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
121014969  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121015025  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
121015111  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121015217  [KO:K05438]
121015308  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
121015457  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
121015466  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
121015682  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
121015686  CRTC2; CREB-regulated transcription coactivator 2 [KO:K16333]
121015920  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
121015922  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
121015982  TP53; cellular tumor antigen p53 [KO:K04451]
121016084  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
121016402  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
121016570  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121016755  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
121017018  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
121017185  VTN; vitronectin [KO:K06251]
121017295  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
121017369  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
121017467  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
121017559  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
121017640  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
121017646  EPO; LOW QUALITY PROTEIN: erythropoietin [KO:K05437]
121017700  YWHAG; 14-3-3 protein gamma [KO:K16198]
121017912  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
121017923  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
121018030  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
121018664  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
121018739  FGF21; fibroblast growth factor 21 [KO:K22429]
121018749  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
121018756  NTF4; neurotrophin-4 [KO:K12457]
121018775  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
121018816  [KO:K03259]
121018940  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
121019131  TGFA; protransforming growth factor alpha [KO:K08774]
121019302  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
121019546  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
121019662  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
121019674  TSC2; tuberin isoform X1 [KO:K07207]
121019680  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
121019755  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
121019899  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
121019932  LAMA5; laminin subunit alpha-5 [KO:K06240]
121020018  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
121020145  ITGB3; integrin beta-3 [KO:K06493]
121020162  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
121020441  PRL; prolactin [KO:K05439]
121020585  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121020758  [KO:K02991]
121020761  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
121021042  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
121021049  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
121021085  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
121021222  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
121021362  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
121021368  PSPN; persephin [KO:K25416]
121021435  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
121021465  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
121021482  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
121021539  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
121021710  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
121021803  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
121021881  FGF22; fibroblast growth factor 22 [KO:K04358]
121021950  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
121021952  FGF23; fibroblast growth factor 23 [KO:K22428]
121021966  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
121021990  FGF6; fibroblast growth factor 6 [KO:K04358]
121021991  VWF; von Willebrand factor [KO:K03900]
121022079  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
121022119  NTF3; neurotrophin-3 [KO:K04356]
121022226  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121022329  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
121022388  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
121022465  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
121022503  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
121022610  OSM; oncostatin-M isoform X1 [KO:K05418]
121022654  YWHAH; 14-3-3 protein eta [KO:K16198]
121022826  HRAS; GTPase HRas isoform X1 [KO:K02833]
121022935  RHEB; GTP-binding protein Rheb [KO:K07208]
121022952  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
121023018  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121023145  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X1 [KO:K04541]
121023683  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
121023725  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
121023732  VEGFB; vascular endothelial growth factor B [KO:K16858]
121023744  FGF19; fibroblast growth factor 19 [KO:K22603]
121023745  FGF4; fibroblast growth factor 4 [KO:K04358]
121023815  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
121023852  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
121023947  BAD; bcl2-associated agonist of cell death [KO:K02158]
121023959  RELA; transcription factor p65 [KO:K04735]
121023964  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
121023965  INS; insulin [KO:K04526]
121023990  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
121024675  [KO:K02991]
121024820  MTCP1; protein p13 MTCP-1 [KO:K16837]
121024990  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
121025049  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
121025193  EFNA4; ephrin-A4 [KO:K05462]
121025256  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
121025312  EFNA3; ephrin-A3 [KO:K05462]
121025338  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
121025344  FGF16; fibroblast growth factor 16 [KO:K04358]
121025662  VEGFD; vascular endothelial growth factor D [KO:K05449]
121025749  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
121025762  [KO:K06237]
121025897  CHAD; chondroadherin [KO:K06248]
121026443  [KO:K10159]
121026463  [KO:K10159]
121026669  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
121026678  [KO:K05069]
121026680  [KO:K05069]
121026716  [KO:K04659]
121026718  [KO:K04659]
121026924  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
121027050  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
121027198  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
121027253  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
121027288  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
121027385  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
121027393  LPAR3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
121027429  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
121027641  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
121027738  NRAS; GTPase NRas [KO:K07828]
121027749  NGF; beta-nerve growth factor [KO:K02582]
121028117  PDGFC; platelet-derived growth factor C [KO:K05450]
121028276  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
121028280  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
121028446  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
121028557  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
121028638  IL6; interleukin-6 isoform X1 [KO:K05405]
121028649  ITGB8; integrin beta-8 [KO:K06591]
121028725  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
121028731  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
121028732  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
121028738  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
121028796  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
121028806  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
121028845  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
121028875  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
121028897  LAMB1; laminin subunit beta-1 [KO:K05636]
121028898  LAMB4; laminin subunit beta-4 [KO:K06245]
121029363  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
121029442  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
121029472  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
121029504  VEGFA; vascular endothelial growth factor A [KO:K05448]
121029518  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
121029643  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
121029870  FOXO3; forkhead box protein O3 [KO:K09408]
121029920  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
121030066  FGF2; fibroblast growth factor 2 isoform X1 [KO:K18497]
121030128  IL2; interleukin-2 [KO:K05429]
121030255  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
121030602  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
121030700  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
121030728  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
121030775  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
121030799  ITGAV; integrin alpha-V [KO:K06487]
121030974  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
121031012  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
121031014  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
121031029  FN1; fibronectin isoform X1 [KO:K05717]
121031535  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
121031653  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
121031737  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
121031761  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
121031875  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
121031882  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
121032059  PGF; placenta growth factor isoform X1 [KO:K16859]
121032108  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
121032300  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
121032306  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
121032358  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121032410  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
121032687  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
121032688  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
121032847  SPP1; osteopontin isoform X1 [KO:K06250]
121032895  [KO:K06253]
121032915  [KO:K16197]
121033084  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
121033166  LAMA1; laminin subunit alpha-1 [KO:K05637]
121033454  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
121033657  [KO:K06238]
121033659  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
121033660  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
121033707  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
121033710  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
121033733  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
121034018  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121034022  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
121034351  AREG; amphiregulin [KO:K09782]
121034362  EREG; proepiregulin [KO:K09784]
121034375  LAMC3; laminin subunit gamma-3 [KO:K06247]
121034394  [KO:K05415]
121034395  [KO:K05414]
121034508  RPS6; 40S ribosomal protein S6 [KO:K02991]
121034541  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
121034643  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
121034676  [KO:K06630]
121034828  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
121034834  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
121034886  TNC; tenascin isoform X1 [KO:K06252]
121034896  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
121035073  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
121035151  TSC1; hamartin isoform X1 [KO:K07206]
121035166  [KO:K05414]
121035373  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
121035466  [KO:K04540]
121035518  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
121035532  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
121035565  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
121035838  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
121035839  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
121035993  IFNAR1; LOW QUALITY PROTEIN: interferon alpha/beta receptor 1 [KO:K05130]
121035995  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
121036286  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
121036354  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
121036765  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
121036970  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
121037105  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
121037313  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
121037402  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
121037464  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
121037542  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
121037646  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
121037709  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
121037864  [KO:K02991]
121038088  IL7; interleukin-7 isoform X1 [KO:K05431]
121038165  SGK3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
121038440  ITGA5; integrin alpha-5 [KO:K06484]
121038496  ITGB7; LOW QUALITY PROTEIN: integrin beta-7 [KO:K06590]
121038506  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
121038550  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
121038661  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
121038670  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
121038809  KRAS; GTPase KRas isoform X1 [KO:K07827]
121038826  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
121038909  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
121039432  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
121039602  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
121039641  VEGFC; vascular endothelial growth factor C [KO:K05449]
121039795  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
121039831  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
121039893  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
121039962  FGF20; fibroblast growth factor 20 [KO:K04358]
121040318  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
121040328  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
121040515  HSP90B1; endoplasmin [KO:K09487]
121040524  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
121040655  KITLG; kit ligand [KO:K05461]
121040772  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
121040857  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
121040944  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
121040954  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
121040972  ITGA7; LOW QUALITY PROTEIN: integrin alpha-7 [KO:K06583]
121041241  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121041482  THBS1; thrombospondin-1 [KO:K16857]
121041681  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
121041716  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
121041807  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
121041863  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
121041896  ITGA11; integrin alpha-11 [KO:K06587]
121042474  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121042720  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
121042783  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
121042850  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
121042977  MYC; myc proto-oncogene protein [KO:K04377]
121043038  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
121043449  PRLR; prolactin receptor [KO:K05081]
121043454  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
121043476  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
121043625  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
121043684  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
121043807  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
121043998  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
121044073  YWHAQ; 14-3-3 protein theta [KO:K16197]
121044224  GHR; growth hormone receptor isoform X1 [KO:K05080]
121044367  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
121044420  FGF10; fibroblast growth factor 10 [KO:K04358]
121044434  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
121044475  ITGA1; integrin alpha-1 [KO:K06480]
121044484  ITGA2; integrin alpha-2 [KO:K06481]
121044690  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
121044798  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
121044805  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
121044817  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
121044824  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
121044914  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
121044924  CSF3; granulocyte colony-stimulating factor [KO:K05423]
121045000  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
121045013  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
121045051  G6PC1; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
121045059  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
121045083  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
121045100  ITGA2B; integrin alpha-IIb [KO:K06476]
121045294  RBL2; retinoblastoma-like protein 2 [KO:K16332]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
pyu00010  Glycolysis / Gluconeogenesis
pyu04010  MAPK signaling pathway
pyu04012  ErbB signaling pathway
pyu04062  Chemokine signaling pathway
pyu04064  NF-kappa B signaling pathway
pyu04068  FoxO signaling pathway
pyu04110  Cell cycle
pyu04115  p53 signaling pathway
pyu04150  mTOR signaling pathway
pyu04210  Apoptosis
pyu04370  VEGF signaling pathway
pyu04510  Focal adhesion
pyu04620  Toll-like receptor signaling pathway
pyu04630  JAK-STAT signaling pathway
pyu04662  B cell receptor signaling pathway
pyu04910  Insulin signaling pathway
KO pathway
ko04151   

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